Marko Ljubos

Europski poduzetnički pothvat, materijaliziran u obliku ekipiranog i naoru- žanog trgovačkog broda sposobnog da oplovi i osvoji globus, stvorio je moderni svijet - kao svijet sa samo jednom, ali mondijaliziranom stranom, Zapadom. Da bi takav svijet danas bio globaliziran, on se mora iznova umrežiti, ali sada kao mnogostruka i višesmjerna poduzetnička povratna sprega. Suvremeni globalni li- beralni intervencionizam i vladino

The article shows that globalization makes the largest influence on three significant guarantees of national identity (and freedom) preservation: language, economic and political independence. The possibilities to preserve and to consolidate freedom are discussed as well. The first theme analyzed is the worship and promotion of language, cultural and national values which mean not only safety but also openness and

The turbulent development of science and technology has lead to major changes in all spheres of man's existence, As such, it has resulted in the necessity of applying multidisciplinary approach to solving problems encountered by both individuals and corporations. Industry convergence, technological complexity, solution selling, and the globalization of consumers are increasing the importance and disper- sion of relevant new

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

Dedicated to Professor Emeritus Miha Tišler on the occasion of his 75th birthdayTreatment of methyl (S)-5-[(E)-(dimethylamino)methylidene]-2-oxotetrahydrofuran-5-carboxylate (2) with potassium cyanide in acetic acid gave (S)-5-[(E)-cyanomethylidene]-2-oxotetrahydrofuran-5-car-boxylate (3), which was used as chiral dipolarophile in 1,3-dipolar cycloadditions. Reactions of 3 with diazomethane (4) and nitrile oxides 5a-c afforded spirolactones 6–8 in 24-34% diastereomeric excess, while with diazomethane (4) in the presence of triethylamine, methyl 3-cyanomethyl-2-methoxyfuran-5-carboxylate (12) was obtained.

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

Cycloadditions of various 1,3-dipoles to methyl (S)-1-tert-butoxycarbonyl-3-[(E)-cyanomethylidene]-2-pyrrolidinone-5-carboxylate (9) were studied. Reactions of 9 with diazomethane (10) and 2,4,6-trimethoxy-benzonitrile oxide (11), carried out under neutral conditions, gave the corresponding optically active spiro compounds 16-18 with low diastereoselectivity (20-30% diastereomeric excess). On the other hand, reactions of 9 with nitrile oxide 11 and nitrile imines 14, 15, carried out in the presence of a base, afforded racemic pyrazolo and isoxazolo fused 2-pyrrolidinones 21-23 in 82-86% diastereomeric excess. Optically active dipolarophile 9 was isomerized in the presence of basic alumina to give methyl (RS)-1-tert-butoxy-carbonyl-3-cyanomethyl-1,2-dihydro-2-oxo-5H-pyrrole-5-carboxylate (19). Treatment of the racemic dipolarophile 19 with dipoles 11 and 14, afforded fused 2-pyrrolidinones 23 and 21. These observations support compound 19 as the key-intermediate in the formation of racemic cycloadducts 21-23.