Purpose: The present study was aimed at preparing stable dry adsorbed nanoparticles (DANs) of curcumin (CUR) and piperine (PIP) loaded nanostructured lipid carriers (NLCs). Methods: CUR and PIP-loaded NLCs (CP NLCs) were prepared by... more
Purpose: The present study was aimed at preparing stable dry adsorbed nanoparticles (DANs) of curcumin (CUR) and piperine (PIP) loaded nanostructured lipid carriers (NLCs). Methods: CUR and PIP-loaded NLCs (CP NLCs) were prepared by modified hot-melt emulsification using precirol ATO5 (PRE) as solid lipid, labrafac lipophile WL1349 (LAF) as liquid lipid, and a combination of tween 80 (T80) with gelucire 50/13 (G50/13) as surfactants. The NLCs system was subjected to physical stability, particle size, zeta potential, thermal behaviour, crystallinity study and in-vitro drug release. Further, an evaporative drying technique converted the NLC system into stable DANs by adsorbing onto mannitol (Pearlitol 200SD). The DANs were characterized for redispersion properties, particle size, flow properties and in-vitro drug release. The stability studies were carried out for 30 days. Results: The optimized CP NLCs were of imperfect type and had a mean particle size of 248.5 ± 12.8 nm (size dis...
Skin aging is influenced by many factors including ultraviolet radiation, excess alcohol consumption, tobacco abuse, and environmental pollution. Age-related skin changes are the result of genetically programmed changes (intrinsic... more
Skin aging is influenced by many factors including ultraviolet radiation, excess alcohol consumption, tobacco abuse, and environmental pollution. Age-related skin changes are the result of genetically programmed changes (intrinsic factors) and environmental wear-and-tear on the skin (extrinsic factors). This article also provides information about wrinkles development and the approaches to stimulate collagen formation. This article provides overview on different anti-aging technologies like Intense Pulsed Light System, Liposomal Encapsulation Technology, Nanosomes, Intelligent Nanoparticles Drop Anti-aging Cargo, etc. This article also provides overview on different ant aging products of Salvona and Olay.
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Research Interests: Chemistry, Pharmacy, Chromatography, Drug development, Dosage Form, and 15 moreCurcumin, High Performance Liquid Chromatography, Hydrochlorothiazide, Haloperidol, CHEMICAL SCIENCES, Pharmaceutical Analytical Chemistry, Particle Size, Correlation coefficient, Capsule, Amlodipine, Pharmacy and Pharmaceutical Sciences, Piperine, Olmesartan, Alfuzosin, and Losartan Potassium
Labetalol hydrochloride (LBT), 2-hydroxy-5-[1-hydroxy-2-[(1-methyl-3-phenylpropyl) amino] ethyl]-benzamide, a non-selective alpha, beta-adrenoceptor antagonist is used in the treatment of hypertension. It shows variable bioavailability... more
Labetalol hydrochloride (LBT), 2-hydroxy-5-[1-hydroxy-2-[(1-methyl-3-phenylpropyl) amino] ethyl]-benzamide, a non-selective alpha, beta-adrenoceptor antagonist is used in the treatment of hypertension. It shows variable bioavailability ranging from 10-80% which may be attributed to its minimum solubility in pH range 6 to 10, the pH conditions prevailing at the major site of absorption i.e. small intestine. Also due to its half life of 3 to 6 hrs it is administered twice daily. In the present work non-effervescent sustained release gastroretentive floating tablets of labetalol hydrochloride have been developed using various grades of HPMC and Poloxamer M127 as wetting agent. The tablets were evaluated for in vitro drug release, floating time, floating lag time, swelling studies etc. The tablets formulated with HPMC K4M CR and HPMC K15M CR along with Poloxamer showed negligible floating lag time with a total floating time over 12 hrs with complete release. Formulation was optimized using Stat-Ease Design Expert 7.1 software. Optimized batch was evaluated for the effect of change of osmolarity and pH on drug release, floating and swelling behaviour.
Research Interests: Pharmacology, Chemistry, Water, Chromatography, Kinetics, and 15 morePharmaceutical Chemistry, Medicine, Swelling, Bioavailability, Solubility, Tablets, Drug Compounding, Delayed-Action Preparations, Hydrogen-Ion Concentration, Drug Release, Small Intestine, Poloxamer, Methylcellulose, Antihypertensive agents, and Pharmacology and pharmaceutical sciences
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... Ren et al. have filed a patent for the V. Mohit Á G. Harshal Á D. Neha Á K. Vilasrao Á H. Rajashree (&) Department of Pharmaceutics, Bharati Vidyapeeth's College of Pharmacy, CBD Belapur, Sector-8, Navi Mumbai 400614,... more
... Ren et al. have filed a patent for the V. Mohit Á G. Harshal Á D. Neha Á K. Vilasrao Á H. Rajashree (&) Department of Pharmaceutics, Bharati Vidyapeeth's College of Pharmacy, CBD Belapur, Sector-8, Navi Mumbai 400614, India e-mail: rshirlekar@rediffmail.com 123 ...
Research Interests: Chemistry, Inclusion, Scanning Electron Microscopy, Comparative Study, Nuclear Chemistry, and 10 moreDifferential scanning calorimetry, Cyclodextrin, Dissolution, Solubility, CHEMICAL SCIENCES, Scanning Electron Microscope, Fourier transform infrared spectroscopy, Microwave Irradiation, Spray Drying, and Cefdinir
Carvedilol is an antihypertensive drug used in the treatment of congestive heart failure, cardiac arrhythmias and angina pectoris. It exhibits poor bioavailability of 25-30% which is attributed to its poor solubility and high first pass... more
Carvedilol is an antihypertensive drug used in the treatment of congestive heart failure, cardiac arrhythmias and angina pectoris. It exhibits poor bioavailability of 25-30% which is attributed to its poor solubility and high first pass metabolism. The present work was aimed at overcoming these two limitations. Drug-Methyl-β-cyclodextrin complex was prepared by kneading method and characterized by Fourier Transformation Infrared spectroscopy, Differential Scanning Calorimetry and powder X-Ray Diffractometry studies. Dissolution rate of complex was compared with plain drug and physical mixture. The complex was incorporated into buccal tablet. The buccal tablets were evaluated for drug release, mucoadhesive strength and ex-vivo permeability. Characterization of binary system revealed the formation of inclusion complex of drug with Methyl-β-cyclodextrin. The complex showed complete release as compared to 32.8% and 42.7% from plain drug and physical mixture respectively in 60min. Tablets containing complex showed complete release at the end of 180min compared to 40.23% from tablets containing plain drug. The buccal tablets containing complex had good mucoadhesive strength. The amount of drug permeated from these tablets across the porcine buccal mucosa at the end of 5h was 6.2mg as compared to 2.51mg from tablets containing plain drug. Thus it can be concluded that buccal tablet containing complexed CAR would have improvement in bioavailability.
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Even though oral route is the most preferred one, certain conditions necessitate the use of parenteral dosage form. But this route being invasive, is considered as non-patient compliant. Thus, there came a need for a more patient... more
Even though oral route is the most preferred one, certain conditions necessitate the use of parenteral dosage form. But this route being invasive, is considered as non-patient compliant. Thus, there came a need for a more patient compliant system which led to the development of needleless injection technology. This review intends to throw light on the basic mechanisms by which this technology works, its applications and thereby also discusses the scope it has for the delivery of many new upcoming drugs.
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ABSTRACT Atherosclerosis is the primary cause of coronary heart disease, which is characterized by a narrowing (stenosis) of the arteries that supply blood to tissues of the heart. Over the past decade, the use of "Bare... more
ABSTRACT Atherosclerosis is the primary cause of coronary heart disease, which is characterized by a narrowing (stenosis) of the arteries that supply blood to tissues of the heart. Over the past decade, the use of "Bare metallic stents" during Percutaneous Transluminal Coronary Angioplasty (PTCA) has become a common practice for treating the coronary arterial stenosis. However, the restenosis is common problem in patients receiving stents. Recently, Drug-Eluting Stents (DES) with synthetic polymer coatings which act as drug reservoirs and elute drugs over a period of several weeks or months have emerged to tackle restenosis. The polymer coatings on these stents contain various drugs like immunosuppressive drugs, anti-neoplastic drugs, anti-inflammatory drugs, migration inhibitor drugs and enhanced healing drugs that inhibit thrombus formation, inflammation or cellular proliferation which in turn prevent restenosis. Different methods like dip coating, dip spin coating, ultrasonic spray coating and ink-jet coating help to coat stent uniformly. Drug from the stent can be released by diffusion, dissolution or ion exchange mechanism. There are some disadvantages of the polymer coated stents and hence they are being superseded by completely bioabsorbable stents. Such stents are heading for clinical trials and may hit the market soon. This review gives a glimpse over DES and the future prospects of DES.
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In this work, we illustrate the usefulness of cyclodextrins, namely, methyl-β-cyclodextrin (MβCD), an amorphous, methylated derivative of the natural β-cyclodextrin, as a tool to form an inclusion complex with Valsartan (VAL), a poorly... more
In this work, we illustrate the usefulness of cyclodextrins, namely, methyl-β-cyclodextrin (MβCD), an amorphous, methylated derivative of the natural β-cyclodextrin, as a tool to form an inclusion complex with Valsartan (VAL), a poorly water soluble drug. The phase solubility study showed AL type of curve with slope less than one indicating the formation of complexes in 1:1 molar ratio of
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Abstract The aim of this study was to investigate the effect of hydroxypropyl-b-cyclodextrin (HPbCD) on the solubility and dissolution rate of Cefdinir (CEF). The methods that were employed to prepare CEFHPbCD complexes were Kneading... more
Abstract The aim of this study was to investigate the effect of hydroxypropyl-b-cyclodextrin (HPbCD) on the solubility and dissolution rate of Cefdinir (CEF). The methods that were employed to prepare CEFHPbCD complexes were Kneading (KN), Co-evaporation (CE), Spray ...
Research Interests: Chemistry, Inclusion, Scanning Electron Microscopy, Comparative Study, Nuclear Chemistry, and 11 moreDifferential scanning calorimetry, Cyclodextrin, Dissolution, Solubility, CHEMICAL SCIENCES, X ray diffraction, Fourier transform infrared spectroscopy, Microwave Irradiation, Spray Drying, Nuclear Magnetic Resonance Spectroscopy, and Cefdinir
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Objective: The present study was aimed at preparing stable lyophilized curcumin loaded nanostructured lipid carriers (NLCs). The optimized lyophilized curcumin loaded NLCs were characterized and evaluated for various quality control... more
Objective: The present study was aimed at preparing stable lyophilized curcumin loaded nanostructured lipid carriers (NLCs). The optimized lyophilized curcumin loaded NLCs were characterized and evaluated for various quality control parameters. Methods: The optimized curcumin loaded NLCs were prepared by modified hot emulsification using precirol ATO 5 (PRE), capmul MCM C8 EP (CAP) as solid and liquid lipids, respectively. The combination of tween 80 (T80) and solutol HS 15 (SHS) were used as an emulsifier. The NLCs dispersion was lyophilized into powder form to improve the thermodynamic stability of the formulation. The lyophilized curcumin loaded NLCs were evaluated for particle size, size distribution, zeta potential, entrapment efficiency (EE), drug loading, assay, in vitro drug release, crystallinity and surface morphology studies. Results: The optimized lyophilized curcumin loaded NLCs have a mean particle size of 286.2±11.5 nm with a size distribution of 0.288±0.011, a zeta p...
Research Interests: Chemistry, Chromatography, Nanotechnology, Pharmaceutics, Lung Cancer, and 13 moreNovel drug delivery systems, Curcumin, Physical sciences, Anticancer Drugs, Crystallinity, Non small cell carcinoma, CHEMICAL SCIENCES, Particle Size, Novels biomaterials for treatment of mainly Breast and Lung cancer cells, Zeta Potential, Nanostructured Lipid Carriers, Dispersion stability, and Medical and Health Sciences
Polymers are an important formulation consideration for Gastroretentive Drug Delivery System (GRDDS) as the polymers play an important role in allowing the dosage form to remain in gastrointestinal tract for a longer time thus enabling... more
Polymers are an important formulation consideration for Gastroretentive Drug Delivery System (GRDDS) as the polymers play an important role in allowing the dosage form to remain in gastrointestinal tract for a longer time thus enabling the required quantity of drug to be released and absorbed into the body. The objective of this study was to compare swelling, water uptake [1] and water holding capacity of commonly used grades of Hypromellose (Hydroxypropylmethyl cellulose) for their potential application as polymer for GRDDS. The study found that K100M grade of Hypromellose provided the best results which could facilitate its use as polymer in GRDDS.
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Even though oral route is the most preferred one, certain conditions necessitate the use of parenteral dosage form. But this route being invasive, is considered as non-patient compliant. Thus, there came a need for a more patient... more
Even though oral route is the most preferred one, certain conditions necessitate the use of parenteral dosage form. But this route being invasive, is considered as non-patient compliant. Thus, there came a need for a more patient compliant system which led to the development of needleless injection technology. This review intends to throw light on the basic mechanisms by which this technology works, its applications and thereby also discusses the scope it has for the delivery of many new
Skin aging is influenced by many factors including ultraviolet radiation, excess alcohol consumption, tobacco abuse, and environmental pollution. Age-related skin changes are the result of genetically programmed changes (intrinsic... more
Skin aging is influenced by many factors including ultraviolet radiation, excess alcohol consumption, tobacco abuse, and environmental pollution. Age-related skin changes are the result of genetically programmed changes (intrinsic factors) and environmental wear-and-tear on the skin (extrinsic factors). This article also provides information about wrinkles development and the approaches to stimulate collagen formation. This article provides overview on different anti-aging technologies like Intense Pulsed Light System, Liposomal Encapsulation Technology, Nanosomes, Intelligent Nanoparticles Drop Anti-aging Cargo, etc. This article also provides overview on different ant aging products of Salvona and Olay.
Objective: The aim of this study was to develop the diallyl disulphide (DADS) liposomal dispersion and further the dispersion was to formulate into gel. Methods: The DADS liposomal system was developed using thin film hydration method. 32... more
Objective: The aim of this study was to develop the diallyl disulphide (DADS) liposomal dispersion and further the dispersion was to formulate into gel. Methods: The DADS liposomal system was developed using thin film hydration method. 32 factorial design was employed to study the effect of various factors to obtain the optimized liposomal system. Further, it was converted to gel using suitable gelling agent. The optimized liposomal system and gel formulations were evaluated for various parameters. The optimized gel was evaluated for its in-vitro antifungal efficacy. The stability studies for gel were carried as per International conference on harmonisation (ICH) guidelines. Results: The optimized liposomal system was having vesicle size of 208.6nm, % entrapment was 91.7±1.16% and loading was 11.12±0.23%. % drug permeation was 61.10±0.85%. The zeta potential showed moderate stability. The optimized DADS liposomal gel showed satisfactory results. Ex-vivo permeation studies showed tha...
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Research Interests:
Labetalol hydrochloride (LBT), 2-hydroxy-5-[1-hydroxy-2-[(1-methyl-3-phenylpropyl) amino] ethyl]-benzamide, a non-selective alpha, beta-adrenoceptor antagonist is used in the treatment of hypertension. It shows variable bioavailability... more
Labetalol hydrochloride (LBT), 2-hydroxy-5-[1-hydroxy-2-[(1-methyl-3-phenylpropyl) amino] ethyl]-benzamide, a non-selective alpha, beta-adrenoceptor antagonist is used in the treatment of hypertension. It shows variable bioavailability ranging from 10-80% which may be attributed to its minimum solubility in pH range 6 to 10, the pH conditions prevailing at the major site of absorption i.e. small intestine. Also due to its half life of 3 to 6 hrs it is administered twice daily. In the present work non-effervescent sustained release gastroretentive floating tablets of labetalol hydrochloride have been developed using various grades of HPMC and Poloxamer M127 as wetting agent. The tablets were evaluated for in vitro drug release, floating time, floating lag time, swelling studies etc. The tablets formulated with HPMC K4M CR and HPMC K15M CR along with Poloxamer showed negligible floating lag time with a total floating time over 12 hrs with complete release. Formulation was optimized using Stat-Ease Design Expert 7.1 software. Optimized batch was evaluated for the effect of change of osmolarity and pH on drug release, floating and swelling behaviour.
Research Interests: Pharmacology, Chemistry, Water, Chromatography, Kinetics, and 15 morePharmaceutical Chemistry, Swelling, Bioavailability, Solubility, Pharmaceutical Formulation Technology, Tablets, Drug Compounding, Delayed-Action Preparations, Hydrogen-Ion Concentration, Drug Release, Small Intestine, Poloxamer, Methylcellulose, Antihypertensive agents, and Pharmacology and pharmaceutical sciences
Objective: The present study was aimed to develop a simple, sensitive and precise high performance liquid chromatographic (HPLC) method for the simultaneous estimation of curcumin and piperine and to implement the developed method for the... more
Objective: The present study was aimed to develop a simple, sensitive and precise high performance liquid chromatographic (HPLC) method for the simultaneous estimation of curcumin and piperine and to implement the developed method for the estimation of curcumin and piperine in the nanoparticulate formulation.Methods: Method development was performed using various solvent, buffer-solvent ratios, at different flow rates for adequate separation of both drugs. The developed method was validated in accordance with the international conference on harmonization (ICH) guidelines. The developed method was implemented to estimate the amount of curcumin and piperine in the nanoparticulate formulation.Results: Chromatographical conditions were optimized, and the best chromatographical conditions with adequate resolution for curcumin and piperine was achieved using enable C18G reverse phase column, using a mobile phase combination of acetonitrile and phosphate buffer (pH 3)in a ratio of 70:30 v/...
Research Interests: Chemistry, Pharmacy, Chromatography, Drug development, Dosage Form, and 15 moreCurcumin, Hydrochlorothiazide, Haloperidol, CHEMICAL SCIENCES, Pharmaceutical Analytical Chemistry, Particle Size, Reproducibility, Correlation coefficient, Capsule, Amlodipine, Pharmacy and Pharmaceutical Sciences, Piperine, Olmesartan, Alfuzosin, and Losartan Potassium
In the present work effect of methyl-I²-cyclodextrin (MI²CD) on physical properties and dissolution rate of Irbesartan (IRB) was studied.Based on AL-type ofphase solubility diagram obtained, solid binary systems of the drug with MI²CD... more
In the present work effect of methyl-I²-cyclodextrin (MI²CD) on physical properties and dissolution rate of Irbesartan (IRB) was studied.Based on AL-type ofphase solubility diagram obtained, solid binary systems of the drug with MI²CD were prepared in 1:1 molar ratio by various methods. Complexes were characterized using Differential Scanning Calorimetry and powder X-Ray Diffractometry. It could be concluded that IRB can form inclusion complex with MI²CD. The dissolution profiles of inclusion complexes were compared with those of IRB alone and the physical mixture. The dissolution rate of IRB was increased remarkably by MI²CD inclusion complexation.
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Carvedilol is an antihypertensive drug used in the treatment of congestive heart failure, cardiac arrhythmias and angina pectoris. It exhibits poor bioavailability of 25-30% which is attributed to its poor solubility and high first pass... more
Carvedilol is an antihypertensive drug used in the treatment of congestive heart failure, cardiac arrhythmias and angina pectoris. It exhibits poor bioavailability of 25-30% which is attributed to its poor solubility and high first pass metabolism. The present work was aimed at overcoming these two limitations. Drug-Methyl-β-cyclodextrin complex was prepared by kneading method and characterized by Fourier Transformation Infrared spectroscopy, Differential Scanning Calorimetry and powder X-Ray Diffractometry studies. Dissolution rate of complex was compared with plain drug and physical mixture. The complex was incorporated into buccal tablet. The buccal tablets were evaluated for drug release, mucoadhesive strength and ex-vivo permeability. Characterization of binary system revealed the formation of inclusion complex of drug with Methyl-β-cyclodextrin. The complex showed complete release as compared to 32.8% and 42.7% from plain drug and physical mixture respectively in 60min. Tablet...
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Even though oral route is the most preferred one, certain conditions necessitate the use of parenteral dosage form. But this route being invasive, is considered as non-patient compliant. Thus, there came a need for a more patient... more
Even though oral route is the most preferred one, certain conditions necessitate the use of parenteral dosage form. But this route being invasive, is considered as non-patient compliant. Thus, there came a need for a more patient compliant system which led to the development of needleless injection technology. This review intends to throw light on the basic mechanisms by which this technology works, its applications and thereby also discusses the scope it has for the delivery of many new upcoming drugs.
The present study was aimed at preparing stable dry adsorbed nanoparticles (DANs) of silymarin loaded nanostructured lipid carriers (NLCs). The prepared silymarin loaded NLCs and DANs were characterized for various quality parameters.... more
The present study was aimed at preparing stable dry adsorbed nanoparticles (DANs) of silymarin loaded nanostructured lipid carriers (NLCs). The prepared silymarin loaded NLCs and DANs were characterized for various quality parameters. Silymarin loaded NLCs were prepared by a modified hot melt emulsification ultra-sonication method using glyceryl monostearate (GMS), capmul MCM C8 EP (CAP) and gelucire 50/13 (G50/13) as solid lipid, liquid lipid and surfactant respectively. For better stability, NLC dispersion was converted into DANs by adsorbing them onto some suitable carriers. NLCs and DANs were characterized for particle size, polydispersity index, zeta potential, entrapment efficiency, drug loading, assay, thermal behavior, crystallinity and morphological study. The optimized NLCs have a mean particle size of 206.1±012.5 nm (size distribution of 0.249±0.058), a zeta potential of -32.5±1.2 mV with high entrapment of 95.60±0.45% and drug loading of 1.90±0.08%. The X-ray diffraction...
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Research Interests:
Vaccines represent a useful contribution to the field of biotechnology as they supply protection against various diseases. But, the major obstacle to oral vaccination is the digestion of macromolecule antigenic protein within the stomach... more
Vaccines represent a useful contribution to the field of biotechnology as they supply protection against various diseases. But, the major obstacle to oral vaccination is the digestion of macromolecule antigenic protein within the stomach due to extremely acidic pH. To address this issue, scientist Arntzen introduced the concept of edible vaccines. Edible vaccines are prepared by using the science of genetic engineering in which the selected genes are introduced into the plants by means of various methods. The transgenic plant is then induced to manufacture the encoded protein which acts as a vaccine. Owing to its low cost, it will be affordable for developing countries like India. Edible vaccines are used to treat various diseases like malaria, measles, hepatitis B, stopping autoimmunity in type-1 diabetes, cholera, enterotoxicogenic E.coli (ETEC), HIV and anthrax. This review comprises mechanism of action, methods of development, candidate plants, applications, clinical trials and ...
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Aim of the present work was to investigate the effect of methyl-β-cyclodextrin (MβCD) on the solubility and dissolution rate of carvedilol (CAR), a drug used orally for the treatment of hypertension. Phase solubility studies showed an... more
Aim of the present work was to investigate the effect of methyl-β-cyclodextrin (MβCD) on the solubility and dissolution rate of carvedilol (CAR), a drug used orally for the treatment of hypertension. Phase solubility studies showed an AL-type diagram indicating the formation of inclusion complex in 1:1 molar ratio. Solid binary systems of the drug with MβCD were prepared by various methods. Physicochemical characterizations were performed using Fourier Transformation Infrared Spectroscopy, Differential Scanning Calorimetry and powder X-Ray Diffractometry. It could be concluded that CAR can form inclusion complex with MβCD. The dissolution profiles of inclusion complexes were determined and compared with those of CAR alone and the physical mixture. The dissolution rate of CAR was increased by MβCD inclusion complexation remarkably.
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Aims: The present study was aimed at preparing stable lyophilized curcumin loaded nanostructured lipid carriers (NLCs). The optimized lyophilized curcumin loaded NLCs were characterized and evaluated for various quality control... more
Aims: The present study was aimed at preparing stable lyophilized curcumin loaded nanostructured lipid carriers (NLCs). The optimized lyophilized curcumin loaded NLCs were characterized and evaluated for various quality control parameters. Methodology: The optimized curcumin loaded NLCs were prepared by modified hot emulsification using compritol 888 ATO (CMPR), capmul MCM C8 EP (CAP) as solid and liquid lipids respectively. The combination of tween 80 (T80) and solutol HS 15 (SHS) were used as an emulsifier. The NLCs dispersion was lyophilized into powder form to improve the thermodynamic stability of the formulation. The lyophilized curcumin loaded NLCs were evaluated for particle size, size distribution, zeta potential, entrapment efficiency (EE), drug loading, assay, in-vitro drug release, crystallinity, thermal behavior and surface morphology studies. Results: The optimized lyophilized curcumin loaded NLCs have a mean particle size of 332.88 ± 5.9 nm with a size distribution of...
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Carbon nanotubes (CNTs) are allotropes of carbon with a nanostructure that can have a length-to-diameter ratio greater than 1,000,000. These cylindrical carbon molecules have novel properties that make them potentially useful in many... more
Carbon nanotubes (CNTs) are allotropes of carbon with a nanostructure that can have a length-to-diameter ratio greater than 1,000,000. These cylindrical carbon molecules have novel properties that make them potentially useful in many applications in nanotechnology. Their unique surface area, stiffness, strength and resilience have led to much excitement in the field of pharmacy. Nanotubes are categorized as single-walled nanotubes and multiple walled nanotubes. Techniques have been developed to produce nanotubes in sizeable quantities, including arc discharge, laser ablation, chemical vapor deposition , silane solution method and flame synthesis method. The properties and characteristics of CNTs are still being researched heavily and scientists have barely begun to tap the potential of these structures. They can pass through membranes, carrying therapeutic drugs, vaccines and nucleic acids deep into the cell to targets previously unreachable. Overall, recent studies regarding CNTs h...
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Medicated chewing gums are one of the very compliant dosage forms. These drug delivery systems have gained a wide range of acceptability over past few decades owing to its ease of administration and local effects. No intake of water is... more
Medicated chewing gums are one of the very compliant dosage forms. These drug delivery systems have gained a wide range of acceptability over past few decades owing to its ease of administration and local effects. No intake of water is required for these delivery systems and comparatively less gastro-intestinal irritation occurs. Moreover, these dosage forms are excellent drug delivery systems when it comes to freshening of breaths and cleansing of teeth. Advances have been seen in these formulations over past few decades, due to consumer satisfaction and increasing demands by mass population. Different technologies have been used to manufacture and evaluate these drug delivery systems.
Diabetes is a disorder related to the deficiency in the secretion or action of insulin - a peptide hormone synthesized by the β cells of islets of pancreas. Insulin is given by the subcutaneous (SC) route. Patient non-compliance is... more
Diabetes is a disorder related to the deficiency in the secretion or action of insulin - a peptide hormone synthesized by the β cells of islets of pancreas. Insulin is given by the subcutaneous (SC) route. Patient non-compliance is frequent with the SC route. To remove the hurdle related to oral insulin delivery various efforts have been made. Thus, oral insulin is a dream of patients. Nanotechnology is an emerging era of science which provides an innovative means to detect, diagnose and to treat a disorder. Nanocarriers have been garnering more attention recently because of their size in nano range and greater surface area. These characteristics improve their absorption in contrast to bigger carriers. This article gives an insight into different novel approaches to get better oral insulin delivery. These novel formulations improve bioavailability; absorption problems associated with insulin and give protection from enzymatic degradation. More research has been done on nanoparticles...
Skin aging is influenced by many factors including ultraviolet radiation, excess alcohol consumption, tobacco abuse, and environmental pollution. Age-related skin changes are the result of genetically programmed changes (intrinsic... more
Skin aging is influenced by many factors including ultraviolet radiation, excess alcohol consumption, tobacco abuse, and environmental pollution. Age-related skin changes are the result of genetically programmed changes (intrinsic factors) and environmental wear-and-tear on the skin (extrinsic factors). This article also provides information about wrinkles development and the approaches to stimulate collagen formation. This article provides overview on different anti-aging technologies like Intense Pulsed Light System, Liposomal Encapsulation Technology, Nanosomes, Intelligent Nanoparticles Drop Anti-aging Cargo, etc. This article also provides overview on different ant aging products of Salvona and Olay.
The purpose of the present study was to develop a buccoadhesive drug delivery system of Metoprolol Tartrate (MT) using combination of natural polymers in order to overcome its first pass metabolism which may improve its bioavailability.... more
The purpose of the present study was to develop a buccoadhesive drug delivery system of Metoprolol Tartrate (MT) using combination of natural polymers in order to overcome its first pass metabolism which may improve its bioavailability. MT is mainly used in cardiovascular disorders and is well absorbed in gastrointestinal tract. However, its extensive first pass metabolism results in poor bioavailability. The tablets of MT were prepared by using semisynthetic polymer such as sodium carboxy methyl cellulose and natural polymers such as gum karaya, xanthan gum and locust bean gum. An impermeable backing layer of ethyl cellulose was applied to give unidirectional drug release. Buccal tablets were evaluated by different parameters such as appearance, physical integrity, hardness, ex vivo mucoadhesive strength, in vitro drug release and ex vivo drug permeation. Results revealed that formulation containing combination of xanthan gum and locust bean gum in 2:1 ratio exhibited complete drug...
Cefdinir (CEF), (6R-(6α,7β(Z))-7-((2-amino-4-thaizolyl) (hydroxyimino) acetyl) amino)-3 -ethenyl-8-oxo-5-thia-1- azabicyclo (4.2.0)-oct-2-ene-2-carboxylic acid, is a semi synthetic third generation oral cephalosporin used in treatment of... more
Cefdinir (CEF), (6R-(6α,7β(Z))-7-((2-amino-4-thaizolyl) (hydroxyimino) acetyl) amino)-3 -ethenyl-8-oxo-5-thia-1- azabicyclo (4.2.0)-oct-2-ene-2-carboxylic acid, is a semi synthetic third generation oral cephalosporin used in treatment of acute chronic bronchitis, rhinosinustis and pharyngitis. The absorption of orally administrated CEF is low with an oral bio- availability of 21-26%, which is mainly due to its poor aqueous solubility and slow dissolution rate. In present work paediatric dispersible tablet containing Cefdinir inclusion complex with β-Cyclodextrin (βCD) by microwave irradiation method have been developed by direct compression method, using various super disintegrants like Primogel and Ac-Di-Sol and diluents like Dicalcium phosphate (DCP), Avicel, starch 1500. The tablets were evaluated for the standard of dispersible tablets like in vitro disintegration time. The tablets formulated with Primogel and starch 1500 showed shortest disintegration time and this C3 batch is ...
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Objective: The principle objective of the present research work was to improve the bioavailability of curcumin (CUR) by decreasing its particle size. Nanosuspension (NS) of CUR was prepared using poloxamer-188 (P188) as a surfactant. The... more
Objective: The principle objective of the present research work was to improve the bioavailability of curcumin (CUR) by decreasing its particle size. Nanosuspension (NS) of CUR was prepared using poloxamer-188 (P188) as a surfactant. The prepared NSs were characterized for particle size, polydispersity index (PDI), zeta potential, drug loading, saturation solubility, and drug release kinetic studies.Methods: Components required for NS preparation, such as solvent, anti-solvent and surfactant were screened. Precipitation high-speed homogenization (HSH) method was used for the preparation of NS using selected components. Evaluation of NS for particle size, PDI, drug loading, saturation solubility and in vitro drug release was done. Pharmacokinetic studies of the NS in sprague dawley (SD) rats were performed.Results: The particle size, PDI and zeta potential of the optimized formulation was 596.5±5 nm, 0.233±0.010 and-23±2 mV respectively. The pH of all the formulations was in the rang...
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Combination of two-dimensional layered materials and intercalation technique offers a new area for developing nanohybrids with desired functionality. Layered double hydroxides (LDHs) are mineral and synthetic materials with positively... more
Combination of two-dimensional layered materials and intercalation technique offers a new area for developing nanohybrids with desired functionality. Layered double hydroxides (LDHs) are mineral and synthetic materials with positively charged brucite type layers of mixed metal hydroxides. Exchangeable anions located in interlayer spaces compensate for positive charge of brucite type layer. Since most biomolecules are negatively charged, can be incorporated between LDHs. A number of cardiovascular, anti-inflammatory agents are either carboxylic acids or carboxylic derivatives and could be ion exchanged with LDHs to have controlled release. LDHs have technological importance in catalysis, separation technology, medical science and nanocomposite material engineering. Introduction Since living matter is composed of biological nanomachines and nanostructures, biology and medicine could be prime field for application of nanotechnology 1 . In particular, combination of two-dimensional laye...
Research Interests:
Research Interests:
... 1574-8855/09 $55.00+.00 ©2009 Bentham Science Publishers Ltd. Ethosomes and its Applications in Transdermal Drug Delivery Rajashree Hirlekar * , Harshal Garse, Suneeta Sonawane, Sujata Londhe and Vilasrao Kadam ... [30] Dubey V,... more
... 1574-8855/09 $55.00+.00 ©2009 Bentham Science Publishers Ltd. Ethosomes and its Applications in Transdermal Drug Delivery Rajashree Hirlekar * , Harshal Garse, Suneeta Sonawane, Sujata Londhe and Vilasrao Kadam ... [30] Dubey V, Mishra D, Jain NK. ...