Tewodros eyob
Jimma University, Clinical pharmacy, Faculty Member
Approximately one third of patients with epilepsy continue to experience seizure despite the prescription of appropriate doses of anti-epileptic drugs. The objective of this study was to assess treatment outcomes and associated factors... more
Approximately one third of patients with epilepsy continue to experience seizure despite the prescription of
appropriate doses of anti-epileptic drugs. The objective of this study was to assess treatment outcomes and
associated factors for poor treatment outcomes among patients taking anti-epileptic drugs at Ambo Hospital,
West Shewa, Ethiopia. A hospital based cross–sectional study was conducted. Verbal consent from participants
was taken before interview. Fifty-nine patients (44.7%) had poor seizure control. The most common seizure
triggering factors were emotional stress (97.4%), sleep deprivation (78.1%), missing meal (29.8%)and missing
medication (21.9%). Seventy one patients (53.8%) were non-adherent to medication. Therefore there is
significant association between level of adherence (P=0.001), number of seizure attacks before anti-epileptic
drugs initiation (p=0.028), electroencephalogram(neurologic abnormality) (p=0.04) and age at onset of seizure
(diagnosis) (p=0.026). Poor treatment outcomes among epileptic patients is associated with level of adherence,
number of seizure attacks before anti-epileptic drugs initiations, electroencephalogram(neurologic
abnormality) and age at onset of seizure (diagnosis). The most common seizure triggering factors were
emotional distress, sleep deprivation, missing meal, missing medication and noise. Strict medication adherence
evaluation and enhancement through continues health education, close follow up with multidisciplinary
approach are fundamental to the successful management of epileptic patients.
appropriate doses of anti-epileptic drugs. The objective of this study was to assess treatment outcomes and
associated factors for poor treatment outcomes among patients taking anti-epileptic drugs at Ambo Hospital,
West Shewa, Ethiopia. A hospital based cross–sectional study was conducted. Verbal consent from participants
was taken before interview. Fifty-nine patients (44.7%) had poor seizure control. The most common seizure
triggering factors were emotional stress (97.4%), sleep deprivation (78.1%), missing meal (29.8%)and missing
medication (21.9%). Seventy one patients (53.8%) were non-adherent to medication. Therefore there is
significant association between level of adherence (P=0.001), number of seizure attacks before anti-epileptic
drugs initiation (p=0.028), electroencephalogram(neurologic abnormality) (p=0.04) and age at onset of seizure
(diagnosis) (p=0.026). Poor treatment outcomes among epileptic patients is associated with level of adherence,
number of seizure attacks before anti-epileptic drugs initiations, electroencephalogram(neurologic
abnormality) and age at onset of seizure (diagnosis). The most common seizure triggering factors were
emotional distress, sleep deprivation, missing meal, missing medication and noise. Strict medication adherence
evaluation and enhancement through continues health education, close follow up with multidisciplinary
approach are fundamental to the successful management of epileptic patients.
Research Interests:
Background: The degree to which an individual follows medical advice is a major concern in every medical specialty. Non-adherence to psychiatric treatment regimens has a profound impact on the disease course, relapse, future recovery,... more
Background: The degree to which an individual follows medical advice is a major concern in every medical specialty. Non-adherence to psychiatric treatment regimens has a profound impact on the disease course, relapse, future recovery, cost of health care, and the outcome for the patient. The aim of this study was to assess medication adherence and its correlates among psychiatric patients at Ayder Referral Hospital, Northern Ethiopia.
Methods: A cross-sectional study was conducted from June to September 2013 at Ayder Referral Hospital, where 423 patients were selected by a systematic random sampling technique from all patients attending the psychiatric clinic at the hospital. Data were collected by trained data collectors through interview of the patients using a structured questionnaire. The collected data were entered into Epi Info version 7 and analyzed by Statistical Package for the Social Sciences version 16 software. Logistic regression was used to assess independent predictors of adherence.
Results: A total of 387 patients completed the interview. Two hundred and sixteen (55.8%) and 113 (29.2%) were patients with a diagnosis of schizophrenia and mood disorder, respectively, while 35 (9%) and 23 (5.9%) had a diagnosis of drug addiction and autistic disorder. Two hundred and seven (71.6%) patients were found to be adherent to their medication. When adherence rates were observed according to type of disorder, 60 (53.1%), 24 (68.6%), 149 (69%), and 18 (78.3%) of patients with mood disorder, drug addiction, schizophrenia, and autism, respectively, were adherent to their medications. Female gender (adjusted odds ratio [AOR] 2.34; 95% confidence interval [CI] 1.45–3.74), tertiary education (AOR 2.69; 95% CI 1.46–4.85), living with family (AOR 2.57; 95% CI 1.66–4.58), and shorter treatment duration (AOR 1.82; 95% CI 1.21–2.84) were among the variables associated with better adherence.
Conclusion: Suboptimal adherence was observed among psychiatric patients in this study. Health professionals in the psychiatric clinic and pharmacists need to focus on and counsel patients about adherence and its implications for their clinical outcome.
Methods: A cross-sectional study was conducted from June to September 2013 at Ayder Referral Hospital, where 423 patients were selected by a systematic random sampling technique from all patients attending the psychiatric clinic at the hospital. Data were collected by trained data collectors through interview of the patients using a structured questionnaire. The collected data were entered into Epi Info version 7 and analyzed by Statistical Package for the Social Sciences version 16 software. Logistic regression was used to assess independent predictors of adherence.
Results: A total of 387 patients completed the interview. Two hundred and sixteen (55.8%) and 113 (29.2%) were patients with a diagnosis of schizophrenia and mood disorder, respectively, while 35 (9%) and 23 (5.9%) had a diagnosis of drug addiction and autistic disorder. Two hundred and seven (71.6%) patients were found to be adherent to their medication. When adherence rates were observed according to type of disorder, 60 (53.1%), 24 (68.6%), 149 (69%), and 18 (78.3%) of patients with mood disorder, drug addiction, schizophrenia, and autism, respectively, were adherent to their medications. Female gender (adjusted odds ratio [AOR] 2.34; 95% confidence interval [CI] 1.45–3.74), tertiary education (AOR 2.69; 95% CI 1.46–4.85), living with family (AOR 2.57; 95% CI 1.66–4.58), and shorter treatment duration (AOR 1.82; 95% CI 1.21–2.84) were among the variables associated with better adherence.
Conclusion: Suboptimal adherence was observed among psychiatric patients in this study. Health professionals in the psychiatric clinic and pharmacists need to focus on and counsel patients about adherence and its implications for their clinical outcome.