This study aimed to assess the efficacy of thalidomide for treatment of experimental endometriosis. This study was a parallel-group, double-blind, stratified, randomized controlled animal trial with 1:1 allocation ratio. Endometriosis was... more
This study aimed to assess the efficacy of thalidomide for treatment of experimental endometriosis. This study was a parallel-group, double-blind, stratified, randomized controlled animal trial with 1:1 allocation ratio. Endometriosis was induced experimentally in 23 mature, nulligravid, female Sprague-Dawley rats, weighing approximately 200 g and aged 2 months. A checkpoint surgery was performed 6 weeks later. Then, the rats were randomly allocated into the thalidomide (22 mg/day p.o.) and control (0.5 mL saline 0.9%/day p.o.) groups of nine. After 6 weeks, they were killed. Before each laparotomy, blood for leukocyte and lymphocyte counts and during them, implants for histopathology and peritoneal fluid for interleukin (IL)-6, tumor necrosis factor-α and vascular endothelial growth factor (VEGF)-A concentrations (by enzyme-linked immunoassay) were collected. Allocation and stratified randomization were done using a computer, based on the obtained histopathology scores of the implants of the checkpoint surgery. The histopathology scores (the main outcome measure) were 2.00 ± 1.55 versus 0.44 ± 1.01 (P = 0.035). The comparisons of after-treatment counts of leukocytes, lymphocytes, VEGF-A and IL-6 between the two groups were statistically significant. The results of this study are in favor of therapeutic implication of thalidomide in experimental endometriosis in rats. This is the first time thalidomide has been evaluated on endometriosis in an animal model.
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Research Interests: Fibers, Thulium Doped Fibers, Optical physics, Wavelength Division Multiplexing, Band Pass Filter, and 17 moreNoise Figure, Amplified Spontaneous Emissions, Light Amplifiers, Optical Filters, Gain Medium, Power Umbilical Cables for Submersible Pump, Electrical And Electronic Engineering, Wavelength Regions, Bandpass Filters, Bending Loss, Shorter Wavelengths, Thulium Doped Fiber Amplifiers, Filter Function, Fundamental Modes, Macro Bending, Micro-bending, and Optical Bandpass Filters
Background: Currently clomiphene citrate is the first-line treatment to induce ovulation in women with polycystic ovarian syndrome (PCOS). Surgical therapy with laparoscopic ovarian drilling (LOD) may avoid or reduce the need for... more
Background: Currently clomiphene citrate is the first-line treatment to induce ovulation in women with polycystic ovarian syndrome (PCOS). Surgical therapy with laparoscopic ovarian drilling (LOD) may avoid or reduce the need for gonadotropins. Objective: To determine the ...
Research Interests:
Research Interests:
Design and Simulation of Filterless Optical Networks: Problem Definition and Performance Evaluation . . . . . . . . . . . . . . . . . 496 Émile Archambault, Daniel O'Brien, Christine Tremblay, François Gagnon, Michel P. Bélanger, and... more
Design and Simulation of Filterless Optical Networks: Problem Definition and Performance Evaluation . . . . . . . . . . . . . . . . . 496 Émile Archambault, Daniel O'Brien, Christine Tremblay, François Gagnon, Michel P. Bélanger, and Éric Bernier Clustering Methods for Hierarchical Traffic Grooming in Large-Scale Mesh WDM Networks . . . . . . . . . . . . . . . . . . . . . . . . . . 502 Bensong Chen, George N. Rouskas, and Rudra Dutta Multilayer Traffic Engineering for IP Over WDM Networks Based on Bayesian Decision Theory . . . . . . . . . . . . . . . . . . . . . . . 515 Víctor López, José Alberto ...