Research Interests: Turkey, Treatment Outcome, Linear models, Western blotting, Prospective studies, and 15 moreProgesterone, Humans, Fertility and Sterility, Female, In Vitro Fertilization, Clinical Sciences, Oocyte Maturation, Adult, Public health systems and services research, Chi Square Distribution, Fertilization in Vitro, Oocytes, Embryos, Follicular Fluid, and Estradiol
Environmental tobacco smoke is an important public health problem. The objective of this study was to evaluate the effect of passive smoking on lower respiratory tract infections (LRTIs) in children aged 2-12 years. A case-control study... more
Environmental tobacco smoke is an important public health problem. The objective of this study was to evaluate the effect of passive smoking on lower respiratory tract infections (LRTIs) in children aged 2-12 years. A case-control study was conducted on matched-pair design. One-hundred and fifty children with LRTIs and 150 healthy children were included in the study. Data were collected through questionnaire and urine samples for the determination of cotinine levels, and were analysed by McNemar chi-square, paired t-test and Pearson correlation tests. The prevalence of parental self-reported, indoor smoking was 71.3% in children with LRTI and 72.0% in healthy children. Employing 30 ng mg(-1), the cut-off level of urinary cotinine/creatinine as commonly accepted, 87.3% of the children with LRTIs and 84.7% of healthy children were found to be passive smokers (p = 0.61, odds ratio (OR) = 0.93; confidence interval (CI) = 0.34-2.53). If 60 ng mg(-1) of urinary cotinine/creatinine was accepted as a cut-off level, it was observed that the rates of passive smoking were 76.7% and 50.7%, respectively (p = 0.000, OR = 4.72; 95% CI = 2.62-8.52). Dose-dependent exposure to environmental tobacco smoke was found to be associated with the incidence of LRTI.
Research Interests:
Research Interests: Humans, Child, Female, Male, Infant, and 12 morePublic health systems and services research, Respiratory Tract Infections, Urban Population, Chi Square Distribution, Chi Square Test, Case Control Study, Passive Smoking, Cotinine, Confidence Interval, Radioimmunoassay, Case Control Studies, and Airway Inflammation
Research Interests: Obstetrics, Metabolism, Calcium, Bone Metabolism, Liver diseases, and 23 morePhosphorus, Postmenopausal Women, Humans, Femur, Chronic Disease, Female, Bone Density, Osteocalcin, Bilirubin, Parathyroid Hormone, Alkaline phosphatase, Middle Aged, Amino Acids, Gynecology, Bone Mineral Density, Biological markers, Bone remodeling, Liver Disease, Cross Sectional Studies, Chronic Liver Disease, Bone and Bones, End Stage Liver Disease, and lumbar vertebrae
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Leptin is mainly synthesised in white adipose tissue. Besides its effects on body weight and metabolic homeostasis, leptin also has effects on puberty, sexual maturation and reproduction. In this study the relationship between leptin,... more
Leptin is mainly synthesised in white adipose tissue. Besides its effects on body weight and metabolic homeostasis, leptin also has effects on puberty, sexual maturation and reproduction. In this study the relationship between leptin, IGF-1, oestradiol (E2) and progesterone levels were investigated in serum and follicular fluid from cows. This study included 72 healthy, Brown Swiss cows aged 4-5 years. Samples from the jugular vein and follicular fluids were collected. Phases of the oestrus cycle of cows were classified according to their serum progesterone levels (< 3.18 nmol/l, follicular phase and the others as luteal phase). Follicles were grouped as large (> or = 8 mm) or small (< 8 mm). Leptin, IGF-1, oestradiol and progesterone levels were measured from serum and follicular fluid. Leptin concentrations were found to be significantly higher in luteal-phase follicular fluid of small follicles (P < 0.05). These were classified as atretic follicles. There was a positive correlation between serum and follicular fluid leptin levels in the luteal phase. Serum leptin was found to have a positive correlation with follicular fluid progesterone level (P = 0.01) in the preovulatory follicles. The present study shows that there is a relationship between the concentration of leptin in follicular fluid and atresia in small follicles.
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To establish the frequency and causes of vitamin D insufficiency in healthy female adolescents in Izmir, Turkey. 64 adolescents from a low--(Ikinci Inönü) and a high--(Ilica) socio-economic settlement were included.... more
To establish the frequency and causes of vitamin D insufficiency in healthy female adolescents in Izmir, Turkey. 64 adolescents from a low--(Ikinci Inönü) and a high--(Ilica) socio-economic settlement were included. Parents' monthly income was classified as low, middle and high. The blood samples were drawn at the end of the summer and winter periods. Vitamin D insufficiency percentages for the end-of-winter period were 59.4% in Ikinci Inönü and 15.6% in Ilica, and for the end of summer 25% and 15.6%, respectively. Calcidiol levels of cases from Ikinci Inönü were found to be lower compared with the levels of cases from Ilica (34+/-15 vs 59+/-24 nmol/l for end of winter, p=0.000; 51+/-22 vs 65+/-28 nmol/l for end of summer, p=0.03). Calcidiol levels of cases whose parental monthly income was low and whose mothers were illiterate were significantly lower than the others (48+/-18 vs 65+/-29 nmol/l for end of summer, p=0.01; 33+/-16 vs 56+/-23 nmol/l for end of winter, p=0.000; 45+/-13 vs 64+/-29 nmol/l for end of summer, p=0.007; 36+/-17 vs 51+/-25 nmol/l for end of winter, p=0.02; respectively). Vitamin D insufficiency was frequent, especially in the end-of-winter period. Basic risk factors were low socio-economic status, illiteracy of mothers and low calcium intake.
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To evaluate the association between follicular fluid levels of propeptide and mature forms of growth differentiation factor (GDF) 9 and bone morphogenetic protein (BMP) 15 with subsequent oocyte and embryo quality. Prospective clinical... more
To evaluate the association between follicular fluid levels of propeptide and mature forms of growth differentiation factor (GDF) 9 and bone morphogenetic protein (BMP) 15 with subsequent oocyte and embryo quality. Prospective clinical study. University hospital. Eighty-one infertile patients who underwent in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI). The expression levels of the propeptide and mature forms of follicular fluid GDF9 and BMP15 were determined by western blot analysis. The levels of follicular fluid hormones (FSH, E2, and P) were measured with automated chemiluminescent enzyme immunoassays. The relationships between the levels of GDF9 and BMP15, hormones, oocyte maturation, and embryo quality. Mature GDF9 levels were significantly correlated with the nuclear maturation of oocytes. The mean mature GDF9 level was 4.87±0.60 in the high-embryo-quality group and 1.45±0.81 in the low-embryo-quality group. There were no statistically significant differ...