Your search for: 'author:("Arosio, Beatrice")' has returned 18 results. (0.016s) Save search

Authors: Di Francesco, Andrea | Arosio, Beatrice | Gussago, Cristina | Dainese, Enrico | Mari, Daniela | D'Addario, Claudio | Maccarrone, Mauro

Article Type: Short Communication

Abstract: Lipoxygenases play a major role in the neuropathology of Alzheimer's disease (AD), even though the underlying mechanisms are as yet poorly understood. Here, we studied the epigenetic regulation of 5-lipoxygenase (5-LOX) in peripheral blood mononuclear cells of subjects with late-onset AD and age-matched controls. We found a significant increase in 5-LOX gene expression in AD subjects compared to healthy controls, paralleled by increased 5-LOX protein and leukotriene B4 , the 5-LOX product. In addition, a consistent reduction in DNA methylation at 5-LOX gene promoter was documented in AD versus healthy subjects. Taken together, our findings further support a role for …5-LOX in vulnerability to neurodegeneration. Show more

Keywords: Alzheimer's disease, biomarker, DNA methylation, fatty acid amide hydrolase, 5-lipoxygenase, peripheral blood mononuclear cells

DOI: 10.3233/JAD-130506

Citation: Journal of Alzheimer's Disease, vol. 37, no. 1, pp. 3-8, 2013

Authors: Arosio, Beatrice | Viazzoli, Chiara | Mastronardi, Luigina | Bilotta, Claudio | Vergani, Carlo | Bergamaschini, Luigi

Article Type: Short Communication

Abstract: Adenosine suppresses immune responses through the adenosine A2A receptors (A2A R). We evaluated the expression of A2A R in blood mononuclear cells (PBMCs) of patients with mild cognitive impairment (MCI), Alzheimer's disease (AD), and controls in order to verify if it may help distinguish different forms of cognitive decline. There was a significant linear increase in both mRNA levels and receptor density from multiple cognitive domain MCI (mcd-MCI) to amnestic MCI (a-MCI), spanning through AD and controls, without any significant difference between the latter two groups of subjects. These data, which need to be confirmed in a larger number of …patients, suggest that expression of A2A R in PBMCs may be a valuable means of differentiating a-MCI and mcd-MCI. Show more

Keywords: Adenosine receptors, Alzheimer's disease, inflammation, mild cognitive impairment

DOI: 10.3233/JAD-2010-090814

Citation: Journal of Alzheimer's Disease, vol. 20, no. 4, pp. 991-996, 2010

Authors: Costa, Andrea Saul | Guerini, Franca Rosa | Arosio, Beatrice | Galimberti, Daniela | Zanzottera, Milena | Bianchi, Anna | Nemni, Raffaello | Clerici, Mario

Article Type: Research Article

Abstract: The SNARE complex plays a crucial role in the synaptic exocytosis of neurotransmitters, a process involved in the Alzheimer’s disease (AD), the most common form of dementia. SNAP-25, STX1a, and VAMP2 are the core proteins of the SNARE complex, and changes in protein level are suggested to contribute to cognitive impairment and neuropsychiatric disorders. Single nucleotide polymorphisms (SNPs) in SNARE complex genes were shown to be associated with different diseases and different cognitive impairments. Chi-square analysis was used to compare case-control difference of ApoE4, SNAP-25 rs363039, rs363043, rs363950, STX1a rs4717806, rs2293489, and VAMP2 26bp Ins/Del genotype distribution in 192 AD, …187 mild cognitive impairment (MCI), and 200 healthy controls (HC). Results of genotype and allelic distribution of SNAP-25 rs363050 showed that AA genotype (AD versus HC: p  = 1.5×10–4 ; MCI versus HC: p  = 8.7×10–3 ) as well as A allele (AD versus HC: p  = 6.0×10–4 ; MCI versus HC: p  = 5.7×10–3 ) are significantly more frequent in AD and MCI compared to HC. Genotype distribution of STX1a rs4717806 and rs2293489 resulted significantly different in AD compared to HC (p  = 0.032 and p  = 0.047, respectively). Moreover, distribution of the STX1a rs4717806 allele in SNAP-25 rs363050 AA carriers was significantly different between MCI and HC (p  = 0.018). Notably, in MCI, visual selective attention impairment was associated with the STX1a rs4717806 AA (pc  = 0.027) genotype as well as the SNAP-25/STX1a rs363050/rs4717806 AA/A (pc  = 0.022) combination. These data suggest that SNPs in SNARE complex genes may interfere and/or modulate the activity of the SNARE complex resulting in impairments of neurotransmission that involve attention brain areas. Show more

Keywords: Alzheimer’s disease, cognitive impairment, gene polymorphisms, mild cognitive impairment, SNAP-25, SNARE, SNPs, STX1a, VAMP2

DOI: 10.3233/JAD-190147

Citation: Journal of Alzheimer's Disease, vol. 69, no. 1, pp. 179-188, 2019

Authors: Arosio, Beatrice | Casati, Martina | Gussago, Cristina | Ferri, Evelyn | Abbate, Carlo | Scortichini, Valeria | Colombo, Elena | Rossi, Paolo Dionigi | Mari, Daniela

Article Type: Review Article

Abstract: As the European population gets older, the incidence of neurological disorders increases with significant impact on social costs. Despite differences in disease etiology, several brain disorders in the elderly (e.g., Alzheimer’s disease, vascular dementia, normal pressure hydrocephalus) share dementia as a common clinical feature. The current treatment for the majority of these diseases is merely symptomatic and does not modify the course of the illness. Symptoms of normal pressure hydrocephalus are the only ones that can be modified if they are recognized in time and treated appropriately. Therefore, an important clinical strategy may be disclosed by pathogenic pathways that can …be modified and to find drugs that can slow down or even arrest disease progression. Possibly a way to answer this question could be by re-examining all the molecules which have so far succeeded in improving many aspects of cognitive deterioration in some neurodegenerative conditions, that were not considered because of controversial opinions. The main purpose of this summary is to further substantiate the hypothesis that the pathway of adenosine type A2A receptor could be used as a potential target to develop new/old therapeutic strategies. Show more

Keywords: Adenosine, adenosine receptors, elderly, neurodegeneration

DOI: 10.3233/JAD-160324

Citation: Journal of Alzheimer's Disease, vol. 54, no. 2, pp. 417-425, 2016

Authors: Abbate, Carlo | Trimarchi, Pietro D. | Inglese, Silvia | Damanti, Sarah | Dolci, Giulia A.M. | Ciccone, Simona | Rossi, Paolo D. | Mari, Daniela | Arosio, Beatrice | Bagarolo, Renzo | Giunco, Fabrizio | Cesari, Matteo

Article Type: Research Article

Abstract: Background: Alzheimer’s disease (AD) is a clinically heterogeneous disease. Multiple atypical syndromes, distinct from the usual amnesic phenotype, have been described. In this context, the existence of a right variant of AD (RAD), characterized by enduring visuospatial impairment associated with right-sided asymmetric brain damage, has been proposed. However, to date, this phenotype remains controversial. In particular, its peculiar characteristics and the independence from more prevalent cases (especially the posterior cortical atrophy syndrome) have to be demonstrated. Objective: To explore the existence of focal RAD on the basis of existing literature. Methods: We performed a literature search for the description of …atypical AD presentations, potentially evoking cases of focal RAD. To be considered as affected by RAD, the described cases had to present: 1) well documented right-sided asymmetry at neuroimaging; 2) predominant cognitive deficits localizable on the right hemisphere; 3) no specific diagnosis of a known variant of AD. Results: Twenty-one cases were found in the literature, but some of them were subsequently excluded because some features of a different clinical syndrome were overlapped with the clinical features of RAD. Thirteen positive cases, three of them with pathologically confirmed AD, remained. A common right clinical-radiological syndrome, characterized by memory and visuospatial impairment with temporal and parietal involvement, consistently emerged. However, the heterogeneity among the reports prevented a definitive and univocal description of the syndrome. Conclusion: Even if sporadic observations strongly support the existence of a focal RAD, no definitive conclusions can still be drawn about it as an independent condition. Show more

Keywords: Alzheimer’s disease, cognitive manifestations, left right asymmetry, right Alzheimer’s disease, right hemisphere, syndromic diversity, variant of Alzheimer’s disease, visuospatial ORCID: 0000-0002-0368-3834

DOI: 10.3233/JAD-190338

Citation: Journal of Alzheimer's Disease, vol. 71, no. 2, pp. 405-420, 2019

Authors: Galimberti, Daniela | Arosio, Beatrice | Fenoglio, Chiara | Serpente, Maria | Cioffi, Sara M.G. | Bonsi, Rossana | Rossi, Paolo | Abbate, Carlo | Mari, Daniela | Scarpini, Elio

Article Type: Short Communication

Abstract: We genotyped for the C9ORF72 hexanucleotide repeat expansion a population of 156 non-demented elderly subjects, recruited in a geriatric unit as control group for association studies in patients with Alzheimer's disease (AD), and found two carriers (1.2%). The first was referred for subjective memory complaints, at age 81. He was followed up until age 84 and did not develop dementia. The second was an 80-year old volunteer (spouse and caregiver of a patient with AD), non-demented at time of recruitment. We have not had information on her condition since that time. These results suggest that the penetrance of the mutation …is definitely incomplete. Show more

Keywords: C9ORF72 hexanucleotide repeat expansion, dementia, elderly, frontotemporal lobar degeneration, penetrance

DOI: 10.3233/JAD-131172

Citation: Journal of Alzheimer's Disease, vol. 39, no. 1, pp. 19-22, 2014

Authors: Abbate, Carlo | Arosio, Beatrice | Galimberti, Daniela | Nicolini, Paola | Chiara, Lo Russo | Rossi, Paolo Dionigi | Ferri, Evelyn | Gussago, Cristina | Deriz, Milena | Fenoglio, Chiara | Serpente, Maria | Scarpini, Elio | Mari, Daniela

Article Type: Short Communication

Abstract: We describe a sporadic case of frontotemporal lobar degeneration, associated with the C9ORF72 mutation, with prominent behavioral changes and semantic deficits. Predominant deficits in naming, vocabulary, word comprehension, and face and object recognition emerged on neuropsychological assessment. Amnesia, behavioral changes, and isolated psychotic symptoms were also present. Hyposmia was an unspecific prodromal sign. Brain imaging showed basofrontal and temporopolar hypometabolism bilaterally, and predominantly left-sided atrophy. Levels of cerebrospinal fluid biomarkers (amyloid-β, tau and p-tau) were normal. This description further confirms the heterogeneous presentation of the C9ORF72 mutation.

Keywords: C9ORF72, frontotemporal lobar degeneration, hyposmia, phenotype, semantic dementia

DOI: 10.3233/JAD-132075

Citation: Journal of Alzheimer's Disease, vol. 40, no. 4, pp. 849-855, 2014

Authors: Gussago, Cristina | Arosio, Beatrice | Casati, Martina | Ferri, Evelyn | Gualandris, Federica | Tedone, Enzo | Nicolini, Paola | Rossi, Paolo Dionigi | Abbate, Carlo | Mari, Daniela

Article Type: Short Communication

Abstract: The line between vascular dementia (VaD) and Alzheimer's disease (AD) is often blurred. In this study we investigated whether adenosine A2A receptor (A2A R) expression can be used to differentiate between VaD and AD. We evaluated the expression of this receptor in the peripheral blood mononuclear cells of patients with VaD, mild cognitive impairment, AD, and controls. We found statistically significant lower levels of A2A R mRNA in VaD compared to AD subjects. These data suggest that A2A R expression may help in the differential diagnosis between VaD and AD.

Keywords: Adenosine receptors, Alzheimer's disease, biomarker, vascular dementia

DOI: 10.3233/JAD-131652

Citation: Journal of Alzheimer's Disease, vol. 40, no. 1, pp. 45-49, 2014

Authors: Serpente, Maria | Fenoglio, Chiara | Clerici, Francesca | Bonsi, Rossana | Arosio, Beatrice | Cioffi, Sara M.G. | Rotondo, Emanuela | Franceschi, Massimo | Boneschi, Filippo Martinelli | Mari, Daniela | Mariani, Claudio | Scarpini, Elio | Galimberti, Daniela

Article Type: Short Communication

Abstract: We carried out an association study of transmembrane protein 106B gene (TMEM106B) rs1020004 A/G, rs6966915C/T, and rs1990622 A/G in a population of 656 patients with Alzheimer's disease (AD) and 619 controls, and tested whether the rs1990622 influences plasma progranulin levels. No differences in allele and genotype distribution were observed between cases and controls, even stratifying according to APOE status (p > 0.05). No differences in progranulin plasma levels were found between carriers of the rs1990622 and non-carriers. TMEM106b variability does not influence AD risk or plasma levels. Replication, preferably in a population with pathological confirmation, is required to confirm these …results. Show more

Keywords: Alzheimer's disease, progranulin, TDP-43, TMEM106b

DOI: 10.3233/JAD-141167

Citation: Journal of Alzheimer's Disease, vol. 43, no. 3, pp. 757-761, 2015

Authors: Sorrentino, Federica | Fenoglio, Chiara | Sacchi, Luca | Serpente, Maria | Arighi, Andrea | Carandini, Tiziana | Arosio, Beatrice | Ferri, Evelyn | Arcaro, Marina | Visconte, Caterina | Rotondo, Emanuela | Scarpini, Elio | Galimberti, Daniela

Article Type: Research Article

Abstract: Background: The longevity gene Klotho (KL ) was recently associated with neurodegenerative diseases including Alzheimer’s disease (AD). Its role in the brain has not been completely elucidated, although evidence suggests that KL-VS heterozygosity is associated with a reduced risk of AD in Apolipoprotein E ɛ 4 carriers. Conversely, no data about genetic association with frontotemporal dementia (FTD) are available so far. Objective: To investigate the involvement of KL in AD and FTD by the determination of the genetic frequency of KL-VS variant and the expression analysis of KL gene. Methods: A population consisting of 438 patients and 240 age-matched controls …was enrolled for the study. KL-VS and APOE genotypes were assessed by allelic discrimination through a QuantStudio 12K system. KL gene expression analysis was performed in a restricted cohort of patients consisting of 43 AD patients, 41 FTD patients and 19 controls. KL gene expression was assessed in peripheral blood mononuclear cells with specific TaqMan assay. Statistical analysis was performed using GraphPad 9 Prims software. Results: KL-VS frequency was comparable to the ones found in literature and no differences were found in both allelic and genotypic frequencies between patients and controls were found. Conversely, KL expression levels were significantly lower in AD and FTD patients compared with controls (mean fold regulation – 4.286 and – 6.561 versus controls in AD and FTD, respectively, p  = 0.0037). Conclusion: This is the first study investigating KL in FTD. We showed a decreased expression of the gene in AD and FTD, independent of the genotype, suggesting a role of Klotho in common steps during neurodegeneration. Show more

Keywords: Alzheimer’s disease, expression, frontotemporal dementia, Klotho, neurodegeneration

DOI: 10.3233/JAD-230322

Citation: Journal of Alzheimer's Disease, vol. 94, no. 3, pp. 1225-1231, 2023