A 34-year-old woman presented to our outpatient clinic with photosensitivity, photophobia, and fa... more A 34-year-old woman presented to our outpatient clinic with photosensitivity, photophobia, and facial pruritus (Figure 1). She had brown eyes and fair skin, hair, eyelashes, and eyebrows since birth. Her sister had similar skin and hair pigments. The patient had no systemic disease and was not taking any medication. Her parents were second-degree relatives. A dermatologic examination revealed small hyperkeratotic papules with an erythematous background, minimal desquamation, and some excoriation over the nose, zygomatic arch, and forehead consistent with actinic keratosis and solar damage. An ophthalmological examination demonstrated impaired visual acuity (60/100 in both eyes, reaching 80/100 in the left eye with best correction). Hypopigmentation at the albinotic retinal midperiphery (Figure 2) by fundoscopy was noted. She had no nystagmus or strabismus. The patient had no complaints or symptoms of the neurological, gastrointestinal, or respiratory system, and she had no recurrent skin or systemic infection.
Background and design: Mucocutaneous fungal infections are common in patients with diabetes melli... more Background and design: Mucocutaneous fungal infections are common in patients with diabetes mellitus (DM). However, fungal infections do not develop in every patient with DM. In this study, we aimed to determine the risk factors for developing mucocutaneous fungal infections in patients with type 2 DM. Materials and methods: A total of 302 type 2 DM patients with mucocutaneous fungal infections and 326 type 2 DM patients without mucocutaneous fungal infections were enrolled. Demographic and clinical features, HbA1c levels, DM durations, body mass indexes (BMIs), and DM related complications of patients were compared and risk factors for developing mucocutaneous fungal infections were determined. Results: Of the 302 patients with mucocutaneous fungal infections, 81.2% (n=245) had dermatophytosis, 16.9% (n=51) had candidal infections, 2.0% (n=6) had pityriasis versicolor. Frequency of male gender, diabetic nephropathy, neuropathy and retinopathy; DM durations and ages of patients were...
Pityriasis rubra pilaris (PRP) is a rare skin disease characterized by erythematous follicular pa... more Pityriasis rubra pilaris (PRP) is a rare skin disease characterized by erythematous follicular papules and desquamation. Clinically follicular keratosis, perifollicular erythema, and palmoplantar hyperkeratosis are observed but erythroderma may occur rarely. PRP is one of the rare causes of erythroderma. We identified a PRP case that rapidly progressed to erythroderma in a 49-year-old male patient with no PRP diagnosis before. It is presented due to being a rare case of erythroderma
Background: Since oxidative stress induced by ultraviolet exposure has been shown to cause develo... more Background: Since oxidative stress induced by ultraviolet exposure has been shown to cause development of cutaneous cancers, solar ultraviolet radiation (UVR) is considered to be a major etiological factor for non-melanoma skin tumors (NMSTs). We aimed to compare the oxidative stress parameters between patients with NMST and healthy individuals. Material and Methods: A total of 28 patients with clinically and histologically proven NMSTs (24 basal cell carcinoma, 4 squamous cell carcinoma) and 33 control subjects who were matched for age and gender were included in the study. Serum total oxidant status (TOS), total antioxidant status (TAS), paraoxonase (PON), arylesterase (ARE), high density lipoprotein (HDL), low density lipoprotein (LDL), triglyceride (TG) and total cholesterol levels of the participants were measured. The oxidative stress index (OSI) was determined. Results: The TAS and ARE levels of patients with NMSTs were statistically lower than control subjects (P=0.005 and P...
Acromegaly is a systemic syndrome caused by overproduction of growth hormone. The syndrome affect... more Acromegaly is a systemic syndrome caused by overproduction of growth hormone. The syndrome affects cutaneous, endocrine, cardiovascular, skeletal, and respiratory systems. Cutaneous manifestations of acromegaly are various, usually being the first presenting findings of the disease. Forty-nine patients with acromegaly, followed-up at a tertiary referral hospital, underwent dermatological examination. There were 27 (55.1%) female and 22 (44.9%) male patients. The age at onset of the disease was older in females than males (P=0.045). Most patients had acral enlargements, large triangular nose, coarse face, thickened lower lip, and prognathism. Fourteen (28.6%) patients had multiple cherry angiomas, five (10.2%) had varicose veins in lower limbs, and two (4.1%) had psoriasis. In conclusion, a wide spectrum of cutaneous symptoms and features may be associated with acromegaly. Detailed dermatological examination of patients with acromegaly should be an essential component of systemic eva...
Acquired perforating dermatosis (APD) is a rare group of skin disorders characterized by transepi... more Acquired perforating dermatosis (APD) is a rare group of skin disorders characterized by transepidermal elimination of dermal tissue material. There are only a few studies of APD. We aimed to review the clinicopathologic features of patients with APD and evaluate the outcomes of treatments. The medical records of 25 patients who were clinically and histopathologically diagnosed as having APD between 2006 and 2013 were retrospectively reviewed. The histopathologic sections and the results of elastic, trichrome and periodic acid Shiff (PAS) staining were evaluated. Of the patients, 17 (68%) had ARPC, 7 (28%) had perforating folliculitis, 1 (4%) had Kyrle's disease. Male/female ratio was 1.3. The mean age was 51.8 ± 12.8 years. The disease duration ranged between 15 days and 96 months. Diabetes mellitus was the most common disease associated with APD (48%). The walls of vessels were PAS positive in the lesions of 6 of 13 diabetic patients. After various treatments, almost all lesions regressed in 15 (60%) patients. Acquired perforating dermatosis may present with various clinical features and is mostly associated with diabetes mellitus. Diabetes mellitus may be involved in the pathogenesis of APD via microangiopathy and other mechanisms.
Focal epithelial hyperplasia (FEH) is a rare and benign papillomatous disease of the oral cavity,... more Focal epithelial hyperplasia (FEH) is a rare and benign papillomatous disease of the oral cavity, which is closely associated with human papillomavirus (HPV) type 13 and 32. Genetic susceptibility to HPV infections are supported by recent studies involving the human leukocyte antigen system (HLA). In this report, we aimed to determine the clinicopathological features of a Turkish family with FEH and to detect the shared HLA DR and DQ types. HPV DNA typing of tissue samples and HLA determination from blood samples of four family members were performed by polymerase chain reaction. Histopathological examination of all patients revealed acanthotic papillomatous epidermis, koilocytes, apoptotic keratinocytes, and mitosoid bodies. HPV13 was detected by polymerase chain reaction. HLA DQA1*0501, HLA DQB1*0302, and HLA DRB1*11 alleles were common in all family members. HLA DRB1*04 was detected in three of them. This report is the first step for the investigation of involvement of HLA types in the pathogenesis of Turkish patients with FEH.
Turkish Journal of Dermatology / Türk Dermatoloji Dergisi, 2010
ABSTRACT Palmoplantar keratodermas, also known as palmoplantar hyperkeratosis or keratosis palmar... more ABSTRACT Palmoplantar keratodermas, also known as palmoplantar hyperkeratosis or keratosis palmaris et plantaris, are a group of diseases characterized by marked thickening of the skin of the palms and soles. Palmoplantar keratodermas may be acquired or hereditary. Clubbing is defined as hypertrophy of the soft tissue components of the digital pulp and increased longitudinal and horizontal curvature of the nail plate. Clubbing is usually acquired. The diagnosis of familial or idiopathic clubbing is made only after exclusion of underlying systemic diseases. Hereditary palmoplantar keratodermas may be associated with a wide variety of disorders. Herein we present a case of hereditary palmoplantar keratoderma in conjunction with primary digital clubbing, which is a rare association.
... Two siblings with Netherton syndrome. Selma EMRE 1 , Ahmet METİN 1 , D. Deniz DEMİRSEREN 1 , ... more ... Two siblings with Netherton syndrome. Selma EMRE 1 , Ahmet METİN 1 , D. Deniz DEMİRSEREN 1 , Ahu YORULMAZ 1 , Aykut ONURSEVER 2 , Burçin KAFTAN 1 1 Department of Dermatology, Atatürk Training and Research Hospital, Ankara - TURKEY 2 Department of ...
A 34-year-old woman presented to our outpatient clinic with photosensitivity, photophobia, and fa... more A 34-year-old woman presented to our outpatient clinic with photosensitivity, photophobia, and facial pruritus (Figure 1). She had brown eyes and fair skin, hair, eyelashes, and eyebrows since birth. Her sister had similar skin and hair pigments. The patient had no systemic disease and was not taking any medication. Her parents were second-degree relatives. A dermatologic examination revealed small hyperkeratotic papules with an erythematous background, minimal desquamation, and some excoriation over the nose, zygomatic arch, and forehead consistent with actinic keratosis and solar damage. An ophthalmological examination demonstrated impaired visual acuity (60/100 in both eyes, reaching 80/100 in the left eye with best correction). Hypopigmentation at the albinotic retinal midperiphery (Figure 2) by fundoscopy was noted. She had no nystagmus or strabismus. The patient had no complaints or symptoms of the neurological, gastrointestinal, or respiratory system, and she had no recurrent skin or systemic infection.
Background and design: Mucocutaneous fungal infections are common in patients with diabetes melli... more Background and design: Mucocutaneous fungal infections are common in patients with diabetes mellitus (DM). However, fungal infections do not develop in every patient with DM. In this study, we aimed to determine the risk factors for developing mucocutaneous fungal infections in patients with type 2 DM. Materials and methods: A total of 302 type 2 DM patients with mucocutaneous fungal infections and 326 type 2 DM patients without mucocutaneous fungal infections were enrolled. Demographic and clinical features, HbA1c levels, DM durations, body mass indexes (BMIs), and DM related complications of patients were compared and risk factors for developing mucocutaneous fungal infections were determined. Results: Of the 302 patients with mucocutaneous fungal infections, 81.2% (n=245) had dermatophytosis, 16.9% (n=51) had candidal infections, 2.0% (n=6) had pityriasis versicolor. Frequency of male gender, diabetic nephropathy, neuropathy and retinopathy; DM durations and ages of patients were...
Pityriasis rubra pilaris (PRP) is a rare skin disease characterized by erythematous follicular pa... more Pityriasis rubra pilaris (PRP) is a rare skin disease characterized by erythematous follicular papules and desquamation. Clinically follicular keratosis, perifollicular erythema, and palmoplantar hyperkeratosis are observed but erythroderma may occur rarely. PRP is one of the rare causes of erythroderma. We identified a PRP case that rapidly progressed to erythroderma in a 49-year-old male patient with no PRP diagnosis before. It is presented due to being a rare case of erythroderma
Background: Since oxidative stress induced by ultraviolet exposure has been shown to cause develo... more Background: Since oxidative stress induced by ultraviolet exposure has been shown to cause development of cutaneous cancers, solar ultraviolet radiation (UVR) is considered to be a major etiological factor for non-melanoma skin tumors (NMSTs). We aimed to compare the oxidative stress parameters between patients with NMST and healthy individuals. Material and Methods: A total of 28 patients with clinically and histologically proven NMSTs (24 basal cell carcinoma, 4 squamous cell carcinoma) and 33 control subjects who were matched for age and gender were included in the study. Serum total oxidant status (TOS), total antioxidant status (TAS), paraoxonase (PON), arylesterase (ARE), high density lipoprotein (HDL), low density lipoprotein (LDL), triglyceride (TG) and total cholesterol levels of the participants were measured. The oxidative stress index (OSI) was determined. Results: The TAS and ARE levels of patients with NMSTs were statistically lower than control subjects (P=0.005 and P...
Acromegaly is a systemic syndrome caused by overproduction of growth hormone. The syndrome affect... more Acromegaly is a systemic syndrome caused by overproduction of growth hormone. The syndrome affects cutaneous, endocrine, cardiovascular, skeletal, and respiratory systems. Cutaneous manifestations of acromegaly are various, usually being the first presenting findings of the disease. Forty-nine patients with acromegaly, followed-up at a tertiary referral hospital, underwent dermatological examination. There were 27 (55.1%) female and 22 (44.9%) male patients. The age at onset of the disease was older in females than males (P=0.045). Most patients had acral enlargements, large triangular nose, coarse face, thickened lower lip, and prognathism. Fourteen (28.6%) patients had multiple cherry angiomas, five (10.2%) had varicose veins in lower limbs, and two (4.1%) had psoriasis. In conclusion, a wide spectrum of cutaneous symptoms and features may be associated with acromegaly. Detailed dermatological examination of patients with acromegaly should be an essential component of systemic eva...
Acquired perforating dermatosis (APD) is a rare group of skin disorders characterized by transepi... more Acquired perforating dermatosis (APD) is a rare group of skin disorders characterized by transepidermal elimination of dermal tissue material. There are only a few studies of APD. We aimed to review the clinicopathologic features of patients with APD and evaluate the outcomes of treatments. The medical records of 25 patients who were clinically and histopathologically diagnosed as having APD between 2006 and 2013 were retrospectively reviewed. The histopathologic sections and the results of elastic, trichrome and periodic acid Shiff (PAS) staining were evaluated. Of the patients, 17 (68%) had ARPC, 7 (28%) had perforating folliculitis, 1 (4%) had Kyrle's disease. Male/female ratio was 1.3. The mean age was 51.8 ± 12.8 years. The disease duration ranged between 15 days and 96 months. Diabetes mellitus was the most common disease associated with APD (48%). The walls of vessels were PAS positive in the lesions of 6 of 13 diabetic patients. After various treatments, almost all lesions regressed in 15 (60%) patients. Acquired perforating dermatosis may present with various clinical features and is mostly associated with diabetes mellitus. Diabetes mellitus may be involved in the pathogenesis of APD via microangiopathy and other mechanisms.
Focal epithelial hyperplasia (FEH) is a rare and benign papillomatous disease of the oral cavity,... more Focal epithelial hyperplasia (FEH) is a rare and benign papillomatous disease of the oral cavity, which is closely associated with human papillomavirus (HPV) type 13 and 32. Genetic susceptibility to HPV infections are supported by recent studies involving the human leukocyte antigen system (HLA). In this report, we aimed to determine the clinicopathological features of a Turkish family with FEH and to detect the shared HLA DR and DQ types. HPV DNA typing of tissue samples and HLA determination from blood samples of four family members were performed by polymerase chain reaction. Histopathological examination of all patients revealed acanthotic papillomatous epidermis, koilocytes, apoptotic keratinocytes, and mitosoid bodies. HPV13 was detected by polymerase chain reaction. HLA DQA1*0501, HLA DQB1*0302, and HLA DRB1*11 alleles were common in all family members. HLA DRB1*04 was detected in three of them. This report is the first step for the investigation of involvement of HLA types in the pathogenesis of Turkish patients with FEH.
Turkish Journal of Dermatology / Türk Dermatoloji Dergisi, 2010
ABSTRACT Palmoplantar keratodermas, also known as palmoplantar hyperkeratosis or keratosis palmar... more ABSTRACT Palmoplantar keratodermas, also known as palmoplantar hyperkeratosis or keratosis palmaris et plantaris, are a group of diseases characterized by marked thickening of the skin of the palms and soles. Palmoplantar keratodermas may be acquired or hereditary. Clubbing is defined as hypertrophy of the soft tissue components of the digital pulp and increased longitudinal and horizontal curvature of the nail plate. Clubbing is usually acquired. The diagnosis of familial or idiopathic clubbing is made only after exclusion of underlying systemic diseases. Hereditary palmoplantar keratodermas may be associated with a wide variety of disorders. Herein we present a case of hereditary palmoplantar keratoderma in conjunction with primary digital clubbing, which is a rare association.
... Two siblings with Netherton syndrome. Selma EMRE 1 , Ahmet METİN 1 , D. Deniz DEMİRSEREN 1 , ... more ... Two siblings with Netherton syndrome. Selma EMRE 1 , Ahmet METİN 1 , D. Deniz DEMİRSEREN 1 , Ahu YORULMAZ 1 , Aykut ONURSEVER 2 , Burçin KAFTAN 1 1 Department of Dermatology, Atatürk Training and Research Hospital, Ankara - TURKEY 2 Department of ...
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