Despite the vast availability of antibiotics, bacterial infections remain a leading cause of deat... more Despite the vast availability of antibiotics, bacterial infections remain a leading cause of death worldwide. In an effort to enhance the armamentarium against resistant bacterial strains, 1,2,3-triazole () and sulfonate () analogues of natural bioactive precursors were designed and synthesized. Preliminary screening against two Gram-positive ( and ) and four Gram-negative bacterial strains (, , , and ) was performed to assess the potency of these analogues as antibacterial agents. Among all triazole analogues, (derived from carvacrol) and (derived from 2-hydroxy 1,4-naphthoquinone) bearing carboxylic acid functionality emerged as potent antibacterial agents against (IC: 62.53 and 39.33 μg/mL), (IC: 36.66 and 61.09 μg/mL), and (IC: 15.28 and 22.57 μg/mL). Furthermore, and also demonstrated moderate efficacy against multidrug-resistant strains and were therefore selected for further biological studies. Compound in combination with ciprofloxacin displayed a synergistic effect on multi...
Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology], Jan 12, 2018
Escalating burden of antibiotic resistance that has reached new heights present a grave concern t... more Escalating burden of antibiotic resistance that has reached new heights present a grave concern to mankind. As the problem is no longer confined to clinics, we hereby report identification of a pandrug resistant Escherichia coli isolate from heavily polluted Delhi stretch of river Yamuna, India. E. coli MRC11 was found sensitive only to tobramycin against 21 antibiotics tested, with minimum inhibitory concentration values >256μg/mL for amoxicillin, carbenicillin, aztreonam, ceftazidime and cefotaxime. Addition of certain heavy metals at higher concentrations were ineffective in increasing susceptibility of E. coli MRC11 to antibiotics. Withstanding sub-optimal concentration of cefotaxime (10μg/mL) and mercuric chloride (2μg/mL), and also resistance to their combinatorial use, indicates better adaptability in heavily polluted environment through clustering and expression of resistance genes. Interestingly, E. coli MRC11 harbours two different variants of blaTEM (blaTEM-116 and bla...
... Arif Tasleem Jana,b, Mudsser Azama, Arif Alib, and Qazi Mohd. Rizwanul Haqa* aDepartment of B... more ... Arif Tasleem Jana,b, Mudsser Azama, Arif Alib, and Qazi Mohd. Rizwanul Haqa* aDepartment of Biosciences, Jamia Millia Islamia, Moulana Mohammad Ali Jauhar Marg, New Delhi 110025, India; bDepartment of Biotechnology, Jamia Millia Islamia, New Delhi 110025, India ...
Despite the vast availability of antibiotics, bacterial infections remain a leading cause of deat... more Despite the vast availability of antibiotics, bacterial infections remain a leading cause of death worldwide. In an effort to enhance the armamentarium against resistant bacterial strains, 1,2,3-triazole () and sulfonate () analogues of natural bioactive precursors were designed and synthesized. Preliminary screening against two Gram-positive ( and ) and four Gram-negative bacterial strains (, , , and ) was performed to assess the potency of these analogues as antibacterial agents. Among all triazole analogues, (derived from carvacrol) and (derived from 2-hydroxy 1,4-naphthoquinone) bearing carboxylic acid functionality emerged as potent antibacterial agents against (IC: 62.53 and 39.33 μg/mL), (IC: 36.66 and 61.09 μg/mL), and (IC: 15.28 and 22.57 μg/mL). Furthermore, and also demonstrated moderate efficacy against multidrug-resistant strains and were therefore selected for further biological studies. Compound in combination with ciprofloxacin displayed a synergistic effect on multi...
Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology], Jan 12, 2018
Escalating burden of antibiotic resistance that has reached new heights present a grave concern t... more Escalating burden of antibiotic resistance that has reached new heights present a grave concern to mankind. As the problem is no longer confined to clinics, we hereby report identification of a pandrug resistant Escherichia coli isolate from heavily polluted Delhi stretch of river Yamuna, India. E. coli MRC11 was found sensitive only to tobramycin against 21 antibiotics tested, with minimum inhibitory concentration values >256μg/mL for amoxicillin, carbenicillin, aztreonam, ceftazidime and cefotaxime. Addition of certain heavy metals at higher concentrations were ineffective in increasing susceptibility of E. coli MRC11 to antibiotics. Withstanding sub-optimal concentration of cefotaxime (10μg/mL) and mercuric chloride (2μg/mL), and also resistance to their combinatorial use, indicates better adaptability in heavily polluted environment through clustering and expression of resistance genes. Interestingly, E. coli MRC11 harbours two different variants of blaTEM (blaTEM-116 and bla...
... Arif Tasleem Jana,b, Mudsser Azama, Arif Alib, and Qazi Mohd. Rizwanul Haqa* aDepartment of B... more ... Arif Tasleem Jana,b, Mudsser Azama, Arif Alib, and Qazi Mohd. Rizwanul Haqa* aDepartment of Biosciences, Jamia Millia Islamia, Moulana Mohammad Ali Jauhar Marg, New Delhi 110025, India; bDepartment of Biotechnology, Jamia Millia Islamia, New Delhi 110025, India ...
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