Behcet's Disease (BD) is a rare disease, of unknown origin that generally causes an inflammation in the subcutaneous tissue, eyes and brain vessels, and related with the immune system, predominantly seen in male patients and the mean age... more
Behcet's Disease (BD) is a rare disease, of unknown origin that generally causes an inflammation in the subcutaneous tissue, eyes and brain vessels, and related with the immune system, predominantly seen in male patients and the mean age at onset is mainly in the third decade. The aim of the study was to present our experiences with the cases of arterial pseudoaneurysms that we treated conservatively without surgical or radiological intervention. Eleven patients with Behcet's disease who developed arterial pseudoaneuryms and responsed to the medical treatment are included in the study. The operation requirement, the complication rates, and factors that influence morbidity and mortality are evaluated. The mean age of the patients was 29,5 (18-35) years. Nine of the patients were male and 2 were female. The mean period of hospitalization was 18 (11-34) days. Six patients redeveloped aneurysm during their follow-up. Three of these patients were treated with surgery. Five patients had no complication during an average of 20 months of follow-up period. Arterial pseudoaneurysm is a rare complication of Behcet's disease. Despite the good response to conservative treatment at the beginning period, the patients should be closely followed up and redevelopment of the aneurysm should be kept in mind.
Research Interests: Surgery, Adolescent, Medicine, Complication, Humans, and 12 moreFemale, Pubmed, Animals, Disease, Male, Diagnostic Imaging, Adult, Prognosis, Aneurysm, Arteries, Aneurysm False, and pseudoaneurysm
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Introduction: In the current study, we present single surgeon experience of a new radiofrequency ablation system, the catheter, and the device. Patients and Methods: The new system, which comprises a generator and an intervally... more
Introduction: In the current study, we present single surgeon experience of a new radiofrequency ablation system, the catheter, and the device. Patients and Methods: The new system, which comprises a generator and an intervally illuminated radiofrequency ablation catheter, was used for the treatment of 272 consecutive patients with chronic venous insufficiency of the great saphenous vein between November 2017 and October 2018. Mean age of the patients was 53.40 ± 11.91 years. Mean saphenous vein diameter was 8.51 ± 2.45 mm. Bilateral great saphenous vein reflux disease was present in 19% (51 cases) of the patients. At the end of the procedure, the closure of the great saphenous vein was confirmed with Doppler ultrasonography. Results: Procedures could be successfully performed in all, except 1 obese (BMI> 30 kg/m2) male patient. At the 3rd month, outpatient clinic follow-up control Doppler USG revealed successful ablation of the treated great saphenous vein in 260 patients (96%), whereas in 12 cases (4%), there was continuing reflux. The diameters of the saphenous veins in these patients ranged between 6.9 mm and 19.5 (mean: 10.68 ± 3.41) mm. Ten patients could be treated successfully with ablation with the same device controlled both at the interventional section as well as on the 3rd month outpatient clinic follow-up. The remaining patients underwent high ligation of the great saphenous vein. Paresthesia occurred in 1 patient and had been permanent. Hematoma occurred in a male patient and resolved spontaneously. Conclusion: Preliminary results of our new radiofrequency ablation device with illumination guidance for the treatment of great saphenous vein reflux disease indicated successful results with enhanced physician utilization, comfort, and reliability.
Research Interests: Surgery, Reflux, Medicine, Varicose Veins, Radiofrequency Ablation, and 3 moreAblation, Catheter, and Vein
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Aim: Venous thromboembolism (VTE) is a relatively common public health problem. In addition to increasing mortality due to complications, it also causes an increase in the cost of the country's economy and loss of labor due to the... more
Aim: Venous thromboembolism (VTE) is a relatively common public health problem. In addition to increasing mortality due to complications, it also causes an increase in the cost of the country's economy and loss of labor due to the morbidity it creates. Considering that the recurrence of VTE is a common condition, the importance of this disease for the society increases even more. Although we have come a long way in treatment and follow-up, we see that VTE and its related complications maintain their place as a significant risk factor in the society at increasing rates. Material and Methods: This is an additional analysis of a multicentral, retrospective descriptive study, CAT-TR (Assessment of Patient Characteristic in Cancer Associated Venous Thrombosis in Turkey). The aim of the CAT-TR study was to evaluate patient characteristic and treatment patterns of cancer-induced VTE in Turkey. This article aims to evaluate the incidence and prevalence of cancer-induced VTE in two regio...
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Research Interests: Medicine and Gynecology
Introduction: In the current study, we present single surgeon experience of a new radiofrequency ablation system, the catheter, and the device. Patients and Methods: The new system, which comprises a generator and an intervally... more
Introduction: In the current study, we present single surgeon experience of a new radiofrequency ablation system, the catheter, and the device. Patients and Methods: The new system, which comprises a generator and an intervally illuminated radiofrequency ablation catheter, was used for the treatment of 272 consecutive patients with chronic venous insufficiency of the great saphenous vein between November 2017 and October 2018. Mean age of the patients was 53.40 ± 11.91 years. Mean saphenous vein diameter was 8.51 ± 2.45 mm. Bilateral great saphenous vein reflux disease was present in 19% (51 cases) of the patients. At the end of the procedure, the closure of the great saphenous vein was confirmed with Doppler ultrasonography. Results: Procedures could be successfully performed in all, except 1 obese (BMI> 30 kg/m2) male patient. At the 3rd month, outpatient clinic follow-up control Doppler USG revealed successful ablation of the treated great saphenous vein in 260 patients (96%),...
Research Interests: Surgery, Reflux, Medicine, Varicose Veins, Radiofrequency Ablation, and 3 moreAblation, Catheter, and Vein
We read with interest the case report of Kitamura et al. in which authors presented consequent coronary revascularization and thoracoabdominal replacement in a patient with coronary artery disease, thoracoabdominal aneurysm, and Leriche... more
We read with interest the case report of Kitamura et al. in which authors presented consequent coronary revascularization and thoracoabdominal replacement in a patient with coronary artery disease, thoracoabdominal aneurysm, and Leriche syndrome. We believe the manuscript contains certain issues to be discussed in details. The internal thoracic arteries are among the major blood supplies to the lower extremities in case of Leriche syndrome. They may dilate to provide sufficient blood flow to the legs. The dilatation process may also be associated with increased risk of atherosclerosis and fragility. When patients with Leriche syndrome requires coronary revascularization two concerns arise:
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Introduction:In this report, we aim to present our algorithm and results of patients with congenital cardiac disorders who underwent surgical or interventional procedures during the peak phase of the pandemics in our country.Patients and... more
Introduction:In this report, we aim to present our algorithm and results of patients with congenital cardiac disorders who underwent surgical or interventional procedures during the peak phase of the pandemics in our country.Patients and methods:The first COVID-19 case was diagnosed in Turkey on 11 March, 2020, and the peak phase seemed to end by the end of April. All the patients whom were referred, treated, or previously operated but still at the hospital during the peak phase of COVID-19 pandemics in the country were included into this retrospective study. Patient’s diagnosis, interventions, adverse events, and early post-procedural courses were studied.Results:Thirty-one patients with various diagnoses of congenital cardiovascular disorders were retrospectively reviewed. Ages of the patients ranged between 2 days and 16 years. Seventeen cases were males and 14 cases were females. Elective cases were postponed. Priority was given to interventional procedures, and five cases were ...
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Treatment of the aneurysms comprising the aortic arch is challenging. Surgical reconstruction usually requires aortic cross-clamping, cardiac arrest, and even deep hypothermia for a bloodless field. In this report, we present our surgical... more
Treatment of the aneurysms comprising the aortic arch is challenging. Surgical reconstruction usually requires aortic cross-clamping, cardiac arrest, and even deep hypothermia for a bloodless field. In this report, we present our surgical technique providing normothermic ascending aorta, aortic arch, and proximal descending aorta replacement with selective cannulation and perfusion of the whole body.
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PURPOSE: Evaluate the effects of iloprost administration in the early period of ischemic colitis and the mechanism that how these effects develop. METHODS: Thirty two Wistar albino female rats with an average weight of 220g were divided... more
PURPOSE: Evaluate the effects of iloprost administration in the early period of ischemic colitis and the mechanism that how these effects develop. METHODS: Thirty two Wistar albino female rats with an average weight of 220g were divided into four groups of eight rats. In group 1 the rats were given iloprost and sacrificed after 24 hours and in group 2 they were sacrificed after 24 hours without any iloprost. The rats in group 3 were administrated iloprost and sacrificed after 72 hours and in group 4 they were sacrificed at 72th hour without iloprost. The differences between the groups as tissue damage, vascularization or apoptosis were assessed statistically. RESULTS: Oxidative damage and apoptosis were less pronounced and vascularization was better developed in rats that were given iloprost and sacrificed at 24th hour later in contrast to the rats that were not treated with iloprost. But there was no statistical difference among the groups at 72th hour. CONCLUSION: Iloprost inhibit...
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OBJECTIVES Treating aortic arch aneurysms with conventional open surgical and endovascular stent graft procedures is challenging due to the complex anatomy of the arch and the arteries arising from it that nourish the brain. Cerebral... more
OBJECTIVES Treating aortic arch aneurysms with conventional open surgical and endovascular stent graft procedures is challenging due to the complex anatomy of the arch and the arteries arising from it that nourish the brain. Cerebral protection is of the utmost importance during the treatment of thoracic aneurysms involving the aortic arch. METHODS Between May 2014 and November 2018, 7 patients with thoracic aortic aneurysms involving the aortic arch who underwent aortic arch cervical debranching with our technique were reviewed retrospectively. Because all the patients being considered for conventional surgical aortic arch replacement had serious comorbidities, they were selected to receive hybrid therapy. The mean age of the patients was 71.2 ± 9.4 years. One patient was a woman and 6 patients were men. One patient was given general anaesthesia; the remaining 6 patients had a regional block. A crossover temporary bypass was performed between the external carotid arteries with a 6-...
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... takılması nedeniyle ortaya çıkan kitle etkisine bağlı olarak safen sinir yaralanmasının potansiyel bir komplikasyon olduğu uzun süredir bilinmektedir.[3,4] Variköz ven ameliyatlarında safen veni total sıyırma işleminden sonra safen... more
... takılması nedeniyle ortaya çıkan kitle etkisine bağlı olarak safen sinir yaralanmasının potansiyel bir komplikasyon olduğu uzun süredir bilinmektedir.[3,4] Variköz ven ameliyatlarında safen veni total sıyırma işleminden sonra safen sinir hasarı %7-%40 arasında bildirilmiştir.[2-4] ...
IntroductionAlthough most ischaemic strokes are due to cardioembolism, about 25–40% of strokes are cryptogenic. Patent foramen ovale has been associated with cryptogenic stroke; however, the precise mechanism of this association has not... more
IntroductionAlthough most ischaemic strokes are due to cardioembolism, about 25–40% of strokes are cryptogenic. Patent foramen ovale has been associated with cryptogenic stroke; however, the precise mechanism of this association has not been demonstrated. The aim of this study was to evaluate the association between inflammatory markers and cryptogenic stroke in patients with patent foramen ovale.Material and methodsWe included 206 patients with patent foramen ovale. Ninety-four (45.63%) out of 206 patients had had stroke, and 112 (54.37%) had not had stroke. The ratio of the total neutrophil count to the total lymphocyte count was defined as the neutrophil to lymphocyte ratio, and the ratio of the absolute platelet count to the absolute lymphocyte count was determined as the platelet to lymphocyte count.ResultsThe neutrophil to lymphocyte ratio was significantly higher in patients who had stroke than in those who did not (2.41 ±1.69 vs. 2.19 ±1.74, p = 0.047). Although the platelet...
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IntroductionThe aim of this study was to investigate the effect of elective cardiac surgery on health-related quality of life (HRQoL).Material and methodsOne hundred and eight (35 women and 73 men, mean age 62.3 ±12.7 years) patients... more
IntroductionThe aim of this study was to investigate the effect of elective cardiac surgery on health-related quality of life (HRQoL).Material and methodsOne hundred and eight (35 women and 73 men, mean age 62.3 ±12.7 years) patients undergoing open heart surgery were enrolled in the study. Physical and mental domains of quality of life were measured using the 36-item Medical Outcomes Short-Form Health Survey (SF-36) self-administered questionnaire, and anxiety symptoms were assessed using the Spielberger State-Trait Anxiety Inventory (STAI). At baseline 108 patients filled out the SF-36 and STAI, and 102 patients at 6-month follow-up.ResultsIt was found that there was significant improvement in three out of eight health domains: physical functioning (p < 0.02), role physical (p < 0.01), and social functioning (p < 0.04), at 6-month follow-up. The two STAI sub-scores: the State Anxiety Inventory and the Trait Anxiety Inventory were found to be high (≥ 40) both preoperativel...
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Aneurysms and occlusive pathologies of the aorta are frequently associated with atherosclerosis; however, thoracoabdominal aortic aneurysm accompanied by Leriche syndrome is an extremely rare condition with challenging treatment strategy... more
Aneurysms and occlusive pathologies of the aorta are frequently associated with atherosclerosis; however, thoracoabdominal aortic aneurysm accompanied by Leriche syndrome is an extremely rare condition with challenging treatment strategy and without established surgical treatment protocols. In this report, we present our treatment strategy in a 64-year-old male patient with ischemic heart disease and type 5 thoracoabdominal aortic aneurysm accompanied by Leriche syndrome.
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OBJECTIVE We aimed to evaluate the results of the combined use of rotational atherectomy (RA) followed by drug-coated balloon (DCB) treatment against DCB angioplasty alone in patients who had significantly calcified and symptomatic... more
OBJECTIVE We aimed to evaluate the results of the combined use of rotational atherectomy (RA) followed by drug-coated balloon (DCB) treatment against DCB angioplasty alone in patients who had significantly calcified and symptomatic femoropopliteal peripheral arterial disease (PAD). MATERIALS AND METHODS Patients presented to the clinic with symptoms of chronic limb ischemia of femoropopliteal segment such as moderate or severe claudication and rest pain, who received endovascular therapy between January 2016 and January 2018 in our hospital comprised the study cohort and investigated retrospectively. Patients with minor or major tissue loss were excluded from the study. We evaluated the effect of RA system followed by DCB with DCB alone in 121 patients and a total of 226 significantly calcified and symptomatic femoropopliteal lesions. Fifty-eight patients and 112 (49.5%) lesions were treated with RA+DCB whereas 63 patients and 114 (50.5%) lesions were treated with DCB only. The mean age was 61.2 ± 9.7 years. Primary patency is evaluated with duplex ultrasound/angiography at 6, 12 and 24 months and with angiography on 12 and 24 months. Patients were followed up for 24 months to assign clinically driven target lesion revascularization (TLR). Overall survival rates were 96,5% (56/58) in RA+DCB group and 93,6% (59/63) in DCB alone group both at one year and two years follow up. Amputation free survival rates of RA+DCB and DCB only groups are 96,5% (56/58) to 87,3% (55/63) at one year, and 94,8% (55/58) to 82,5% (52/63) at two years, respectively. RESULTS Baseline characteristics of groups were similar. The lesions were longer in the RA+DCB group when compared with the DCB alone group (14.4±5.2 cm vs. 10.2±3.1 cm; p=0.05). The technical success rate in the RA+DCB group was superior to that of DCB only group (95.4% vs. 84.8%, p= 0.006). The 12-month and 24-month patency rates with angiography in the RA-DCB group were similar to those in the DCB only group (85.7% vs.74.6% and 73.2% vs. 62.7%, respectively). The rates of bail-out stenting were significantly lower among patients treated with RA+DCB (n=3; 5,1% vs. n=13; 20,6%, p<0.001). The rates of flow-limiting dissections and vessel recoils after procedures were significantly in RA+DCB group (n=2; 3,4% vs. n=8; 12,6%, p<0.001) compared to DCB only (n=1; 1,7% vs. n=4; 6,3%, p<0.002). The freedom from TLR rate was significantly increased in the RA+DCB group at 12 months (95.2% vs. 76.3%, p=0.002) and 24 months (93.4% vs. 63.7%, p=0.002). The mean ankle brachial index at discharge in the RA-DCB group improved by 0.35±0.24, and in the DCB only group it was 0.30±0.23 (p=0.683). CONCLUSION Combined use of RA and DCB treatment is an effective, safe and durable method for the treatment of the complex femoropopliteal lesions. Combination of RA and DCB angioplasty reveals increased technical success, fewer flow-limiting dissections, significantly reduced TLR and bail-out stenting rates compared with sole DCB angioplasty.
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Objective In this study, we aimed to evaluate the efficiency of rotational thrombectomy device in pharmaco-mechanical thrombolysis for symptomatic acute ilio-femoral deep vein thrombosis. Materials and methods Between August 2013 and May... more
Objective In this study, we aimed to evaluate the efficiency of rotational thrombectomy device in pharmaco-mechanical thrombolysis for symptomatic acute ilio-femoral deep vein thrombosis. Materials and methods Between August 2013 and May 2018,82 patients with acute deep vein thrombosis comprising the iliofemoral segment whom underwent Pharmaco-mechanical thrombolysis were evaluated retrospectively. The Cleaner thrombectomy device was used. The resolution of thrombi was examined and graded. Development of post-thrombotic syndrome was assessed with Villalta scores. Results 75 patients (91.4%) had complete thrombus resolution. Between 50–99% resolution was noted in 6 patients (7.4%) and in one (1.2%) case less than %50 thrombus resolution was obtained. Seventy-five patients (91%) of the cohort could be treated in a single session; 7 patients (8.6%) required reintervention(s). Although improved post-thrombotic syndrome rates were lower at the short term, Villalta scores gradually increa...
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Development anomalies of the aortic arch and its major branches are rare congenital cardiovascular disorders. In this article, we present aberrant left subclavian artery associated with right aortic arch.
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The use of extracorporeal membrane oxygenation (ECMO) in acute respiratory distress syndrome (ARDS) and cardio-circulatory shock has been widely accepted. In recent years, a variety of novel and exceptional indications for ECMO have been... more
The use of extracorporeal membrane oxygenation (ECMO) in acute respiratory distress syndrome (ARDS) and cardio-circulatory shock has been widely accepted. In recent years, a variety of novel and exceptional indications for ECMO have been proposed; however, experience with ECMO use in the presence of multiple penetrating injuries is limited. In this report, we present successful ECMO application in a patient with multiple firearm injuries. Veno-venous ECMO was applied for ARDS and converted to the venoarterial mode when the patient developed septic cardiomyopathy. The clinical status of the patient gradually improved, and the patient was discharged from the hospital after 24 days, successfully.
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Carotid artery kinking is a frequent finding in duplex ultrasonography. However, isolated morphological changes without significant carotid stenosis is rarely symptomatic. Neck pain is a rare symptom in patients with carotid artery kinks.... more
Carotid artery kinking is a frequent finding in duplex ultrasonography. However, isolated morphological changes without significant carotid stenosis is rarely symptomatic. Neck pain is a rare symptom in patients with carotid artery kinks. The vascular etiology in patients with persistent neck pain is usually overlooked. A fifty-eight-year-old female patient with chronic neck pain presented to our clinic. Following multidisciplinary team review, the symptoms were found due to the kinking of the internal carotid artery. In this report, we present the clinical presentation of the patient with the kinking of the internal carotid artery without stenosis, surgical management of the pathology and a brief literature review.
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IntroductionHeart-type fatty acid-binding protein (H-FABP) is a novel indicator of myocardial damage. The aim of the study was to compare the levels of H-FABP in off-pump and on-pump coronary artery bypass grafting (CABG).Material and... more
IntroductionHeart-type fatty acid-binding protein (H-FABP) is a novel indicator of myocardial damage. The aim of the study was to compare the levels of H-FABP in off-pump and on-pump coronary artery bypass grafting (CABG).Material and methodsThirty non-randomised 30 patients who underwent CABG between January 2009 and January 2010 were enrolled in the study. Patients were divided into two equal size (n = 15) groups as group A (off-pump CABG group) and group B (on-pump CABG group). Three arterial blood samples were obtained for H-FABP after sternotomy (H-FABP 1), after the last distal anastomosis in group A and immediately after the cross clamp was removed from the aorta in group B (H-FABP 2) and 24 h after the operation (H-FABP 3). Renal and liver functions and circulating fatty acid binding protein (FABP) levels were also assessed in blood samples obtained 24 h before and 1 h after the operation.ResultsAt all three assessment points patients in group B had significantly higher H-FA...
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To determine whether glutamat and aspartat enriched cold crystalloid cardioplegia which was given in antegrade way has any effect on the myocardial protection during cardiopulmonary bypass. Thirty-four patients who were electively... more
To determine whether glutamat and aspartat enriched cold crystalloid cardioplegia which was given in antegrade way has any effect on the myocardial protection during cardiopulmonary bypass. Thirty-four patients who were electively undergone open heart surgery at Osmangazi University Faculty of Medicine, thoracic and cardiovascular surgery department, between March 2001 and May 2001 were included in this study. The patients were divided in two groups, each consisting of 17 patients. In group 1 coronary artery bypass surgery (CABG) was performed in 11 patients, mitral valve replacement (MVR) in 3 patients, aortic valve replacement (AVR) in 1 patient and AVR and MVR in 2 patients. While in group 2 CABG was performed in 13 patients and MVR was done in 4 patients. Group 1 patients received antegrade glutamat and aspartat (15 mmol/L) enriched cold crystalloid cardioplegia and group 2 patients were given cold crystalloid cardioplegia by antegrade route. Age, gender, diabetes mellitus, hype...
Research Interests: Cardiology, Diabetes mellitus, Blood sampling, Article, Creatine Kinase, and 15 moreClinical Sciences, Cardioplegia, Cigarette Smoking, Drug effect, Cardiovascular Diseases, Chi Square Test, Bicarbonate, Coronary artery bypass surgery, Citric Acid, Clinical Article, Defibrillation, Cardiopulmonary bypass, Aortic Valve Replacement, aspartate, and Coronary Artery Bypass
Research Interests: Cardiology, Medicine, Humans, Internal Medicine, Female, and 15 moreMale, Clinical Sciences, Middle Aged, C reactive protein, Endothelial Function, Adult, Biological markers, Internal medicine Doppler ultrasonography, Lower Extremity, Interleukin, Brachial artery, Arterial Occlusive Diseases, Ankle brachial index, leukocyte Count, and Inflammation Mediators
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ABSTRACT Rationnelle La fonction endothéliale est mesurée au mieux par la méthode non invasive de dilatation médiée par le flux (DMF) de l&#39;artère brachiale. Les maladies artérielles périphériques et les maladies cardio-vasculaires... more
ABSTRACT Rationnelle La fonction endothéliale est mesurée au mieux par la méthode non invasive de dilatation médiée par le flux (DMF) de l&#39;artère brachiale. Les maladies artérielles périphériques et les maladies cardio-vasculaires systémiques ont un effet de réduction de la DMF. Les effets de l&#39;ischémie de membre inférieur sont associés à l&#39;inflammation du muscle et à la claudication, qui peuvent mener à un stress artériel. Le but de cette étude était d&#39;étudier les effets de la revascularisation artérielle périphérique sur les fonctions endothéliales par la méthode non invasive de la DMF de l&#39;artère brachiale. Méthodes Entre janvier 2007 et février 2008, 54 patients avec diagnostic de maladie artérielle des membres inférieurs revascularisée ont été inclus dans l&#39;étude. La fonction endothéliale est mesurée en préopératoire et à la quatrième semaine postopératoire par la méthode de la DMF de l&#39;artère brachiale. Des prises de sang ont été réalisées aux mêmes intervalles pour la mesure de l&#39;interleukin-6, de la numération des leucocytes, du facteur-alpha de nécrose tumorale, et de la teneur en oxyde nitrique. Résultats Un pontage fémoro-poplité a été réalisé chez tous les patients avec un greffon synthétique. L&#39;index bras-cheville moyen dans la période préopératoire était de 0,29 ± 0,083, et après l&#39;opération, les artères pédieuses et/ou tibiales postérieures sont devenues palpables chez tous les patients. L&#39;oxyde nitrique, l&#39;interleukin-6, la protéine C-réactive de haut-sensibilité, et les niveaux de facteur-alpha de nécrose tumorale ont diminué de manière significative à 4 semaines postopératoire par rapport aux niveaux préopératoires (p &lt; 0,05). La DMF de l&#39;artère brachiale postopératoire par écho-doppler a augmenté de la valeur 9,2 ± 2,1 en préopératoire à 16,2 ± 4,5 (p &lt; 0,01) à la 4ième semaine postopératoire. Conclusions L&#39;inflammation systémique et l&#39;ischémie musculaire mènent à une réduction des fonctions endothéliales. Après la revascularisation réussie de membre inférieur, les fonctions endothéliales s&#39;améliorent spectaculairement, et peuvent être facilement détectées avec la méthode non invasive de DMF de l&#39;artère brachiale.
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Research Interests: Cardiology, Electron Microscopy, Scanning Electron Microscopy, Transmission Electron Microscopy, Medicine, and 15 moreHumans, Internal Medicine, Blood Glucose, Diabetes mellitus, Female, Male, Vascular endothelium, Glycemic Index, Artery, Clinical Sciences, Aged, Middle Aged, ENDOTHELIUM, Cardiovascular medicine and haematology, and Coronary Artery Bypass
Background: It is widely believed that venous ulcers result from venous insufficiency related to venous valve damages. To further investigate the pathogenesis of venous ulcers, we compared the influence of oxidative stress in venous... more
Background: It is widely believed that venous ulcers result from venous insufficiency related to venous valve damages. To further investigate the pathogenesis of venous ulcers, we compared the influence of oxidative stress in venous valvular tissue on stasis ulcer formation in patients with venous ulcers secondary to superficial venous reflux disease. Methods: Thirty-nine consecutive patients with superficial venous reflux who underwent saphenectomy were included in the study. Patients were divided into 2 groups: with healed venous ulcers (group 1, n = 15) and without ulcers (group 2, n = 24). All patients were preoperatively evaluated with duplex ultrasound scanning and their blood samples were obtained to examine leukocyte count, interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and C-reactive protein (CRP) levels. All patients underwent standard above-knee saphenectomy. Extracted saphenous vein segments were from the saphenofemoral junction, the first valve along. The bioche...