Your search for: 'author:("Scortichini, Valeria")' has returned 1 result. (0.005s) Save search

Authors: Arosio, Beatrice | Casati, Martina | Gussago, Cristina | Ferri, Evelyn | Abbate, Carlo | Scortichini, Valeria | Colombo, Elena | Rossi, Paolo Dionigi | Mari, Daniela

Article Type: Review Article

Abstract: As the European population gets older, the incidence of neurological disorders increases with significant impact on social costs. Despite differences in disease etiology, several brain disorders in the elderly (e.g., Alzheimer’s disease, vascular dementia, normal pressure hydrocephalus) share dementia as a common clinical feature. The current treatment for the majority of these diseases is merely symptomatic and does not modify the course of the illness. Symptoms of normal pressure hydrocephalus are the only ones that can be modified if they are recognized in time and treated appropriately. Therefore, an important clinical strategy may be disclosed by pathogenic pathways that can …be modified and to find drugs that can slow down or even arrest disease progression. Possibly a way to answer this question could be by re-examining all the molecules which have so far succeeded in improving many aspects of cognitive deterioration in some neurodegenerative conditions, that were not considered because of controversial opinions. The main purpose of this summary is to further substantiate the hypothesis that the pathway of adenosine type A2A receptor could be used as a potential target to develop new/old therapeutic strategies. Show more

Keywords: Adenosine, adenosine receptors, elderly, neurodegeneration

DOI: 10.3233/JAD-160324

Citation: Journal of Alzheimer's Disease, vol. 54, no. 2, pp. 417-425, 2016