ABSTRACT
Certain jaesekanadiol p-hydroxy- and p-methoxybenzoates - typical of Ferula communis and Ferula arrigonii sardinian plants - show antiproliferative activity on human colon cancer less. The inhibitory doses 50%, calculated after 72 h of... more
Certain jaesekanadiol p-hydroxy- and p-methoxybenzoates - typical of Ferula communis and Ferula arrigonii sardinian plants - show antiproliferative activity on human colon cancer less. The inhibitory doses 50%, calculated after 72 h of treatment, revealed that the antiproliferative capacity of the compounds was in the following descending order: ferutinin > 2alpha-OH-ferutidin > ferutidin > siol anisate > lapiferin > jaeskeanadiol. Evidence is presented that interaction with type II estrogen-binding sites (EBS) underlies this activity.
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... This compound also exhibits strong dermatophyte inhibition (Mares, Fasulo & Bruni, 1990). ... Good growth inhibition was observed in all dermatophytes treated with the highest dose (50 lgml ")as long as treatment was followed... more
... This compound also exhibits strong dermatophyte inhibition (Mares, Fasulo & Bruni, 1990). ... Good growth inhibition was observed in all dermatophytes treated with the highest dose (50 lgml ")as long as treatment was followed by uv-A irradiation. ...
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Research Interests:
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Supercritical fluid extraction (SFE) of seeds of Amaranthus caudatus (Amaranthaceae) and the use of ultrasound as a co-adjuvant in the extraction process were compared with methods traditionally used in the extraction of tocopherols and... more
Supercritical fluid extraction (SFE) of seeds of Amaranthus caudatus (Amaranthaceae) and the use of ultrasound as a co-adjuvant in the extraction process were compared with methods traditionally used in the extraction of tocopherols and fatty acids. The use of readily available ultrasound equipment as an adjunct to the classical methods employed for the extraction of tocols provided qualitatively acceptable results more rapidly and more economically. SFE gave quantitatively better yields in shorter times, with solvent-free extracts obtained under conditions that minimised the degradation of thermolabile components. No significant variations were observed in the profile of the fatty acids extracted from amaranth oil by SFE or other methods, thus confirming the qualitative comparability of the faster supercritical extraction with the more time-consuming classical techniques even when processed with the aid of ultrasound.
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The reduction of acetophenone 1 and the hydrolysis of 1-acetoxy-2-methylcyclohexene 3 with various commercially available plants to the corresponding S-carbinol 2 and S-ketone 4 are described. The further incubation of... more
The reduction of acetophenone 1 and the hydrolysis of 1-acetoxy-2-methylcyclohexene 3 with various commercially available plants to the corresponding S-carbinol 2 and S-ketone 4 are described. The further incubation of 2-methylcyclohexanone 4 with some plants affords the enantiomerically pure trans- and/or cis-alcohol 5 and 6, respectively.
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Research Interests:
ABSTRACT Biological activity (mortality and genotoxicity) of four thiophene compounds [a-terthienyl (a-T); 5-(4-hydroxy-1-butinyl)-2,2'-bithienyl (BBTOH); 5-(3-buten-1-ynyl)-2,2'-bithienyl (BBT);... more
ABSTRACT Biological activity (mortality and genotoxicity) of four thiophene compounds [a-terthienyl (a-T); 5-(4-hydroxy-1-butinyl)-2,2'-bithienyl (BBTOH); 5-(3-buten-1-ynyl)-2,2'-bithienyl (BBT); 5-(4-acetoxy-1-butinyl)-2,2'-bithienyl (BBTOAc)] was evaluated on Saccharomyces cerevisiae D7 strain cells. An high percentage of mortality was found with BBTOAc at all concentrations tested. A significant effect was also detected with a-T but only at the highest concentration. BBTOH stimulated colonies growth only at the lowest concentration, while BBT showed no effects. None of the tested compounds presented genotoxic activity.