Twenty-one alkaloids and related compounds were found in Sternbergia colchiciflora (Amaryllidaceae), a hitherto not studied plant species. Twenty of them were detected by GC-MS in the crude extracts of this plant species. Ten alkaloids... more
Twenty-one alkaloids and related compounds were found in Sternbergia colchiciflora (Amaryllidaceae), a hitherto not studied plant species. Twenty of them were detected by GC-MS in the crude extracts of this plant species. Ten alkaloids were isolated and their structures confirmed by NMR, MS and CD measurements. Many of the compounds found in this species, such as lycorine, tazettine, haemanthidine, are known to possess strong bioactivity. Variations in the alkaloid pattern were found during the phenological cycle of the plant. Lycorine-type compounds were dominant in the plant organs during both the flowering period and dormancy. The alkaloid pattern during both periods of leaf development and fructification was dominated by haemanthamine-type in the leaves and lycorine-type compounds in the bulbs, respectively.
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Phytochemical studies on Galanthus elwesii resulted in the isolation of five alkaloids: incartine, hordenine, hippeastrine, 8-O-demethylhomolycorine and lycorine. The NMR data given previously for incartine were revised and completed by... more
Phytochemical studies on Galanthus elwesii resulted in the isolation of five alkaloids: incartine, hordenine, hippeastrine, 8-O-demethylhomolycorine and lycorine. The NMR data given previously for incartine were revised and completed by two-dimensional 1H-1H and 1H-13C chemical shift correlation experiments. In vitro studies on the bioactivity of incartine were carried out.
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Crinum zeylanicum is used in folk medicine as a rubefacient in rheumatism, a treatment for malaria or as a poison. Complex alkaloid profiles in C. zeylanicum plant organs were revealed by GC-MS analysis, including several bioactive... more
Crinum zeylanicum is used in folk medicine as a rubefacient in rheumatism, a treatment for malaria or as a poison. Complex alkaloid profiles in C. zeylanicum plant organs were revealed by GC-MS analysis, including several bioactive compounds. Crinine, lycorine, 11-O-acetoxyambelline, ambelline, 6-hydroxybuphanidrine and 6-ethoxybuphanidrine (an artefact of the isolation procedure) were isolated. Crinine, 6-hydroxybuphanidrine and 6-ethoxybuphanidrine showed antiproliferative effects against human tumor cell lines, crinine being the most active (IC₅₀ 14.04 μM against HL-60/Dox). The latter compound induced apoptosis in a dose-dependent manner in HL-60 and MDA-MB-231 cell lines. Structure-activity relationships in the studied molecules indicated that the hydrogenation of the double bond at C1-C2 leads to a loss of activity, whereas substitutions at C6, C8 and C11 affect their cytotoxicity.
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The Amaryllidaceae alkaloids represent a large (over 300 alkaloids have been isolated) and still expanding group of biogenetically related isoquinoline alkaloids that are found exclusively in plants belonging to this family. In spite of... more
The Amaryllidaceae alkaloids represent a large (over 300 alkaloids have been isolated) and still expanding group of biogenetically related isoquinoline alkaloids that are found exclusively in plants belonging to this family. In spite of their great variety of ...
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Research Interests: Chemical Ecology, Plant Biology, Environmental Biotechnology, Applied, Applied Phycology, and 10 moreFisheries Sciences, Programmed cell death, Fatty Acid, Gas Chromatography/mass Spectrometry, Amino Acid Profile, Yeast Metabolite Profiling, Chemical Composition, Electron Impact Ionization, Methyl Ester, and Organic Acid
Research Interests: Engineering, Technology, Complementary and Alternative Medicine, Plant Biology, Process, and 16 moreRaw materials, Plant Secondary Metabolism, Cholinesterase inhibitors, Process biochemistry, Plant species, Liliaceae, Callus induction, Dry Matter, Culture Media, Callus Culture, Galantamine, Time Course, Murashige and Skoog, Acoustic Waves, Biochemistry and cell biology, and Jasmonic Acid
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Sixty-six tropane alkaloids from crude leaf and root alkaloid mixtures of 12 different species and their varieties and subspecies from tribe Datureae were determined by GCMS. The alkaloids 3β-hydroxy-6β-acetoxytropane,... more
Sixty-six tropane alkaloids from crude leaf and root alkaloid mixtures of 12 different species and their varieties and subspecies from tribe Datureae were determined by GCMS. The alkaloids 3β-hydroxy-6β-acetoxytropane, 3-propionyloxy-6-hyroxytropane, 3β-hydroxy-6β- ...