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    Cretinism: Amira Fithri R. Supervisor: Dr. Imam Kusmadi, Sp. A

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    Amira FR
    This document discusses cretinism, a condition caused by congenital hypothyroidism. It defines cretinism as inadequate thyroid hormone production in newborns. Causes can be endogenous or exogenous and include defects in the thyroid gland itself such as agenesis, hypoplasia, or dysplasia. Signs and symptoms include poor feeding, decreased activity, large fontanelle, and developmental delay. Diagnosis involves laboratory tests of thyroid stimulating hormone and thyroid hormone levels. Treatment is with levothyroxine to normalize thyroid hormone levels and achieve a target TSH range, with long-term monitoring required.

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    Cretinism: Amira Fithri R. Supervisor: Dr. Imam Kusmadi, Sp. A

    Uploaded by

    Amira FR
    172 views27 pages
    This document discusses cretinism, a condition caused by congenital hypothyroidism. It defines cretinism as inadequate thyroid hormone production in newborns. Causes can be endogenous or exogenous and include defects in the thyroid gland itself such as agenesis, hypoplasia, or dysplasia. Signs and symptoms include poor feeding, decreased activity, large fontanelle, and developmental delay. Diagnosis involves laboratory tests of thyroid stimulating hormone and thyroid hormone levels. Treatment is with levothyroxine to normalize thyroid hormone levels and achieve a target TSH range, with long-term monitoring required.

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    Cretinism

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    This document discusses cretinism, a condition caused by congenital hypothyroidism. It defines cretinism as inadequate thyroid hormone production in newborns. Causes can be endogenous or exogenous and include defects in the thyroid gland itself such as agenesis, hypoplasia, or dysplasia. Signs and symptoms include poor feeding, decreased activity, large fontanelle, and developmental delay. Diagnosis involves laboratory tests of thyroid stimulating hormone and thyroid hormone levels. Treatment is with levothyroxine to normalize thyroid hormone levels and achieve a target TSH range, with long-term monitoring required.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    172 views27 pages

    Cretinism: Amira Fithri R. Supervisor: Dr. Imam Kusmadi, Sp. A

    Uploaded by

    Amira FR
    This document discusses cretinism, a condition caused by congenital hypothyroidism. It defines cretinism as inadequate thyroid hormone production in newborns. Causes can be endogenous or exogenous and include defects in the thyroid gland itself such as agenesis, hypoplasia, or dysplasia. Signs and symptoms include poor feeding, decreased activity, large fontanelle, and developmental delay. Diagnosis involves laboratory tests of thyroid stimulating hormone and thyroid hormone levels. Treatment is with levothyroxine to normalize thyroid hormone levels and achieve a target TSH range, with long-term monitoring required.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    of 27

    CRETINISM

    Amira Fithri R.

    Supervisor: dr. Imam Kusmadi, Sp. A


    “CRETINISM = CONGENITAL
    HYPOTHYROID”

    Inadequate thyroid hormone


    production in newborn infants
    CAUSES

    ENDOGENOUS / EXOGENOUS
    Anatomy of Thyroid
    Gland
    Histology of Thyroid
    Gland
    Pathophysiology
    Cretinism
    Hypothyroidism

    Endemic Sporadic
    Primary Congenital Hypothyroid
    Defects in the
    thyroid gland
    itself

    AGENESIS HYPOPLASIA DYSPLASIA

    DYSHORMONO ECTOPIC
    GENESIS THYROID
    Central Congenital Hypothyroid

    • Abnormal
    development
    • Genetic alterations Caused by dysfunction of
    hypothalamic or pituitary
    control of the thyroid axis
    Signs and Symptoms
    Cretinism
    Poor feeding
    Decrease Large anterior
    and weight
    d activity fontanelle gain

    Decreased Hypotoni
    Small stature
    stooling
    or poor growth a
    (constipation)

    Hoarse
    cry
    Physical Findings
    Cretinism
    Coarse facial Macroglo Large
    features ssia Fontanelle

    Umbilical Developme
    Hernia ntal Delay Pallor
    Cutis
    Marmorata Goiter
    Workups
    Cretinism
    Laboratory
    Findings

    Thyroid
    Serum Thyroid
    Stimulating
    Hormone Hormone
    Treatments
    Cretinism
    Levothyroxine
    • Class: Thyroid hormones
    • Contents: Thyroxine Na
    • Dosage: 10-15 mcg/kg/day, innitial dose for
    newborn: 50 mcg
    • Presentation / Packing: Euthyrox Tab 150 mcg,
    Euthyrox Tab 100 mcg, Euthyrox Tab 50 mcg,
    Euthyrox Tab 25 mcg
    • Administration: Tablets should be crushed and
    mixed with a few milliliters of formula, breast
    milk, or water. Tablets can be chewed also.

    • Normalize the serum T4


    level within 2 weeks (fT4
    GOAL > 2 ng/dL)
    • Achieving a TSH level of
    1 to 2 mlU/L
    Long-term Monitoring

    First 6
    1st year of 2-3 years:
    Innitial months:
    4-6 weeks life: every every 3-4
    therapy every 1-2
    2-3 months months
    months
    THANK YOU

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