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    Wa0038

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    Shehzad Qureshi
    The document summarizes the structure and components of skeletal muscle fibers. It notes that skeletal muscle fibers are composed of sarcolemma, myofibrils, actin and myosin filaments, Z disks, sarcomeres, titin filaments, sarcoplasm, and sarcoplasmic reticulum. The myosin and actin filaments overlap within the myofibrils to form light and dark bands that are important for muscle contraction through cross-bridge cycling interactions.

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    Wa0038

    Uploaded by

    Shehzad Qureshi
    17 views10 pages
    The document summarizes the structure and components of skeletal muscle fibers. It notes that skeletal muscle fibers are composed of sarcolemma, myofibrils, actin and myosin filaments, Z disks, sarcomeres, titin filaments, sarcoplasm, and sarcoplasmic reticulum. The myosin and actin filaments overlap within the myofibrils to form light and dark bands that are important for muscle contraction through cross-bridge cycling interactions.

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    dpt

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    DOC-20190413-WA0038

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    The document summarizes the structure and components of skeletal muscle fibers. It notes that skeletal muscle fibers are composed of sarcolemma, myofibrils, actin and myosin filaments, Z disks, sarcomeres, titin filaments, sarcoplasm, and sarcoplasmic reticulum. The myosin and actin filaments overlap within the myofibrils to form light and dark bands that are important for muscle contraction through cross-bridge cycling interactions.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    17 views10 pages

    Wa0038

    Uploaded by

    Shehzad Qureshi
    The document summarizes the structure and components of skeletal muscle fibers. It notes that skeletal muscle fibers are composed of sarcolemma, myofibrils, actin and myosin filaments, Z disks, sarcomeres, titin filaments, sarcoplasm, and sarcoplasmic reticulum. The myosin and actin filaments overlap within the myofibrils to form light and dark bands that are important for muscle contraction through cross-bridge cycling interactions.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    of 10

    Dr.

    Muhammad Uzair Rehman


     About 40 percent of the body is skeletal
    muscle, and perhaps another 10 percent is
    smooth and cardiac muscle.
     Each fiber extends the entire length of the
    muscle.
     Except for about 2 percent of the fibers, each
    fiber is usually innervated by only one nerve
    ending, located near the middle of the fiber.
     The Sarcolemma Is a Thin Membrane
    Enclosing a Skeletal Muscle Fiber:
    ◦ sarcolemma consists of a true cell membrane,
    called the plasma membrane, and an outer coat
    made up of a thin layer of polysaccharide material
    that contains numerous thin collagen fibrils.
    ◦ At each end of the muscle fiber, this surface layer
    of the sarcolemma fuses with a tendon fiber.
     Each muscle fiber contains several hundred to
    several thousand myofibrils
     Each myofibril is composed of about 1500
    adjacent myosin filaments and 3000 actin
    filaments, which are large polymerized
    protein molecules that are responsible for the
    actual muscle contraction.
     The myosin and actin filaments partially
    interdigitate and thus cause the myofibrils to
    have alternate light and dark bands.
     light bands contain only actin filaments and
    are called I bands because they are isotropic
    to polarized light. The dark bands contain
    myosin filaments, as well as the ends of the
    actin filaments where they overlap the
    myosin, and are called A bands because they
    are anisotropic to polarized light.
     Small projections from the sides of the
    myosin filaments are cross bridges It is the
    interaction between these cross-bridges and
    the actin filaments that causes contraction.
     Ends of the actin filaments are attached to a Z
    disk. From this disc, these filaments extend
    in both directions to interdigitate with the
    myosin filaments.
     Z disk, which is composed of filamentous
    proteins different from the actin and myosin
    filaments, passes crosswise across the
    myofibril and also crosswise from myofibril to
    myofibril, attaching the myofibrils to one
    another all the way across the muscle fiber.
     The portion of the myofibril (or of the whole
    muscle fiber) that lies between two successive
    Z disks is called a sarcomere.
     Titin Filamentous Molecules Keep the Myosin
    and Actin Filaments in Place
     Sarcoplasm Is the Intracellular Fluid between
    Myofibrils
    ◦ containing large quantities of potassium,
    magnesium, and phosphate, plus multiple protein
    enzymes.
     Sarcoplasmic Reticulum Is a Specialized
    Endoplasmic Reticulum of Skeletal Muscle
     This reticulum has a special organization that
    is extremely important in regulating calcium
    storage, release, and reuptake and therefore
    muscle contraction.

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