Research Interests:
Research Interests:
Research Interests:
Research Interests:
Research Interests:
Research Interests:
Research Interests:
Objective. Sclerostin is a Wnt inhibitor produced specifically by osteocytes. However, it is not currently clear whether renal dysfunction has an effect on circulating sclerostin level in patients with type 2 diabetes. The aim of the... more
Objective. Sclerostin is a Wnt inhibitor produced specifically by osteocytes. However, it is not currently clear whether renal dysfunction has an effect on circulating sclerostin level in patients with type 2 diabetes. The aim of the study was to evaluate this relationship. Design and Patients. We conducted a cross-sectional observational study of 302 type 2 diabetic patients with or without chronic kidney disease. Serum sclerostin level was analyzed by ELISA, and renal function was assessed by estimated glomerular filtration rate (eGFR) using chronic kidney disease epidemiology collaboration (CKD-EPI) equation. Results. There was a strong correlation between sclerostin level with renal function presented as serum creatinine (r=0.745, P<0.001) and eGFR (r=-0.590, P<0.001). Serum sclerostin level was significantly higher in patients with CKD-G3 stage than those with CKD-G1/2 stages after adjusting for age, sex, and BMI (P=0.011). Patients with CKD-G4/5 stages had dramatically i...
Research Interests:
The last few years have seen a renewed emphasis on Well Integrity (WI) worldwide, and ADMA-OPCO in particular. ADMA operates, more than 600 wells, in two offshore fields, which include oil producers, water injectors, gas... more
The last few years have seen a renewed emphasis on Well Integrity (WI) worldwide, and ADMA-OPCO in particular. ADMA operates, more than 600 wells, in two offshore fields, which include oil producers, water injectors, gas producers/injectors and observation wells. A dedicated team was setup to focus entirely on WI and related issues. The team was given the objective to achieve the following. –Determine the Well Integrity Status of the entire well stock through risk review and ranking.–Recommend appropriate action plan for each well with unacceptable level of risk. The team used a comprehensive and novel approach for handling this project. This paper is a case study of the methodology adopted by the team to achieve this task. Since the main objective was to risk review and rank the entire well stock, a dedicated risk-ranking process was designed, which served as an automatic guide to risk review and ranking of wells. The industry Risk Ranking matrix was modified to make it more object...
Research Interests:
Research Interests:
Objective: It is well known that i.m. glucagon administration stimulates GH and cortisol release in humans, although the mechanisms are unclear. These effects are similar to those described for ghrelin on somatotroph and corticotroph... more
Objective: It is well known that i.m. glucagon administration stimulates GH and cortisol release in humans, although the mechanisms are unclear. These effects are similar to those described for ghrelin on somatotroph and corticotroph function. The aim of the present study was to investigate the role of ghrelin in mediating the stimulatory effects of glucagon and to evaluate the effect of glucagon on ghrelin secretion. Design and methods: We studied the endocrine and metabolic response to i.m. glucagon administration in 24 subjects (14 men, 10 women; age 19–65 years; body mass index, 25.3 ± 1 kg/m2), who were shown to have an intact anterior pituitary function as evaluated before enclosure. Results: Serum ghrelin concentrations fell significantly at 30, 60, 120 and 180 min after glucagon administration (means ± s.e.m.; baseline, 377.9 ± 34.5 pg/ml; nadir, 294.6 ± 28.3 pg/ml (60 min); P < 0.01). Conversely, i.m. glucagon elicited an increase in GH (baseline, 1.5 ± 0.4 μg/l; peak, 1...