It has been reported that sialic acid containing oligosaccharides play an important role in the adhesion between cancer cells and endothelial cells and metastatic potential of tu- mor cells is proportional to cell surface sialylation. In... more
It has been reported that sialic acid containing oligosaccharides play an important role in the adhesion between cancer cells and endothelial cells and metastatic potential of tu- mor cells is proportional to cell surface sialylation. In the present study, we investigated whether there is a change in serum total and lipid bound sialic acid levels of patients with benign and non-melanom malignant skin tumors and, evaluated whether the mea- surement of sialic acid levels may be useful clinically in distinguishing patients with be- nign skin tumors from those with non-melanom malignant skin tumors. In this study, 27 patients with malignant skin tumors (16 men, age 50.78 ± 12.46 years), 39 patients with benign skin tumors (17 men, age 48.59 ± 16.23 years) were included. Serum total and lipid bound sialic acid determination was performed by the thiobarbituric acid method described by Warren and, the resorsinol method described by Katopodis, respectively. Student's T test and Z test ...
The purpose of this study was to research regeneration and growing properties of an immature rat ear cartilage and its adjacent tissue after a thermal injury. Fifteen 30-day-old male Sprague-Dawley rats were used. Burn wounds were created... more
The purpose of this study was to research regeneration and growing properties of an immature rat ear cartilage and its adjacent tissue after a thermal injury. Fifteen 30-day-old male Sprague-Dawley rats were used. Burn wounds were created by applying a heated plaque. All the rats, based on their tissue sampling day, were placed in two groups for histopathologic evaluation. In group I (n = 5), the burned right auricles were amputated on the first day,and the left auricles were amputated as a control at the same time. In group II (n = 10), the burned right auricles were amputated on the 30th day, and the left auricles were amputated as a control at the same time. Epithelization of skin was completed in period ranging between 12 and 15 days in all burned ears. The skin appendages were few throughout the affected area.Chondroid tissue regenerated from perichondrium and increased capillary vessels were observed.On the first day of the burn injury, electron microscopic findings were karyopyknosis, karyorrhexis, and karyolysis of the nucleus, and there were also signs of necrosis. New chondroblasts were formed around the collagen fibrils in the scar tissue on the 30th day. CD-31 immunohistochemical staining showed increased capillary vessels in the burned ear. The peripheral nerve fibers decreased and regenerative signs of nerves were shown with the use of S-100 immunohistochemical staining. Differentiation of chondroblasts to chondrocytes occurs in the burned immature ear, and new cartilage tissue regenerates from perichondrium. In addition, regenerative signs of nerves appear.
Salivary duct carcinomas of parotid gland are rare, as are the skin metastases from them. Four cases are reported with metastases to the skin. We present an additional case, with subcutaneous metastases of the back and leg. To our... more
Salivary duct carcinomas of parotid gland are rare, as are the skin metastases from them. Four cases are reported with metastases to the skin. We present an additional case, with subcutaneous metastases of the back and leg. To our knowledge, this is the first case reported in the literature in which the nodule on an extremity was the metastasis of a salivary duct carcinoma of parotid gland.
Publication Date: 2005
Publication Name: The American Journal of Dermatopathology
