... Therefore, we believe that the general conclusion reached by Rangel-Moreno et al. that iBALT ... more ... Therefore, we believe that the general conclusion reached by Rangel-Moreno et al. that iBALT formation depends on IL-17 (ref. 1) is inappropriate. ... Primary authors. These authors contributed equally to this work. Immo Prinz &; Reinhold Förster. Affiliations. ...
... Therefore, we believe that the general conclusion reached by Rangel-Moreno et al. that iBALT ... more ... Therefore, we believe that the general conclusion reached by Rangel-Moreno et al. that iBALT formation depends on IL-17 (ref. 1) is inappropriate. ... Primary authors. These authors contributed equally to this work. Immo Prinz &; Reinhold Förster. Affiliations. ...
Journal of immunology (Baltimore, Md. : 1950), 2002
Lymphotoxin-alpha(-/-) (LTalpha(-/-)) mice are thought to be unable to generate effective T and B... more Lymphotoxin-alpha(-/-) (LTalpha(-/-)) mice are thought to be unable to generate effective T and B cell responses. This is attributed to the lack of lymph nodes and the disrupted splenic architecture of these mice. However, despite these defects we found that LTalpha(-/-) mice could survive infection with a virulent influenza A virus. LTalpha(-/-) mice and normal wild-type mice infected with influenza A generated similar numbers of influenza-specific CD8 T cells that were able to produce IFN-gamma and kill target cells presenting influenza peptides. Furthermore influenza-infected LTalpha(-/-) mice produced high titers of influenza-specific IgM, IgG, and IgA. However, both CD8 and B cell immune responses were delayed in LTalpha(-/-) mice by 2-3 days. The delayed cellular and humoral immune response was sufficient to mediate viral clearance in LTalpha(-/-) mice that were infected with relatively low doses of influenza virus. However, when LTalpha(-/-) mice were infected with larger dos...
... Therefore, we believe that the general conclusion reached by Rangel-Moreno et al. that iBALT ... more ... Therefore, we believe that the general conclusion reached by Rangel-Moreno et al. that iBALT formation depends on IL-17 (ref. 1) is inappropriate. ... Primary authors. These authors contributed equally to this work. Immo Prinz &; Reinhold Förster. Affiliations. ...
... Therefore, we believe that the general conclusion reached by Rangel-Moreno et al. that iBALT ... more ... Therefore, we believe that the general conclusion reached by Rangel-Moreno et al. that iBALT formation depends on IL-17 (ref. 1) is inappropriate. ... Primary authors. These authors contributed equally to this work. Immo Prinz &; Reinhold Förster. Affiliations. ...
... Therefore, we believe that the general conclusion reached by Rangel-Moreno et al. that iBALT ... more ... Therefore, we believe that the general conclusion reached by Rangel-Moreno et al. that iBALT formation depends on IL-17 (ref. 1) is inappropriate. ... Primary authors. These authors contributed equally to this work. Immo Prinz &; Reinhold Förster. Affiliations. ...
Journal of immunology (Baltimore, Md. : 1950), 2002
Lymphotoxin-alpha(-/-) (LTalpha(-/-)) mice are thought to be unable to generate effective T and B... more Lymphotoxin-alpha(-/-) (LTalpha(-/-)) mice are thought to be unable to generate effective T and B cell responses. This is attributed to the lack of lymph nodes and the disrupted splenic architecture of these mice. However, despite these defects we found that LTalpha(-/-) mice could survive infection with a virulent influenza A virus. LTalpha(-/-) mice and normal wild-type mice infected with influenza A generated similar numbers of influenza-specific CD8 T cells that were able to produce IFN-gamma and kill target cells presenting influenza peptides. Furthermore influenza-infected LTalpha(-/-) mice produced high titers of influenza-specific IgM, IgG, and IgA. However, both CD8 and B cell immune responses were delayed in LTalpha(-/-) mice by 2-3 days. The delayed cellular and humoral immune response was sufficient to mediate viral clearance in LTalpha(-/-) mice that were infected with relatively low doses of influenza virus. However, when LTalpha(-/-) mice were infected with larger dos...
... Therefore, we believe that the general conclusion reached by Rangel-Moreno et al. that iBALT ... more ... Therefore, we believe that the general conclusion reached by Rangel-Moreno et al. that iBALT formation depends on IL-17 (ref. 1) is inappropriate. ... Primary authors. These authors contributed equally to this work. Immo Prinz &; Reinhold Förster. Affiliations. ...
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