Research Interests: Respiratory Medicine, Asthma, Adolescent, Medicine, Humans, and 15 morePatient Satisfaction, Drug Delivery Systems, Anti-inflammatory agents, Clinical Sciences, Aged, Middle Aged, Adult, Morning, Budesonide, Inhaler, Fluticasone propionate, Costs and Cost Analysis, Tolerability, Cardiovascular medicine and haematology, and Fluticasone
A case of acute bronchiolitis in association with parainfluenza type 2 infection is reported in a previously asymptomatic young adult with evidence of partially reversible severe airways obstruction.
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Introduction The MERGE trial was a multi-centre, randomised, parallel study that showed the beneficial effect of continuous positive airway pressure (CPAP) on quality-of-life in patients with mild obstructive sleep apnea (OSA) (Wimms et... more
Introduction The MERGE trial was a multi-centre, randomised, parallel study that showed the beneficial effect of continuous positive airway pressure (CPAP) on quality-of-life in patients with mild obstructive sleep apnea (OSA) (Wimms et al. 2019); findings that have extended the new NICE guidance [Obstructive sleep apnoea/ hypopnoea syndrome and obesity hypoventilation syndrome in over 16s (NG202)].This post-hoc analysis aimed to determine whether differences between the sexes in symptoms and treatment response exist at the mild end of the OSA disease spectrum. Methods Patients were recruited (Nov 2016 - Feb 2019) to receive either CPAP plus standard care, or standard care alone. Mild OSA was defined as: apnea-hypopnea index (AHI) >5 to ≤15 events/hr. Symptoms and quality-of-life were measured by a range of generic and disease specific questionnaires at baseline and 3 months post CPAP commencement. Results 233 participants (30% female) were included in this analysis. Females were...
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Research Interests: Primary Care, Respiratory Medicine, Asthma, Family Practice, Medicine, and 13 moreHumans, COPD, Differential Diagnosis, Clinical Sciences, Great Britain, Questionnaires, Spirometry, General practitioner, Chronic obstructive pulmonary disease, Clinical Competence, Health Personnel, Cardiovascular medicine and haematology, and Pulmonary Disease Chronic Obstructive
Research Interests: Cystic Fibrosis, Asthma, Adolescent, Humans, Child, and 15 moreEurope, Female, Disease, Life Expectancy, Incidence, Clinical Sciences, Aged, Great Britain, Adult, Chronic obstructive pulmonary disease, Intensive Care Medicine, Health Care Costs, Child preschool, Disease Burden, and Cardiovascular medicine and haematology
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Chronic obstructive pulmonary disease (COPD) affects > 3 million people in the UK. Acute exacerbations of COPD (AECOPD) are the second most common reason for emergency hospital admission in the UK. Pulmonary rehabilitation is usual... more
Chronic obstructive pulmonary disease (COPD) affects > 3 million people in the UK. Acute exacerbations of COPD (AECOPD) are the second most common reason for emergency hospital admission in the UK. Pulmonary rehabilitation is usual care for stable COPD but there is little evidence for early pulmonary rehabilitation (EPR) following AECOPD, either in hospital or immediately post discharge. To assess the feasibility of recruiting patients, collecting data and delivering EPR to patients with AECOPD to evaluate EPR compared with usual care. Parallel-group, pilot 2 × 2 factorial randomised trial with nested qualitative research and an economic analysis. Two acute hospital NHS trusts. Recruitment was carried out from September 2015 to April 2016 and follow-up was completed in July 2016. Eligible patients were those aged ≥ 35 years who were admitted with AECOPD, who were non-acidotic and who maintained their blood oxygen saturation level (pO) within a prescribed range. Exclusions include...
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Background: Chronic obstructive pulmonary disease (COPD) is a common and disabling condition in adults. Information about therapeutic effectiveness and adverse effects of common treatment options and how clinical and spirometric... more
Background: Chronic obstructive pulmonary disease (COPD) is a common and disabling condition in adults. Information about therapeutic effectiveness and adverse effects of common treatment options and how clinical and spirometric characteristics affect outcomes is not well known ...