The present study aimed to re-evaluate the antiepileptic role of taurine (TAU), using pilocarpinized rats as an animal model which highly mimics the temporal lobe (focal) epilepsy in human, and the band-power spectrum as a quantitative... more
The present study aimed to re-evaluate the antiepileptic role of taurine (TAU), using pilocarpinized rats as an animal model which highly mimics the temporal lobe (focal) epilepsy in human, and the band-power spectrum as a quantitative method of EEG analysis. The present data showed marked, almost more highly significant, increases in the band powers of both slow and fast EEG waves, and at all the investigated time intervals after pilocarpine (PIL) injection (300 mg/ kg). The highest increase was in alpha (α) power. The daily intracerebro-ventricular (ICV) administration of TAU (20 µm /kg) for 6 days (15-21 days after PIL injection) resulted in a complete recovery of the power values of β1-, β2-and theta (θ) waves, nonsignificant increase (+13.89%) in α-power, and nonsignificant decrease (-10.20%) in delta (δ) power. According to the present observations, taurine is suggested to possess a biphasic regulatory function in the PIL-induced focal neurons during the interical period, by w...
The use of mobile phones is rapidly increasing all over the world. Few studies deal with the effect of electromagnetic radiation (EMR) on monoamine neurotransmitters in the different brain areas of adult rat. The aim of the present study... more
The use of mobile phones is rapidly increasing all over the world. Few studies deal with the effect of electromagnetic radiation (EMR) on monoamine neurotransmitters in the different brain areas of adult rat. The aim of the present study was to investigate the effect of EMR on the concentrations of dopamine (DA), norepinephrine (NE) and serotonin (5-HT) in the hippocampus, hypothalamus, midbrain and medulla oblongata of adult rats. Adult rats were exposed daily to EMR (frequency 1800 MHz, specific absorption rate 0.843 W/kg, power density 0.02 mW/cm2, modulated at 217 Hz) and sacrificed after 1, 2 and 4 months of daily EMR exposure as well as after stopping EMR for 1 month (after 4 months of daily EMR exposure). Monoamines were determined by high performance liquid chromatography coupled with fluorescence detection (HPLC-FD) using their native properties. The exposure to EMR resulted in significant changes in DA, NE and 5-HT in the four selected areas of adult rat brain. The exposur...
Mobile phone radiation and health concerns have been raised, especially following the enormous increase in the use of wireless mobile telephony throughout the world. The present study aims to investigate the effect of one hour daily... more
Mobile phone radiation and health concerns have been raised, especially following the enormous increase in the use of wireless mobile telephony throughout the world. The present study aims to investigate the effect of one hour daily exposure to electromagnetic radiation (EMR) with frequency of 900 Mz (SAR 1.165 w/kg, power density 0.02 mW/cm2) on the levels of amino acid neurotransmitters in the midbrain, cerebellum and medulla of adult and young male albino rats. Adult and young rats were divided into two main groups (treated and control). The treated group of both adult and young rats was exposed to EMR for 1 hour daily. The other group of both adult and young animals was served as control. The determination of amino acid levels was carried out after 1 hour, 1 month, 2 months and 4 months of EMR exposure as well as after stopping radiation. Data of the present study showed a significant increase in both excitatory and inhibitory amino acids in the cerebellum of adult and young rat...
Status epilepticus (SE) has functional and structural consequences resulting in brain damage. The present study aims to investigate the role of taurine and green tea extract in the neuroprotection against oxidative stress and changes in... more
Status epilepticus (SE) has functional and structural consequences resulting in brain damage. The present study aims to investigate the role of taurine and green tea extract in the neuroprotection against oxidative stress and changes in acetylcholinesterase (AChE) and Na + ,K +-ATPase activities during SE induced by pilocarpine in the hippocampus of adult male rats. Animals received an oral administration of either taurine (100 mg/kg) or green tea extract containing 100 mg/kg epigallocatechin gallate for 3 days before the induction of SE with pilocarpine (380 mg/kg, i.p.) and were sacrificed 1 h after pilocarpine injection. Data indicated that a state of oxidative stress has evolved during SE as evident from the significant increase in lipid peroxidation level and significant decrease in reduced glutathione (GSH) level. Significant decreases in AChE and Na +
