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    Epidemiologi Molekuler 01

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    Nesa nazla Silvia

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    Epidemiologi Molekuler 01

    Uploaded by

    Nesa nazla Silvia
    67 views13 pages

    Original Title

    EPIDEMIOLOGI MOLEKULER 01

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    Copyright:

    © All Rights Reserved
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    Download as ppt, pdf, or txt
    67 views13 pages

    Epidemiologi Molekuler 01

    Uploaded by

    Nesa nazla Silvia

    Copyright:

    © All Rights Reserved
    Download as PPT, PDF, TXT or read online from Scribd
    Download as ppt, pdf, or txt
    of 13

    PENGERTIAN EPIDEMIOLOGI MOLEKULER

    Definisi
    Ruang lingkup
    Peran dalam Kesehatan Masyarakat
    Masyarakat Sehat
    (healthy people)

    Masyarakat dalam risiko


    (Risk People)

    Masyarakat sakit
    (sick people)

    Figure of Condition of health in community


    Contoh Kasus

    Disfungsi tiroid pada wanita pekerja pembersih


    sisa daun bawang pasca panen. Pajanan gas dari
    kulit bawang selama beberapa tahun
    menyebabkan perubahan genetik; yang berakibat
    pada perubahan fungsi protein yang mengatur
    fungsi kelenjar tiroid sehingga produksi hormon
    tiroid terganggu dan berakibat disfungsi tiroid.
    Pembuktian terjadinya disfungsi tiroid
    menggunakan parameter molekuler, yang dapat
    dideteksi secara dini.
    TIK

    Mahasiswa dapat menjelaskan tentang


    • definisi epidemiologi molekuler
    • ruang lingkup epidemiologi molekuler
    • Peran dan manfaat epidemiologi
    molekuler dalam kesehatan masyarakat
    Definisi Epidemiologi Molekuler
    • Higginson J : “the application of sophisticated techniques
    to the epidemiologic study of biological material”
    • Schulte PA: “molecular epidemiology is the use of
    biologic markers or biologic measurements in
    epidemiologic research”
    • Tompkins LS: “the application of molecular biology to
    the study of infectious disease epidemiology”
    • McMichael AJ: “using molecular biomarkers in
    epidemiology”
    • Groopman JD, Kensler TW, Links JM: “molecular
    epidemiologic research involves the identification of
    relations between previous exposure to some putative
    causative agent and subsequent biological effects in a
    cluster of individuals in populations”
    Definisi Epidemiologi Molekuler
    • Hall A: “the analysis of nucleic acids and proteins in the
    study of health and disease determinants in human
    populations”
    • Shpilberg O, Dorman JS, Ferrell RE, et al.:“molecular
    epidemiology uses molecular techniques to define
    disease and its pre-clinical states, to quantify exposure
    and its early biological effect, and to identify the
    presence of susceptibility genes”
    • Levin BR, Lipsitch M, Bonhoeffer S: “the practical goals
    of molecular epidemiology are to identify the
    microparasites responsible for infectious diseases and
    determine their physical sources, their biological
    relationships, and their route of transmission and those
    of the genes responsible for their virulence,
    vaccinerelevant antigens and drug resistance”
    Ruang lingkup

    • Penggunaan marker/petanda molekuler


    (DNA, RNA, Protein) utk studi epidemiologi
    • Penerapan teknik & metode biologi
    molekuler (PCR, ELISA, elektroforesis)
    – Teknik/cara kerja laboratorik
    • Hasil  informasi genetik (ekspresi,
    mutasi, polimorfisme)
    Objek yg dibahas

    • Penyakit (menular & tidak menular)


    • Respon thd xenobiotics (polutan,
    pestisida, obat, B3 lain)  lingkungan
    Material yg diolah

    • Asam nukleat (DNA, RNA)


    • Asam amino
    • Protein
    Jenjang Material Molekuler
    • Basa
    – Purine (Guanine [G], Cytocine [C])
    – Pyrimidine (Adenine [A], Tymine [T], Uracil
    [U])
    • Asam amino tersusun dr 3 basa
    • Protein  tersusun dr asam amino
    • Enzim (terbntuk dr protein)
    – Membantu metabolisme  ggn metab
    • Hormon (trbntuk dr protein)
    – Mgndalikan produksi enzim  ggn metab
    Riwayat alamiah penyakit

    paparan
    Perubahan biologik
    gejala
    wkt trdeteksi
    mati
    A B C D
    Fase rentan Periode Periode Fase terminal
    Skrining faktor risiko subklinis klinis
    Skining utk diagnosis
    deteksi dini
    dini
    Teknik Molekuler
    Teknik

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