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- International Islamic University, Chittagong, Pharmacy, Graduate StudentWalailak University, School of Allied Health Sciences, Graduate Studentadd
- Good day. I am Naymul Karim from Southern Part of Bangladesh, doing PhD in Food Science under the College of Biosyste... moreGood day. I am Naymul Karim from Southern Part of Bangladesh, doing PhD in Food Science under the College of Biosystems Engineering and Food Science from Zhejiang University, China. I finished MSc in Biomedical Science (from 2015 to 2017), achieving InterGrad scholarship from Walailak University (WU), Thailand. My Master’s research was on “mangosteen and its xanthone derivatives against HFD/STZ-induced type II diabetes”. I did Bachelor in Pharmacy (B. pharma, 4 years) from International Islamic University Chittagong (IIUC), Bangladesh. In PhD, I am working to evaluate the protective effect of functional foods and their bioactive compounds against chronic diseases (e.g. metabolic disease, diabetes, and cancer) using different cell lines and animal model.edit
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Research Interests: Plant Biology and Ecology
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Type II diabetes (T2D) nephropathy, a major cause of end-stage kidney disease, progresses and develops from oxidative stress. Natural polyphenols can protect the kidney from diabetic nephropathy exerting antioxidant activities. The... more
Type II diabetes (T2D) nephropathy, a major cause of end-stage kidney disease, progresses and develops from oxidative stress. Natural polyphenols can protect the kidney from diabetic nephropathy exerting antioxidant activities. The present approach enumerates the reno-protective and anti-apoptotic effects of mangosteen vinegar rind (MVR, a phenolic aqueous extract) against high-fat diet (5 g/day up to five weeks)-/streptozotocin (single ip, dose 30 mg/kgBW)-induced T2D nephropathy of albino mice. In vitro total phenolic content, 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) activity, 2,2-diphenyl-1-picrylhydrazyl (DPPH) antioxidant capacity, and α-amylase inhibition activity as antidiabetic assay of MVR were performed. In vivo mice body weight, oral glucose, and maltose tolerance test, metabolic parameters (plasma glucose, insulin level, omeostasis model assessment-estimated insulin resistance), biochemical parameters (kidney hypertrophy, blood urea nitrogen, creatinine), oxidative stress parameters (malondialdehyde, superoxide dismutase, catalase) were estimated in an intervention study. Additionally, renal morphology and early apoptosis were observed following the H & E staining and TUNEL assay of the tissue frozen section. We found that the aqueous extract of MVR possesses potent in vitro antioxidative and antidiabetic activities. Animal intervention results showed that MVR 100, 200 mg/kgBW, and Glibenclamide 60 mg/kgBW treatments significantly improved (P < 0.05) the abovementioned parameters compared to the diabetic control group. Furthermore, treatments also significantly restored (P < 0.05) kidney histological alterations and reduced cellular apoptosis compared to the diabetic control group. These findings concluded that MVR treatments significantly modulated the glucose intolerance, metabolic alterations, and oxidative stress-induced pathological alterations and cellular apoptosis of diabetic kidney.
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Hyperglycemia is well-known for inducing cellular oxidative damage in type II diabetes (T2D) patients. This research addressed the cytoprotective and anti-genotoxic effect of xanthone derivatives from Garcinia mangostana against hydrogen... more
Hyperglycemia is well-known for inducing cellular oxidative damage in type II diabetes (T2D) patients. This research addressed the cytoprotective and anti-genotoxic effect of xanthone derivatives from Garcinia mangostana against hydrogen peroxide (H 2 O 2)-induced human peripheral blood mononuclear cell (PBMC) and blood leukocytes damage of the normal and T2D volunteers. The cytoprotective effects of an aqueous extract of xanthone (100 and 200 µg/mL) was assessed on cell viability and free radical scavenging activity using the trypan blue exclusion method on PBMC cells. Malondialdehyde (MDA) levels and lactate dehydrogenase (LDH) activity were measured as cellular oxidative damage markers and estimated from culture medium of PBMCs of normal and T2D volunteers. The anti-genotoxicity was assessed as the protective effect of xanthone against H 2 O 2-induce DNA damage of blood leukocytes of the normal volunteers following comet assay technique. Xanthone and Gallic acid (control) concentrations 100, 200 and 100 µg/mL significantly (P < 0.05) protected from H 2 O 2 (20 mM)-induced oxidative damage of PBMCs. It was confirmed by increased cell viability and free radical scavenging activity coupled with the decreased MDA and LDH levels in cell culture medium compared to H 2 O 2 (20 mM)-treated group. In H 2 O 2 (40 mM)-induced blood leukocytes of normal volunteers, different concentration xanthone (50-500 µg/mL) significantly (P < 0.05) improved the anti-genotoxicity effect compared to negative/positive control group by lowering comet formation. Xanthone treatments on PBMCs and blood leukocytes of the normal and T2D volunteers could attenuate the H 2 O 2-induced cellular oxidative damage and cell death via exhibiting antioxidant and free radical scavenging activities.
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Purpose – For the prevention and cure of disease, patient use various types of chemical and drug agents. Along with their curative effect, almost all drugs have some destructive effects and side-effects. Due to the minimal and/or none of... more
Purpose – For the prevention and cure of disease, patient use various types of chemical and drug agents. Along with their curative effect, almost all drugs have some destructive effects and side-effects. Due to the minimal and/or none of unwanted side-effect, recently, the use of herbal remedy as the drug of choice becomes the preference choice. The mangosteen, Garcinia mangostana, contains various types of polyphenols. It has been used as a traditional medicine from the ancient times till present days. The purpose of this paper is to investigate the biological properties of mangosteen in relation to health promotion effects. Design/methodology/approach – Several research papers from well-known database (such as PubMed, Google scholar, Scopus and Sciencedirect) were reviewed without considering publication-times to understand the biological properties of mangosteen. Findings – Mangosteen and its xanthone exerted diverse biological activities such as anti-oxidant, anti-inflammatory, anti-allergy, anti-bacteria, anti-fungal, anti-malaria, anticancer and anti-diabetes. Originality/value – Based on these studies, mangosteen is beneficial dietary supplement of overall human health.
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Naringenin exerts potential protective effect against metabolic disorder.Bioavailability and health effects of naringenin are discussed.Naringenin has the potential to be a dietary supplement against metabolic disease.Potential sources of... more
Naringenin exerts potential protective effect against metabolic disorder.Bioavailability and health effects of naringenin are discussed.Naringenin has the potential to be a dietary supplement against metabolic disease.Potential sources of naringenin are summarized.Metabolic syndromes are the multi-metabolic abnormality characterized by hyperlipidemia, obesity, hyperglycemia, diabetes, hypertension, cardiovascular disease, and neuro-dysfunction. Naringenin, a naturally occurring flavanone compound, abundantly found in citrus fruit, has demonstrated diverse biological activities. In this context, the role of naringenin in the treatment of metabolic disease and alternative sources for high-yield production of naringenin have recently drawn full scientific attention and become an important issue in research.This review focuses on recent findings of naringenin against metabolic disorders including oxidative stress, hyperlipidemia, obesity, diabetes, inflammation, and organ toxicity. Also, this review highlights the potential sources of naringenin production.Naringenin exerts its protective effect against metabolic diseases through multiple mechanisms including its antioxidant activity by scavenging free radicals, inducing antioxidant enzymes and targeting on phosphoinositide 3-kinase/protein Kinase B/nuclear factor (erythroid-derived 2)-like 2 (PI3K/Akt/Nrf2), nuclear factor (erythroid-derived 2)-like 2/antioxidant responsive element (NRf2/ARE), nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB), mitogen-activated protein kinase (MAPK), 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase, peroxisome proliferator-activated receptor (PPAR), and nitric oxide-cGMP-protein kinase G-induced KATP channel (NO-cGMP-PKG-KATP). Moreover, microbial production is recommended as a promising alternative method for large-scale production of naringenin. In conclusion, naringenin is a promising compound for the prevention and management of metabolic diseases. Further clinical studies and trials are needed to prove its protective effects on metabolic syndrome in the human population.
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Diabetes mellitus is described as a metabolic disorder with multiple etiology, characterized by chronic hyperglycemia with disturbances of carbohydrate, fat, and protein metabolisms. Recently, obesity has been identified as a risk factor... more
Diabetes mellitus is described as a metabolic disorder with multiple etiology, characterized by chronic hyperglycemia with disturbances of carbohydrate, fat, and protein metabolisms. Recently, obesity has been identified as a risk factor of developing type II diabetes, at about 80-85 %. 1 out of 3 people with type II diabetes develop kidney disease. Garcinia mangostana is used as a traditional medicine in various types of disease, such as abdominal pain, dysentery, wound infections, suppuration, and chronic ulcers. Previous studies have revealed that G. mangostana has good antioxidant, antitumoral, antiallergic, anti-inflammatory, antibacterial, and antiviral activities. In this study, an aqueous extract of xanthone derivative from G. mangostana was used, and the total phenolic content and total antioxidant capacity was assessed. Mice body weight, plasma glucose level, kidney hypertrophy (KI, kidney damage indicator), kidney function test (BUN, CREA), plasma, and kidney tissue melondialdehyde level (MDA, as oxidative damage marker) were evaluated in a high fat diet/streptozotocin (HFD/STZ)-induced type II diabetes mouse model. The results showed that the total phenolic compound in xanthone was 272.62±2.26 µg GAE/mg extract and, in the case of the total antioxidant capacity, % of inhibition of xanthone was 88.40±0.25 µmol TEAC/mg extract, respectively. This has significant correlation (R 2 = 0.9777) to the total phenolic content. In the in vivo study, increased body weight, plasma glucose level, kidney hypertrophy, plasma kidney profile, plasma, and kidney tissue melondialdehyde levels were significantly increased (P < 0.05) in the HFD/STZ-induced type II diabetes mouse model. Co-treatment with xanthone significantly (P < 0.05) improved all of the biochemical parameters and body weight in the mouse model. Taken together, the results indicate that xanthone possesses a potent renoprotective effect in type II diabetes mice.
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Objective: The present study was designed to investigate the thrombolytic activity of methanolic extract of leaves of Mesua ferrea. Method: Methanolic extract of Mesua ferrea.Was used to evaluate various phytochemical methods.... more
Objective: The present study was designed to investigate the thrombolytic activity of methanolic extract of leaves of Mesua ferrea. Method: Methanolic extract of Mesua ferrea.Was used to evaluate various phytochemical methods. Thrombolytic effect of the fraction was investigated in clot lysis experiment. Result: The extract exerted 36.32% lysis of the blood clot in thrombolytic activity test while 85.45% and 7.5% lysis were obtained for positive control (streptokinase) and negative control respectively. So, the extract possessed considerable thrombolytic activity. Conclusion: Our present investigations indicate that methanolic extract of leaves of Mesua ferrea exhibited considerable thrombolytic activity. There may be many pharmacologically active constituents in the fraction. So, extensive pharmacological and phytochemical experiments are essential.
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Objective: To investigate the Effects of Antidiarrheal and Thrombolytic Activities of methanol extract of Cinnamomum cecidodaphne Meissn. Barks. Castor oil induced diarrhoea test were used to examine the in-vivo antidiarrheal activity in... more
Objective: To investigate the Effects of Antidiarrheal and Thrombolytic Activities of methanol extract of Cinnamomum cecidodaphne Meissn. Barks. Castor oil induced diarrhoea test were used to examine the in-vivo antidiarrheal activity in Swiss albino mice. Results: In vitro clot lysis model was undertaken to investigate the thrombolytic action of the extract. Data were analysed by using statistical software statistical package for social science (SPSS, version 19.0). In this study of antidiarrhel activity Loperamide was used as a standard. For thrombolytic test Streptokinase used as positive control. In case of antidiarrheal study value was found 76.36% 400mg/kg where standard was found 83.33% and the extract shown 35.08% of thrombolysis effect where streptokinase was found 77.06% of clot lysis effect. Conclusion: The extract showed significant activity as compare to standard drugs. Methanol extract of C. cecidodaphne Meissn barks might be triggering the premonition of novel drug discovery in future due to its antidiarrheal effect in animal model.
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The present study was design to look into the thrombolytic and CNS depressant activity of alcoholic leaves extract of Macaranga denticulata. Here in this study, the extract of Macaranga denticulate was evaluate for the central nervous... more
The present study was design to look into the thrombolytic and CNS depressant activity of alcoholic leaves extract of Macaranga denticulata. Here in this study, the extract of Macaranga denticulate was evaluate for the central nervous system depressant effect using these animals behavioral models, such as 10 Hole cross, open field and thiopental sodium induced slumbering time tests for its sedative properties alternatively Thrombolytic effect was investigate in clot lysis try things out. In CNS depressant study the alcoholic remove of Macaranga denticulata displayed dose dependent suppression of motor activity in Hole cross and Open field make sure that you prolongation of the duration of thiopental sodium induced sleeping time in mice with the doses of 200 mg/kg, r. o. and 400 mg/kg, p. o. evaluate with standard 15 Diazepam (1mg/kg, i. m.) since positive control. Besides, the extract exerted 29.282% lysis of the blood clot inside thrombolytic activity test while 75.23% and 15.82% lysis was obtained for optimistic control (streptokinase) and negative control. Thus; the extract possessed much thrombolytic activity. The following experimental studies of leaves extract exhibited significant thrombolytic and CNS depressant activity. So, further comprehensive pharmacological and phytochemical investigations will need to make 20 clear the specific chemical compounds in charge of thrombolytic and CNS depressant activities and their particular mode of actions.
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The present study was designed to investigate the cytotoxic and thrombolytic activity of methanolic extract of fruits of Citrus macroptera. Methanolic extract of Citrus macroptera, was used to evaluate its cytotoxicity in Brine shrimp... more
The present study was designed to investigate the cytotoxic and thrombolytic activity of methanolic extract of fruits of Citrus macroptera. Methanolic extract of Citrus macroptera, was used to evaluate its cytotoxicity in Brine shrimp lethality bioassay where vincristin sulphate was used as standard drug. 10 Thrombolytic effect of the fraction was investigated in clot lysis experiment. In Brine shrimp lethality bioassay, LC50 value of the extract was 30.90μg/ml and vincristin sulphate served as the positive control showed LC50 value 10.51 μg/ml. The extract exerted 48.47% lysis of the blood clot in thrombolytic activity test while 75.18% and 15.82% lysis were obtained for positive control (streptokinase) and negative control respectively. Compared to vincristin sulphate, it is evident that the methanolic extract of 15 fruits of Citrus macroptera was cytotoxic. So, the extract possessed considerable thrombolytic activity. Which compounds is responsible for the present pharmacological actions and to know their mechanism of action, extensive pharmacological and phytochemical experiments are essential.
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The present study was designed to investigate the cytotoxic and thrombolytic activity of ethanol extract of leaves of Elatostema papillosum. Ethanol extract of Elatostema papillosum, was used to evaluate its cytotoxicity in Brine shrimp... more
The present study was designed to investigate the cytotoxic and thrombolytic activity of ethanol extract of leaves of Elatostema papillosum. Ethanol extract of Elatostema papillosum, was used to evaluate its cytotoxicity in Brine shrimp lethality bioassay where vincristin sulphate was used as standard drug. Thrombolytic effect of the fraction was investigated in clot lysis experiment. In Brine shrimp lethality bioassay, LC50 value of the extract was 2467.13μg/mland vincristin sulphate served as the positive control showed LC50 value 10.51 μg/ml. The extract exerted 50.86%lysis of the blood clot in thrombolytic activity test while 85.25%.And7.75%lyses were obtained for positive control (streptokinase) and negative control respectively. Compared to vincristin sulphate, it is evident that the ethanol extractof leaves of Elatostema papillosum were cytotoxic. So, the extract possessed considerable thrombolytic activity. Which compounds is responsible for the present pharmacological actions and to know their mechanism of action, extensive pharmacological and phytochemical experiments are essential.
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Traditionally this plant used as a various types of diseases. The current study was evaluated the in vivo sedative effect of the methanolic fraction of Cinnamomum Cecidodaphne. The sedative activity was tested by four method open field,... more
Traditionally this plant used as a various types of diseases. The current study was evaluated the in vivo sedative effect of the methanolic fraction of Cinnamomum Cecidodaphne. The sedative activity was tested by four method open field, hole cross, thiopental induced sleeping time, EPM test at 200mg/kg and 400mg/kg on the Swiss albino mice. For the comparing we used a standard drug thiopental sodium. We saw the locomotors activity increased and the open field, hole cross EPM test P<0.05 when orally administrated thiopental sodium mice was maximized onset of sleep. The present study revealed that the methanol fraction of the Cinnamomum Cecidodaphne barks has significant sedative properties that may lead to new drug development.
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The present study was designed to investigate the Phytochemical, cytotoxic and thrombolytic activity of methanolic extract of leaves of Dysophylla auricularia. Methanolic extract of Dysophylla auricularia was used to evaluate various... more
The present study was designed to investigate the Phytochemical, cytotoxic and thrombolytic activity of methanolic extract of leaves of Dysophylla auricularia. Methanolic extract of Dysophylla auricularia was used to evaluate various phytochemical methods, cytotoxicity in Brine shrimp lethality bioassay where vincristine sulphate was used as standard drug. Thrombolytic effect of the fraction was investigated in clot lysis experiment. In Brine shrimp lethality bioassay, LC50 value of the extract was 4.18537μg/ml and vincristine sulphate served as the positive control showed LC50 value 10.51μg/ml. So, compared to vincristine sulphate, it is evident that the methanolic extract of leaves of Dysophylla auricularia was cytotoxic. The extract exerted 42.1208% lysis of the blood clot in thrombolytic activity test while 75.18% and 15.82% lysis were obtained for positive control (streptokinase) and negative control respectively. So, the extract possessed considerable thrombolytic activity. The phytochemicals evaluation indicates the presence of chemical constituents including Alkaloids, Glycosides, Tannins and Flavonoids. Our present investigations indicate that methanolic extract of leaves of Dysophylla auricularia exhibited considerable cytotoxic and thrombolytic activity. There may be many pharmacologically active constituents in the fraction. So, extensive pharmacological and phytochemical experiments are essential.
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The present study was designed to investigate the thrombolytic activity of chloroform extract of leaves of Dioscorea bulbifera. Thrombolytic effect of the fraction was investigated in clot lysis experiment. The extract exerted 31.30%lysis... more
The present study was designed to investigate the thrombolytic activity of chloroform extract of leaves of Dioscorea bulbifera. Thrombolytic effect of the fraction was investigated in clot lysis experiment. The extract exerted 31.30%lysis of the blood clot in thrombolytic activity test while 85.77%.And 4.71%lyses were obtained for positive control (streptokinase) and negative control respectively. So, the extract possessed considerable thrombolytic activity which compounds are responsible for the present pharmacological actions and to know their mechanism of action, extensive pharmacological and phytochemical experiments are essential.
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In recent study, the Herbal Anti-atherosclerosis Formulation comprising of Lemon, Garlic, Ginger and Apple fruit extract vinegar have been generally recognized as agents for prevention and treatment of cardiovascular and other metabolic... more
In recent study, the Herbal Anti-atherosclerosis Formulation comprising of Lemon, Garlic, Ginger and Apple fruit extract vinegar have been generally recognized as agents for prevention and treatment of cardiovascular and other metabolic ailments, atherosclerosis, hyperlipidemia, thrombosis, hypertension and diabetes and cholesterol bringing down impact. Accordingly, the present study was intended to investigate thrombolytic properties of Herbal Anti-atherosclerosis Formulation. Natural Anti-atherosclerosis Formulation of demonstrated exceptionally huge (P <0.001) clot lytic properties in different blood samples. The percent clot lytic activity was compared with negative control (water) and standard enzyme positive control (streptokinase). The mean % of clot lysis for water and streptokinase was discovered 4.71% and 86.21% individually. Then again the mean percent clot lytic activity of Herbal Anti-atherosclerosis Formulation was discovered 29.51%, which is huge contrast and the positive and negative control. The present research recommends that Herbal Anti-atherosclerosis
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Objectives: Investigation with the crude ethanolic extract of Argyria captiformis leaves was carried out to evaluate its possible thrombolysis and to analyze in –vivo neuro-pharmacological effects as anxiety is a particular form of... more
Objectives: Investigation with the crude ethanolic extract of Argyria captiformis leaves was carried out to evaluate its possible thrombolysis and to analyze in –vivo neuro-pharmacological effects as anxiety is a particular form of behavioral inhibition that occurs in response to novel environment events and also phytochemical screening of plant extract. Method: Ethanolic extract of Argyria captiformis Leaves was assessed for sedative and anxiolytic activity on Swiss albino mice and Thrombolytic activity was assessed with human blood and also phytochemical screening test was done by various chemical reagents. Sedative activity was evaluated by using hole cross, open field, thiopental sodium-induced sleeping time and anxiolytic property was evaluated by elevated-plus maze(EPM) tests at 400mg/kg while the peripheral and thrombolytic activity determined by percentage of clot lysis. Result: In anxiolytic study, the extract displayed increased percentage of entry into open arm at the dose of 400mg/kg. The extract produced a significant (P<0.01) increase in sleeping duration and reduction of onset of sleep compared to sodium thiopental at doses (400 mg/kg) .The extract (400 mg/kg) also showed suppression of motor activity and exploratory activity of the mice in both open field and hole cross test. Argyria captiformis alone & Argyria captiformis in combination with Streptokinase demonstrated 38.19±4.76% & 77.45±2.97% clot lysis effect respectively & revealed significant with comparison to both the control agent. The presence of tannins, glycosides, saponins, flavonoids, cardiac glycosides, and phytosterols was determined. Conclusion: The pharmacological profiles of the present investigation of the ethanol extract of A. captiformis indicate that the extract possess good CNS depressant and exhibited considerable thrombolytic as it significantly reduced locomotion, onset of sleep, increased duration of sleep and also presence of, glycosides, cardiac glycosides, saponins, flavonoids ,tannins and phytosterols.
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Objective: To research the cytotoxic and thrombolytic action of the methanol extract of Prottium serratum bark. Methods: In vivo brine shrimp lethality bioassay, in vitro clot lysis model was undertaken to investigate the thrombolytic... more
Objective: To research the cytotoxic and thrombolytic action of the methanol extract of Prottium serratum bark. Methods: In vivo brine shrimp lethality bioassay, in vitro clot lysis model was undertaken to investigate the thrombolytic action of the extract.Results: The extract showed potential cytotoxic activity with LC 50 value of 30.90g/ml. Vincristin sulphate served as the positive control for this brine shrimp lethality assay and its LC 50 value was 10.51g/ml. The methanol extract of Prottium serratum bark is exerted 51.24% lysis of the blood clot in thrombolytic activity test while 76.58% and 3.45% lysis were obtained for positive control (streptokinase) and negative control respectively.Conclusion: Methanol extract of Prottium serratum bark might be triggering the premonition of novel drug discovery in future due to its moderate cytotoxic and thrombolytic activity. Cytotoxic and thrombolytic effect of Prottium serratum 61