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... IEEE, Trans. Nuclear science, vol. 44, June 1997. [2] S. Weber et al. “Evaluation of the TierPET system”. IEEE, Trans. Nuclear science, vol. 46, 1999. [3] NH Clinthorne, “Very High Resolution Animal PET”. J. Nucl. Med. Supp., 2000. ...
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Application of advanced imaging techniques, such as PET and x ray CT, can potentially improve detection of breast cancer. Unfortunately, both modalities have challenges in the detection of some lesions. The combination of the two... more
Application of advanced imaging techniques, such as PET and x ray CT, can potentially improve detection of breast cancer. Unfortunately, both modalities have challenges in the detection of some lesions. The combination of the two techniques, however, could potentially lead to an overall improvement in diagnostic breast imaging. The purpose of this investigation is to test the basic performance of a new dedicated breast-PET/CT. The PET component consists of a rotating pair of detectors. Its performance was evaluated using the NEMA NU4-2008 protocols. The CT component utilizes a pulsed x ray source and flat panel detector mounted on the same gantry as the PET scanner. Its performance was assessed using specialized phantoms. The radiation dose to a breast during CT imaging was explored by the measurement of free-in-air kerma and air kerma measured at the center of a 16 cm-diameter PMMA cylinder. Finally, the combined capabilities of the system were demonstrated by imaging of a micro-ho...
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The effect of intercrystal Compton scatter in a small animal PET module was investigated using electron-gamma shower code (EGS4) simulations. The size of detector module is fixed at a 16 mm×16 mm crystal array. Monte Carlo simulations... more
The effect of intercrystal Compton scatter in a small animal PET module was investigated using electron-gamma shower code (EGS4) simulations. The size of detector module is fixed at a 16 mm×16 mm crystal array. Monte Carlo simulations were performed to estimate the effect of intercrystal scatter considering scintillation materials (BGO, LSO, and NaI), detector energy threshold, crystal size, and interaction
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Theoretical studies show our prototype Compton camera, C-SPRINT, matches the 99mTc performance of clinically available mechanically collimated systems if an advantage in sensitivity of ∼45 can be achieved. Imaging at higher energies... more
Theoretical studies show our prototype Compton camera, C-SPRINT, matches the 99mTc performance of clinically available mechanically collimated systems if an advantage in sensitivity of ∼45 can be achieved. Imaging at higher energies substantially reduces the required sensitivity advantage. At ∼400keV, our Compton camera system needs only five times the raw count rate of a mechanically collimated system imaging at 99mTc
... Our ultimate goal is to provide a continuously updated 3D reconstructed image that is re ... We present a GPU-based implementation of the variant of one-pass list-mode OSEM. ... We performedMonte Carlo simulations to obtain simulated... more
... Our ultimate goal is to provide a continuously updated 3D reconstructed image that is re ... We present a GPU-based implementation of the variant of one-pass list-mode OSEM. ... We performedMonte Carlo simulations to obtain simulated data for the proposed PET imaging probe ...
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ABSTRACT The objective of this research is to demonstrate a modified statistical system model and an approach of accelerated Monte Carlo simulation for studying the capability of a dual-planar Compton medical imaging system constructed... more
ABSTRACT The objective of this research is to demonstrate a modified statistical system model and an approach of accelerated Monte Carlo simulation for studying the capability of a dual-planar Compton medical imaging system constructed with silicon and NaI detectors to image 364.4 keV energy photons emitted from I131. The Compton imaging system is a potential medical imaging instrument for effectively observing the process of radionuclide cancer treatments. Since decoupling the tradeoff between spatial resolution and detection efficiency inherent to the absorbing collimation of conventional Anger Camera, the Compton imaging system provides improved imaging performance in both detection efficiency and spatial resolution especially for higher energy photons. In the study, a modified statistical system model of the Compton system was developed considering all factors in the Compton process including Doppler broadening, energy resolution and spatial resolution of the scattering and absorbed detectors in addition to the Compton image formation process. To conquer the limitation of low simulation speed when employing the existent allpurpose Monte Carlo simulation platform due to low Compton interaction cross-section inside of the silicon detector, the developed Monte Carlo simulation involves the techniques of force detection and variance reduction to speed up the simulation. It is proved that two promotion approaches are of benefit to performance analysis and image reconstruction for the Compton imaging system.
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A very large scale integration (VLSI) all digital processor is proposed to recover photon energy deposited in a Nal scintillation detector on Compton based single photon emission computed tomography (C-SPECT) system for high count-rate... more
A very large scale integration (VLSI) all digital processor is proposed to recover photon energy deposited in a Nal scintillation detector on Compton based single photon emission computed tomography (C-SPECT) system for high count-rate events where multiple gamma-rays are overlapped in time. Compared with digital-analog hybrid implementation, this all digital solution offers more flexibility in accommodating different scintillators and higher
Research Interests: Vlsi Design, VLSI, Field-Programmable Gate Arrays, CAD, VERY LARGE SCALE INTEGRATED CIRCUITS, and 11 moreMedian Filter, Look up Table, Field Programmable Gate Array, Power Supply, High Resolution, Chip, Single Photon Emission Computed Tomography, Floating Point, Gamma Ray, First In First Out, and Application Specific Integrated Circuit (ASIC)
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ABSTRACT
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ABSTRACT
Page 1. Joint Maxiniurn Likelihood Estimation of Emission and Attenuation Densities in PET Neal H. Clinthorne, Jeffrey A. Fessler, Gary D. Hutchins, and W. Leslie Rogers The University of Michigan, Division of Nuclear Medicine Ann Arbor,... more
Page 1. Joint Maxiniurn Likelihood Estimation of Emission and Attenuation Densities in PET Neal H. Clinthorne, Jeffrey A. Fessler, Gary D. Hutchins, and W. Leslie Rogers The University of Michigan, Division of Nuclear Medicine Ann Arbor, MI 48109-0552. ...
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This paper presents a feasibility study of a Compton scattering enhanced (CSE) multiple pinhole imaging system for gamma rays with energy of 140keV or higher. This system consists of a multiple-pin hole collimator, a position sensitive... more
This paper presents a feasibility study of a Compton scattering enhanced (CSE) multiple pinhole imaging system for gamma rays with energy of 140keV or higher. This system consists of a multiple-pin hole collimator, a position sensitive scintillation detector as used in standard Gamma camera, and a Silicon pad detector array, inserted between the collimator and the scintillation detector. The problem
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Research Interests:
Page 1. Constrained Least-Squares vs. Maximum Likelihood Reconstructions for Poisson Data Neal H. Clinthorne Division of Nuclear Medicine The University of Michigan Ann Arbor, MI 48109-0552. Abstract Using very small ...