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    John Boren

    This paper examines the current status of research on the efficacy and effectiveness of antidepressants. This paper reviews four meta-analyses of efficacy trials submitted to America's Food and Drug... more
    This paper examines the current status of research on the efficacy and effectiveness of antidepressants. This paper reviews four meta-analyses of efficacy trials submitted to America's Food and Drug Administration (FDA) and analyzes STAR*D (Sequenced Treatment Alternatives to Relieve Depression), the largest antidepressant effectiveness trial ever conducted. Meta-analyses of FDA trials suggest that antidepressants are only marginally efficacious compared to placebos and document profound publication bias that inflates their apparent efficacy. These meta-analyses also document a second form of bias in which researchers fail to report the negative results for the pre-specified primary outcome measure submitted to the FDA, while highlighting in published studies positive results from a secondary or even a new measure as though it was their primary measure of interest. The STAR*D analysis found that the effectiveness of antidepressant therapies was probably even lower than the modest one reported by the study authors with an apparent progressively increasing dropout rate across each study phase. The reviewed findings argue for a reappraisal of the current recommended standard of care of depression.
    Research Interests:
    White rats were trained in a multiple procedure involving avoidance, escape, and extinction. The influence of shock intensity upon these behavioral measures was studied with individual animals over an intensity range varying from... more
    White rats were trained in a multiple procedure involving avoidance, escape, and extinction. The influence of shock intensity upon these behavioral measures was studied with individual animals over an intensity range varying from ineffective to lethal shock. As the shock increased in intensity, the escape latency and the number of shocks decreased, while the avoidance rate and the resistance to extinction increased. As a general rule, the largest changes in the functional relations occurred at the low to medium shock intensities with further increases in the intensity causing relatively little additional effect." From Psyc Abstracts 36:02:2EK20B.
    Recent experiments have shown that both rats and cats will electrically stimulate them-selves through chronically implanted elec-trodes in certain areas of the brain (septal region and caudate nucleus, among others) by pressing a bar (6,... more
    Recent experiments have shown that both rats and cats will electrically stimulate them-selves through chronically implanted elec-trodes in certain areas of the brain (septal region and caudate nucleus, among others) by pressing a bar (6, 7). Such animals can main-tain high, stable ...
    This paper examines the current status of research on the efficacy and effectiveness of antidepressants. This paper reviews four meta-analyses of efficacy trials submitted to America's Food and Drug... more
    This paper examines the current status of research on the efficacy and effectiveness of antidepressants. This paper reviews four meta-analyses of efficacy trials submitted to America's Food and Drug Administration (FDA) and analyzes STAR*D (Sequenced Treatment Alternatives to Relieve Depression), the largest antidepressant effectiveness trial ever conducted. Meta-analyses of FDA trials suggest that antidepressants are only marginally efficacious compared to placebos and document profound publication bias that inflates their apparent efficacy. These meta-analyses also document a second form of bias in which researchers fail to report the negative results for the pre-specified primary outcome measure submitted to the FDA, while highlighting in published studies positive results from a secondary or even a new measure as though it was their primary measure of interest. The STAR*D analysis found that the effectiveness of antidepressant therapies was probably even lower than the modest one reported by the study authors with an apparent progressively increasing dropout rate across each study phase. The reviewed findings argue for a reappraisal of the current recommended standard of care of depression.
    ... ROBERT A. WILTZ, JR., JOHN J. BOREN, JOSEPH M. MOERSCHBAECHER, THOMAS L. CREED, AND JOHN F. SCHROT Bradley University and ... stimuli (Emurian & Weiss, 1972; LoLordo & Hart, 1972; Meltzer & Freeman, 1971; Miller, 1969,... more
    ... ROBERT A. WILTZ, JR., JOHN J. BOREN, JOSEPH M. MOERSCHBAECHER, THOMAS L. CREED, AND JOHN F. SCHROT Bradley University and ... stimuli (Emurian & Weiss, 1972; LoLordo & Hart, 1972; Meltzer & Freeman, 1971; Miller, 1969, 1971; Miller & Ackley, 1970; Wiltz ...
    The acute and chronic effects of cocaine and d-amphetamine on food-reinforced behavior were investigated in pigeons responding on a two-component multiple schedule. In one component, the behavioral task consisted of the same chain of... more
    The acute and chronic effects of cocaine and d-amphetamine on food-reinforced behavior were investigated in pigeons responding on a two-component multiple schedule. In one component, the behavioral task consisted of the same chain of conditional discriminations each session (performance). In the other component, the chain of conditional discriminations was changed from session to session (learning). In comparison to control sessions, both acute cocaine and d-amphetamine increased errors in each component of the multiple schedule. Responding in the learning component, however, was generally disrupted at lower doses than those that affected responding in the performance component. At high doses, both drugs produced pauses in responding in each component in three of the four subjects. Pausing engendered by d-amphetamine was approximately twice as long as that under cocaine. Upon chronic administration, both the pausing and error-increasing effects of each drug diminished. Drug-induced changes in timeout responding, however, did not decrease during chronic administration. Redeterminations of the d-amphetamine dose-effect curves following chronic cocaine administration suggested the existence of cross-tolerance between cocaine and d-amphetamine. Both the acute and chronic data are consistent with the view that conditions of stimulus control may modulate the behavioral effects of drugs.
    A new technique was developed to study the repeated acquisition of conditional discriminations. Using a discrete trial procedure, pigeons were required to learn during each session a different two-member chain of conditional... more
    A new technique was developed to study the repeated acquisition of conditional discriminations. Using a discrete trial procedure, pigeons were required to learn during each session a different two-member chain of conditional discriminations. Key color and geometric forms were used as stimuli. After the pigeons had reached a steady state of relearning (40 to 60 sessions), the technique was used to investigate variables that have previously been shown to affect the repeated acquisition of response sequences. Various (0 to 90 seconds) durations of timeout for errors were investigated in Experiment I. The stimulus change associated with a timeout, rather than its duration, was found to be the critical variable in acquisition of the discrimination. Extended training on a single chain was found to reduce total errors across sessions in Experiment II. Extended training (three sessions) did not, however, change the pattern of within-session error reduction. In some cases, extended training facilitated acquisition of a partially reversed discrimination. In Experiment III, color rather than chain position was found to control behavior, for three of the four birds, as the second stimulus dimension in the conditional situation. The results of these experiments replicate and extend previous findings concerning some of the variables that affect the repeated acquisition of response sequences.
    Variability of response location was studied in monkeys performing in a six-lever chamber. Fixed-ratio schedules, ranging from FR 1 to FR 300, generated a high degree of stereotypy of response location. In contrast, fixed-interval... more
    Variability of response location was studied in monkeys performing in a six-lever chamber. Fixed-ratio schedules, ranging from FR 1 to FR 300, generated a high degree of stereotypy of response location. In contrast, fixed-interval schedules of comparable reinforcement frequencies (0.06 to 4 minutes) generated much greater variability. These results failed to confirm any simple relationship between response variability and intermittence of reinforcement. Rather, variability seems to be determined by the particular characteristics of the reinforcement schedule.
    Male albino rats were trained on an adjusting avoidance schedule in which each lever press accumulated a given amount of shock-free time. Multiple auditory and visual stimuli were programmed for each discrete temporal distance from the... more
    Male albino rats were trained on an adjusting avoidance schedule in which each lever press accumulated a given amount of shock-free time. Multiple auditory and visual stimuli were programmed for each discrete temporal distance from the shock in an effort to place the avoidance behavior under the control of the shock proximity. The effects of the stimuli were further examined by presenting part of them and then by removing them altogether. With the combined auditory and visual stimuli, the rat spent most of the time relatively close to the shock and usually started to respond only when the shock was near. With the visual stimuli only, the rat kept the shock at intermediate temporal distances and responded more variably. The behavior with the auditory stimuli alone was quite similar to that produced by the combined stimuli, thus indicating that the auditory stimuli exercised the greater control. When all stimuli were removed, the animal usually kept the shock as far away as the procedure permitted. When only a single pre-shock stimulus was presented, the rat remained quite close to the shock and started to respond predominantly in the pre-shock step.
    Rats learned to reacquire four similar three-member response sequences. Each sequence member was associated with a different response lever, and the correct sequence of levers (i.e., 3-1-2, 2-1-3, 1-3-2, and 2-3-1) changed each session.... more
    Rats learned to reacquire four similar three-member response sequences. Each sequence member was associated with a different response lever, and the correct sequence of levers (i.e., 3-1-2, 2-1-3, 1-3-2, and 2-3-1) changed each session. The first two correct responses of each sequence postponed shock for a fixed period of time. The third correct response initiated a signalled timeout from avoidance. Incorrect responses did not affect the shock interval or reset the sequence. The effects of manipulating timeout duration on the sequential reacquisition baseline were investigated. All subjects displayed biphasic reacquisition performances similar to those controlled by food. The phases were characterized by an initial increase in accuracy, which reached a stable level during the latter portion of each session. Timeout duration affected rate of sequence completion and shock density, but not percentage of errors. Rate of sequence completion was fastest with intermediate timeouts (15 to 60 sec), and slowest with extreme durations (1 or 120 sec). Shock densities peaked with extreme durations and were at minimum with intermediate timeout values. The percentage of errors was the same across timeout durations. These data extend the generality of sequential reacquisition as a procedure for studying learning, and demonstrate timeout from avoidance to be a controlling variable.
    Several experiments exploring the effects of certain behavioral procedures were performed on a psychiatric ward for delinquent soldiers. Within the context of a point economy, the behavioral procedures were examined for their... more
    Several experiments exploring the effects of certain behavioral procedures were performed on a psychiatric ward for delinquent soldiers. Within the context of a point economy, the behavioral procedures were examined for their applicability to this patient group in a hospital-ward setting. The following procedures were studied: (1) use of points as consequences for specific behaviors compared with demonstration of "model" behavior by a ward officer; (2) punishment by a point-fine to control undesired behavior; (3) use of a chaining-type reinforcement contingency to increase desired behavior; (4) differential reinforcement of the individual versus the group to increase the frequency of a verbal performance; and (5) reinforcement of reports of personal problems versus impersonal problems.
    A behavioral measurement system was designed around a point economy for a psychiatric ward of delinquent patients. The characteristics of the system were: (1) the records of points earned for appropriate patient behavior formed the... more
    A behavioral measurement system was designed around a point economy for a psychiatric ward of delinquent patients. The characteristics of the system were: (1) the records of points earned for appropriate patient behavior formed the primary data. (2) After the points were recorded in a data matrix, graphs were prepared to show the behavior of individual patients, the participation of the patient group in the various ward activities, and an overall index of ward operation. (3) Several techniques were devised for reviewing the graphs so that the ward staff could evaluate the success of their procedures over substantial time periods.