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Research Interests: Genetics, Plant Biology, Flow Cytometry, Lipids, Plant Physiology, and 13 moreCell Differentiation, Fatty acids, Alkaloids, Soil sciences, Plant Physiology and Biochemistry, Fatty Acid, Liliaceae, Phytosterols, Free Fatty Acid, Fatty Alcohols, Hydrogen-Ion Concentration, Callus Culture, and Alpha-linolenic acid
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... times. Ethyl acetate phases were combined and evaporated under vacuum using a rotavapor at 40 °C until dryness (extract 4) (Justesen, Knuthsen, & Leth, 1998). 2.3. Compositional analyses. 2.3.1. Total phenolics. Total... more
... times. Ethyl acetate phases were combined and evaporated under vacuum using a rotavapor at 40 °C until dryness (extract 4) (Justesen, Knuthsen, & Leth, 1998). 2.3. Compositional analyses. 2.3.1. Total phenolics. Total phenolics ...
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Thirteen alkaloids have been isolated from dried bulbs and leaves of flowering Eucharis amazonica (Amaryllidaceae). The alkaloids, 7-methoxyoxoassoanine, 6-O-methylpretazettine and apohaemanthamine, are reported for the first time from a... more
Thirteen alkaloids have been isolated from dried bulbs and leaves of flowering Eucharis amazonica (Amaryllidaceae). The alkaloids, 7-methoxyoxoassoanine, 6-O-methylpretazettine and apohaemanthamine, are reported for the first time from a natural source.
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ABSTRACT ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select... more
ABSTRACT ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
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A simple high-performance liquid chromatography (HPLC) method for the separation and quantitative determination of the main antioxidant phenolic compounds from bitter fennel, Foeniculum vulgare, was developed. The use of a narrow bore... more
A simple high-performance liquid chromatography (HPLC) method for the separation and quantitative determination of the main antioxidant phenolic compounds from bitter fennel, Foeniculum vulgare, was developed. The use of a narrow bore reversed phase (RP) C18 column and an acidic mobile phase enabled ten compounds (caffeoylquinic acids, dicaffeoylquinic acids, flavonoids and rosmarinic acid) to be separated within a 40min time
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Research Interests: Free Radicals, Phytochemistry, Magnetic Resonance Spectroscopy, Free Radical, Biological Sciences, and 9 moreCHEMICAL SCIENCES, Antioxidant Activity, Liquid Chromatography / Electrospray Ionization Mass Spectrometry, Structure Elucidation, Acylation, Chromones, Structure activity Relationship, Glycosides, and Molecular Structure
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Merendera montana (Liliaceae) is an endemic plant broadly, but exclusively, occurring in the Iberian Peninsula where it is one of the most abundant species in rangelands grazed by sheep and on the routes used by migrating sheep herds. In... more
Merendera montana (Liliaceae) is an endemic plant broadly, but exclusively, occurring in the Iberian Peninsula where it is one of the most abundant species in rangelands grazed by sheep and on the routes used by migrating sheep herds. In spite of showing a peculiar phenology adapted to Mediterranean regions (leaves remain green from fall to spring and are absent in summer), this species has also successfully colonized high altitude environments (up to 2300 m), and abundant populations can be found in montane and subalpine pasturcs. Chemical analysis has shown a high forage quality as well as the presence of tropolone alkaloids (similar to other species of the genus Merendera), mainly colchicine, 3-demethylcolchicine, and colchicoside. In general terms, the alkaloid content was significantly lower in the subterranean corms than in the leaves. No remarkable seasonal variations in total alkaloids was found, although an increase of colchicoside in the corms and a decrease of colchicine ...
Research Interests: Chemical Ecology, Reproduction, Chemical, Phenology, Biological Sciences, and 21 moreConcentration, Seasonality, Environmental Sciences, Animals, Plant competition, Alkaloids, Chemical Analysis, Iberian Peninsula, Feeding Behavior, Seasonal variation, CHEMICAL SCIENCES, Forage Quality, Spatial Variation, Mediterranean region, Altitude, Liliaceae, Seasons, High Altitude, Environment, Chemical Defense, and Plant Leaves
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Research Interests: Analytical Chemistry, Principal Component Analysis, Metabolomics, Quality Control, Pharmaceutical industry, and 13 moreRaw materials, Acetylcholinesterase, Analytical Method, Time Factors, In vitro culture, Gas Chromatography/mass Spectrometry, Reproducibility of Results, Rhizome, Liliaceae, Method Validation, Galantamine, Molecular Structure, and Plant Leaves
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Research Interests: Earth Sciences, Mass Spectrometry, Flavonoids, Biological Sciences, Polyphenols, and 11 moreHigh Pressure Liquid Chromatography, Qualitative Analysis, CHEMICAL SCIENCES, Liquid Chromatography / Electrospray Ionization Mass Spectrometry, Phenols, Phenolic compound, Malus, Liquid Chromatography, Dietary fiber, Industrial Waste, and Rapid
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The bulbs of Phaedranassa dubia (Amaryllidaceae) were found to contain the novel compound phaedranamine, together with seven known alkaloids. The structure and stereochemistry of the alkaloids were determined by physical and spectroscopic... more
The bulbs of Phaedranassa dubia (Amaryllidaceae) were found to contain the novel compound phaedranamine, together with seven known alkaloids. The structure and stereochemistry of the alkaloids were determined by physical and spectroscopic methods. An in vitro screening against four different parasitic protozoa was carried out using the isolated compounds. The alkaloids ungeremine, pseudolycorine and haemanthamine showed good activity in in vitro assays against Trypanosoma brucei rhodesiense, T. cruzi and Plasmodium falciparum with IC50 values in the range of 3.66μM or lower.
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From the bulbs of Brunsvigia josephinae (Amaryllidaceae), crinine, buphanisine, buphanidrine, undulatine, 11-O-acetylambelline, brunsbelline and hippadine have been isolated and identified. 11-O-Acetylambelline and brunsbelline are... more
From the bulbs of Brunsvigia josephinae (Amaryllidaceae), crinine, buphanisine, buphanidrine, undulatine, 11-O-acetylambelline, brunsbelline and hippadine have been isolated and identified. 11-O-Acetylambelline and brunsbelline are reported here for the first time. The structure and stereochemistry of the new alkaloids have been determined by spectroscopic analyses and by the application of 2D NMR techniques. 1H and 13C NMR spectra of crinine, buphanisine,
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A phytochemical investigation of the bulbs of Brunsvigia radulosa yielded the new alkaloid 1-O-acetylnorpluviine, together with the known structures 1-epideacetylbowdensine, crinamine, crinine, hamayne, lycorine, anhydrolycorin-6-one and... more
A phytochemical investigation of the bulbs of Brunsvigia radulosa yielded the new alkaloid 1-O-acetylnorpluviine, together with the known structures 1-epideacetylbowdensine, crinamine, crinine, hamayne, lycorine, anhydrolycorin-6-one and sternbergine. All structures were established by spectroscopic evidence. Some of the 13C assignments which were reported for crinamine and hamayne were corrected by means of 2D NMR techniques. In order to provide a further structure for biological testing, crinamine was converted to apohaemanthamine. The alkaloids were tested for activity against two strains of cultured Plasmodium falciparum and for cytotoxicity with BL6 mouse melanoma cells.