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    S&M Cystadenoma, H Mole

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    Shefali Goyal
    Polycystic ovarian disease affects 3-6% of reproductive aged women and is characterized by numerous cystic follicles, often associated with irregular periods. Serous cystadenomas are the most common ovarian neoplasms and present as unilateral, thin walled cysts filled with straw colored fluid. Microscopically, they are lined by low columnar epithelium resembling tubule epithelium. Mucinous cystadenomas also arise from ovarian surface epithelium and present as larger, multilocular cysts containing viscid mucinous fluid. Microscopically, they are lined by tall columnar epithelium with mucinous vacuoles. Gestational trophoblastic diseases include hydatidiform moles,

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    S&M Cystadenoma, H Mole

    Uploaded by

    Shefali Goyal
    8 views35 pages
    Polycystic ovarian disease affects 3-6% of reproductive aged women and is characterized by numerous cystic follicles, often associated with irregular periods. Serous cystadenomas are the most common ovarian neoplasms and present as unilateral, thin walled cysts filled with straw colored fluid. Microscopically, they are lined by low columnar epithelium resembling tubule epithelium. Mucinous cystadenomas also arise from ovarian surface epithelium and present as larger, multilocular cysts containing viscid mucinous fluid. Microscopically, they are lined by tall columnar epithelium with mucinous vacuoles. Gestational trophoblastic diseases include hydatidiform moles,

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    S&M CYSTADENOMA, H MOLE

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    Polycystic ovarian disease affects 3-6% of reproductive aged women and is characterized by numerous cystic follicles, often associated with irregular periods. Serous cystadenomas are the most common ovarian neoplasms and present as unilateral, thin walled cysts filled with straw colored fluid. Microscopically, they are lined by low columnar epithelium resembling tubule epithelium. Mucinous cystadenomas also arise from ovarian surface epithelium and present as larger, multilocular cysts containing viscid mucinous fluid. Microscopically, they are lined by tall columnar epithelium with mucinous vacuoles. Gestational trophoblastic diseases include hydatidiform moles,

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    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    8 views35 pages

    S&M Cystadenoma, H Mole

    Uploaded by

    Shefali Goyal
    Polycystic ovarian disease affects 3-6% of reproductive aged women and is characterized by numerous cystic follicles, often associated with irregular periods. Serous cystadenomas are the most common ovarian neoplasms and present as unilateral, thin walled cysts filled with straw colored fluid. Microscopically, they are lined by low columnar epithelium resembling tubule epithelium. Mucinous cystadenomas also arise from ovarian surface epithelium and present as larger, multilocular cysts containing viscid mucinous fluid. Microscopically, they are lined by tall columnar epithelium with mucinous vacuoles. Gestational trophoblastic diseases include hydatidiform moles,

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    POLYCYSTIC OVARIES

     Polycystic ovarian disease (PCOD; formerly


    termed SteinLeventhal syndrome) affects 3% to
    6% ofreproductive-age women. The central
    pathologic abnormality is numerous cystic
    follicles or folliclecysts, often associated with
    oligomenorrhea. Women with PCOD have
    persistent anovulation, obesity (40%), hirsutism
    (50%).
    SEROUS CYSTADENOMA
     MOST COMMON NEOPLASMS OF OVARY
     CAN BE FOUND AT ANY AGE
     MC BETWEEN 20-50 YRS OF AGE
     BILATERAL INVOLVEMENT OCCUR IN 20%
    CASES
    GROSS
     IT IS UNILOCULAR, THIN WALLED CYST
    FILLED WITH STRAW COLOURED WATERY
    FLUID
     EXTERNAL SURFACE IS
    SEMITRANSLUCENT, SMOOTH
     IT MAY BE LESS THAN 1 CM TO AS MUCH
    AS 30 CM IN DIAMETER
    MICROSCOPIC EXAMINATION
     IT IS LINED BY PROPERLY ORIENTED LOW
    COLUMNAR EPITHELIUM WHICH IS
    CILIATED AND RESEMBLES TUBULE
    EPITHELIUM

     MICROSCOPIC PAPILLAE MAY BE FOUND


    MUCINOUS CYSTADENOMA
     MUCINOUS CYSTADENOMA ALSO ARISES
    FROM SURFACE EPITHELIUM OF OVARY
    BUT ARE LESS COMMON THAN SEROUS
    CYSTADENOMA
     THEY OCCUR PRINCIPALLY IN MID ADULT
    LIFE & ARE RARE BEFORE PUBERTY &
    AFTER MENOPAUSE
     BILATERAL INVOLVEMENT IS RARE &
    OCCURS IN 5% CASES
    GROSS
     THEY ARE LARGER THAN SEROUS
    TUMOURS
     THEY ARE TYPICALLY MULTILOCULAR
     THIN WALLED CYST WITH SMOOTH
    EXTERNAL SURFACE CONTAINING
    STICKY, VISCID, GELATINOUS FLUID RICH
    IN GLYCOPROTEIN
     LOCULI VARY IN SIZE & OFTEN TUMOUR
    MAY BE COMPOSED OF ONE MAJOR
    CAVITY WITH MANY DAUGHTER CYST
    MICROSCOPIC EXAMINATION
     IT IS CHARACTERISED BY LINING OF NON
    CILIATED, TALL, COLUMNAR EPITHELIUM
    CELLS WITH BASAL NUCLEI & APICAL
    MUCINOUS VACUOLES SIMILAR TO
    BENIGN CERVICAL & INTESTINAL
    EPITHELIUM
     THERE IS VERY LITTLE TENDENCY TO
    PAPILLARY PROLIFERATION OF THE
    EPITHELIUM
    GESTATIONAL AND PLACENTAL DISORDERS

     Diseases of pregnancy and pathologic conditions


    of the placenta are important causes of
    intrauterine or perinatal death, congenital
    malformations, intrauterine growth retardation,
    maternal death, and a great deal of morbidity for
    both mother and child.
     The placenta is composed of chorionic villi that
    sprout from the chorion to provide a large contact
    area between the fetal and maternal circulations.
    HYDATIFORM MOLE
     It is characterised histologically by cystic
    swelling of chorionic villi
     Accompanied by variable trophoblastic
    proliferation
     In the past, most patients presented with 4-5
    months of pregnancy with vaginal bleeding
     Nowadays, they are diagnosed earlier due to
    regular ultrasound
     H. mole may be invasive & non invasive
     Two types of non invasive moles-
     1.Complete/ classic mole
     2.Partial mole
    CLINICAL FEATURES.

     Most women with partial and early complete moles


    present with spontaneous pregnancy loss or undergo
    curettage because of abnormalities in ultrasound
    showing diffuse villous enlargement.
     In complete moles quantitative analysis of human
    chorionic gonadotropin (HCG) shows levels of hormone
    greatly exceeding those produced during a normal
    pregnancy of similar gestational age.
     The vast majority of moles are removed by thorough
    curettage.
    COMPLETE MOLE
     IN THIS, ALL OR MOST OF THE VILLI ARE
    EDEMATOUS & THERE IS
    CIRCUMFERENTIAL PROLIFERATION

     THE CYTOLOGICAL STUDY SHOWS


    DIPLOID PATTERN (44XX) IN 90% CASES
    PARTIAL MOLE
     IN THIS, SOME VILLI SHOW EDEMATOUS
    CHANGES WHILE OTHER ARE NORMAL

     TROPHOBLASTIC PROLIFERATION IS
    FOCAL

     THE KARYOTYPE IS MOSTLY TRIPLOID


    GROSS
     UTERINE CAVITY IS FILLED WITH
    DELICATE FRIABLE MASSES OF THIN
    WALLED TRANSLUCENT CYSTIC GRAPE
    LIKE STRUCTURES

     FOETAL PARTS ARE SEEN IN PARTIAL


    MOLE NOT IN COMPLETE MOLE
    MICROSCOPIC EXAMINATION
     IN PARTIAL MOLE, VILLOUS EDEMA INVOLVES
    PORTION OF VILLI
     THE TROPHOBLASTIC PROLIFERATION IS FOCAL
     IN COMPLETE MOLE, HYDROPIC CHANGES
    INVOLVE MOST OF THE VILLI & THERE IS
    ABSENCE OF VASCULATURE IN THESE VILLI
     THE CIRCUMFERENTIAL PROLIFERATION OF
    TROPHOBLASTIC CELLS PRODUCES SHEETS &
    MASSES OF CELLS
     IN COMPLETE MOLE, BOTH
    SYNCYTIOTROPHOBLAST &
    CYTOTROPHOBLASTS ARE
    PROLIFERATING WHEREAS IN PARTIAL
    MOLE, SYNCYTIOTROPHOBLASTS ARE
    PROLIFERATING

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