Given the impact of transportation costs in both supplier selection and inventory management decisions in today’s enterprises, this article addresses both problems simultaneously by developing a mixed integer nonlinear programming model... more
Given the impact of transportation costs in both supplier selection and inventory management decisions in today’s enterprises, this article addresses both problems simultaneously by developing a mixed integer nonlinear programming model to properly allocate order quantities to the selected set of suppliers while taking into account the purchasing, inventory, and transportation costs under suppliers’ capacity and quality constraints. In particular, we focus on the usage of trucks as a means of transporting goods and the option of the full-truck-load versus less-than-truckload (LTL) is studied. Since actual LTL transportation costs are neither differentiable nor convex, they are modeled with a piecewise linear function using binary variables. It is shown that, considering actual transportation costs in inventory planning, not only affects the order quantities shipped from selected suppliers but also the actual selection of suppliers.
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This article incorporates quantity discounts on the purchased units into the Economic Order Quantity (EOQ) model with transportation costs. Some of the key components of transportation that companies must examine are the various modes of... more
This article incorporates quantity discounts on the purchased units into the Economic Order Quantity (EOQ) model with transportation costs. Some of the key components of transportation that companies must examine are the various modes of transportation available and their costs. Different ...
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Given the impact of transportation costs on both supplier selection and inventory replenishment decisions in today’s enterprises, this article addresses both problems simultaneously by proposing a mixed integer nonlinear programming model... more
Given the impact of transportation costs on both supplier selection and inventory replenishment decisions in today’s enterprises, this article addresses both problems simultaneously by proposing a mixed integer nonlinear programming model to properly allocate order quantities to the selected set of suppliers while taking into account the purchasing, holding and transportation costs under suppliers’ capacity and quality constraints. It is shown that incorporating transportation costs in the process of selecting suppliers and establishing an inventory policy, not only affects the order quantity shipped from selected suppliers, but also the actual selection of suppliers. Because of the difficulty that arises when working with actual transportation freight rates in large-scale problems, two continuous functions that estimate actual freight rates are analyzed. It is shown that the use of these functions is very practical and easy to implement.
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Taxanes form a large family of terpenes comprising over 350 members, the most famous of which is Taxol (paclitaxel), a billion-dollar anticancer drug. Here, we describe the first practical and scalable synthetic entry to these natural... more
Taxanes form a large family of terpenes comprising over 350 members, the most famous of which is Taxol (paclitaxel), a billion-dollar anticancer drug. Here, we describe the first practical and scalable synthetic entry to these natural products via a concise preparation of (+)-taxa-4(5),11(12)-dien-2-one, which has a suitable functional handle with which to access more oxidized members of its family. This route enables a gram-scale preparation of the 'parent' taxane--taxadiene--which is the largest quantity of this naturally occurring terpene ever isolated or prepared in pure form. The characteristic 6-8-6 tricyclic system of the taxane family, containing a bridgehead alkene, is forged via a vicinal difunctionalization/Diels-Alder strategy. Asymmetry is introduced by means of an enantioselective conjugate addition that forms an all-carbon quaternary centre, from which all other stereocentres are fixed through substrate control. This study lays a critical foundation for a planned access to minimally oxidized taxane analogues and a scalable laboratory preparation of Taxol itself.
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ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full... more
ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
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ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
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ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full... more
ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
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One of the current challenges in organic chemistry is the development of tandem reactions (domino or cascade reactions) that provide complex molecules from readily available starting compounds. 1 A major subject of research in this field... more
One of the current challenges in organic chemistry is the development of tandem reactions (domino or cascade reactions) that provide complex molecules from readily available starting compounds. 1 A major subject of research in this field is the exploration of new ...
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ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full... more
ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
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Cascade (domino) reactions provide an efficient way to construct complex molecular structures from readily avail-able organic compounds.[1] Particularly interesting is the syn-thesis of heterocycles through cascade reactions, involving... more
Cascade (domino) reactions provide an efficient way to construct complex molecular structures from readily avail-able organic compounds.[1] Particularly interesting is the syn-thesis of heterocycles through cascade reactions, involving the intramolecular addition of a heteroatomic ...
