Abstract The K-SADS-K psychiatric interview was administered to children and parents from families containing proband parent's who had previously been depressed or who were normal Agreement between parents and their children about... more
Abstract The K-SADS-K psychiatric interview was administered to children and parents from families containing proband parent's who had previously been depressed or who were normal Agreement between parents and their children about depressive symptoms in the symptoms in the children was significant but low Boy's reports agreed more highly with their parents reports about them than did girls' reports Overall, the children reported more depressive symptoms than their parents reports about them and the overall pattern suggests that parents are relatively insensitive to their children's depressive symptomatology. but their reports show high specificity The implications of research findings for research and clinical work are discussed.
Research Interests:
Research Interests:
Research Interests:
It is difficult to identify genes that predispose to prostate cancer due to late age at diagnosis, presence of phenocopies within high-risk pedigrees and genetic complexity. A genome-wide scan of large, high-risk pedigrees from Utah has... more
It is difficult to identify genes that predispose to prostate cancer due to late age at diagnosis, presence of phenocopies within high-risk pedigrees and genetic complexity. A genome-wide scan of large, high-risk pedigrees from Utah has provided evidence for linkage to a locus on chromosome 17p. We carried out positional cloning and mutation screening within the refined interval, identifying a gene, ELAC2, harboring mutations (including a frameshift and a nonconservative missense change) that segregate with prostate cancer in two pedigrees. In addition, two common missense variants in the gene are associated with the occurrence of prostate cancer. ELAC2 is a member of an uncharacterized gene family predicted to encode a metal-dependent hydrolase domain that is conserved among eukaryotes, archaebacteria and eubacteria. The gene product bears amino acid sequence similarity to two better understood protein families, namely the PSO2 (SNM1) DNA interstrand crosslink repair proteins and the 73-kD subunit of mRNA 3' end cleavage and polyadenylation specificity factor (CPSF73).
Research Interests:
Research Interests:
Research Interests:
Research Interests:
Recent investigations on the bifurcation behavior of power electronic DC-DC converters have revealed that most of the observed bifurcations do not belong to generic classes such as saddle-node, period doubling, or Hopf bifurcations. Since... more
Recent investigations on the bifurcation behavior of power electronic DC-DC converters have revealed that most of the observed bifurcations do not belong to generic classes such as saddle-node, period doubling, or Hopf bifurcations. Since these systems yield piecewise smooth maps under stroboscopic sampling, a new class of bifurcations occur in such systems when a fixed point crosses the border between the smooth regions in the state space. In this paper we present a systematic analysis of such bifurcations through a normal form: the piecewise linear approximation in the neighborhood of the border. We show that there can be many qualitatively different types of border collision bifurcations, depending on the parameters of the normal form. We present a partitioning of the parameter space of the normal form showing the regions where different types of bifurcations occur. We then use this theoretical framework to explain the bifurcation behavior of the current programmed boost converter