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Article
Open AccessEg5 UFMylation promotes spindle organization during mitosis
UFMylation is a highly conserved ubiquitin-like post-translational modification that catalyzes the covalent linkage of UFM1 to its target proteins. This modification plays a critical role in the maintenance of...
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Article
Open AccessProteogenomic insights into the biology and treatment of pan-melanoma
Melanoma is one of the most prevalent skin cancers, with high metastatic rates and poor prognosis. Understanding its molecular pathogenesis is crucial for improving its diagnosis and treatment. Integrated anal...
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Article
Open AccessUncovering the role of TET2-mediated ENPEP activation in trophoblast cell fate determination
Early trophoblast differentiation is crucial for embryo implantation, placentation and fetal development. Dynamic changes in DNA methylation occur during preimplantation development and are critical for cell f...
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Article
Characterization of a membrane Fcγ receptor in largemouth bass (Micropterus saloumoides) and its response to bacterial challenge
Fc receptors (FcRs), specific to the Fc portion of immunoglobulin (Ig), are required to regulate immune responses against pathogenic infections. However, FcγR is a member of FcRs family, whose structure and fu...
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Article
Open AccessAmlodipine inhibits Synaptotagmin-4’s oncogenic activity on gastric cancer proliferation by targeting calcium signaling
Background: Gastric cancer (GC) remains a leading cause of cancer mortality globally. Synaptotagmin-4 (SYT4), a calcium-sensing synaptic vesicle protein, has been implicated in the oncogenesis of diverse malig...
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Article
Open AccessAndrogen dihydrotestosterone promotes bladder cancer cell proliferation and invasion via EPPK1-mediated MAPK/JUP signalling
The incidence of bladder cancer (BLCA) in men is higher than that in women. Differences in androgen levels between men and women are considered the main causes of incidence rate differences. In this study, dih...
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Article
Open AccessThe SWine IMputation (SWIM) haplotype reference panel enables nucleotide resolution genetic mapping in pigs
Genetic mapping to identify genes and alleles associated with or causing economically important quantitative trait variation in livestock animals such as pigs is a major goal in animal genetic improvement. Des...
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Article
Open AccessMapping splice QTLs reveals distinct transcriptional and post-transcriptional regulatory variation of gene expression and identifies putative alternative splicing variation mediating complex trait variation in pigs
Alternative splicing is an important step in gene expression, generating multiple isoforms for the same genes and greatly expanding the diversity of proteomes. Genetic variation in alternative splicing contrib...
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Article
Ex situ reproduction and recruitment of scleractinian coral Galaxea fascicularis
Sexual reproduction plays an important role in population and community structure maintenance in scleractinian corals, particularly in growth and development after larvae settlement. Despite this, only a few s...
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Article
Open AccessA web-based database server using 43,710 public RNA-seq samples for the analysis of gene expression and alternative splicing in livestock animals
Livestock animals is of great significance in agricultural production. However, the role of specific gene expression, especially alternative splicing in determining phenotype, is not well understood. The lives...
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Article
Open AccessA composite strategy of genome-wide association study and copy number variation analysis for carcass traits in a Duroc pig population
Carcass traits are important in pig breeding programs for improving pork production. Understanding the genetic variants underlies complex phenotypes can help explain trait variation in pigs. In this study, we ...
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Protocol
Human Trophectoderm Spheroid Derived from Human Embryonic Stem Cells
The use of human embryos for studying the early implantation processes and trophoblast is restricted by ethical concerns. The development of models mimicking the peri-implantation embryos is critical for under...
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Article
Open AccessSingle-cell RNA transcriptome reveals the intra-tumoral heterogeneity and regulators underlying tumor progression in metastatic pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) is the most frequent and aggressive pancreatic tumor characterized by high metastatic risk and special tumor microenvironment. To comprehensively delineate the complex i...
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Article
Open AccessRho-kinase inhibitor hydroxyfasudil protects against HIV-1 Tat-induced dysfunction of tight junction and neprilysin/Aβ transfer receptor expression in mouse brain microvessels
HIV-1 transactivator protein (Tat) induces tight junction (TJ) dysfunction and amyloid-beta (Aβ) clearance dysfunction, contributing to the development and progression of HIV-1-associated neurocognitive disord...
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Article
Identification of a microalgae-yeast coculture system for nutrient removal in shrimp culture wastewater
The accumulation of nitrogen and phosphorous has detrimental effects on aquatic animals and negatively influences the economic benefits of aquaculture; thus, the control of water quality is of significance for...
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Article
Open AccessA bioenergetic shift is required for spermatogonial differentiation
A bioenergetic balance between glycolysis and mitochondrial respiration is particularly important for stem cell fate specification. It however remains to be determined whether undifferentiated spermatogonia sw...
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Article
Open AccessGenome-wide association analyses identify known and novel loci for teat number in Duroc pigs using single-locus and multi-locus models
More teats are necessary for sows to nurse larger litters to provide immunity and nutrient for piglets prior to weaning. Previous studies have reported the strong effect of an insertion mutation in the Vertebr...
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Article
Fine Mapping of the High-pH Tolerance and Growth Trait-Related Quantitative Trait Loci (QTLs) and Identification of the Candidate Genes in Pacific White Shrimp (Litopenaeus vannamei)
High-pH tolerance and growth are important traits for the shrimp culture industry in areas with saline-alkali water. In the present study, an F1 full-sib family of Pacific white shrimp (Litopenaeus vannamei) was ...
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Article
Open AccessASlive: a database for alternative splicing atlas in livestock animals
Alternative splicing is an important biological process whose precision must be tightly regulated during growth and development. Although there are species, disease (e.g. cancers), or study specific databases ...
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Article
Genetic diversity and large-scale connectivity of the scleractinian coral Porites lutea in the South China Sea
In light of recent declines in scleractinian communities worldwide, research on the genetic structure of and connectivity among coral populations has assumed importance. However, the genetic structure of coral...