Objective: To determine the efficacy of ovarian drilling in PCO patients who failed to achieve pregnancy with medical treatment. Methods and Main Results: 75 patients with a diagnosis ofPCO of whom 48(64%) were primary infertile and... more
Objective: To determine the efficacy of ovarian drilling in PCO patients who failed to achieve pregnancy with medical treatment. Methods and Main Results: 75 patients with a diagnosis ofPCO of whom 48(64%) were primary infertile and 27(36%) were secondary infertile were clomi phene resistant. The other methods like bromocriptin, gonadotropins, GnRH -a and metformin had been given to these patients for infertility treatment without benefit. After ovarian drilling, pregnancy was achieved in 41 patients (54.6%), 30(40%) in group I (primary infertile group) and 11 (14.6%) in group II (secondary infertile group). During the operation adhesiolysis was necessary in 14( 18.6%) and removal of endometriotic lesions was indicated in 5(6.6%) in both groups. Conclusion: Ovarian drilling is an ideal technique in PCO patients with failure of medical treatment, considering the benefit of also performing other necessary surgical interventions. MJIRl, Vol. 19, No.3, 237-240, 2005.
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Background: For more than four decades clomiphene citrate has been the first line of the treatment for ovulatory disorders. The aim of this study was to compare the effects of letrozole and clomiphene citrate on ovulation and pregnancy... more
Background: For more than four decades clomiphene citrate has been the first line of the treatment for ovulatory disorders. The aim of this study was to compare the effects of letrozole and clomiphene citrate on ovulation and pregnancy rate in patients with polycystic ovary syndrome. Methods: In this prospective double-blind study, 100 patients with polycystic ovary syndrome were randomized into two equal groups. The first group received letrozole, 5mg daily (per oral) and the second group received clomiphene, 100mg daily during the 3rd-7th days of the menstrual cycles. Intra-muscular human chorionic gonadotropin (hCG) (10,000 IU) was administered to trigger ovulation when at least one mature follicle (≥ 18mm) was developed. Results: Ovulation occurred in 30 patients (60%) of the letro-zole group and in 16 patients (32%) of the clomiphene group, which showed a statistically significant difference (P=0.009). The mean number of follicles with diameter >14 mm on the day of administr...
Research Interests: Endocrinology, Medicine, Internal Medicine, Nitriles, Fertility and Sterility, and 15 moreFemale, Animals, Menstrual Cycle, Clinical Sciences, Ovarian Follicle, Luteinizing Hormone, Endometrium, Estradiol, Follicle stimulating hormone, Letrozole, Cell count, Clomiphene, Clomiphene citrate, Human Chorionic Gonadotropin, and follicle
Background: Recurrent spontaneous abortion impacts almost 1% of couples. The sera from women with unexplained recurrent spontaneous abortion (URSA) have toxic effects on embryos that grow in the uterus. Therefore, the abnormal condition... more
Background: Recurrent spontaneous abortion impacts almost 1% of couples. The sera from women with unexplained recurrent spontaneous abortion (URSA) have toxic effects on embryos that grow in the uterus. Therefore, the abnormal condition of the uterus may also affect sperm qualities. Objective: The objectives of this study were to search if these sera could induce DNA denaturation in sperm nuclei and also it could reduce sperm motility. Materials and Methods: Sera of 20 women with URSA history and sera from 20 women with at least two healthy children were added to the sperms samples from 20 healthy men for 2 hours. The sperm motility was assessed after incubation with sera. The samples were stained with Tdt mediated dUTP nick end labeling (TUNEL) assay for DNA fragmentation. The samples were analyzed with flow cytometry and the percentage of the TUNEL positive sperms were calculated. The data were analyzed by t-test. Results: The incubation of the sperm samples in sera with URSA lead...
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Background: The purpose of this study was to evaluate whether a random urinary protein / creatinine ratio is a clinically useful predictor of significant proteinuria (≥300 mg/24 hr) instead of 24- hours urine protein, among women with... more
Background: The purpose of this study was to evaluate whether a random urinary protein / creatinine ratio is a clinically useful predictor of significant proteinuria (≥300 mg/24 hr) instead of 24- hours urine protein, among women with suspected preeclampsia. Methods: Women with suspected preeclampsia and gestational age of ≥20 weeks were included in a prospective study. Patients with chronic hypertension, diabetes mellitus, or preexisting renal disease were excluded. Protein/creatinine ratio was obtained before 24-hours urine collection. Positive and negative predictive values and sensitivity and specificity of the protein/creatinine ratio for significant proteinuria (≥ 300 mg) were calculated, based on 24hours urine total protein. Results: 100 women were evaluated totally. Mean maternal and gestational ages were 27.3 years and 33.26 weeks, respectively.73% of cases had significant proteinuria based on 24-hours urine collection. Good correlations were found between the protein/creat...
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bjective: To determine the difference between two laparoscopic methods for the management of endoetriomas with regard to recurrence of signs and symptoms and pregnancy rate. esign: Prospective, randomized clinical trial. etting:... more
bjective: To determine the difference between two laparoscopic methods for the management of endoetriomas with regard to recurrence of signs and symptoms and pregnancy rate. esign: Prospective, randomized clinical trial. etting: Infertility and gynecologic endoscopy units of two medical university hospitals. atient(s): One hundred patients with endometriomas who had either infertility or pelvic pain. ntervention(s): Patients were randomly divided into two groups; one group underwent cystectomy (group 1), nd fenestration and coagulation were performed for the other (group 2). ain Outcome Measure(s): A comparison of recurrence of signs and symptoms of endometriomas and regnancy rates in two groups. esult(s): Fifty-two patients were studied in group 1 and 48 in group 2. The recurrence of symptoms, such s pelvic pain and dysmenorrhea, was 15.8% in group 1 and 56.7% in group 2 after 2 years. The rate of eoperation was 5.8% in group 1 and 22.9% in group 2 and these differences were statis...
Background: For more than four decades clomiphene citrate has been the first line of the treatment for ovulatory disorders. The aim of this study was to compare the effects of letrozole and clomiphene citrate on ovulation and pregnancy... more
Background: For more than four decades clomiphene citrate has been the first line of the treatment for ovulatory disorders. The aim of this study was to compare the effects of letrozole and clomiphene citrate on ovulation and pregnancy rate in patients with polycystic ovary syndrome. Methods: In this prospective double-blind study, 100 patients with polycystic ovary syndrome were randomized into two equal groups. The first group received letrozole, 5mg daily (per oral) and the second group received clomiphene, 100mg daily during the 3rd-7th days of the menstrual cycles. Intramuscular human chorionic gonadotropin (hCG) (10,000 IU) was administered to trigger ovulation when at least one mature follicle (≥ 18mm) was developed. Results: Ovulation occurred in 30 patients (60%) of the letrozole group and in 16 patients (32%) of the clomiphene group, which showed a statistically significant difference (P=0.009). The mean number of follicles with diameter >14 mm on the day of administrat...
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Recurrent spontaneous abortion impacts almost 1% of couples. The sera from women with unexplained recurrent spontaneous abortion (URSA) have toxic effects on embryos that grow in the uterus. Therefore, the abnormal condition of the uterus... more
Recurrent spontaneous abortion impacts almost 1% of couples. The sera from women with unexplained recurrent spontaneous abortion (URSA) have toxic effects on embryos that grow in the uterus. Therefore, the abnormal condition of the uterus may also affect sperm qualities. The objectives of this study were to search if these sera could induce DNA denaturation in sperm nuclei and also it could reduce sperm motility. Sera of 20 women with URSA history and sera from 20 women with at least two healthy children were added to the sperms samples from 20 healthy men for 2 hours. The sperm motility was assessed after incubation with sera. The samples were stained with Tdt mediated dUTP nick end labeling (TUNEL) assay for DNA fragmentation. The samples were analyzed with flow cytometry and the percentage of the TUNEL positive sperms were calculated. The data were analyzed by t-test. The incubation of the sperm samples in sera with URSA lead to a decrease in the percentage of the motile sperm from 55% in control to 41% in the treated group, significantly (p=0.038). The percentage of the sperm with abnormal fragmented DNA increased after incubation with URSA (26.6%) compare to the control (21.2%); however, it was not significant. It seems that sera from URSA patients could not induce a significant increase in the percentage of the sperms with nuclei contain DNA fragmentation. However, the sera of women with URSA could affect the fertility rate by reduction of the sperm motility.
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Research Interests: Physiology, Research Methodology, Primary Health Care, Clinical Trial, Biology, and 20 moreDeveloping Countries, Health, Folic acid, Adolescent, Medicine, Insulin Resistance, Prospective studies, Humans, Insulin, Female, Gynecology and Obstetrics, Follow-up studies, Incidence, Homocysteine, Polycystic Ovary Syndrome, Gynecology, Adult, Clients, Endocrine System Mediators, and hyperhomocysteinemia
Research Interests: Treatment Outcome, Prospective studies, Pregnancy, Humans, Fertility and Sterility, and 14 moreFemale, Cystectomy, Recurrence, Clinical Sciences, Adult, Public health systems and services research, Endometriosis, Dysmenorrhea, Pelvic Pain, Female Infertility, Laparoscopy, Pregnancy Rate, Cumulant, and Reoperation
Research Interests: Surgery, Andrology, Treatment, Fertility, Comparative Study, and 15 moreHumans, Fertility and Sterility, Female, Ovulation Induction, Clinical Sciences, Gynecology, Adult, Public health systems and services research, Endometriosis, Fertilization in Vitro, Ovarian cysts, Ovary, Female Infertility, Laparoscopy, and Follicular phase
Research Interests: Prospective studies, Pregnancy, Humans, Nitriles, Female, and 14 moreAdult, Endometriosis, Gonadotropin Releasing Hormone, Group, Randomized Clinical Trial, Triazoles, Female Infertility, Aromatase Inhibitor, Laparoscopy, SECONDARY PREVENTION, Pregnancy Rate, Control Group, Postoperative Period, and GnRH Agonist
Methicillin-resistant Staphylococcus aureus (MRSA) is a well-known pathogen with a worldwide distribution. Given the increasing rate of MRSA infections, implementing of reliable, accurate and rapid testing for diagnosis of MRSA is... more
Methicillin-resistant Staphylococcus aureus (MRSA) is a well-known pathogen with a worldwide distribution. Given the increasing rate of MRSA infections, implementing of reliable, accurate and rapid testing for diagnosis of MRSA is necessary. The aim of this study was to compare four diagnostic methods for detection of MRSA isolates. From December 2012 to April 2014, 120 S. aureus isolates were collected from three hospitals affiliated with Tehran University of Medical Sciences. MRSA isolates were detected by four different methods including cefoxitin disc diffusion test, oxacillin disc diffusion test, minimum inhibitory concentration (MIC) of oxacillin as determined by MIC test strip, and mecA detection by PCR. Out of 120 S. aureus isolates, cefoxitin disc diffusion test, oxacillin disc diffusion test and MIC test strip identified 60 (50%), 48 (40%), 55 (45.83%) isolates as MRSA, respectively. The sensitivity and specificity for oxacillin disc diffusion, cefoxitin disc diffusion and...