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ABSTRACT zet: Bu araştırmada, Türkiye'de yaygın bir şekilde yetiştirilen korunga bitkisinin (Onobrychis viciifolia) fitokimyasal içeriği ile ekstraktının farelerde ağızdan akut ÖD 50 miktarının belirlenmesi amaçlanmıştır. Korunga... more
ABSTRACT zet: Bu araştırmada, Türkiye'de yaygın bir şekilde yetiştirilen korunga bitkisinin (Onobrychis viciifolia) fitokimyasal içeriği ile ekstraktının farelerde ağızdan akut ÖD 50 miktarının belirlenmesi amaçlanmıştır. Korunga bitkisinin kimyasal incelemesinde; alkaloidlerin, saponinlerin, tanenlerin, peptid/proteinlerin, şekerlerin, aminoasitlerin, fenoller ve fenolik asitlerin, kolin ve flavonoidlerin varlığı araştırıldı. Akut ÖD 50 miktarının belirlenmesi için 25–35 g ağırlığında, yaklaşık 2 aylık Wistar Albino soyu, 60 dişi ve 60 erkek toplam 120 adet fare kullanıldı. Farelerde ağızdan akut ÖD 50 değerinin erkeklerde ≥19000 ve dişilerde ≥20000 mg/kg olduğu ve bitkinin veya ekstraktının fitokimyasal incelemesinde tanen, aminoasit, protein, sukroz, fenol ve flavonoidlerin olduğu, alkaloid, basit şeker, saponin ve kolin varlığının olmadığı gözlendi. Bitkinin farelerdeki ağızdan akut zehirliliğinin düşük olduğu ve hayvanlar tarafından güvenle tüketilebileceği sonucuna varılmıştır. Anahtar sözcükler: Fare, fitokimyasal içerik, korunga, ÖD 50 . Determined of phytochemical properties of sainfoin (Onobrychis viciifolia) and acute orally LD 50 in mice Summary: This in vitro study was aimed to determine the phytochemical properties and acute LD 50 of oral administration of the extract of sainfoin (Onobrychis viciifolia) which is largely distributed in Turkey. The phytochemical properties of the sainfoin extract were determined presence of alkaloids, saponins, tannins, peptide/proteins, sugars, amino acids, phenols and phenolic acid, choline and flavonoids. Sixty female and 60 male of total 120 numbers of wistar albino mice, 25-35g weight, approximately two months age were used to determine acute LD 50 level of the sainfoin extract. Acute oral LD 50 of sainfoin was found ≥19000 mg/kg for males and ≥20000 mg/kg for females and phytochemical analysis of the extract or plant showed the presence of tannins, amino acids, proteins, sucrose, phenolic contents; but the presence of alkaloids, simple sugars, saponins and choline were not observed. We concluded that the acute toxicity of the plant orally administered to mice was low, which suggested that animal can consume safely it.
Research Interests: Biology and Phytochemical
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Bu calisma ile alabaliklarda florfenikol (FF) ve ana metaboliti florfenikol amin (FFA) kalintilarinin belirlenmesi icin yontem uyarlamasi, bu yontemle kalintilarinin belirlenmesi, sonuclarin gida guvenligi ve halk sagligi acisindan... more
Bu calisma ile alabaliklarda florfenikol (FF) ve ana metaboliti florfenikol amin (FFA) kalintilarinin belirlenmesi icin yontem uyarlamasi, bu yontemle kalintilarinin belirlenmesi, sonuclarin gida guvenligi ve halk sagligi acisindan degerlendirilmesi amaclandi. Numuneler etil asetatla ekstrakte edildi. Hekzanla yaglari uzaklastirildiktan sonra kati-faz ekstraksiyonla temizlendi ve BSTFA+TMCS [(N,O-bis (trimethylsilyl) trifluoroacetamide)+TMCS (trimethylchlorosiane) (99:1)] ile turevlendirildikten sonra GC-MS'e uygulandi. Yapilan hesaplamada CCα ve CCβ sirasiyla, FF icin 533,56 ve 585,28 ppb, FFA icin 540,95 ve 601,83 ppb olarak bulundu. FF icin ortalama geri kazanim % 93,04, FFA icin % 93,67 olarak tespit edildi. Metot validasyon parametreleri belirlendikten ve yontemin gecerliligi gosterildikten sonra analize alinan 100 adet balik orneginin hic birinde FF veya FFA kalintisina rastlanmamistir. Uyarlanan yontemin, analiz suresinin kisa, basit, duyarli ve tekrarlanabilir olmasi nedenleriyle avantajli oldugu sonucuna varilmistir. AbstractThis study was aimed to adapt a method for detection of florfenicol (FF) and its main metabolite florfenicol amine (FFA), detection of its residues by using this method, assessment the results in terms of food safety and public health. The samples were extracted with ethyl acetate. After removing the fats with hexan, cleaned up with solid-phase extraction and after derivatization with BSTFA+TMCS [(N,O-bis (trimethylsilyl) trifluoroacetamide)+TMCS (trimethylchlorosiane) (99:1)], injected to GC-MS. CCα and CCβ were 533,56 and 585,28 ppb for FF, 540,95 and 601,83 ppb for FFA were detected respectively in calculating. Mean recovery was detected as 93,04 % for FF and 93,67 % for FFA. After determination of method validation parameters and to be shown the validity of the method, FF and FFA residues were not detected in any analysed 100 fish samples. The adapted method was concluded as advantageous because of the lenght of time for analysis is short, being easy, sensitive and reproducible.
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Environmental estrogen active compounds are strong determinants of estrogen receptor (ER)-positive breast cancers, and increased evidence indicates their contribution to chemotherapy resistance. In the current study, the efficacy of... more
Environmental estrogen active compounds are strong determinants of estrogen receptor (ER)-positive breast cancers, and increased evidence indicates their contribution to chemotherapy resistance. In the current study, the efficacy of vincristine and tamoxifen, with the presence of diethylhexyl phthalate (DEHP) and bisphenol A (BPA) and the possible involvement of estrogen and estrogen receptor-related mechanisms, was evaluated in an ER+ mammary tumor cancer cell line, MCF-7. Chemotherapeutics tamoxifen as an estrogen receptor modulator and vincristine as an antimitotic compound were selected for evaluation against the presence of common endocrine disrupters. BPA and DEHP preincubation at their proliferative concentrations for 4 h was found to decrease the cytotoxicity of vincristine. mRNA and protein expression of ESR1 and ESR 2 were decreased by vincristine, while this decrease was reversed by DEHP and BPA. Both BPA and DEHP were able to interfere with the cytotoxic activity of vincristine against MCF-7 cells through ESR1 and ESR2. This study provides in vitro toxicological evidence for vincristine resistance and its relation to estrogen active environmental pollutants in ER+ breast cancer cells.
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SARS-CoV-2'nin neden olduğu yeni koronavirüs hastalığı (COVID-19) global bir pandemi olarak tanımlanmıştır. Tüm dünyada yoğun araştırmalara karşın halen etkili bir tedavisi veya aşısı bulunmamaktadır. Bu nedenle korunma, erken virüs... more
SARS-CoV-2'nin neden olduğu yeni koronavirüs hastalığı (COVID-19) global bir pandemi olarak tanımlanmıştır. Tüm dünyada yoğun araştırmalara karşın halen etkili bir tedavisi veya aşısı bulunmamaktadır. Bu nedenle korunma, erken virüs tespiti ve tanımlanma yöntemleri hastalığın kontrolü için önem taşımaktadır. Kontrollü randomize klinik araştırmaların sonuçları ile sürekli olarak tedavi protokolleri güncellenmektedir; ancak çok sayıda hasta ile yapılan araştırmaların çoğunluğu halen devam etmektedir. Bireysel farklılıklara (değişen fenotip, diğer kronik hastalıklar gibi) bağlı ilaç etkinliği ve güvenirliğine ilişkin değişiklikler nedeniyle tedavide tek tip ilaç uygulaması bulunmamaktadır. Tedavi protokolleri sürekli güncellenmektedir ve yapay zeka/in siliko araştırmalarla yeni ilaçların geliştirilmesi ve ilaç yeniden konumlandırma araştırmaları hızla devam etmektedir. Bu derleme, COVID-19 tedavisinde kullanılan bazı ajanlar hakkında güncel bilgi sunmaktadır.
Research Interests: Medicine and Gynecology
... Personal Authors, Bilgili, A.,Sanli, Y.,Kaya, S.,Yavuz, H.,Akar, F.,Akkaya, R.,Filazi, A. (Ankara Univ., Faculty of Veterinary Medicine, Ankara (Turkey)). ... Availability number, 2000000217. Serial Title, The Journal of Etlik... more
... Personal Authors, Bilgili, A.,Sanli, Y.,Kaya, S.,Yavuz, H.,Akar, F.,Akkaya, R.,Filazi, A. (Ankara Univ., Faculty of Veterinary Medicine, Ankara (Turkey)). ... Availability number, 2000000217. Serial Title, The Journal of Etlik Veterinary Microbiology (Turkey). Serial number, v. 8(4) p. 93-110 ...
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ÖZET: Androctonus crassicauda türü akreplerden maserasyon ve elektrik uyarımı ile elde edilen venomların farelerdeki öldürücü doz-50 (LD50) düzeylerinin belirlenmesi amaçlandı. Şanlıurfa (Harran)'dan toplanan A. crassicauda türü... more
ÖZET: Androctonus crassicauda türü akreplerden maserasyon ve elektrik uyarımı ile elde edilen venomların farelerdeki öldürücü doz-50 (LD50) düzeylerinin belirlenmesi amaçlandı. Şanlıurfa (Harran)'dan toplanan A. crassicauda türü akreplere ait kuyruklardan 10 adet telson ile ...
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Nanopartiküller (NP’ler) 1 ile 100 nm arasında bulunan partiküllere verilen isimdir. NP’ler normal malzemelerden farklı belirli fiziksel ve kimyasal özelliklerinden dolayı ticari kullanım için yapay olarak sentezlenmekte, endüstriyel... more
Nanopartiküller (NP’ler) 1 ile 100 nm arasında bulunan partiküllere verilen isimdir. NP’ler normal malzemelerden farklı belirli fiziksel ve kimyasal özelliklerinden dolayı ticari kullanım için yapay olarak sentezlenmekte, endüstriyel üretim esnasında kasıtsız bir yan ürün veya doğal olarak meydana gelmektedir. Her gün gelişmekte olan nanoteknoloji, elektronik, tıp, inşaat, kozmetik, tekstil, otomotiv, çevre, gıda, ev aletleri, yenilebilir enerji, petrol, tarım, matbaacılık, spor ve sağlık gibi alanlarda kullanılmaktadır. En yaygın kullanılan NP’ler ise gümüş (Ag), titanyum (Ti) ve silikon dioksit (SiO2) veya karbon (C) tabanlı olanlardır. Ticari olarak üretilen NP'ler, üretim aşamalarında veya yaşam döngülerinin son aşamasında atık ürünler olarak sucul ortama deşarj edilebilmektedir. Bu NP'ler yüzey veya yeraltı suyu ortamlarına geçebilmektedir. Su kaynaklarına doğrudan, yağış veya topraktan süzülüp gelen NP’ler balık, kabuklular ve hatta tek hücreli organizmalar gibi sucul organizmalara yönelik önemli etkilere neden olabilmektedirler. Sucul organizmalar NP’lere solungaçları, yutma, dermal temas, hücrelere adsorpsiyon gibi yollarla maruz kalmaktadırlar. NP’ler canlılarda lipid peroksidasyonuna, hücre yapısının bozulmasına, mitokondride bozulmaya, protein oksidasyonuna ve DNA hasarı gibi etkilere neden olmaktadırlar. NP’ler çevresel risk değerlendirmeleri çoğunlukla tüm risk faktörlerini dikkate almayan standart laboratuvar koşulları altında gerçekleştirilmektedir. Bu nedenle çevre ve atık su ortamları gibi karmaşık ortamlara salınan NP’lerin bu ortamlardaki davranışları laboratuvar ortamından farklı olabilmektedir.
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Abstract Bee products produced in environments with persistent organic pollutants (POPs) may be contaminated by these compounds. Propolis usually consists of beeswax, resins, water, inorganic and phenolic substances, and essential oils.... more
Abstract Bee products produced in environments with persistent organic pollutants (POPs) may be contaminated by these compounds. Propolis usually consists of beeswax, resins, water, inorganic and phenolic substances, and essential oils. Although there are some studies on the detection of POPs in honey and some bee products, these are quite limited. Because propolis is a botanical-based and highly complex matrix, and thus difficult to analyze, a reliable and selective method based on solid-phase extraction (SPE) combined with gas chromatography-mass spectrometry was developed for the determination of organochlorine pesticides (OCPs), polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs) in the propolis. All analytes were extracted with acetonitrile and centrifuged for 10 min at 4000 rpm and 6 °C in a refrigerated centrifuge. The samples were filtered using a homemade SPE cartridge containing C18, primary-secondary amine, and magnesium sulfate. The residue collected with acetonitrile was subsequently analyzed by gas chromatography – mass spectrometry (GC-MS). The proposed method was validated according to the Eurachem guidelines and applied directly to the collected propolis samples. The results show that the method may be used successfully in residue monitoring laboratories for the determination of OCPs, PCBs and PBDEs in propolis.
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Polychlorinated biphenyl (PCB) residues in food are an important food safety concern. Simple and sensitive analytical methods are needed to monitor PCB residues and ensure that food is safe for consumption. The aim of this study was to... more
Polychlorinated biphenyl (PCB) residues in food are an important food safety concern. Simple and sensitive analytical methods are needed to monitor PCB residues and ensure that food is safe for consumption. The aim of this study was to adapt a selective, sensitive, quick, and easy sample treatment for purification of animal fat matrices and to measure the level of PCB28, PCB52, PCB101, PCB118, PCB138, PCB153, and PCB180 in samples of meat products (salami, soudjouk, and sausage) produced in Turkey. The extraction and purification of meat products were performed via the modified quick, easy, cheap, effective, rugged, and safe (QuEChERS) method and PCB levels determined by gas chromatography–mass spectrometry. The linearity was satisfactory for all compounds studied, with correlation coefficients ≥0.99. The limits of determination and the limits of quantification were in the range of 0.144–0.382 and 0.479–1.274 ng g−1, respectively. Recovery at 3 different spiking concentrations was 95.7–101 % and the relative standard deviations were <3.5 %. This validated method was observed to be more economic and eco-friendly, as it uses a smaller volume of extraction solvents that are also less toxic. The validated method was successfully applied to the analysis of selected PCBs in meat products with satisfactory results. The method’s results indicated the presence of PCBs in some of the meat product samples, although the levels were below the maximum residue limit for food products of animal origin in Turkey (40 ng g−1 of fat), which is in accordance with EU and Turkish levels.
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Research Interests: Chemistry, Food Science, Dairy Science, Chromatography, Multidisciplinary, and 15 moreAnimal Production, Humans, Animals, Infant, High Performance Liquid Chromatography, Milk, High Pressure Liquid Chromatography, Cheese, Cattle, Melamine, Dairy Products, Food Contamination, Food Sciences, Infant Formula, and ENVIRONMENTAL SCIENCE AND MANAGEMENT
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Abstract Primary tissue cultures from Unio pictorum were developed for utilization in ecotoxicology studies. Cytotoxic effects of selected plasticizers (BPA, DiNP, DiDP, DMP) were tested on digestive gland, gonad, gill and mantle cells.... more
Abstract Primary tissue cultures from Unio pictorum were developed for utilization in ecotoxicology studies. Cytotoxic effects of selected plasticizers (BPA, DiNP, DiDP, DMP) were tested on digestive gland, gonad, gill and mantle cells. DiNP on gill and BPA on digestive gland were the highest and lowest cytotoxic compounds (IC50 0.111, 170.718 ppt). Mantle cells were the most suitable, reliable and easy to maintain cells; for toxicity assays. Unio primary cell culture provide valuable tool for testing/screening effects of xenobiotics in vitro, have potential for further development in terms of potential cryopreservation and stability comply with the 3 R principle.
Research Interests: Ecotoxicology and Biology
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... J. Vet. Res., 48, 1725–1732. PMid:3434919 2. Afifi, NA and El-Sooud, KA (1997). Tissue concentration and pharmacokinetics of florfenicol in broiler chickens. ... 57. Şanlı, Y. (1999), Veteriner Klinik Farmakoloji ve İlaçla Sağaltım... more
... J. Vet. Res., 48, 1725–1732. PMid:3434919 2. Afifi, NA and El-Sooud, KA (1997). Tissue concentration and pharmacokinetics of florfenicol in broiler chickens. ... 57. Şanlı, Y. (1999), Veteriner Klinik Farmakoloji ve İlaçla Sağaltım İlkeleri, Özkan Matbaacılık, s.719-872, Ankara. 58. ...
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Aim: Due to the environmental usage, these substances can be applied to the placental blood industry due to the shelves and the deteriorated membrane transportation. It is intended that their environmental effects can be influenced by... more
Aim: Due to the environmental usage, these substances can be applied to the placental blood industry due to the shelves and the deteriorated membrane transportation. It is intended that their environmental effects can be influenced by these transport proteins. Materials and Methods: Within the scope of the study, in the placenta of the owner and endotheliochorial dog; Good by analysis of 28 good (PCB, PBDE, PAH and Organic chlorinated pesticides); The expression profile of the placental whole genome was investigated by RNAseq, evaluated in silico (mole clamping) and in vitro (SLC and ABCB1 mRNA analysis in the placental cell line HTR8/SVneo treated with PCB 101, PCB118). Results: PCB101 826.4μg/kg in one of the 60 samples tested; In 23 samples, PCB118 was found to be between 0.14 and 41.9μg/kg. In 55 samples in the sequence analysis in bioinformatics, PCB was found in 742 genes between positive and negative (p
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Mycotoxins which are secondary metabolites of fungi have been reported to be carcinogenic, genotoxic, teratogenic, nephrotoxic and hepatotoxic. Mycotoxins, which are found in all stages of food and feed industry, also cause economic... more
Mycotoxins which are secondary metabolites of fungi have been reported to be carcinogenic, genotoxic, teratogenic, nephrotoxic and hepatotoxic. Mycotoxins, which are found in all stages of food and feed industry, also cause economic losses. Therefore, research and development studies for the control of mycotoxins are being carried out quite widely. Methods for the control of mycotoxins in food and feedstuffs are carried out in two stages: prevention of contamination of mycotoxins and detoxification after contamination. Methods for preventing the formation of mycotoxins include management of environmental factors, good agricultural and production practices, and appropriate conservation practices. Detoxification methods of mycotoxins include physical, chemical and biological applications. Apart from these, there are innovative and environmentally friendly methods. This review aims to briefly explain all methods used in the control of mycotoxins and to make predictions for the future, ...
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Abstract This study aims to develop a reliable and valid awareness scale that assesses levels of Endocrine Disruptor Chemicals (EDCs) engagement among allied health professionals for risk management. Preliminary item pool was created in... more
Abstract This study aims to develop a reliable and valid awareness scale that assesses levels of Endocrine Disruptor Chemicals (EDCs) engagement among allied health professionals for risk management. Preliminary item pool was created in collaboration with the expert research team and classification of the items to the sub-domains of awareness was done by the subject experts. When considering the similarities between the items, the domains were measured as general, impact, exposure, and protection awareness sub-dimensions since no model for the components were previously available. Revision of EDC items from the pool and classification to the sub-domains of awareness were completed by taking the opinions of field, measurement and language experts, other than the research team. EDC pilot test form were then applied to 380 health care workers; where inconsistent responders were excluded. Factorial structure (EFA and CFA) were simultaneously determined and reliability of EDC awareness subscales and scale measurement results were later confirmed. Finally, the EDC awareness for health care professionals with 24 items, consisting of general, impact, and exposure and protection awareness subscales, each consisting of eight items, was introduced to the scientific world. Analyses indicated that the EDC awareness scale for health professionals is statistically reliable and valid for its purpose. The EDC Awareness Scale can be used to determine the EDCs awareness levels for risk management for health care professionals.
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Çevre kirliliği, çevrenin fiziksel, kimyasal ve biyolojik kalitesindeki bozul-mayı ifade etmek için kullanılan bir terimdir. 1 Farklı kirleticilerin daha çok insan eliyle yüksek konsantrasyonlarda ve yaygın boyutlarda çevreye... more
Çevre kirliliği, çevrenin fiziksel, kimyasal ve biyolojik kalitesindeki bozul-mayı ifade etmek için kullanılan bir terimdir. 1 Farklı kirleticilerin daha çok insan eliyle yüksek konsantrasyonlarda ve yaygın boyutlarda çevreye yayı-labildiği ve bunların doğrudan veya dolaylı olarak insan ve hayvan sağlığını etkile-yebileceği bilinmektedir. 2 DERLEME Ö ÖZ ZE ET T Çevrenin fiziksel, kimyasal ve biyolojik kalitesindeki bozulmaya çevre kirliliği adı verilir. Çevre kirliliğine neden olan maddeler çevrede kalıcılıklarına göre biyolojik olarak parçalanabilen ve parçalanmayan olmak üzere 2 sınıfa ayrılırlar. Biyolojik olarak parçalanabilen kirleticiler, çev-rede kolayca dekompoze olurlar ve yalnızca geçici sorunlara neden olurlar. Metaller, plastikler, bazı pestisitler, deterjanlar ile radyoetkin izotoplar gibi çevrede biyolojik olarak parçalanmayan maddeler ise uzun süreli ve kalıcı olumsuzluklara neden olurlar. Bunların çoğunluğu petrol rafine-rileri, organik kimya ve sentetik kimya endüstrileri, demir-çelik ile madencilik, tekstil ve kâğıt en-düstrilerinden kaynaklanır. Bu nedenle bu derlemede insan, hayvan ve bitki sağlığını sürekli tehdit eden ve biyolojik olarak parçalanmayan kirleticiler ve toksisiteleri üzerinde durulmuştur. Sonuç olarak sanayi tesislerinde kurulması zorunlu olan atık arıtma tesislerine rağmen, özellikle geliş-mekte olan ülkelerde çevrede bulunan önemli miktarda kirletici olumsuzluklara neden olabilir. İnsan/hayvan ve çevre sağlığının bu türden kirleticilerin olumsuz etkilerinden korunabilmesi için sıkı kurallar konulması ve bunlara uyulmasının sürekli denetlenmesi gerekir. A An na ah h t ta ar r K Ke e l li i m me e l le er r: : Çevre kirleticileri; zehirlenme A AB BS S T TR RA AC CT T Contamination of the physical, chemical and biological conditions and alter the quality of the environment is referred as environmental pollution. According to their stability in the environment , these contaminants are divided into as degredable and non degredable pollutants. Biologically degredable contaminants are decomposed easily in the environment and cause only temporary problems. Among biologically nondegredable substances; metals, plasticizers, some pesticides , detergents and radioactive isotopes stay in the environment for a long time and cause adverse effects. Most of these pollutants derive from petroleum rafineries, organic/synthetic chemical production industries, mining industries including iron-steel production, textile and paper industries. This manuscript reviews about these nondegredable pollutants and their effects on human, animal and plant health along with their toxic effects. To sum up, eventhough sewage systems are sited in the industrial plants as obligatory, still their treatening effects on the environment is possible especially in the developing countries. In order to protect human/animal health as well as the environmental biota from these pollutants, strict rules should be introduced and monitored regularly .
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Poliklorlu bifenil (PCB) bilesikler gecmiste sanayide genis bir sekilde kullanildiklarindancevrede ve gidalarda yaygin bir sekilde bulunurlar. Ancak endokrin bozucu etkiye yol acarak sagligiolumsuz yonde etkilediklerinden uluslar arasi... more
Poliklorlu bifenil (PCB) bilesikler gecmiste sanayide genis bir sekilde kullanildiklarindancevrede ve gidalarda yaygin bir sekilde bulunurlar. Ancak endokrin bozucu etkiye yol acarak sagligiolumsuz yonde etkilediklerinden uluslar arasi alanda sinirlandirmalara maruz kalmislardir. Gidalardabulunan PCB kalintilari insanlara yonelik olumsuz etkileri nedeniyle gida guvenliginde endiseye nedenolmuslardir. Bu nedenle gidanin guvenli bir sekilde tuketilebilmesini saglamak icin kalinti analizlerindebasit ve duyarli analitik yontemlerin gelistirilmesi gereklidir. Salam, sucuk ve sosis bir veya birden cokhayvan turunden koken alan fermente et urunleridir. Taze etin saglanmasinin yetersiz oldugu veyalezzetinin artirilmasi istendiginde yapilan bu et urunleri, yaklasik 30-40 gun boyunca oda isisindabozulmadan saklanabildiklerinden Turkiye’de geleneksel olarak tuketilmektedirler.Bu calismada Ocak ve Mart 2015 doneminde Ankara’da 5 farkli marketten alinan 5 farkli ureticiye ait,25 salam, 25 sosis ...
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This investigation was carried out to determine the effect of amitraz poisoning on the the formation of methemoglobin and osmotic fragility of erytrocytes. in this study, 12 guinea-pigs, weighing 250-300 gr were used. They were equally... more
This investigation was carried out to determine the effect of amitraz poisoning on the the formation of methemoglobin and osmotic fragility of erytrocytes. in this study, 12 guinea-pigs, weighing 250-300 gr were used. They were equally divided into two groups, control and experimental. The animals in the experimental group were intraperitoneally injected with amitraz at a dose of 1 mg/kg body weight. One hour after amitraz injections, erytrocyte, hematocrit, hemoglobin levels and also percent hemolysis of erytrocytes were measured in the blood samples taken from the control and experimental groups. In the experimental group, the value of hemoglobin was lower while the value of methemoglobin was higher than those of the control group (p
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The current study evaluated certain emerging contaminants in the Susurluk sub-basin, which is under significant anthropogenic pollution pressure. Polychlorinated Biphenyls (PCBs), polybrominated diphenyl ethers (PBDEs), organochlorine... more
The current study evaluated certain emerging contaminants in the Susurluk sub-basin, which is under significant anthropogenic pollution pressure. Polychlorinated Biphenyls (PCBs), polybrominated diphenyl ethers (PBDEs), organochlorine insecticides, and microplastics were investigated from both surface and sediment samples collected in dry and wet seasons. In the Kocaçay river reaching the Marmara Sea, γ-HCH and β-HCH were detected in the dry season. Dieldrin was also observed in very high concentrations in river sediments during the dry season. Nilüfer stream is a significant waterway close to industrial and urban areas resulting in pollution of high concentrations of PCBs, DDT, and its metabolites. Sediment samples contained higher contaminants: DDT and metabolites in the sediment from almost all stations. According to the Hazard quotient coefficient, all detected pollutants were found to be >1, indicating a high risk in the river system. Fiber was the dominant microplastic. The...
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The aim of this study was to determine the effects of different cooking (boiling, frying) and storage (+4°C, 15°-20°C) procedures on the gentamicin levels in eggs obtained from laying hens that had received subcutaneous application of... more
The aim of this study was to determine the effects of different cooking (boiling, frying) and storage (+4°C, 15°-20°C) procedures on the gentamicin levels in eggs obtained from laying hens that had received subcutaneous application of gentamicin. Gentamicin residues in eggs from 50 ISA brown laying hens were analysed using HPLC-fluorescence. The recovery study showed that approximately 90% of the gentamicin could be recovered from the egg. The lowest detection limit was 0.01 μg/g in the whole egg. The retention times of the combined peaks of three components of gentamicin were 4.0 to 4.1 min. Their initial concentrations of the gentamicin residues were retained for up to fourteen days at both refrigerated (+4°C) and room temperatures (15°-20°C), but started to lose strength on day 21 of storage. On the 28 th day, gentamicin residues in the eggs kept at room temperature were lower than those kept at the refrigerated temperatures. The different cooking procedures did not affect the ge...
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Since bees are indispensable creatures for continuation of life, it was aimed to give information about chemical substances causing poisoning and to draw attention to the subject. Honey bees can be exposed to many natural and synthetic... more
Since bees are indispensable creatures for continuation of life, it was aimed to give information about chemical substances causing poisoning and to draw attention to the subject. Honey bees can be exposed to many natural and synthetic sources. Some natural toxins are well tolerated by the bees and are even beneficial, while others cause adverse effects, especially at high concentrations. Likewise, some synthetic pesticides are used by beekeepers for treatment and prevention, but most of them cause detrimental effects when used carelessly. The most important role in bee toxicology is playing pesticides. Although there are many legal regulations on these, the risk of poisoning with organophosphates, carbamates, pyrethroids and especially the emerging neonicotinoid pesticides continues. However, hydroxymethylfurfural, which is formed by heating sugar under acidic conditions, and poisoning caused by inappropriate dosing of the drugs are more frequently encountered. As a result, there is no the appropriate therapeutic measures against such poisoning, so beekeepers are advised to apply protective measures more strictly.