Nasr M Radwan

Background Soy protein is an important component of soybeans and is one the 8 most significant food allergens. Yet, the prevalence of soy allergy in the pediatric population is not well defined. Objectives To evaluate the incidence of IgE mediated soy protein sensitization among children with clinical manifestation of atopic disorders by the use of skin prick test (SPT) for soy protein. Methods Two hundred patients with atopic manifestations attending the Pediatric Allergy and Immunology Clinic at the Pediatric Department of Ain shams University, were recruited between January 2017 till January 2018. They were subjected to SPT to soy protein, measurement of total serum IgE and eosinophilic count in the peripheral blood. Results Of the 200 patients, 108 (54%) were males and 92 (46%) were females with a male to female ratio of 1.17:1. Their ages ranged between 2 years and 15 years (mean±SD; 6.0±33.3 years). Seven patients (3.5%) had positive skin prick test to soy protein. The mean va...

Background and Objec-tives: The present study aimed to evaluate the protective and curative effects of the 15 KD protein isolated from the seeds of Peganum harmala L. against carbon tetrachloride (CCl 4) induced oxidative stress in rats. Materials and Methods: In the protective study, animals were pretreated intraperitoneally with 15 KD isolated protein at doses of 4 and 8 mg/kg body weight as well as vitamin C (250 mg/kg body weight p.o) for 7 days and then chal-lenged with CCl 4 orally (1 ml/kg body weight) in olive oil (50%) for 2 days. In the curative study, rats were administered CCl 4 orally for 2 days, then treated intraperitoneally with 15 KD protein (4 and 8 mg/kg body weight) and orally with vitamin C. Results: Administration of CCl 4 induced in-duction in malondialdehyde (MDA) and de-crease in reduced glutathione (GSH) levels as well as glutathione-S-transferase (GST) activi-ty in brain, testes and erythrocytes. The activi-ty of acetylcholinesterase (AchE) in brain was al...

Parkinson’s disease (PD) is the second most prevalent neurodegenerative disease worldwide and represents a challenge for clinicians. The present study aims to investigate the effects of cerebrolysin and/or lithium on the behavioral, neurochemical and histopathological alterations induced by reserpine as a model of PD. The rats were divided into control and reserpine-induced PD model groups. The model animals were further divided into four subgroups: rat PD model, rat PD model treated with cerebrolysin, rat PD model treated with lithium and rat PD model treated with a combination of cerebrolysin and lithium. Treatment with cerebrolysin and/or lithium ameliorated most of the alterations in oxidative stress parameters, acetylcholinesterase and monoamines in the striatum and midbrain of reserpine-induced PD model. It also ameliorated the changes in nuclear factor-kappa and improved the histopathological picture induced by reserpine. It could be suggested that cerebrolysin and/or lithium...

The extensive use of mobile phones worldwide has raised increasing concerns about the effects of electromagnetic radiation (EMR) on the brain due to the proximity of the mobile phone to the head and the appearance of several adverse neurological effects after mobile phone use. It has been hypothesized that the EMR-induced neurological effects may be mediated by amino acid neurotransmitters. Thus, the present study investigated the effect of EMR (frequency 1800 MHz, specific absorption rate 0.843 W/kg, power density 0.02 mW/cm, modulated at 217 Hz) on the concentrations of amino acid neurotransmitters (glutamic acid, aspartic acid, gamma aminobutyric acid, glycine, taurine, and the amide glutamine) in the hippocampus, striatum, and hypothalamus of juvenile and young adult rats. The juvenile and young adult animals were each divided into two groups: control rats and rats exposed to EMR 1 h daily for 1, 2, and 4 months. A subgroup of rats were exposed daily to EMR for 4 months and then...

Multiple sclerosis (MS) is an immune mediated, inflammatory demyelinating neurodegenerative disease of the central nervous system (CNS). Experimental autoimmune encephalomyelitis (EAE) is a well-established animal model of MS. MS is considered as one of the most important causes of disability in adults. It is a chronic progressive, potentially disabling disorder with considerable social impact and economic consequences. Unfortunately, it is not currently possible to cure MS, the treatments available up to now have centered their action on the anti-inflammatory and disease course-modifying effect, and the purpose of treatment is to prevent recurrence of relapses and accumulation of disability. In addition, all the approved drugs for MS treatment have potentially serious side effects.Therefore the aim of the present study was to investigate the protective as well as the possible ameliorative effects of N. sativa seeds (a natural non-toxic product) in EAE-induced Wistar female rats.

Electromagnetic radiation (EMR) of cellular phones may affect biological systems by increasing free radicals and changing the antioxidant defense systems of tissues, eventually leading to oxidative stress. Green tea has recently attracted significant attention due to its health benefits in a variety of disorders, ranging from cancer to weight loss. Thus, the aim of the present study was to investigate the effect of EMR (frequency 900 MHz modulated at 217 Hz, power density 0.02 mW/cm(2), SAR 1.245 W/kg) on different oxidative stress parameters in the hippocampus and striatum of adult rats. This study also extends to evaluate the therapeutic effect of green tea mega EGCG on the previous parameters in animals exposed to EMR after and during EMR exposure. The experimental animals were divided into four groups: EMR-exposed animals, animals treated with green tea mega EGCG after 2 months of EMR exposure, animals treated with green tea mega EGCG during EMR exposure and control animals. EMR...

Preliminary phytochemical screening of the plant Thymus capitatus exhibited the presence of saponins, resins, flavonoids, essential and fixed oils. Aqueous and ethanolic extracts (10–200 mg/ml) as well as saponin, resin and essential oil of the plant (10–5000 μg/ml) inhibited ...

Status epilepticus (SE) has functional and structural consequences resulting in brain damage. The present study aims to investigate the role of taurine and green tea extract in the neuroprotection against oxidative stress and changes in acetylcholinesterase (AChE) and Na + ,K +-ATPase activities during SE induced by pilocarpine in the hippocampus of adult male rats. Animals received an oral administration of either taurine (100 mg/kg) or green tea extract containing 100 mg/kg epigallocatechin gallate for 3 days before the induction of SE with pilocarpine (380 mg/kg, i.p.) and were sacrificed 1 h after pilocarpine injection. Data indicated that a state of oxidative stress has evolved during SE as evident from the significant increase in lipid peroxidation level and significant decrease in reduced glutathione (GSH) level. Significant decreases in AChE and Na +

Mobile phone radiation and health concerns have been raised, especially following the enormous increase in the use of wireless mobile telephony throughout the world. The present study aims to investigate the effect of one hour daily exposure to electromagnetic radiation (EMR) with frequency of 900 Mz (SAR 1.165 w/kg, power density 0.02 mW/cm2) on the levels of amino acid neurotransmitters in the midbrain, cerebellum and medulla of adult and young male albino rats. Adult and young rats were divided into two main groups (treated and control). The treated group of both adult and young rats was exposed to EMR for 1 hour daily. The other group of both adult and young animals was served as control. The determination of amino acid levels was carried out after 1 hour, 1 month, 2 months and 4 months of EMR exposure as well as after stopping radiation. Data of the present study showed a significant increase in both excitatory and inhibitory amino acids in the cerebellum of adult and young rat...

The present study aimed to re-evaluate the antiepileptic role of taurine (TAU), using pilocarpinized rats as an animal model which highly mimics the temporal lobe (focal) epilepsy in human, and the band-power spectrum as a quantitative method of EEG analysis. The present data showed marked, almost more highly significant, increases in the band powers of both slow and fast EEG waves, and at all the investigated time intervals after pilocarpine (PIL) injection (300 mg/ kg). The highest increase was in alpha (α) power. The daily intracerebro-ventricular (ICV) administration of TAU (20 µm /kg) for 6 days (15-21 days after PIL injection) resulted in a complete recovery of the power values of β1-, β2-and theta (θ) waves, nonsignificant increase (+13.89%) in α-power, and nonsignificant decrease (-10.20%) in delta (δ) power. According to the present observations, taurine is suggested to possess a biphasic regulatory function in the PIL-induced focal neurons during the interical period, by w...

51 ESCME Sci. Med. J., Jul-oct. 2006; 18 (3-4): 51-66 The Effect of Fluoxetine on Some Amino Acid Neurotransmitters and Electrocorticogram of The Cortex in Reserpinized Rats Heba Aboul Ezz, Nawal Ahmed, Tagreed Abd El Rahman, Nasr Radwan, Neveen Noor Department of ...

ABSTRACT At a pond in Kottenforst, Bonn, West Germany, the calling period of the water frog Rana lessonae began on the first of May and ended by the end of June, 1983. The population is of the mixed type: 80-85 % of the individuals are classified as R. lessonae, the rest as R. esculenta. The reproductive period is subdivided into 3 successive phases: pre-spawning, spawning and post-spawning. Various exogenous factors, such as temperature, rainfall and sunlight, influence the reproductive period, and they particularly affect calling activity. The male frogs do not produce mating calls when the water temperature is below 14°C, or above 26°C. Female frogs prefer sunny places in the water during the spawning phase. Sexual activity is more intense in male R. lessonae than in male R. esculenta. Medium- and large-size male R. lessonae are more successful than small males in choosing suitable territories and in maintaining of amplexus with females. Male R. lessonae give four basic types of calls-mating call, two territorial calls and release call-and in addition two transitional calls. The basic types are given throughout the calling period, whereas the transitional calls are not. An increase in water temperature induces a decrease in call duration, intercall interval and pulse-group duration of the mating call. On the other hand, the frequencies and the repetition rate of the pulse groups are raised. Similarly, the duration of both territorial calls decreases at higher water temperatures, whereas their dominant frequencies are subjected to a notable increase. Body size has a prominent effect on the mating call. The number of pulses per pulse group and the different frequencies of the call decrease with increasing male body length. The lower pitch in the mating call produced by medium- and large-size males is assumed to play a role in their mating-success. The repetition rate of pulses and the dominant frequency in the territorial calls decrease as the body size of the frogs increases.