Aim This paper seeks to illumine how families with children and adult members with intellectual d... more Aim This paper seeks to illumine how families with children and adult members with intellectual disabilities manage to manifest a buoyant and durable capacity over time. It is therefore concerned centrally with the idea of resilience. Method Drawing from diverse theoretical literatures from child development and protection and gerontology, the paper begins with a review of constructions of resilience. In an attempt to assess where there seems to be support for resilience in families, the core of the paper tests empirical evidence about positive experiences of families supporting children and adults with intellectual disabilities against the theoretical literature on resilience. Result and Conclusions The findings are used to suggest conditions under which resilience is produced and maintained, and to identify emergent elements of a psycho-social model of resilience in families with children and adult members with intellectual disabilities.
With its spread of chapters covering key issues across the life cycle this text has established i... more With its spread of chapters covering key issues across the life cycle this text has established itself as the foundational primer for those studying the lived experiences of people with learning disabilities and their families, and outcomes achieved through services and support systems. Recognising learning disability as a lifelong disability, this accessible book is structured around the life cycle. The second edition is refreshed and expanded to include seven new chapters, covering: Aetiology, Breaking news (about disability) and early intervention, Transition to adulthood, The sexual lives of women, Employment, Personalisation, People with hidden identities. With contributions from respected figures from a range of disciplines, the book draws heavily upon multidisciplinary perspectives and is based on the latest research and evidence for practice. The text is informed by medical, social and legal models of learning disability, exploring how "learning disability" is produced, reproduced and understood. Extensive use is made of real-life case studies, designed to bring theory, values, policy and practice to life. Narrative chapters describe, in the words of people with learning disabilities themselves, their lives and aspirations. They helpfully show readers the kinds of roles played by families, advocates and services in supporting people with learning disabilities. New exercises and questions have been added to encourage discussion and reflection on practice. Learning Disability is core reading for students entering health and social care professions to work with people with learning disabilities. It is a compelling reference text for practitioners as it squarely addresses the challenges facing people with learning disability, their loved ones and the people supporting them.
' l"' r1 xler ,-Pr oblems-Jn the Improvement. or tte dine • l ra-Rill Book Comp ny ,. !nc. , Me Y... more ' l"' r1 xler ,-Pr oblems-Jn the Improvement. or tte dine • l ra-Rill Book Comp ny ,. !nc. , Me Yor k, 1946p. 86. '"; A , "fr ' "I'll be heading for B'~~!'l1n, To~.c-yo, or :T.~.yb~ South America. ! '11 fly faster than t::ll"'se :f'e llc-t 8 • to;. In ~ ~. .. 't plt3r •s I •11 be thel"e snd back before thes~ plan.e:1 can even get there. Why, with the planes '-•
Whole language may be described as authentic and purposeful experiences with language in a child'... more Whole language may be described as authentic and purposeful experiences with language in a child's natural environment-it is a philosophy that combines all content area subjects into a meaningful process. The teaching of whole language over the entire spectrum of the curriculum was observed in the Catholic Primary Schools of the Archdiocese of Sydney, Australia. Each school promoted learning through its own strategies pertinent to the needs of the student. Classrooms were curious, imaginative places that challenged the children. Teachers needed to be well prepared because groups of children were often involved in a variety of activities. Classroom observations indicated that children did not need to be "spoon fed" but that they could actively participate in learning activities. Instruments of evaluatio_i through the school visits were usually informal such as teacher observation, journal writing, visual materials, written projects, and research participation through performance. In general, classroom teachers feel that whole language: (1) enriches learning in the classroom and the teaching/learning process; (2) gives children the freedom to explore for themselves; (3) makes connections with oral, written, and reading comprehension; (4) encourages children to look at literature in depth; and (5) uses all modes of communication in an integrating manner stressing language as a whole. (Contains eight references.) (RS)
We've come a long way since Lister discovered and preached the value of aseptic technique in ... more We've come a long way since Lister discovered and preached the value of aseptic technique in surgery and wound care. And while it is unlikely that new discoveries in wound care research will so profoundly affect patient care as those of Lister, our understanding of the biologic mechanisms of healing has evolved to such a point that we can now look forward to controlling and perhaps accelerating the healing process. Only a decade ago, the accepted approach to wound management was cautious and passive-achieve hemostasis, dress the wound carefully, remove sutures early, and let nature do its work. Now, however, in the laboratory and in some clinical settings, a more aggressive approach to wound care is being advocated. The major advances that have brought wound care research to a new potential have occurred in cell biology. Among the findings that are signaling new and aggressive approaches to wound care are discoveries about the function of the
Journal of Cardiovascular Translational Research, 2022
Ultrasound enhancing agents are approved to delineate the endocardial border and opacify the left... more Ultrasound enhancing agents are approved to delineate the endocardial border and opacify the left ventricle cavity (LVC). We present a nested phase change agent (NPCA) designed to enable selective myocardial enhancement without enhancing the LVC by employing a dual-activation mechanism dependent on sufficient ultrasound intensity and the microenvironment of the myocardium. Swine received bolus injections of NPCA while echocardiograms were collected and processed to determine background-subtracted acoustic intensities (AI) in the LVC and septal myocardium. At mechanical index (MI) ≥ 0.8, the NPCA enhanced the myocardium selectively ( p < 0.001) while the LVC remained at baseline AI. A 5-mL bolus of NPCA enhanced swine myocardium and enhancement persisted for > 5 min at 1.4 MI, while hemodynamics and EKG remained normal. Our findings demonstrate that the NPCA enhances swine myocardium selectively without enhancing the LVC. The NPCA could have utility for functional and structural echocardiographic studies with clinical ultrasound using standard settings. Graphical abstract
Echocardiographers with specialized expertise sometimes perform myocardial perfusion imaging usin... more Echocardiographers with specialized expertise sometimes perform myocardial perfusion imaging using U.S. Food and Drug Administration-approved microbubbles in an off-label capacity, correlating microbubble replenishment in the near field with blood flow through the myocardium. This study reports the in vivo clinical feasibility of a voltage-sensitive ultrasound enhancing agent (UEA) for myocardial perfusion imaging. Four UEAs were injected into Sprague-Dawley rats while ultrasound images were collected to quantify brightness in the left ventricular (LV) cavity, septal wall, and posterior wall in systole and diastole. Formulation IV, a phase change agent nested within a negatively charged phospholipid bilayer, increased the tissue-to-cavity ratio in both systole and diastole in the septal wall, 6 dB, and in the posterior wall, 5 dB, while leaving the LV cavity at baseline. This outcome improves the signal of the myocardium relative to the LV cavity and shows promise as a myocardial perfusion UEA.
The mean values for serum total cholesterol for 47 males, aged 32 to 62 yr who, over a 10 1/2 mon... more The mean values for serum total cholesterol for 47 males, aged 32 to 62 yr who, over a 10 1/2 month study ate, within a self-selected diet, beef as the only meat for 3 months, poultry and fish for 3 months, and pork for 3 months showed no statistically significant difference, whereas 17 of 29 females of the same age who participated in the same study had borderline statistically significant differences in mean values (p less than 0.055). When data from all subjects were considered together, no statistically significant changes in mean serum total cholesterol or serum triglycerides were noted, but there were significant changes in mean high-density lipoprotein cholesterol values, both upward and downward. The important results of this study are documentary to the lack of influence of &amp;amp;quot;meat&amp;amp;quot; and its fat on effecting a significant change in serum total cholesterol within a self-selected diet.
The current paper aims to advance research on occupational health disparities among racial and et... more The current paper aims to advance research on occupational health disparities among racial and ethnic minorities. We review the historical context and development of the field of occupational health disparities, and review a diverse set of national research frameworks. Our work is based on the Diversified Portfolio Model (DPM) of adaptability (Chandra and Leong 2016) which maintains that diversification promotes greater adaptability. Since diversification bestows adaptive advantages in multiple arenas of human endeavor, we proposed that an analysis of diverse theoretical models for studying occupational health disparities would also benefit the field of Occupational Health Science. The theoretical frameworks reviewed include: (a) The National Institute of Aging's (NIA) health disparities framework, (b) An Epidemiological Framework, (c) The Transformation for Health Framework, and (d) The Cultural Adaptations Framework. We summarize lessons and highlight the need for incorporating change perspectives, prevention-oriented approaches, and mixed-methods approaches to address occupational health disparities. Keywords Occupational health disparities. Racial and ethnic minorities. Diversified Portfolio Model Racial and ethnic minority groups have a disproportionate share of disease, disability, and premature death compared to the general population (Leong et al. 2017). Such disparate impact has been observed across different fields ranging from health to education and various explanations for these effects have been posited (
Aim This paper seeks to illumine how families with children and adult members with intellectual d... more Aim This paper seeks to illumine how families with children and adult members with intellectual disabilities manage to manifest a buoyant and durable capacity over time. It is therefore concerned centrally with the idea of resilience. Method Drawing from diverse theoretical literatures from child development and protection and gerontology, the paper begins with a review of constructions of resilience. In an attempt to assess where there seems to be support for resilience in families, the core of the paper tests empirical evidence about positive experiences of families supporting children and adults with intellectual disabilities against the theoretical literature on resilience. Result and Conclusions The findings are used to suggest conditions under which resilience is produced and maintained, and to identify emergent elements of a psycho-social model of resilience in families with children and adult members with intellectual disabilities.
With its spread of chapters covering key issues across the life cycle this text has established i... more With its spread of chapters covering key issues across the life cycle this text has established itself as the foundational primer for those studying the lived experiences of people with learning disabilities and their families, and outcomes achieved through services and support systems. Recognising learning disability as a lifelong disability, this accessible book is structured around the life cycle. The second edition is refreshed and expanded to include seven new chapters, covering: Aetiology, Breaking news (about disability) and early intervention, Transition to adulthood, The sexual lives of women, Employment, Personalisation, People with hidden identities. With contributions from respected figures from a range of disciplines, the book draws heavily upon multidisciplinary perspectives and is based on the latest research and evidence for practice. The text is informed by medical, social and legal models of learning disability, exploring how "learning disability" is produced, reproduced and understood. Extensive use is made of real-life case studies, designed to bring theory, values, policy and practice to life. Narrative chapters describe, in the words of people with learning disabilities themselves, their lives and aspirations. They helpfully show readers the kinds of roles played by families, advocates and services in supporting people with learning disabilities. New exercises and questions have been added to encourage discussion and reflection on practice. Learning Disability is core reading for students entering health and social care professions to work with people with learning disabilities. It is a compelling reference text for practitioners as it squarely addresses the challenges facing people with learning disability, their loved ones and the people supporting them.
' l"' r1 xler ,-Pr oblems-Jn the Improvement. or tte dine • l ra-Rill Book Comp ny ,. !nc. , Me Y... more ' l"' r1 xler ,-Pr oblems-Jn the Improvement. or tte dine • l ra-Rill Book Comp ny ,. !nc. , Me Yor k, 1946p. 86. '"; A , "fr ' "I'll be heading for B'~~!'l1n, To~.c-yo, or :T.~.yb~ South America. ! '11 fly faster than t::ll"'se :f'e llc-t 8 • to;. In ~ ~. .. 't plt3r •s I •11 be thel"e snd back before thes~ plan.e:1 can even get there. Why, with the planes '-•
Whole language may be described as authentic and purposeful experiences with language in a child'... more Whole language may be described as authentic and purposeful experiences with language in a child's natural environment-it is a philosophy that combines all content area subjects into a meaningful process. The teaching of whole language over the entire spectrum of the curriculum was observed in the Catholic Primary Schools of the Archdiocese of Sydney, Australia. Each school promoted learning through its own strategies pertinent to the needs of the student. Classrooms were curious, imaginative places that challenged the children. Teachers needed to be well prepared because groups of children were often involved in a variety of activities. Classroom observations indicated that children did not need to be "spoon fed" but that they could actively participate in learning activities. Instruments of evaluatio_i through the school visits were usually informal such as teacher observation, journal writing, visual materials, written projects, and research participation through performance. In general, classroom teachers feel that whole language: (1) enriches learning in the classroom and the teaching/learning process; (2) gives children the freedom to explore for themselves; (3) makes connections with oral, written, and reading comprehension; (4) encourages children to look at literature in depth; and (5) uses all modes of communication in an integrating manner stressing language as a whole. (Contains eight references.) (RS)
We've come a long way since Lister discovered and preached the value of aseptic technique in ... more We've come a long way since Lister discovered and preached the value of aseptic technique in surgery and wound care. And while it is unlikely that new discoveries in wound care research will so profoundly affect patient care as those of Lister, our understanding of the biologic mechanisms of healing has evolved to such a point that we can now look forward to controlling and perhaps accelerating the healing process. Only a decade ago, the accepted approach to wound management was cautious and passive-achieve hemostasis, dress the wound carefully, remove sutures early, and let nature do its work. Now, however, in the laboratory and in some clinical settings, a more aggressive approach to wound care is being advocated. The major advances that have brought wound care research to a new potential have occurred in cell biology. Among the findings that are signaling new and aggressive approaches to wound care are discoveries about the function of the
Journal of Cardiovascular Translational Research, 2022
Ultrasound enhancing agents are approved to delineate the endocardial border and opacify the left... more Ultrasound enhancing agents are approved to delineate the endocardial border and opacify the left ventricle cavity (LVC). We present a nested phase change agent (NPCA) designed to enable selective myocardial enhancement without enhancing the LVC by employing a dual-activation mechanism dependent on sufficient ultrasound intensity and the microenvironment of the myocardium. Swine received bolus injections of NPCA while echocardiograms were collected and processed to determine background-subtracted acoustic intensities (AI) in the LVC and septal myocardium. At mechanical index (MI) ≥ 0.8, the NPCA enhanced the myocardium selectively ( p < 0.001) while the LVC remained at baseline AI. A 5-mL bolus of NPCA enhanced swine myocardium and enhancement persisted for > 5 min at 1.4 MI, while hemodynamics and EKG remained normal. Our findings demonstrate that the NPCA enhances swine myocardium selectively without enhancing the LVC. The NPCA could have utility for functional and structural echocardiographic studies with clinical ultrasound using standard settings. Graphical abstract
Echocardiographers with specialized expertise sometimes perform myocardial perfusion imaging usin... more Echocardiographers with specialized expertise sometimes perform myocardial perfusion imaging using U.S. Food and Drug Administration-approved microbubbles in an off-label capacity, correlating microbubble replenishment in the near field with blood flow through the myocardium. This study reports the in vivo clinical feasibility of a voltage-sensitive ultrasound enhancing agent (UEA) for myocardial perfusion imaging. Four UEAs were injected into Sprague-Dawley rats while ultrasound images were collected to quantify brightness in the left ventricular (LV) cavity, septal wall, and posterior wall in systole and diastole. Formulation IV, a phase change agent nested within a negatively charged phospholipid bilayer, increased the tissue-to-cavity ratio in both systole and diastole in the septal wall, 6 dB, and in the posterior wall, 5 dB, while leaving the LV cavity at baseline. This outcome improves the signal of the myocardium relative to the LV cavity and shows promise as a myocardial perfusion UEA.
The mean values for serum total cholesterol for 47 males, aged 32 to 62 yr who, over a 10 1/2 mon... more The mean values for serum total cholesterol for 47 males, aged 32 to 62 yr who, over a 10 1/2 month study ate, within a self-selected diet, beef as the only meat for 3 months, poultry and fish for 3 months, and pork for 3 months showed no statistically significant difference, whereas 17 of 29 females of the same age who participated in the same study had borderline statistically significant differences in mean values (p less than 0.055). When data from all subjects were considered together, no statistically significant changes in mean serum total cholesterol or serum triglycerides were noted, but there were significant changes in mean high-density lipoprotein cholesterol values, both upward and downward. The important results of this study are documentary to the lack of influence of &amp;amp;quot;meat&amp;amp;quot; and its fat on effecting a significant change in serum total cholesterol within a self-selected diet.
The current paper aims to advance research on occupational health disparities among racial and et... more The current paper aims to advance research on occupational health disparities among racial and ethnic minorities. We review the historical context and development of the field of occupational health disparities, and review a diverse set of national research frameworks. Our work is based on the Diversified Portfolio Model (DPM) of adaptability (Chandra and Leong 2016) which maintains that diversification promotes greater adaptability. Since diversification bestows adaptive advantages in multiple arenas of human endeavor, we proposed that an analysis of diverse theoretical models for studying occupational health disparities would also benefit the field of Occupational Health Science. The theoretical frameworks reviewed include: (a) The National Institute of Aging's (NIA) health disparities framework, (b) An Epidemiological Framework, (c) The Transformation for Health Framework, and (d) The Cultural Adaptations Framework. We summarize lessons and highlight the need for incorporating change perspectives, prevention-oriented approaches, and mixed-methods approaches to address occupational health disparities. Keywords Occupational health disparities. Racial and ethnic minorities. Diversified Portfolio Model Racial and ethnic minority groups have a disproportionate share of disease, disability, and premature death compared to the general population (Leong et al. 2017). Such disparate impact has been observed across different fields ranging from health to education and various explanations for these effects have been posited (
Sports Medicine, Training and Rehabilitation, 1990
Conditioned runners may be able to endure higher levels of stress and pain during racing due to t... more Conditioned runners may be able to endure higher levels of stress and pain during racing due to the presence of elevated endogenous opiates. To test this hypothesis, intravenous naloxone 10 mg or saline was administered in a repeated measures randomized, double-blind protocol to 15 male runners. About 20 minutes after the injection, the subjects ran a 400 meter race, with the elapsed time being recorded. Pre-and post-run mood and post-run global pain status were measured. Contrary to the hypothesis, naloxone had no statistically significant effect on mean race time, mean pre-to post-race mood, or upon a post-race global pain rating when compared with saline; a trend in the analysis (p = 0.12) did suggest that naloxone injection was associated with faster run times. Three runners showed a marked improvement in racing time following naloxone, suggesting that some athletes may gain advantage by having blocked endorphins during maximal performances.
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