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Article
Hot-Isostatic Pressed Al Melt-Spun Ribbons with Tailored Microstructures and Mechanical Properties for Metallic Optics
This work demonstrates rapid solidification and precision machining to achieve 6061 aluminum alloys with extremely small surface roughness (2.05 nm), good tensile strength (325 MPa), and uniformly distributed ...
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Article
Open AccessThe optimal second-line therapy for older adults with type 2 diabetes mellitus: protocol for a systematic review and network meta-analysis using individual participant data (IPD)
Due to increasing life expectancy, almost half of people with type 2 diabetes are aged 65 years or over worldwide. When metformin alone does not control blood sugar, the choice of which second-line therapy to ...
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Article
Characterization of a membrane Fcγ receptor in largemouth bass (Micropterus saloumoides) and its response to bacterial challenge
Fc receptors (FcRs), specific to the Fc portion of immunoglobulin (Ig), are required to regulate immune responses against pathogenic infections. However, FcγR is a member of FcRs family, whose structure and fu...
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Article
Computing offloading and resource scheduling based on DDPG in ultra-dense edge computing networks
To address the current challenge of smart devices in healthcare Internet of things (IoT) struggling to efficiently process intensive applications in real-time, a collaborative cloud-edge offloading model tailo...
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Article
Open AccessBone marrow stromal cells dictate lanosterol biosynthesis and ferroptosis of multiple myeloma
Ferroptosis has been demonstrated a promising way to counteract chemoresistance of multiple myeloma (MM), however, roles and mechanism of bone marrow stromal cells (BMSCs) in regulating ferroptosis of MM cells...
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Article
Open AccessStudy on the material source and enrichment mechanism of REE-rich phosphorite in Zhijin, Guizhou
Rare earth element (REE)-rich phosphorite in the Guizhou region mainly exists in the Doushantuo Formation and Gezhongwu Formation in early Cambrian strata, which are some of the important strata containing pho...
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Article
Open AccessQuantification of preexisting lung ground glass opacities on CT for predicting checkpoint inhibitor pneumonitis in advanced non-small cell lung cancer patients
Immune checkpoint inhibitors (ICIs) can lead to life-threatening pneumonitis, and pre-existing interstitial lung abnormalities (ILAs) are a risk factor for checkpoint inhibitor pneumonitis (CIP). However, the ...
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Article
PD-L1 Expression Is Increased in LPS-Induced Acute Respiratory Distress Syndrome by PI3K-AKT-Egr-1/C/EBPδ Signaling Pathway
The role of programmed death ligand 1 (PD-L1) has been extensively investigated in adaptive immune system. However, increasing data show that innate immune responses are also affected by the immune checkpoint...
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Article
Study of the micro-yielding behavior in a SiCp/Mg–Zn–Ca composite using synchrotron radiation diffraction
The present study investigates the mechanical behavior of a SiCp/Mg–5Zn–0.2Ca composite under tensile loading using in-situ synchrotron X-ray diffraction. The composite exhibited a yield strength of 167 MPa, ulti...
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Article
Open AccessComprehensive analysis the prognostic and immune characteristics of mitochondrial transport-related gene SFXN1 in lung adenocarcinoma
Mitochondria, which serve as the fundamental organelle for cellular energy and metabolism, are closely linked to the growth and survival of cancer cells. This study aims to identify and assess Sideroflexin1 (S...
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Article
Investigating alcohol consumption in China via wastewater-based epidemiology
Alcohol abuse and addiction is a public health issue of global concern. Wastewater-based epidemiology (WBE) is a forceful and effective complementary tool for investigating chemical consumption. This study exa...
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Chapter and Conference Paper
Optimization of Takagi-Sugeno-Kang Fuzzy Model Based on Differential Evolution with Lévy Flight
In this article, a novel evolutionary algorithm called differential evolution with Lévy flight (DEFL) algorithm was proposed to optimize the Takagi-Sugeno-Kang fuzzy model (TSK fuzzy model) by finding the opti...
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Article
Clinico-pathological characteristics of IGFR1 and VEGF-A co-expression in early and locally advanced-stage lung adenocarcinoma
Although targeted therapies and immunotherapy have achieved significant clinical benefits in patients with certain pathological types of lung cancer. However, prognosis for patients with lung adenocarcinoma st...
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Article
Open AccessModulating activity of PVN neurons prevents atrial fibrillation induced circulation dysfunction by electroacupuncture at BL15
Circulation dysfunction is a major contributing factor to thrombosis in patients with atrial fibrillation (AF) for which effective interventions are lacking. Growing evidence indicates that regulating the para...
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Article
First-Principles Study of F and H Adsorption on Corrosion Resistance of Titanium Bipolar Plates
The adsorption energy of F, H on the titanium surface with 46 doping elements was calculated in the first-principles approach. Compared with Ti in fuel cell environment, the adsorption energy would decrease wi...
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Article
Open AccessAnlotinib plus icotinib as a potential treatment option for EGFR-mutated advanced non-squamous non-small cell lung cancer with concurrent mutations: final analysis of the prospective phase 2, multicenter ALTER-L004 study
Non-small cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) mutation and concurrent mutations have a poor prognosis. This study aimed to examine anlotinib plus icotinib as a first-...
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Article
Open AccessDeacetylation induced nuclear condensation of HP1γ promotes multiple myeloma drug resistance
Acquired chemoresistance to proteasome inhibitors is a major obstacle in managing multiple myeloma but key regulators and underlying mechanisms still remain to be explored. We find that high level of HP1γ is a...
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Article
Dominant Deformation Mechanisms in Mg–Zn–Ca Alloy
The coaddition of Zn and Ca has great potential to improve the ductility of Mg alloys. Herein, the mechanical properties of an extruded Mg–Zn–Ca solid-solution alloy were studied by quasi-in situ electron back...
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Article
Hypoxia induces chemoresistance to proteasome inhibitors through orchestrating deSUMOylation and ubiquitination of SRC-3 in multiple myeloma
The bone marrow microenvironment in multiple myeloma (MM) is hypoxic and provides multi-advantages for the initiation of chemoresistance, but the underlying mechanisms and key regulators are still indistinct. ...
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Article
Open AccessTowards development of a high-strength stainless Mg alloy with Al-assisted growth of passive film
Magnesium alloys with high strength and excellent corrosion resistance are always sought-after in light-weighting structural components for automotive and aerospace applications. However, for most magnesium al...