Thermoreversible gelation of a copolymer, poly (vinylidene fluoride-co-chlorotrifluoroethylene), has been studied in a series of aromatic diesters (phthalates) with varying aliphatic chain length, n. The gelation rate gradually increases... more
Thermoreversible gelation of a copolymer, poly (vinylidene fluoride-co-chlorotrifluoroethylene), has been studied in a series of aromatic diesters (phthalates) with varying aliphatic chain length, n. The gelation rate gradually increases with increasing n, ...
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Coupling of heteroaromatic vicinal alkynylcarbonyl derivatives (I), (VIII) and (XI) with Fischer carbene complexes and an external or internal dienophile offers an interesting route to different annulated nitrogen heterocycles.
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The reaction of the N‐heterocyclic substrates with carbene complex (II) produces azaisobenzofuran intermediates.
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ABSTRACT A new regioselective one–pot procedure to synthesize pyranoquinolinones from readily available 2-alkynyl 3-formylquinolines under mild NaClO2/H2O2 conditions in good yields have been explored. This reaction sequence, involving... more
ABSTRACT A new regioselective one–pot procedure to synthesize pyranoquinolinones from readily available 2-alkynyl 3-formylquinolines under mild NaClO2/H2O2 conditions in good yields have been explored. This reaction sequence, involving oxidation followed by regioselective electrophlic 6-endo-dig cyclization is more efficient over the traditional Pd(0)-mediated synthesis. When scavenger-free conditions were used, unusual chlorinated furoquinolinone derivatives were obtained.
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Research Interests: Pharmacology, Biochemistry, Biophysics, Materials Science, Inorganic Chemistry, and 13 moreDevelopmental Biology, Molecular Biology, Biotechnology, Cancer, Fluorescence, Nanoparticle, Nanotechnology, Space Science, Medicine, Surface Chemistry, Magnetic nanoparticles, Approach, and Magnetic Nanoparticles
Aggregation induced emission (AIE) active molecules are widely used for fluorescence “turn-on” detection applications with the unique advantages over conventional fluorescent probes. Transformation of AIE molecule into functional... more
Aggregation induced emission (AIE) active molecules are widely used for fluorescence “turn-on” detection applications with the unique advantages over conventional fluorescent probes. Transformation of AIE molecule into functional nanoparticle can greatly expand their biomedical application potential. Here we report an approach for preparation of 20–80 nm size functional nanoparticle made of AIE molecule. The approach involves aggregation of AIE active tetraphenylethene (TPE) molecule in the presence of functional TPE molecule. Following this approach we have synthesized TPE-based nanoparticle functionalized with polyethylene glycol, primary amine, aspartic acid, glucose, and arginine. Compared to reported methods of making AIE-based nanoparticles, presented nanoparticles have distinct advantages that they are composed of AIE molecules only (without any non-AIE molecule/polymer) and wide variety of surface functionalization can be achieved by this approach. Nanoparticles have good colloidal stability with ...
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o‐Alkynyl substituted N‐heterocyclic ketones of type (I) and (V) react with the chromium carbene complex (II) to generate a dienylazaisobenzofuran intermediate which undergoes [8 + 2] cycloaddition with DMAD.
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ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full... more
ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
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Four dibenzo[a, c]phenazine based donor–acceptor tetra branched molecules were synthesized. The optical (including absorption, steady state and time resolved fluorescence) and electrochemical properties of these compounds were... more
Four dibenzo[a, c]phenazine based donor–acceptor tetra branched molecules were synthesized. The optical (including absorption, steady state and time resolved fluorescence) and electrochemical properties of these compounds were investigated. The emitting behavior of these molecules depends on the donor strength of the side‐arms. Tuning of optical properties has been performed by varying side‐arms. Electron deficient 4‐(2‐benzothiazolyl)phenyl side‐arm compound emit light in the blue region. Weak donor (4‐methoxyphenyl substituted) compound shows red shifted emission in green region. With strong donor (thiophene and triphenylamine) substituted compounds exhibits red and orange‐red emission respectively.
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Luminescent materials containing both the mechanoluminescence and electroluminescence properties are the quest for sensing and optoelectronic applications. We report on the synthesis of a new tailor-made luminogen,... more
Luminescent materials containing both the mechanoluminescence and electroluminescence properties are the quest for sensing and optoelectronic applications. We report on the synthesis of a new tailor-made luminogen, 1,2-bis(4-(1-([1,1'-biphenyl]-4-yl)-2,2-diphenylvinyl)phenyl)-1,2-diphenylethene (TPE 5) using Suzuki coupling reaction with high yield. Aggregation induced emission (AIE) active complex TPE 5 forms supramolecular spherical aggregates at the air-water interface of a Langmuir trough. As a consequence, a large enhancement of luminescence is obtained from the mono and multilayer Langmuir Blodgett films of TPE 5 owing to the AIE effect. The luminogen TPE 5 exhibits reversible mechanoluminescence response displaying photoluminescence switching due to change in the crystalline states under external stimuli. The unique feature of luminescence enhancement upon aggregate formation is utilized for the fabrication of light emitting diodes with low threshold voltage using supramo...
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Amyloid protein fibrillation is associated with a variety of neurodegenerative and other diseases, and their efficient detection and monitoring can greatly advance early diagnosis and therapy. Herein, we report a fluorescent... more
Amyloid protein fibrillation is associated with a variety of neurodegenerative and other diseases, and their efficient detection and monitoring can greatly advance early diagnosis and therapy. Herein, we report a fluorescent "switch-on" probe for the reliable detection and monitoring of amyloid fibrils. The probe consists of a peptide component for binding with amyloid structure and a color component with an aggregation-induced green emission property. This probe is nonfluorescent in the presence of amyloid forming monomer protein/peptide, but fluorescence "switch-on" occurs after binding with amyloid fibrils. Compared to conventionally used thioflavin T, this probe offers a high signal-to-noise ratio, which is unaffected by the quencher ion/nanoparticle. The proposed new probe has been used for the detection and monitoring of amyloid fibrils produced by a wide variety of amyloid protein/peptides and can be extended for in vitro diagnostic applications.
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Pyrene–tetraphenylethylene based monomers and tetramers were synthesized. Photophysical and electrochemical properties were investigated. Spacer, architecture and substituent dependent aggregation behavior were reported.
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A novel route for the synthesis of furo[2,3‐h]quinoline and furo[2,3‐h]isoquinoline derivatives is developed by coupling pyridine‐bridged enynes with the Fischer carbene complex (II).
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Y. Koda, EA Omer, T. Yoshihara, H. Shibata, S. Sakamura and Y. Okazawa Plant Cell Physiol. 29 (1988), p. 1047. Y. Koda, EA Omer, T. Yoshihara, H. Shibata, S. Sakamura and Y. Okazawa Agric. Biol. Chem. 54 (1990) in press and references... more
Y. Koda, EA Omer, T. Yoshihara, H. Shibata, S. Sakamura and Y. Okazawa Plant Cell Physiol. 29 (1988), p. 1047. Y. Koda, EA Omer, T. Yoshihara, H. Shibata, S. Sakamura and Y. Okazawa Agric. Biol. Chem. 54 (1990) in press and references cited therein .
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... Chem. 2010, 6, No. 52. doi:10.3762/bjoc.6.52; (e) Mukherjee, S.; Roy, P.; Ghorai, BK Synthesis 2011, 1419 1426. 4. For a review of azaisobenzofuran, see: Basak, S.; Ghosh, SK; Sarkar, TKJ Indian Inst. Sci. 2001, 81, 431 452. ...
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ABSTRACT Direct metallation of 2,4-dialkoxy-5-bromopyrimidine with lithium diisopropylamide and consequent trapping by dimethylformamide resulted unexpectedly in the formation of 2,6-dialkoxy-5-dimethylaminopyrimidine-4-carboxaldehyde via... more
ABSTRACT Direct metallation of 2,4-dialkoxy-5-bromopyrimidine with lithium diisopropylamide and consequent trapping by dimethylformamide resulted unexpectedly in the formation of 2,6-dialkoxy-5-dimethylaminopyrimidine-4-carboxaldehyde via displacement of bromine by dimethylamine moiety of dimethylformamide.
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One-pot three-component coupling of o-alkynylheteroaryl carbonyl derivatives with Fischer carbene complexes and dienophiles leading to the synthesis of quinoxaline and phenazine ring systems has been investigated. This involves the... more
One-pot three-component coupling of o-alkynylheteroaryl carbonyl derivatives with Fischer carbene complexes and dienophiles leading to the synthesis of quinoxaline and phenazine ring systems has been investigated. This involves the generation of furo[3,4-b]pyrazine and furo[3,4-b]quinoxaline as transient intermediates, which were trapped with Diels–Alder dienophiles. This is the first report on furo[3,4-b]pyrazine intermediates.
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ABSTRACT The total synthesis of epijasmonoids, (±)-methyl cucurbate and (±)-methyl epijasmonate is described starting from aldehyde 14, where the key step is a highly stereocontrolled 5- (3,4) ene cyclization 17 → 18.
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... Applications to the Synthesis of Cyclic 1,2Dinitrogen Compounds Tarun K. Sarkar,* Binay K.Ghorai, Shyamal K. Das, Pulak Gangopadhyay and PSVSubba Rao Department of Chemistu, Indian Institute of Technology ... For a review see :... more
... Applications to the Synthesis of Cyclic 1,2Dinitrogen Compounds Tarun K. Sarkar,* Binay K.Ghorai, Shyamal K. Das, Pulak Gangopadhyay and PSVSubba Rao Department of Chemistu, Indian Institute of Technology ... For a review see : Lambert, JB Tetrahedron.1990, 46, 2677. ...
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... Silicon-directed Bamford-Stevens Reaction of P-Trimethylsilyl N-Aziridinylimines Tarun K. Sarkar" and Binay K. Ghorai Department of Chemistry, Indian Institute of Technology, Kharagpur 72 1302, India ... 2/01 939F References 1... more
... Silicon-directed Bamford-Stevens Reaction of P-Trimethylsilyl N-Aziridinylimines Tarun K. Sarkar" and Binay K. Ghorai Department of Chemistry, Indian Institute of Technology, Kharagpur 72 1302, India ... 2/01 939F References 1 For a review see: R. H. Shapiro, Org. Reactiony. ...