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Research Interests: Toxicology, Cell line, Humans, Mice, Pesticides, and 5 moreAnimals, Male, Hepatocytes, Carbamates, and Enzyme Induction
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Abstract The psychological workload a pilot is exposed to during military flying is considered to be high, and good stress tolerance is needed. During military flying a huge amount of environmental information is transformed to neural... more
Abstract The psychological workload a pilot is exposed to during military flying is considered to be high, and good stress tolerance is needed. During military flying a huge amount of environmental information is transformed to neural signals which finally lead to motor and ...
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Research Interests: Environmental Science, Metabolism, Toxicology, Kinetics, Mass Spectrometry, and 17 moreDrug metabolism, Enzyme Inhibitors, Risk assessment, Humans, Liver, Female, Male, Young Adult, High Performance Liquid Chromatography, Middle Aged, Adult, Isoenzymes, Risk Assessment, Monoterpenes, LC MS, Recombinant Proteins, and Biochemistry and cell biology
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The metabolism of hyperforin, one of the pharmacologically most active components of St. John's wort (Hypericum perforatum), was characterized in vitro using human liver microsomes and... more
The metabolism of hyperforin, one of the pharmacologically most active components of St. John's wort (Hypericum perforatum), was characterized in vitro using human liver microsomes and recombinant heterologously expressed P450 enzymes. A total of 57 hyperforin metabolites were detected. Of those, six were identified as monohydroxylations (M1-M6), while the others were formed via two or more hydroxylation reactions, via dehydrogenation, or by combinations of these reactions. A combined approach of cDNA-expressed recombinant CYPs, CYP-selective chemical inhibitors and correlation with CYP-specific marker activities indicated a central role of the CYP2C and CYP3A families in the metabolism of hyperforin. In addition, hyperforin was found to inhibit CYP2D6 and CYP3A4 model activities quite potently.
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In this work, the homogeneity of both the B 0 and B 1 fields was studied. Both B 0 and B 1 field homogeneities are the basic assumptions of high resolution liquid state NMR. Although some inhomogeneity of both of the fields is always... more
In this work, the homogeneity of both the B 0 and B 1 fields was studied. Both B 0 and B 1 field homogeneities are the basic assumptions of high resolution liquid state NMR. Although some inhomogeneity of both of the fields is always present, the spectrometers can be operated, ...
Research Interests: Microbiology, Plant Biology, Fungi, Antioxidants, Phylogeny, and 13 moreSiderophores, Staphylococcus aureus, Rhododendron, Endophytic Fungi, Mycorrhizal Fungi, Antibacterial activity, Anti-Bacterial Agents, Fungal Biology, Pinus sylvestris, Microbial Sensitivity Tests, Scots Pine, Plant Leaves, and Molecular Sequence Data
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Abstract Eighty-seven endophytic fungi were isolated from asymptomatic leaf tissues of Rhododendron tomento-sum. Most of the isolates were non-sporulating and therefore difficult to identify exclusively based on morpho-logical characters.... more
Abstract Eighty-seven endophytic fungi were isolated from asymptomatic leaf tissues of Rhododendron tomento-sum. Most of the isolates were non-sporulating and therefore difficult to identify exclusively based on morpho-logical characters. Eighteen isolates that were morpholog-ically ...
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Research Interests: Environmental Science, Metabolism, Toxicology, Mass Spectrometry, Drug metabolism, and 22 moreRisk assessment, Humans, Liver, Pesticides, Female, Male, Nitrogen, Detoxification, Chemico-biological Interactions, High Performance Liquid Chromatography, Enzyme, Middle Aged, Adult, Isoenzymes, Biotransformation, Xenobiotic, Risk Assessment, Metabolic pathway, LC MS, Carbamates, Biochemistry and cell biology, and Molecular Structure
Research Interests: Environmental Science, Metabolism, Toxicology, Drug metabolism, Risk assessment, and 25 moreDogs, In Vitro, Humans, Mice, Pesticides, Female, Animals, Male, Nitrogen, Detoxification, Tandem Mass Spectrometry, Chemico-biological Interactions, High Performance Liquid Chromatography, Middle Aged, Rats, Adult, Swine, Biotransformation, Risk Assessment, Metabolic pathway, Species Specificity, Rabbits, Toxicokinetics, Carbamates, and Biochemistry and cell biology
The effect of oral contraceptives (OCs) on melatonin metabolism was studied in 29 subjects genotyped for CYP1A2 SNP g.-163C>A polymorphism. Plasma... more
The effect of oral contraceptives (OCs) on melatonin metabolism was studied in 29 subjects genotyped for CYP1A2 SNP g.-163C>A polymorphism. Plasma melatonin and 6-OH-melatonin concentrations were measured after a 6-mg dose of melatonin using a validated liquid chromatography/mass spectrometry method. The mean melatonin AUC and C(max) values were 4- to 5-fold higher in OC users than in non-OC users (P < .0001), whereas the weight-adjusted clearance was significantly lower in OC users (P < .0001). No significant difference in melatonin pharmacokinetics between the genotypes and no additional effect by the genotype on the OC-induced increase in melatonin exposure were evident. Melatonin exposure had no significant effect on the subjects' state of alertness. In conclusion, a significant inhibitory effect of OCs on the CYP1A2-catalyzed melatonin metabolism was seen; thereby, OC use can alter CYP1A2-phenotyping results.
Research Interests: Physiology, Research Methodology, Polymorphism, Biology, Attention, and 22 moreDrug interactions, Clinical Pharmacology, Health, Public Health, Medicine, Safety, Melatonin, Population, Humans, Female, Male, The, Shell Half-Life, Developed Countries, Liquid Chromatography / Electrospray Ionization Mass Spectrometry, Genotype, Adult, Body Weight, Hydroxylation, Healthy Subjects, Area Under Curve, and Oral Contraceptive
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Earlier reports have shown that ALP has an internal interaction site. We were able to stabilize the structure of this unfolded part to a great extent by aspartic acid, which allowed the backbone assignment. No secondary structure of the... more
Earlier reports have shown that ALP has an internal interaction site. We were able to stabilize the structure of this unfolded part to a great extent by aspartic acid, which allowed the backbone assignment. No secondary structure of the polypeptide was observed.
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Phenolic compounds from leaves of lingonberry (Vaccinium vitis-idaea L.), bilberry (Vaccinium myrtillus L.), and the natural hybrid of bilberry and lingonberry (Vaccinium x intermedium Ruthe L., hybrid bilberry) were identified using... more
Phenolic compounds from leaves of lingonberry (Vaccinium vitis-idaea L.), bilberry (Vaccinium myrtillus L.), and the natural hybrid of bilberry and lingonberry (Vaccinium x intermedium Ruthe L., hybrid bilberry) were identified using LC/TOF-MS and LC/MS/MS after extraction from the plant material in methanol in an ultrasonicator. The phenolic profiles in the plants were compared using the LC/TOF-MS responses. This is the first thorough report of phenolic compounds in hybrid bilberry. In total, 51 different phenolic compounds were identified, including flavan-3-ols, proanthocyanidins, flavonols and their glycosides, and various phenolic acid conjugates. Of the identified compounds, 35 were detected in bilberry, 36 in lingonberry, and 46 in the hybrid. To our knowledge, seven compounds were previously unreported in Vaccinium genus and many of the compounds are reported for the first time from bilberry and lingonberry.
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1. J Magn Reson B. 1996 Nov;113(2):184-9. Absolute quantification of phospholipid metabolites in brain-tissue extracts by 1H NMR spectroscopy. Ala-Korpela M, Posio P, Mattila S, Korhonen A, Williams SR. AI Virtanen Institute ...