AGTR1

Angiotenzinski II receptor, tip 1
Identifikatori
Simboli	AGTR1; AG2S; AGTR1A; AGTR1B; AT1; AT1B; AT2R1; AT2R1A; AT2R1B; HAT1R
Vanjski ID	OMIM: 106165 MGI: 87964 HomoloGene: 3556 IUPHAR: AT1 GeneCards: AGTR1 Gene
Ontologija gena
Molekularna funkcija	• aktivnost rodopsinu-sličnog receptora; • receptorska aktivnost; • aktivnost angiotenzin tip II receptora; • aktivnost bradikininskog receptora; • aktivnost C-X-C hemokinskog receptora;
Celularna komponenta	• ćelijska membrana; • integralno sa ćelijskom membranom; • membrana; • integralno sa membranom;
Biološki proces	• prenos signala; • signalni put G-protein spregnutog receptora; • G-protein signalizacija, spregnuta sa IP3 sekundarnim glasnikom (aktivacija fosfolipaze C); • elevacija koncentracije citosolnih jona kalcijuma; • sekrecija fluida; • cirkulacija;
Pregled RNK izražavanja
	podaci
Ortolozi

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AGTR1 (Angiotenzinski II receptor, tip 1, AT₁ receptor) je angiotenzinski receptor. On ima simpatomimetičko dejstvo i reguliše sekreciju aldosterona. On je značajan efektor kontrole krvnog pritiska i zapremine u kardiovaskularnom sistemu. Antagonisti angiotenzin II receptora su lekovi za hipertenziju, dijabetesnu nefropatiju i srčanu insuficijenciju. AGTR1 je najbolje istraženi angiotenzinski receptor.

Mehanizam

Angiotenzinski receptori se aktiviraju vazokonstriktivnim peptidom angiotenzin II. Aktivirani receptor se spreže sa G_q/11, aktivira fosfolipazu C i povišava koncentraciju citosolnog Ca²⁺, čime se zatim inicira ćelijski respons kao što je stimulacija proteinske kinaze C. Aktivirani receptor takođe inhibira adenilat ciklazu i razne tirozinske kinaze.^[1]

Reference

↑ Higuchi S, Ohtsu H, Suzuki H, Shirai H, Frank GD, Eguchi S (2007). „Angiotensin II signal transduction through the AT1 receptor: novel insights into mechanisms and pathophysiology”. Clin. Sci. 112 (8): 417–28. DOI:10.1042/CS20060342. PMID 17346243.

Literatura

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Elton TS, Martin MM (2003). „Alternative splicing: a novel mechanism to fine-tune the expression and function of the human AT1 receptor.”. Trends Endocrinol. Metab. 14 (2): 66–71. DOI:10.1016/S1043-2760(02)00038-3. PMID 12591176.
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Mauzy CA, Hwang O, Egloff AM, et al. (1992). „Cloning, expression, and characterization of a gene encoding the human angiotensin II type 1A receptor.”. Biochem. Biophys. Res. Commun. 186 (1): 277–84. DOI:10.1016/S0006-291X(05)80804-6. PMID 1378723.
Curnow KM, Pascoe L, White PC (1992). „Genetic analysis of the human type-1 angiotensin II receptor.”. Mol. Endocrinol. 6 (7): 1113–8. DOI:10.1210/me.6.7.1113. PMID 1508224.
Furuta H, Guo DF, Inagami T (1992). „Molecular cloning and sequencing of the gene encoding human angiotensin II type 1 receptor.”. Biochem. Biophys. Res. Commun. 183 (1): 8–13. DOI:10.1016/0006-291X(92)91600-U. PMID 1543512.
Takayanagi R, Ohnaka K, Sakai Y, et al. (1992). „Molecular cloning, sequence analysis and expression of a cDNA encoding human type-1 angiotensin II receptor.”. Biochem. Biophys. Res. Commun. 183 (2): 910–6. DOI:10.1016/0006-291X(92)90570-B. PMID 1550596.
Bergsma DJ, Ellis C, Kumar C, et al. (1992). „Cloning and characterization of a human angiotensin II type 1 receptor.”. Biochem. Biophys. Res. Commun. 183 (3): 989–95. DOI:10.1016/S0006-291X(05)80288-8. PMID 1567413.
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Curnow KM, Pascoe L, Davies E, et al. (1996). „Alternatively spliced human type 1 angiotensin II receptor mRNAs are translated at different efficiencies and encode two receptor isoforms.”. Mol. Endocrinol. 9 (9): 1250–62. DOI:10.1210/me.9.9.1250. PMID 7491117.
Marrero MB, Schieffer B, Paxton WG, et al. (1995). „Direct stimulation of Jak/STAT pathway by the angiotensin II AT1 receptor.”. Nature 375 (6528): 247–50. DOI:10.1038/375247a0. PMID 7746328.

Vanjske veze

„Angiotensin Receptors: AT₁”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2014-02-28.

[pmid17346243-1] Higuchi S, Ohtsu H, Suzuki H, Shirai H, Frank GD, Eguchi S (2007). „Angiotensin II signal transduction through the AT1 receptor: novel insights into mechanisms and pathophysiology”. Clin. Sci. 112 (8): 417–28. DOI:10.1042/CS20060342. PMID 17346243.

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