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Article
Open AccessEvaluation of the significance of complement-related genes mutations in atypical postinfectious glomerulonephritis: a pilot study
Postinfectious glomerulonephritis with C3-dominant glomerular deposition (C3-PIGN) involves C3-dominant glomerular deposition without immunoglobulin. Atypical C3-PIGN involves persistent hypocomplementemia. We...
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Article
Open AccessFOXM1 maintains fatty acid homoeostasis through the SET7-H3K4me1-FASN axis
Reprogramming of metabolic genes and subsequent alterations in metabolic phenotypes occur widely in malignant tumours, including glioblastoma (GBM). FOXM1 is a potent transcription factor that plays an oncogen...
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Article
Open AccessRobot-assisted percutaneous balloon compression for trigeminal neuralgia- preliminary experiences
This study aims to discuss the availability of robot-assisted percutaneous balloon compression (PBC) for trigeminal neuralgia (TN) and share our preliminary experiences.
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Article
Open AccessThe gut microbiota and metabolite profiles are altered in patients with spinal cord injury
Metabolites secreted by the gut microbiota may play an essential role in microbiota–gut–central nervous system crosstalk. In this study, we explored the changes occurring in the gut microbiota and their metabo...
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Article
Variations in mitochondrial DNA coding and d-loop region are associated with early embryonic development defects in infertile women
Mitochondrial DNA (mtDNA) plays a critical role in oocyte maturation, fertilization, and early embryonic development. Defects in mtDNA may determine the alteration of the mitochondrial function, affecting cell...
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Article
Open AccessSupplemental N-acyl homoserine lactonase alleviates intestinal disruption and improves gut microbiota in broilers challenged by Salmonella Typhimurium
Salmonella Typhimurium challenge causes a huge detriment to chicken production. N-acyl homoserine lactonase (AHLase), a quorum quenching enzyme, potentially inhibits the growth and virulence of Gram-negative bac...
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Article
Open AccessMolecular insights into the distinct signaling duration for the peptide-induced PTH1R activation
The parathyroid hormone type 1 receptor (PTH1R), a class B1 G protein-coupled receptor, plays critical roles in bone turnover and Ca2+ homeostasis. Teriparatide (PTH) and Abaloparatide (ABL) are terms as long-act...
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Article
Hydrothermal carbon modified Cu–Fe oxide with enhanced Fe(II)/Fe(III) cycle to activate peroxydisulfate for phenol removal
Phenol is a typical organic pollutant in wastewater, which will cause considerable damage and threat to the ecosystem and human health. In this work, hydrothermal carbon (HTC) modified copper-iron oxide (CFO) ...
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Article
Open AccessAssociation of SNPs in the FK-506 binding protein (FKBP5) gene among Han Chinese women with polycystic ovary syndrome
Polycystic ovary syndrome (PCOS) is a common endocrine disorder in premenopausal women, whose etiology remains uncertain, although it is known to be highly heterogeneous and genetically complex. PCOS often pre...
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Article
Hierarchical porous polystyrene-based activated carbon spheres for CO2 capture
It is rather essential to design porous carbon adsorbents with high CO2 capture performance for improving global warming and climate change. Activated carbon spheres with high specific surface area and hierarchic...
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Article
Open AccessEfficacy of Chinese herbal medicine Jiangniaosuan formula for treatment of hyperuricemia: study protocol for a double-blinded non-inferiority randomized controlled clinical trial
Jiangniaosuan formula (JNSF) is commonly used in China for treating hyperuricemia, but there is little research-based evidence to support its use. This randomized controlled trial aims to assess the efficacy a...
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Article
Open AccessThe altered immunological status of children conceived by assisted reproductive technology
With the increased use of assisted reproductive technology (ART), assessing the potential health risks of children conceived on ART important to public health. Most research in this area has focused on the eff...
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Article
Synthesis of millimeter-sized porous carbon spheres derived from different precursors for CO2 capture
Activated carbon spheres (ACSs) with high surface area and controlled microporous structure were prepared from alkyl phenols and formaldehyde via suspension polymerization and steam activation. The effects of ...
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Article
Variation Screening of Zygote Arrest 1(ZAR1) in Women with Recurrent Zygote Arrest During IVF/ICSI Programs
Human zygote arrest during in vitro culture is rare and the etiology is unclear. The oocyte-specific gene Zar1 plays an essential role in oocyte-embryo transition, and most embryos from Zar1 knockout female mice ...
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Article
Open AccessQuercetin promotes in vitro maturation of oocytes from humans and aged mice
Maternal fertility declines irreversibly with aging, and advanced maternal age is mostly related to impaired oocyte quality. The flavonol compound quercetin is considered to be an anti-aging agent due to its c...
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Article
Open AccessCannabinoid CB1 receptor agonist ACEA alleviates brain ischemia/reperfusion injury via CB1–Drp1 pathway
Activation of the cannabinoid CB1 receptor induces neuroprotection against brain ischemia/reperfusion injury (IRI); however, the mechanism is still unknown. In this study, we used oxygen-glucose deprivation/re...
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Article
Open AccessEffectiveness and long-term outcomes of different crossing strategies for the endovascular treatment of iliac artery chronic Total occlusions
The iliac occlusive disease is usually treated with endovascular procedures in recent years. The effectiveness of different crossing approaches for these occlusions is not precisely known. We performed a retro...
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Article
Photocatalytic Reduction of CO2 to CO over 3D Bi2MoO6 Microspheres: Simple Synthesis, High Efficiency and Selectivity, Reaction Mechanism
It has been a promising approach for directly utilizing solar energy to convert CO2 into clean renewable chemical fuels over photocatalysts with excellent photoreactivity, CO2 adsorption capacity and reasonable r...
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Article
Open AccessIdentification of anti-tumoral feedback loop between VHLα and hnRNPA2B1 in renal cancer
Our previous study identified a novel VHLα isoform which negatively modulated hnRNPA2B1 expression and therefore influenced pyruvate kinase transcript splicing in renal cancer, while the regulation and initiat...
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Article
Synthesis of MnO2 modified porous carbon spheres by preoxidation-assisted impregnation for catalytic oxidation of indoor formaldehyde
Resin-based porous carbon spheres with well dispersed MnO2 particles were sucessfully synthesised by steam activation and preoxidation-assisted impregnation of manganese nitrate salt. X-ray diffractometer (XRD), ...