aziz aksoy
Bitlis Eren University, Nutrition, Department Member
Özet Bu çalışmada, diş hekimlerinin enfekte hastaları muayene ve tedavi işlemleri sırasında, bazı bulaşıcı hastalıklara maruz kalmaları durumuna karşı; bilgi düzeyleri, tutum ve davranışlarının incelenmesi amaçlanmıştır. Çalışma 52 tane... more
Özet Bu çalışmada, diş hekimlerinin enfekte hastaları muayene ve tedavi işlemleri sırasında, bazı bulaşıcı hastalıklara maruz kalmaları durumuna karşı; bilgi düzeyleri, tutum ve davranışlarının incelenmesi amaçlanmıştır. Çalışma 52 tane diş hekiminin katılımı ile gerçekleştirilmiştir. Özellikle yakın temas durumlarında damlacık ve benzeri şekilde doğrudan ve dolaylı olarak bulaşma riskleri olan AIDS, Hepatit B, tüberküloz, grip ve kabakulak hastalıkları ele alınmıştır. Çalışmada, diş hekimlerinin hastalarla doğrudan ilgilendiği alanlarda hazırlamış olduğumuz 18 soruluk anket diş hekimlerine uygulanmıştır. Elde edilen verilerin istatistiksel olarak değerlendirilmesi IBM SPSS 20® programında, sıklık ve Pearson ki-kare testleriuygulanarak yapılmıştır. Elde ettiğimiz istatistiksel analiz sonuçlarına göre; diş hekimlerinin %61.5'inin muayene ettikleri hastaların bulaşıcı hastalığının olup, olmadığını sorguladıkları, %38.5'inin ise sorgulamadıkları belirtmiştir. Diş hekimlerinin %...
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Aim: In this study, it was tried to investigate the obesity tendency of the students of Bitlis Eren University with Bioelectrical Impedance Body Analyzer. Materials and Methods: A total of 400 volunteer students, 200 girls and 200 boys,... more
Aim: In this study, it was tried to investigate the obesity tendency of the students of Bitlis Eren University with Bioelectrical Impedance Body Analyzer. Materials and Methods: A total of 400 volunteer students, 200 girls and 200 boys, were included in the study. Findings: According to Body Mass Index (BMI) values were found that 19.5% of the girl students were weak, 68.5% of them were normal weight, 11.0% of them were overweight and 1.0% of them were obese, 4.5% of the boy students were weak, 71.0% of them were normal weight, 22.0% of them were overweight and 2.5% of them were obese. According to body fat ratio were determined that 40.0% of the girl students were in the obesity tendency risk group and 48.0% of them were obese, 56.0% of the boy students were in the obesity tendency risk group and 26.0% of them were obese. According to the waist/hip ratio were revealed that 95.5% of the girl students were in the obesity tendency group and 4.0% of them were obese, 85.5% of the boy st...
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Bu calismada, dis hekimlerinin enfekte hastalari muayene ve tedavi islemleri sirasinda, bazi bulasici hastaliklara maruz kalmalari durumuna karsi; bilgi duzeyleri, tutum ve davranislarinin incelenmesi amaclanmistir. Calisma 52 tane dis... more
Bu calismada, dis hekimlerinin enfekte hastalari muayene ve tedavi islemleri sirasinda, bazi bulasici hastaliklara maruz kalmalari durumuna karsi; bilgi duzeyleri, tutum ve davranislarinin incelenmesi amaclanmistir. Calisma 52 tane dis hekiminin katilimi ile gerceklestirilmistir. Ozellikle yakin temas durumlarinda damlacik ve benzeri sekilde dogrudan ve dolayli olarak bulasma riskleri olan AIDS, Hepatit B, tuberkuloz, grip ve kabakulak hastaliklari ele alinmistir. Calismada, dis hekimlerinin hastalarla dogrudan ilgilendigi alanlarda hazirlamis oldugumuz 18 soruluk anket dis hekimlerine uygulanmistir. Elde edilen verilerin istatistiksel olarak degerlendirilmesi IBM SPSS 20® programinda, siklik ve Pearson ki-kare testleri uygulanarak yapilmistir. Elde ettigimiz istatistiksel analiz sonuclarina gore; dis hekimlerinin %61.5’inin muayene ettikleri hastalarin bulasici hastaliginin olup, olmadigini sorguladiklari, %38.5’inin ise sorgulamadiklari belirtmistir. Dis hekimlerinin %34.6’si cali...
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Bu calismada 2014 yilinda, Bitlis Ilinde ikamet eden, obez cocuga sahip 50 ailenin obeziteye ve cocuklarina olan yaklasimlarinin belirlenmesi amaclanmistir. Ailelere, c ocuklarin ve ebeveynlerin demografik ve antropometrik ozelliklerini... more
Bu calismada 2014 yilinda, Bitlis Ilinde ikamet eden, obez cocuga sahip 50 ailenin obeziteye ve cocuklarina olan yaklasimlarinin belirlenmesi amaclanmistir. Ailelere, c ocuklarin ve ebeveynlerin demografik ve antropometrik ozelliklerini (yas, boy uzunlugu ve vucut agirligi) sorgulayan bilgi formu ve obeziteye ve obez cocuklarina olan yaklasimlarini degerlendirmeyi saglayacak 25 soruluk bir anket formu uygulanmistir. Elde edilen veriler IBM SPSS 20® programinda, siklik ve Paerson ki-kare testleriyle degerlendirilmis, p<0,05 duzeyi istatistiki acidan anlamli kabul edilmistir. Ailelerin %68’i (n=34) cocuklarinin diger cocuklara gore sagliksiz oldugunu ve %76’si (n=38) obez cocuklarinin kilo sorunu oldugunu dusundugunu ifade etmistir. Ailelerin %72’si (n=36) yeme-icme konusunda obez cocuklarina baski yapmadigini, %28’i (n=14) ise fiziksel veya psikolojik baski uyguladigini belirtmistir. Ailelerin %40’i (n=20) bu sorunu ortadan kaldirmak icin herhangi bir yonteme basvurmadigini dile g...
Research Interests: Art and Childhood Obesity
Obesity, according to its simplest definition, is excessive accumulation of fat in the body. Obesity is a health problem that is observed commonly in almost all societies and it is starting to become a global epidemic. In this study,... more
Obesity, according to its simplest definition, is excessive accumulation of fat in the body. Obesity is a health problem that is observed commonly in almost all societies and it is starting to become a global epidemic. In this study, physical activity and obesity statuses for individuals between the ages of 18-30 with different body types were tried to be associated via bioelectrical impedance analysis device and metabolic holter measurements. It was determined according to the results of the study that body fat ratio increases and number of steps decreases with increasing age, that there are statistically significant differences between gender and AEC, TEC, muscle weight and total body water and that this ratio is greater in men in comparison with women. Statistically significant differences (P<0.05) were determined between the muscle weight and total body water, BMI, waist/hip ratio, TEC, AEC; between total body water and BMI, waist/hip ratio, TEC and AEC; between the body mass...
There were 200 participants in total, on a voluntary basis in the study. Of these participants, 100 were male students aged 18-25 years who exercised regularly and vigorously, and 100 were male aged 1825 years who did not participate in... more
There were 200 participants in total, on a voluntary basis in the study. Of these participants, 100 were male students aged 18-25 years who exercised regularly and vigorously, and 100 were male aged 1825 years who did not participate in any physical activity. The measurements of BMI, body fat composition, hip-to-waist ratio, and skinfolds measured at nine different anatomical areas of their bodies (pectoral, biceps, triceps, subscapular, abdominal, suprailiac, thigh, midaxillary and the medial part of the leg) using skinfold caliper were recorded in the Excel format. It was determined that there was a significant difference (p<0.05) between the BMI of those who exercised regularly and of those who did not, and that there were significant differences (p<0.05) between muscle weights, hip-to-waist ratio, body fat composition, total body water, and basal metabolic rates of the participants who exercised regularly and of those who did not. It was determined that the total body wate...
Objectives We compared the laboratory and clinical symptoms of coronavirus disease 2019 (COVID-19), other viral (beside COVID-19), and bacterial conjunctivitis patients with the values of controls. Methods Twenty COVID-19, 15 other viral,... more
Objectives We compared the laboratory and clinical symptoms of coronavirus disease 2019 (COVID-19), other viral (beside COVID-19), and bacterial conjunctivitis patients with the values of controls. Methods Twenty COVID-19, 15 other viral, 15 bacterial patients, and 15 control group were included in the study. COVID-19 was diagnosed with the real time reverse transcription–polymerase chain reaction while the indirect immunofluorescent antibody test was used in the detection of other viral agents. Bacterial agents were determined with the detection of the agent. The ophthalmologic examination of all cases was carried out by direct penlight, and the anterior segment evaluation was performed. The laboratory findings of all cases included in the study were obtained from the hospital records. Results It was determined that 5% conjunctivitis and 5% diplopia developed in patients diagnosed with COVID-19, 20% conjunctivitis developed in patients due to other viral agents, and 66.6% conjuncti...
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Abstract Pathogens can be transferred to microgreens from seeds, irrigation water and growth media. The purpose of this study was to evaluate the contamination of Shiga toxin-producing Escherichia coli (STEC O157:H7) and generic E. coli... more
Abstract Pathogens can be transferred to microgreens from seeds, irrigation water and growth media. The purpose of this study was to evaluate the contamination of Shiga toxin-producing Escherichia coli (STEC O157:H7) and generic E. coli to lettuce and radish microgreens grown in spray and bottom irrigated peat moss and perlite. Lettuce and radish seeds were grown in nalidixic acid resistant E. coli strains inoculated peat moss and perlite. Populations of cells were enumerated on edible and inedible part of plants. Survival of E. coli strains were also examined in growth media for 28 days. Type of irrigation did not affect the population of cells transferred to edible part of plants (P > 0.05). Populations of E. coli contaminating the inedible part of plant were higher in perlite than those in peat moss (P
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The purpose of our investigative work has been to determine whether there can be therapeutic roles in the administration of sildenafil citrate, heparin and several neuropeptides on an animal model where gastric ulcers were induced with... more
The purpose of our investigative work has been to determine whether there can be therapeutic roles in the administration of sildenafil citrate, heparin and several neuropeptides on an animal model where gastric ulcers were induced with acetic acid, and to compare their efficacy. The animals were divided into 13 groups, with 4 animals in each. Gastric ulcers was induced in the animals of 12 groups with one untreated group being left as the control (Group I - control; given normal saline (NS)). The other groups were: Group II (ulcer+NS); Group III (5mg/kg sildenafil citrate, low dose); Group IV (10mg/kg sildenafil citrate, high dose); Group V (0.6mg/kg heparin, low dose); Group VI (6mg/kg heparin, high dose); Group VII (20nmol/kg des-acyl ghrelin); Group VIII (40nmol/kg des-acyl ghrelin); Group IX (4nmol/kg acyl ghrelin); Group X (8nmol/kg acly ghrelin); Group XI (20pmol/kg Nesfatin-1); Group XII (15nmol/kg Obestatin) and Group XIII (5nmol/kg Neuropeptide Y). Gastric neuropeptide expression was measured using an immunohistochemical method, and the amount in circulation was detected using ELISA. To compare with no treatment, the controls and other treatment groups, we recorded loss of the surface epithelium of the stomach, erosion, bleeding and inflammatory cell infiltration in the upper halves of the gastric glands. The muscularis and the layers beneath it were, however, apparently normal. The gastric mucosa healed with little or no inflammation when sildenafil citrate, low dose heparin, ghrelin, NUCB2/Nesfatin-1, obestatin, Neuropeptide Y were administered. Overall the data indicate that low dose heparin, and especially sildenafil citrate and neuropeptides, can be used clinically as an alternative approach in the treatment of the gastric ulcer.
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Research Interests: Psychology and Nutrition
Hepatitis B is one of the most common infectious diseases in the world, and 350 million people have been estimated to be chronic hepatitis B virus carriers world-wide. Hepatitis B virus (HBV) has been classified into 8 genotypes (A-H)... more
Hepatitis B is one of the most common infectious diseases in the world, and 350 million people have been estimated to be chronic hepatitis B virus carriers world-wide. Hepatitis B virus (HBV) has been classified into 8 genotypes (A-H) based on an intergroup divergence of 8% or more in the complete nucleotide sequence. Different genotypes of the hepatitis B virus may influence the clinical outcome of the disease. HBV genotyping method using restriction fragment length polymorphism (RFLP) can reliably identify genotypes. HBV genotyping with S gene sequence is consistent with genetic analysis using the full genomic sequences. The aim of this study was to determine the genotypes of HBV by using restriction fragment length polymorphism (RFLP) method in the region of Elazig. A total of 127 HBV-DNA positive patients (74 male, 53 female) were included in the study. Semi-nested polymerase chain reaction (PCR) was performed to amplify the specific parts of HBV S gene. In the first step, 685 base paired (bp) region was amplified by sense primer HBMF1 and anti-sense primer HBMR2, while in the second step 485 bp region was amplified by using inner-sense primer HBMF2 and anti-sense primer HBMR2. PCR products were then digested by the restriction enzymes, Alwl, Earl, Hphl, Ncil and NlalV. The RFLP assay indicated that genotype D was the only detected type in our samples. In conclusion, genotype D is the predominant type among hepatitis B patients in our region. RFLP is considered to be an easy and useful method for genotyping HBV strains.
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Research Interests: Health Care and Medicine
Research Interests: Psychology and Nutrition
Hepatitis B is one of the most common infectious diseases in the world, and 350 million people have been estimated to be chronic hepatitis B virus carriers world-wide. Hepatitis B virus (HBV) has been classified into 8 genotypes (A-H)... more
Hepatitis B is one of the most common infectious diseases in the world, and 350 million people have been estimated to be chronic hepatitis B virus carriers world-wide. Hepatitis B virus (HBV) has been classified into 8 genotypes (A-H) based on an intergroup divergence of 8% or more in the complete nucleotide sequence. Different genotypes of the hepatitis B virus may influence the clinical outcome of the disease. HBV genotyping method using restriction fragment length polymorphism (RFLP) can reliably identify genotypes. HBV genotyping with S gene sequence is consistent with genetic analysis using the full genomic sequences. The aim of this study was to determine the genotypes of HBV by using restriction fragment length polymorphism (RFLP) method in the region of Elazig. A total of 127 HBV-DNA positive patients (74 male, 53 female) were included in the study. Semi-nested polymerase chain reaction (PCR) was performed to amplify the specific parts of HBV S gene. In the first step, 685 b...
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This study examines the levels of acylated and desacylated ghrelin, preptin, leptin, and nesfatin-1 peptide changes related to the body mass index (BMI). The subjects were allocated to 5 groups depending on their BMIs as follows: Group I... more
This study examines the levels of acylated and desacylated ghrelin, preptin, leptin, and nesfatin-1 peptide changes related to the body mass index (BMI). The subjects were allocated to 5 groups depending on their BMIs as follows: Group I (BMI <18.5 kg/m2); Group II (BMI 18.5–24.9 kg/m2); Group III (BMI 25–29.9 kg/m2); Group IV (BMI 30–39.9 kg/m2); Group V (BMI >40 kg/m2). Serum acylated and desacylated ghrelin, preptin, and leptin levels were measured by the enzyme-linked immunosorbent assay (ELISA) and nesfatin-1 was measured by the enzyme immunoassay (EIA). Desacylated ghrelin levels showed a gradual and statistically significant drop from Group I to Group V, while preptin and leptin levels exhibited a gradual and significant increase from Group I to Group IV. Serum nesfatin-1 levels gradually, but not significantly, increased from Group I to Group III and showed a significant decrease in Groups IV and V. In conclusion, leptin, preptin, and acylated ghrelin (AG) levels incre...
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This study was undertaken to ascertain whether human milk contains preptin, salusin-alpha (salusin-α) and -beta (salusin-β) and pro-hepcidin and hepcidin-25, and whether there are relationships between plasma and milk preptin, salusin-α... more
This study was undertaken to ascertain whether human milk contains preptin, salusin-alpha (salusin-α) and -beta (salusin-β) and pro-hepcidin and hepcidin-25, and whether there are relationships between plasma and milk preptin, salusin-α and -β and pro-hepcidin and hepcidin-25 concentrations in lactating mothers with and without gestational diabetes mellitus (GDM). Blood was obtained from non-lactating women (n = 12), non-diabetic lactating women (n = 12), and GDM lactating women (n = 12). Colostrum, transitional milk, and mature milk samples were collected just before suckling from healthy and GDM lactating women. Peptides concentrations were determined by ELISA and EIA. Mammary gland tissues were screened immunohistochemically for these peptides. Women with GDM had significantly higher plasma and colostum preptin concentrations than healthy lactating women during the colostral and transitional milk period. Salusin-alpha and -beta levels in milk and plasma were lower in women with GDM. Salusin-α and -β were significantly lower in both plasma and colostrums of GDM than of healthy lactating women. Women with GDM had significantly higher colostum prohepcidin and hepcidin-25 concentrations than healthy lactating women during the colostral period. Plasma prohepcidin was also higher in women with GDM than in healthy lactating women during the colostral period, but plasma prohepcidin and hepcidin-25 levels decreased during mature milk period. Transitional milk pro-hepcidin and hepcidin-25 levels in women with GDM were higher than in healthy lactating women. All these results revealed that the mammary gland produces those peptides, which were present in milk at levels correlating with plasma concentrations.
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During the past 20 y, there has been much interest in sugars and especially fructose in relation to human health. Over the past decade, considerable scientific debate and controversy have arisen about the potential health effects of... more
During the past 20 y, there has been much interest in sugars and especially fructose in relation to human health. Over the past decade, considerable scientific debate and controversy have arisen about the potential health effects of sucrose, high-fructose corn syrup (HFCS), and fructose itself. HFCS increasingly has been used as a sweetener in thousands of food products and soft drinks, leading to the development of obesity, diabetes, dyslipidemia, and metabolic syndrome (MetS) in both rodents and humans, which is associated with an increase in body weight. There is a need for detailed research on the mechanism underlying MetS that could lead to a remedy. This review will first systematically present a definition of MetS, its history, prevalence, and comparative diagnostic criteria. We will then consider fructose and its effects on human health, the diet-induced obesity model (various fat contents), the hypercholesterolemic model, the diabetes model, the hypertensive model, the MetS or insulin resistance model, and biomarkers related to MetS, in light of contemporary data using multiple databases (PubMed, MEDLINE, and OVID).
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... [Epub ahead of print] To what extent is it right to measure serum vaspin, obestatin, and apelin-36 levels without a protease inhibitor in nonalcoholic fatty liver disease? Aydin S, Sahin I, Demirel U, Aksoy A. PMID: 21397283 [PubMed -... more
... [Epub ahead of print] To what extent is it right to measure serum vaspin, obestatin, and apelin-36 levels without a protease inhibitor in nonalcoholic fatty liver disease? Aydin S, Sahin I, Demirel U, Aksoy A. PMID: 21397283 [PubMed - as supplied by publisher]. Publication Types: ...
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The goal of this study was to compare levels of acyl and des-acyl ghrelin, obestatin, nesfatin-1 and leptin in healthy gravidas to hyperemesis gravidarum (HG) patients. Twenty pregnant women with HG and twenty healthy pregnant women all... more
The goal of this study was to compare levels of acyl and des-acyl ghrelin, obestatin, nesfatin-1 and leptin in healthy gravidas to hyperemesis gravidarum (HG) patients. Twenty pregnant women with HG and twenty healthy pregnant women all of similar ages, BMI and all at similar pregnancy development comprised the study cohort. Fasting serum samples were obtained and measured for acyl and des-acyl ghrelin, leptin, obestatin and nesfatin-1. Nesfatin-1 concentrations in the HG group were higher compared to the control group whereas; leptin concentrations during pregnancy were lower in the HG group as compared to the control group. The two groups did not differ with regard to acyl and des-acyl ghrelin and obestatin. This pilot study suggests a possible role of leptin and nesfatin-1, which might be involved in the pathology of the disease.
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... Aziz AKSOY**, Aykut ÖZDARENDELİ ... SN-PCR yönteminin birinci aşamasında anlamlı primer HBMF1 ve karşıt anlamlı primer HBMR2 kullanılarak 685 baz çiftlik bölgenin, ikinci aşamasında ise iç anlamlı primer HBMF2 ve karşıt anlamlı primer... more
... Aziz AKSOY**, Aykut ÖZDARENDELİ ... SN-PCR yönteminin birinci aşamasında anlamlı primer HBMF1 ve karşıt anlamlı primer HBMR2 kullanılarak 685 baz çiftlik bölgenin, ikinci aşamasında ise iç anlamlı primer HBMF2 ve karşıt anlamlı primer HBMR2 kullanılarak 485 baz çiftlik ...
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The present study aims to establish the levels of acylated ghrelin, desacylated ghrelin, obestatin and preptin, during pregnancy and the postpartum period in pregnant women with Gestational Diabetes Mellitus (GDM) and healthy pregnancy... more
The present study aims to establish the levels of acylated ghrelin, desacylated ghrelin, obestatin and preptin, during pregnancy and the postpartum period in pregnant women with Gestational Diabetes Mellitus (GDM) and healthy pregnancy women. The study registered 20 pregnant women with GDM and 20 healthy pregnant women. Fasting venous blood samples were collected from all cases between weeks 24 and 28 of pregnancy and after 24h postpartum. Hormones were analyzed using ELISA method. Serum acylated ghrelin (p:0.001), desacylated ghrelin (p:0.001), obestatin (p:0.006) and preptin (p:0.001) levels were all found statistically higher in both groups during the postpartum period, when compared to the pregnancy period. A positive correlation was established between desacylated ghrelin and acylated ghrelin (p:0.008), desacylated ghrelin and preptin (p:0.012) and preptin and insulin (p:0.039) in the GDM group during pregnancy. The studied hormones (especially desacylated ghrelin and obestatin) are critical in GDM pathophysiology based on the comparison of measure after and before the delivery.
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Although, the exact mechanisms underlying the development of the metabolic syndrome (MetS) are not still completely understood, obesity, circulated peptide hormone levels and their interaction with genetic factors are considered largely... more
Although, the exact mechanisms underlying the development of the metabolic syndrome (MetS) are not still completely understood, obesity, circulated peptide hormone levels and their interaction with genetic factors are considered largely responsible. The purpose of this study is to explore how the levels of ghrelin, obestatin (OBS) and NUCB2/nesfatin-1 (NES)/NUCB2 change in serum and the reproductive tissues of female and male rats with fructose-induced metabolic syndrome, and whether the levels of each hormone is correlated with the hormones involved with fertility. Experiments were conducted on 5-week-old Sprague-Dawley male and female rats assigned to either a control group or a MetS group. Controls were fed standard rat food and water ad libitum, while the MetS group was fed standard food with 10% (v/v) fructose solution added to their drinking water for 12 weeks with a 12/12h photoperiod circle. Then, all animals were sacrificed after a one night fast. Peptides levels in the serum and reproductive tissues of rats were studied using the ELISA method while the immunoreactivity of reproductive system peptide hormones were shown by immunohistochemical staining method. Furthermore, the other biochemical parameters were measured using Konelab-60 equipment and infertility hormones were measured with Immulite2000. Fasting serum insulin, glucose, triglyceride, alanine aminotransferase (ALT), gamma glutamyl transpeptidase (GGT), low-density lipoprotein cholesterol (LDL-C), and total cholesterol (TC) levels were statistically significantly higher, and the amount of high density lipoprotein cholesterol (HDL-C) was significantly lower, in the MetS groups. Serum and tissue supernatant NES levels were significantly higher in the rats with MetS than the control group. Ghrelin, OBS and NES were expressed in the cytoplasm, concentrated around the apical parts of the epithelial cells in the reproductive tissues of the rats. The amounts of ghrelin were lower in the reproductive tissues of the animals with MetS, while NES levels in the same tissues increased. Obestatin also decreased, though not in the seminal glands.