Background: Major depressive disorder is a difficult-to-treat psychological disorder. Approximately 30% of patients with major depressive disorder do not respond to conventional therapies; thus, the efficacy of alternative therapies for... more
Background: Major depressive disorder is a difficult-to-treat psychological disorder. Approximately 30% of patients with major depressive disorder do not respond to conventional therapies; thus, the efficacy of alternative therapies for treating major depressive disorder, such as neurofeedback, a non-invasive neuromodulation method used in the treatment of psychiatric diseases, must be investigated. Objective: We aimed to evaluate the efficacy of neurofeedback in minimizing and treating major depressive disorder and its application as a substitute to or an adjuvant with conventional therapies. Methods: We searched for experimental studies published between 1962-2021 in Scopus, PubMed, Web of Science, and Embase databases and identified 1,487 studies, among which 13 met the inclusion exclusion criteria. Results: We noted that not all patients responded to neurofeedback. Based on depression scales, major depressive disorder significantly improved in response to neurofeedback only in a few individuals. Additionally, the number of training sessions did not influence the results. Conclusion: Neurofeedback can reduce depression symptoms in patients; however, not all patients respond to the treatment. Therefore, further studies must be conducted to validate the effectiveness of neurofeedback in treating major depressive disorder.
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Background: Alzheimer’s disease (AD) has several risk factors. APOE4 is the main one, and it has been suggested that there may be a synergy between it and BCHE-K as a risk factor. Objective: To investigate the association between APOE4... more
Background: Alzheimer’s disease (AD) has several risk factors. APOE4 is the main one, and it has been suggested that there may be a synergy between it and BCHE-K as a risk factor. Objective: To investigate the association between APOE4 and BCHE-K as a risk factor for AD. Methods: We searched PubMed, Web of Science, Embase, and Scopus on August 8, 2021 for studies that analyzed the association of APOE4 and BCHE-K with AD. The random effect model was performed in meta-analysis according to age group. A chi-square was performed with the meta-analysis data to verify if the effect found is not associated only with the E4 allele. Results: Twenty-one studies with 6,853 subjects (3,528 AD and 3,325 Controls) were included in the meta-analysis. The quality of the evidence is moderate. There is a positive E4-K association for subjects with AD as shown by the odds ratio of 3.43. The chi-square meta test, which measures the probability that the E4-K association is due to chance, has an odds rat...
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O forame oval patente se caracteriza como um defeito na estrutura cardíaca, no qual após o nascimento um orifício permanece aberto comunicando as câmaras atriais direita e esquerda. Na vida intra-uterina essa abertura é importante para a... more
O forame oval patente se caracteriza como um defeito na estrutura cardíaca, no qual após o nascimento um orifício permanece aberto comunicando as câmaras atriais direita e esquerda. Na vida intra-uterina essa abertura é importante para a correta oxigenação e circulação sanguínea do feto, mas se essa comunicação entre os átrios persistir aberta durante a vida adulta, pode resultar em diversas complicações para o indivíduo, principalmente neurológicas e embólicas, como o AVC. O objetivo do estudo é abordar as características fisiopatológicas e anatômicas do FOP, incidência, riscos, diagnóstico, formas de tratamento e a presença dessa patologia na infância. Trata-se de uma revisão narrativa, com foco em artigos publicados entre 2013 e 2023, nas bases de dados Scielo, Lilacs, Pubmed e Google Acadêmico, com utilização dos descritores “Forame Oval Patente”, “Cardiologia”, “Pediatria”, “Cardiopatia Congênita” em língua portuguesa e inglesa. Conclui-se que o FOP é incidente em 15% da popula...
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Em março de 2020, a Organização Mundial de Saúde decretou a pandemia por Covid-19. Dados do Ministério da Saúde revelam que, até agosto de 2022, o Brasil teve mais de 34 milhões de casos. Diante dessa situação, várias estratégias foram... more
Em março de 2020, a Organização Mundial de Saúde decretou a pandemia por Covid-19. Dados do Ministério da Saúde revelam que, até agosto de 2022, o Brasil teve mais de 34 milhões de casos. Diante dessa situação, várias estratégias foram desenvolvidas na tentativa de frear a pandemia. Este estudo objetivou realizar um levantamento patentométrico acerca de registros de patentes sobre a Covid-19 no âmbito da CT&I. A metodologia adotada foi uma busca do estado da arte por meio de patentometria no software Orbit Questel. Foram selecionadas dez patentes com tecnologias direcionadas para o combate à Covid-19, que trazem propostas com uso de robótica, inteligência artificial e fármacos. Nesse cenário, o Brasil possui quatro patentes, correspondendo a 2% da produção e situando-se em 12º lugar em um ranking de 20 países. Conclui-se que buscar ferramentas e produzir inventividades em uma situação como a pandemia é essencial.
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Research Interests: Neuroscience, Oxidative Stress, Pathophysiology, Insulin Resistance, Diabetes mellitus, and 13 morecyclic AMP, Disease, Peptides, Apolipoprotein E, Amyloid Beta, Endocannabinoids, Alzheimer Disease, Excitotoxicity, Neurochemical, Beta amyloids, Tau protein, Tau proteins, and Glycogen Synthase Kinase
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Background The preventive role of muscular strength on diminishing neuroinflammation is yet unknown. In this study, the role of the prophylactic muscular strength exercise was investigated in order to verify whether it would diminish... more
Background The preventive role of muscular strength on diminishing neuroinflammation is yet unknown. In this study, the role of the prophylactic muscular strength exercise was investigated in order to verify whether it would diminish cognitive alterations and modify the antioxidant intracellular scenery in an animal neuroinflammatory model in of the CA1 region of the hippocampus. Methods The animals received muscular strength training (SE) three times a week for eight weeks. Subsequently, the stereotaxic surgery was performed with an intra-hippocampal infusion of either saline solution (SAL) or lipopolysaccharide (LPS). Next, we performed the behavioral tests: object recognition and social recognition. Then, the animals were euthanized, and their hippocampus and prefrontal cortex were collected. In another moment, we performed the dosage of the antioxidant activity and histological analysis. Results The results showed that the muscular strength exercises could show a beneficial prop...
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Alzheimer's disease (AD) affects a large portion of the elderly worldwide and is the most common dementia in this population. AD is usually accompanied by concurrent comorbidities leading to the simultaneous use of several drugs to... more
Alzheimer's disease (AD) affects a large portion of the elderly worldwide and is the most common dementia in this population. AD is usually accompanied by concurrent comorbidities leading to the simultaneous use of several drugs to improve the quality of life, which renders AD patients vulnerable to drug interactions and adverse reactions. This study assessed the frequency of polypharmacy based on comorbidities in AD patients from the city of Guarapuava, Parana, Brazil. This is a cross-sectional study in non-institutionalized and volunteer AD patients. The Clinical Dementia Rating (CDR) scale was applied to classify the AD stage and a socio-economic survey was used to identify possible comorbidities and medications taken. Medications were evaluated according to the Kussano’s criteria (2010) to identify polypharmacy. The incidence of polypharmacy was high (up to 65.9%, n = 27); hypertension was the most frequent comorbidity (58.54%, n = 24). AD patients inappropriately take drugs...
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Background: The preventive role of muscular strength in the diminishing of a neuroinflammation is yet unknown. In this study, the role of the prophylactic muscular strength exercise was investigated, whether it would diminish cognitive... more
Background: The preventive role of muscular strength in the diminishing of a neuroinflammation is yet unknown. In this study, the role of the prophylactic muscular strength exercise was investigated, whether it would diminish cognitive alterations and modify the antioxidant intracellular scenery in an animal neuroinflammation model of the CA1 region of the hippocampus. Methods: The animals received muscular strength training for eight weeks, three times a week. Subsequently, the stereotaxic surgery, with intra-hippocampal infusion of either saline solution or l ipopolysaccharide (LPS) was performed. Next, behavioral tests were performed: objects and social recognition. At last, the animals were euthanized and the collect of the hippocampus and the prefrontal cortex were performed and, later, the dosage of the antioxidant activity was performed. Results: The results showed that the muscular strength exercises was capable of showing a beneficial prophylactic effect in the oxidative st...
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Curcumin is a natural compound known for hepatic and nephroprotective actions, however, there is little research related to its possible side effects. The research aimed to study hematological, biochemical parameters and histopathology of... more
Curcumin is a natural compound known for hepatic and nephroprotective actions, however, there is little research related to its possible side effects. The research aimed to study hematological, biochemical parameters and histopathology of hepatic and renal tissues to evaluate the effects of curcumin toxicity in male rats. A group of Wistar male rats (n = 10) was orally treated for five days with 100 mg/kg of curcumin diluted in vegetable oil, and the other group (n=10) was treated with vegetable oil (control). Statistical difference was observed in the levels of creatinine, hematocrit, hemoglobin, and red blood cells count between the control and curcumin treated group. However, despite these differences, the values observed were within the normal ranges for of Wistar male rats. Histopathological alterations were not observed. Therefore, our results show that curcumin is relatively non-toxic and, because of its demonstrated pharmacological effects, it can be developed as a promising...
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The entorhinal cortex is perhaps the area of the brain in which neurofibrillary tangles and amyloid plaques are first detectable in old age with or without mild cognitive impairment, and very particularly in Alzheimer's disease. It... more
The entorhinal cortex is perhaps the area of the brain in which neurofibrillary tangles and amyloid plaques are first detectable in old age with or without mild cognitive impairment, and very particularly in Alzheimer's disease. It plays a key role in memory formation, retrieval, and extinction, as part of circuits that include the hippocampus, the amygdaloid nucleus, and several regions of the neocortex, in particular of the prefrontal cortex. Lesions or biochemical impairments of the entorhinal cortex hinder extinction. Microinfusion experiments have shown that glutamate NMDA receptors, calcium and calmodulin-dependent protein kinase II, and protein synthesis in the entorhinal cortex are involved in and required for extinction. Aging also hinders extinction; it is possible that its effect may be in part mediated by the entorhinal cortex.
Research Interests: Neuroscience, Psychology, Aging, Medicine, Memory, and 4 moreHumans, Animals, Neural plasticity, and Entorhinal Cortex
Research Interests: Cognitive Science, Molecular Biology, Cognition, Long Term Potentiation, Cell Biology, and 15 moreSignal Transduction, Learning, Memory Consolidation, Memory, Hippocampus, Brain, Humans, Models, Animals, Complex network, Elsevier, Potentiation, Neurosciences, Cingulate cortex, and Basolateral Amygdala
The effects of the administration of monosialoganglioside (GM1) on methylmalonic acid (MMA)-induced convulsions, production of thiobarbituric acid reactive substances (TBARS) and on the striatal content of ascorbic acid and total... more
The effects of the administration of monosialoganglioside (GM1) on methylmalonic acid (MMA)-induced convulsions, production of thiobarbituric acid reactive substances (TBARS) and on the striatal content of ascorbic acid and total non-protein thiol (SH) groups were evaluated in adult male rats. Animals received two intraperitoneal injections of GM1 (50 mg/kg) or saline (0.85% NaCl) spaced 24h apart. Thirty minutes after the second GM1 or saline injection, L-MMA (6 micromol) or NaCl (9 micromol) was injected into the right striatum and the animals were observed for the appearance of convulsions for 15 min. The animals were sacrificed and their striatal content of ascorbic acid, SH groups and TBARS was measured. The effect of GM1 on MMA-induced TBARS production in striatal homogenates was also evaluated in vitro.MMA injection caused convulsions (Sal-MMA: 9.8+/-1.4 episodes, which lasted 271+/-48 s) and increased the striatal content of TBARS (Sal-MMA: 149.0+/-11.5 nmol MDA/g tissue), but did not alter total striatal SH or ascorbic acid contents. GM1 pretreatment decreased MMA-induced convulsions (GM1-MMA: 6.3+/-2.0 episodes, which lasted 115.1+/-42.2s) and TBARS increase (GM1-MMA: 102.4+/-19.5 nmol MDA/g tissue). GM1 pretreatment increased ascorbic acid content of the striata (saline-pretreated: 1514+/-75.9; GM1-pretreated: 1878.6+/-102.8 microg ascorbic acid/mg tissue). MMA increased TBARS production in vitro, and GM1 had no effect on such MMA-induced effect. This study provides evidence that GM1 increases striatal ascorbic acid content and decreases MMA-induced neurotoxicity assessed by behavioral and neurochemical parameters.
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Ensinar conteúdos relacionados à inovação e à propriedade intelectual é essencial para preparar indivíduos críticos e atuantes na sociedade. Por isso, é importante que os profissionais da educação, responsáveis por transmitir o... more
Ensinar conteúdos relacionados à inovação e à propriedade intelectual é essencial para preparar indivíduos críticos e atuantes na sociedade. Por isso, é importante que os profissionais da educação, responsáveis por transmitir o conhecimento, tenham embasamento e formação sobre o tema. Este artigo retrata as principais conclusões de uma pesquisa que propôs a elaboração de uma cartilha, a fim de transmitir informações sobre inovação tecnológica para profissionais da educação. Por meio de uma revisão de literatura, conteúdos acerca da temática foram reunidos, constituindo um material inovador e de fácil compreensão em formato de cartilha. Seu manuseio e acesso foi estruturado em uma linguagem que contemplasse desde profissionais da educação básica até a pós-graduação. O estudo demonstrou a necessidade de elaboração de materiais para capacitação docente no âmbito de inovação e tecnologia. Ademais, as informações da cartilha são úteis para aprimorar as ações pedagógicas e direcionar o tr...
ISSN 1981-9900 versão eletrônica P e r i ó d i c o do I n s t i t u t o B r a s i l e i r o d e P e sq u i s a e E n si n o e m F i s i o l o gi a do E x e r c í c i o w w w. i b p e f e x. c o m. b r / w w w. r b p f e x. c o m. b r... more
ISSN 1981-9900 versão eletrônica P e r i ó d i c o do I n s t i t u t o B r a s i l e i r o d e P e sq u i s a e E n si n o e m F i s i o l o gi a do E x e r c í c i o w w w. i b p e f e x. c o m. b r / w w w. r b p f e x. c o m. b r AVALIAÇÃO RESUMO O objetivo desse estudo foi de avaliar e comparar a perda hídrica no futsal masculino em quatro diferentes situações como técnico/tático, coletivo, físico e jogo. A amostra foi constituída por 12 atletas com idade média de 29,7 +/-3,8 anos. Os resultados encontrados mostram que a situação técnico/tático foi a que menos teve perda hídrica comparado as demais condições, e em contra partida a situação jogo foi a que apresentou maior perda hídrica, porém não encontrou-se diferença significativa com o coletivo. A condição coletiva e física representam similaridades quando comparadas. Assim pode-se afirmar que houve diferenças de perda hídrica na maioria das condições, exceto quando comparado a situação coletivo com físico e coletivo com jogo...
Alzheimer's disease (AD) is characterized by disorders that can impair the nutrition of the patient and lead to weight loss and nutritional deficits during the course of the disease. The aim of this study was to assess the nutritional... more
Alzheimer's disease (AD) is characterized by disorders that can impair the nutrition of the patient and lead to weight loss and nutritional deficits during the course of the disease. The aim of this study was to assess the nutritional status and food intake of Brazilian patients with Alzheimer's disease at 3 different stages of the disease. The sample consisted of 30 subjects of both genders, mean age 77 years, with probable AD. Subjects were assessed by collecting anthropometric data, the Mini Nutritional Assessment (MNA), serum albumin content, Mini Mental State Examination and 24-hour records of food and drink. Although a steady decrease in average weight was observed as the disease progressed (CDR1: 70.8±15.9 kg; CDR2: 61.4±15.7 kg; CDR3: 56.1± 8.4 kg), the differences were not significant. MNA and serum albumin both fell during the progression of the disease (p = 0.042; p = 0.047, respectively) and, at the severe stage, half the patients were found to be undernourished ...
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Copyright © 2011 Cristiano AndréKöhler et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original... more
Copyright © 2011 Cristiano AndréKöhler et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Encoding for several memory types requires neural changes and the activity of distinct regions across the brain. These areas receive broad projections originating in nuclei located in the brainstem which are capable of modulating the activity of a particular area. The histaminergic system is one of the major modulatory systems, and it regulates basic homeostatic and higher functions including arousal, circadian, and feeding rhythms, and cognition. There is now evidence that histamine can modulate learning in different types of behavioral tasks, but the exact course of modulation and its mechanisms are controversial. In the present paper we review the involvement of the histaminergic system and the effects histaminergic recepto...
This is an Open Access article distributed under the terms of the Creative
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Alzheimer's disease (AD) is characterized by cognitive impairment and progressive memory loss and drug treatments have limited efficacy. Thus, non-pharmacological interventions, such as music therapy, have shown to be promising as... more
Alzheimer's disease (AD) is characterized by cognitive impairment and progressive memory loss and drug treatments have limited efficacy. Thus, non-pharmacological interventions, such as music therapy, have shown to be promising as supporting pharmacological treatment and, therefore, may arouse commercial interest regarding the development of this type of product. Thus, this study aims to carry out a patentometric survey on patent registrations with music therapy in the treatment of AD. A systematic search was carried out from 2000 to 2020 on the Orbti-Questel website, searching for documents referring to music therapies in AD. The terms “Alzheimer music methodology active therapy” and “Alzheimer music methodology passive therapy” were used. After searching, reading, and excluding duplicate results, we found four patent families referring to music therapy in AD and all were selected as a result, which was considered little compared to the number of studies published on the subject.
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Although malnutrition and risk of falls in the elderly have increased in recent years, uncertainties exist as to whether these conditions are associated after controlling for sociodemographic variables, body composition, metabolic... more
Although malnutrition and risk of falls in the elderly have increased in recent years, uncertainties exist as to whether these conditions are associated after controlling for sociodemographic variables, body composition, metabolic condition, and Alzheimer’s disease (AD). This study aimed to analyze the association between nutritional status and risk of fall in the elderly population. Participants were matched by gender and age, after they had been grouped on the basis of diagnosis of AD. The risk of falls, nutritional status, and mental status were assessed using the Downton Fall Risk Score (FRS), Mini Nutritional Assessment (MNA), and Mini Mental State Evaluation (MMSE), respectively. Logistic regression models adjusted for the main confounders were used in the analyses. Among the 68 elderly individuals studied, participants who were malnourished or at risk of malnutrition were more likely to fall (odds ratio = 8.29; 95% confidence interval = 1.49-46.04) than those with normal nutr...
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Objective: to compare the circulating/ serum levels of pro-inflammatory and anti-inflammatory cytokines and levels of leptin between Alzheimer’s disease (AD) patients and healthy older adults, correlating the levels of cytokines and... more
Objective: to compare the circulating/ serum levels of pro-inflammatory and anti-inflammatory cytokines and levels of leptin between Alzheimer’s disease (AD) patients and healthy older adults, correlating the levels of cytokines and leptin with nutritional status and global cognition. Methods: A case control study, which 32 older adults participated in the study, divided in two groups: AD Group (AD; n=16) and Non-dement older adults as Control Group (CG; n=16). The groups were paired by age, sex and comorbidities in relation to AD group. To identify the levels of cytokines and leptin, Enzyme linked immune sorbent assay were used. The Mini-Nutritional Assessment was used to measure the nutritional status and the Mini-Mental State Exam, global cognition. Comparisons between the case-control groups were performed by t-test and Hedge’s g effect size was calculated. Pearson's correlation test was used to analyze the associations between the observed and paired differences. Simple lin...
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Alzheimer's disease (AD) is a neurodegenerative pathology that affects elderly people all over the world. Several studies have demonstrated that oxidative stress is an aggravating factor for AD development and progression. Therefore,... more
Alzheimer's disease (AD) is a neurodegenerative pathology that affects elderly people all over the world. Several studies have demonstrated that oxidative stress is an aggravating factor for AD development and progression. Therefore, this study aimed to evaluate the activity of two oxidative stress markers, glutathione peroxidase (GPx) and δ-aminolevulinate dehydratase (δ-ALA-D), as well as correlate them with blood metal levels and AD progression. For this purpose, 88 elderly individuals were divided in two groups: AD group (34 patients diagnosed with AD) and control group (34 subjects paired by age with the AD group). The Mini-Mental State Examination and the Clinical Dementia Rating (CDR) were used as tools to classify the AD progression. GPx and δ-ALA-D activities were measured in all subjects through blood tests. Both enzymes' activities were decreased in AD patients when compared to the age-matched control group, regardless of the CDR. Moreover, GPx activity was positi...
O futsal e uma das modalidades coletivas que mais cresceu nos ultimos dez anos, mas mesmo com esse crescimento ainda e pouco pesquisada pela comunidade cientifica. Em uma partida de futsal todas as fontes de energia sao utilizadas pelos... more
O futsal e uma das modalidades coletivas que mais cresceu nos ultimos dez anos, mas mesmo com esse crescimento ainda e pouco pesquisada pela comunidade cientifica. Em uma partida de futsal todas as fontes de energia sao utilizadas pelos atletas (aerobia, anaerobia latica e anaerobia alatica) sendo os sprints os estimulos predominantes em uma partida. O objetivo deste estudo foi comparar o limiar anaerobico de atletas de futsal entre a pre temporada e alta temporada. A amostra foi constituida por 20 jogadores profissionais (27,7 +/5,1 anos) nos dois momentos. Os sujeitos realizaram o teste proposto por Tegtbur, Buss e Braumann (1993) para o lactato sanguineo, e para calcular o vo2max foi utilizado o protocolo de Luc leger e Lambert (1982). Os resultados encontrados no estudo demonstraram que existiu variacao no limiar anaerobico nas valencias de velocidade do limiar anaerobico e no %limvo2max.
Background: Elderly patients frequently have concomitant diseases, triggering the necessity of utilizing several different medications, which can cause adverse events associated with therapy, called polypharmacy. This study aimed to... more
Background: Elderly patients frequently have concomitant diseases, triggering the necessity of utilizing several different medications, which can cause adverse events associated with therapy, called polypharmacy. This study aimed to evaluate the main concomitant diseases with Alzheimer's disease (AD) and discuss possible interactions between drugs utilized to treat dementia and its comorbidities, and indicate safe medicines for patients with AD . Methods: 41 individuals with AD who withdraw medicines for dementia from the Brazilian public health system (SUS) participated in this study. Data collection was performed using three questionnaires: 1) Clinical Dementia Rating, to verify disease stage; 2) Mini–mental state examination, to measure cognitive impairment; and 3) Sociodemographic analysis, to evaluate concomitant diseases, utilized drugs, drug-drug interactions, among other demographic variables. Statistical analyses were performed using SPSS and data was presented as relat...
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O processo de envelhecimento humano traz modificações na capacidade funcional dos idosos. O risco para a incapacidade funcional se agrava quando o idoso é acometido pela Doença de Alzheimer (DA). Nosso objetivo foi avaliar a... more
O processo de envelhecimento humano traz modificações na capacidade funcional dos idosos. O risco para a incapacidade funcional se agrava quando o idoso é acometido pela Doença de Alzheimer (DA). Nosso objetivo foi avaliar a funcionalidade, de idosos com DA, por meio das atividades instrumentais de vida diária (AIVDs) e relacioná-la com o estágio da doença. A amostra foi composta por 56 idosos com DA, para avaliação das AIVDs utilizou-se a Escala de Lawton e Brody e para avaliar o estágio da doença a Escala de Avaliação Clínica da Demência (CDR). Os dados foram apresentados na forma de estatística descritiva. A maior parte dos participantes encontrava-se no estágio grave da doença (CDR3: 41,1%) e a minoria deles no estágio inicial (CDR1: 23,2%). Em relação às AIVDs a maioria dos idosos com foi classificada com dependência total (35,7%), e os idosos no estágio grave da doença foram os que mais apresentaram dependência total (30,3%). Apenas idosos do grupo que se encontrava no estágio...
A presente pesquisa investiga a proteção legal da população idosa frente aos avanços tecnológicos e, consequentemente, aos crimes cometidos no ciberespaço. O objetivo da pesquisa é analisar se a recente Lei Geral de Proteção de Dados... more
A presente pesquisa investiga a proteção legal da população idosa frente aos avanços tecnológicos e, consequentemente, aos crimes cometidos no ciberespaço. O objetivo da pesquisa é analisar se a recente Lei Geral de Proteção de Dados resguarda, substancialmente, os idosos, visto que são as vítimas preferenciais dos cibercriminosos, os quais se utilizam de habilidosas engenharias sociais para perpetrar fraudes financeiras. A pesquisa foi realizada através de revisão bibliográfica, de caráter exploratório junto à doutrina, notícias jornalísticas e dados estatísticos. O estudo foi realizado por meio de análise de conteúdo, na modalidade temática, seguindo as etapas de pré-análise, com organização do material coletado; exploração do material; tratamento e interpretação dos resultados com a realização da síntese interpretativa, interligando os artigos científicos e as informações documentais. Ao final, pôde-se concluir que a lei analisada resguarda os direitos à intimidade, privacidade e...
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Os avanços tecnológicos e a globalização propiciaram a construção de uma nova sociedade, essa baseada na comunicação e na transmissão de informação de forma rápida e eficaz, principalmente no que se refere à tecnologia virtual/internet.... more
Os avanços tecnológicos e a globalização propiciaram a construção de uma nova sociedade, essa baseada na comunicação e na transmissão de informação de forma rápida e eficaz, principalmente no que se refere à tecnologia virtual/internet. Entretanto, nesse mundo tecnológico, as informações pessoais são guardadas em diferentes bancos de dados, não havendo privacidade dos usuários. Nesse contexto, a atual sociedade passa por uma remodelação no que tange a preservação da privacidade dos dados, principalmente através de normativas legais. O presente artigo tem como objetivo contextualizar sobre a Lei Geral de Proteção de Dados, Lei n.º 13.709/2018. A metodologia utilizada foi uma revisão bibliográfica, sendo consultadas periódicos, monografias, dissertações e teses sobre a temática. Como conclusão, a LGPD foi um marco legal no Brasil, pois assegurou a privacidade e a proteção de dados pessoais, bem como criou normas que regulamentam a coleta e o tratamento desses dados pelas empresas.
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Smoking is considered to be a chronic disease caused by the nicotine dependence. The passive smoking is the leading cause of childhood respiratory disease. This research aimed to evaluate the conceptions that 2nd year-students of the... more
Smoking is considered to be a chronic disease caused by the nicotine dependence. The passive smoking is the leading cause of childhood respiratory disease. This research aimed to evaluate the conceptions that 2nd year-students of the Elementary School of two public schools at Guarapuava-PR, aging between 6 and 8 years, have about cigarettes and passive smoking. The work was performed at three moments: (1) without a preliminary intervention, the students answered a semi-structured questionnaire composed of 5 questions on cigarette and passive smoking (Pre-test, PT); (2) the students participated of activities where they saw an educational video and read a comic book whose theme dealt with the influence of the cigarette and the physiology of the respiratory system; (3) after 1 week and after 1 month, the students answered the same questionnaire offered in the PT (called respectively post-test 1 week, PTS, and post-test 1 month, PTM). More than 50% of students said they live with smoke...
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SUMMARY OBJECTIVE: We studied the users of the Specialized Drug Distribution Program of the public health network. METHODS: A prospective cohort examined the elderly at two intervals of three years and included 30 patients in phase I and... more
SUMMARY OBJECTIVE: We studied the users of the Specialized Drug Distribution Program of the public health network. METHODS: A prospective cohort examined the elderly at two intervals of three years and included 30 patients in phase I and 16 in phase II. The methodology was composed of home visits, anthropometric, nutritional and hematological evaluation. For the progression of AD, the Clinical Dementia Rating (CDR) scale was used. RESULTS: According to the CDR, the disease evolved, since in 2014 most of the patients were in CDR 3. In the analysis of the micronutrients, only the B vitamins (B1, B2, B3, B5, B6) presented a significant reduction in 2014. The consumption of carbohydrates and lipids increased in the 2014 evaluation, and protein consumption decreased. As for the average weight of the elderly, there was an increase in 2014, 65.9 (± 15.6) Kg, with a BMI of 26.75 (± 4, 5), in 2011 the average weight was 62.44 kg (± 14, 36), BMI 24.64 (± 4.97). CONCLUSION: The hypothesis that...
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Background: Elderly patients frequently have concomitant diseases, triggering the necessity of utilizing several different medications, which can cause adverse events associated with therapy, called polypharmacy. This study aimed to... more
Background: Elderly patients frequently have concomitant diseases, triggering the necessity of utilizing several different medications, which can cause adverse events associated with therapy, called polypharmacy. This study aimed to evaluate the main concomitant diseases with Alzheimer's disease (AD) and discuss possible interactions between drugs utilized to treat dementia and its comorbidities, and indicate safe medicines for patients with AD. Methods: 41 individuals with AD who withdraw medicines for dementia from the Brazilian public health system (SUS) participated in this study. Data collection was performed using three questionnaires: 1) Clinical Dementia Rating, to verify disease stage; 2) Mini–mental state examination, to measure cognitive impairment; and 3) Sociodemographic analysis, to evaluate concomitant diseases, utilized drugs, drug-drug interactions, among other demographic variables. Statistical analyses were performed using SPSS and data was presented as relati...
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Introduction: Dementia is a common health problem in elderly people, Alzheimer disease (AD) being the most prevalent. AD can be considered as a cause of death and must be registered on the death certificate of the patients. However, most... more
Introduction: Dementia is a common health problem in elderly people, Alzheimer disease (AD) being the most prevalent. AD can be considered as a cause of death and must be registered on the death certificate of the patients. However, most of the time, the main cause of death registered is not related to AD, but as an underlying or contributing cause. For example, individuals who have AD and die from myocardium infarction. This study aimed to analyze if nutritional status was associated with survival and mortality for AD, and if AD was reported as actual cause of death on the death certificate Methods: The study was carried out as a cross-sectional study with elderly citizens of the community registered in the National Health System (SUS), with cognitive, nutritional, biochemical and hematological evaluations of 30 AD patients in Guarapuava, Paraná state, Brazil. Results: Significant differences were not observed between live and dead patients when evaluated considering the methods ap...
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Background: Stress can impact human health in multiple ways. Among the related mechanisms are the hormonal systems of the hypothalamic–pituitary–adrenal axis, which produces cortisol. Current research aims to evaluate the relationship... more
Background: Stress can impact human health in multiple ways. Among the related mechanisms are the hormonal systems of the hypothalamic–pituitary–adrenal axis, which produces cortisol. Current research aims to evaluate the relationship between the daily variation of salivary cortisol dosages and the level of stress in caregivers of patients with Alzheimer's disease (AD). Methods: A sociodemographic questionnaire was applied to 25 caregivers, as well as the 36 Item Short-Form Health Survey and Beck’s Depression Inventory. In the 25 patients of the caregivers, the Instrumental Activities of Daily Living of the patient and Clinical Dementia Rating were assessed. Saliva samples were collected to assess the cortisol level of the caregivers three times over one day for each caregiver, (morning, afternoon and evening) to investigate the correlation of the aforementioned questionnaires with the age and degree of kinship among caregivers of elderly patients to investigate the correlation ...
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Background: Alzheimer's disease (AD) is the most common cause of dementia, with a multifactorial etiology, in which the person has great difficulty identifying feelings of hunger, satiety, and feeding, which may affect their... more
Background: Alzheimer's disease (AD) is the most common cause of dementia, with a multifactorial etiology, in which the person has great difficulty identifying feelings of hunger, satiety, and feeding, which may affect their nutritional status. Pathologically, it is associated with neurodegeneration of synapses followed by neuronal loss, accompanied by glial proliferation surrounded by neurofibrillary tangles, beta-amyloid peptide (Aβ) deposition, inflammation and cerebrovascular injury hindering the ability to perform activities of daily living. This study aimed to analyze quantitatively the differences between an elderly group with AD and a control group, in terms of macro and micronutrient consumption evaluation. Methods: the study involved 69 participants who were assessed via collection of anthropometric measurements (weight, height and body mass index) with nutritional status being assessed by 24-hour food recall and three-day food record. Cognitive assessments were perfor...