Akridin

Akridin
	Akridin
Identifikacija
CAS registarski broj	260-94-6
PubChem	9215
ChemSpider	8860
ChEBI	36420
ChEMBL	CHEMBL39677
Jmol-3D slike	Slika 1; Slika 2
SMILES
	n1c3c(cc2c1cccc2)cccc3 c1ccc2c(c1)cc3ccccc3n2
InChI
	InChI=1S/C13H9N/c1-3-7-12-10(5-1)9-11-6-2-4-8-13(11)14-12/h1-9H ; Kod: DZBUGLKDJFMEHC-UHFFFAOYSA-N InChI=1/C13H9N/c1-3-7-12-10(5-1)9-11-6-2-4-8-13(11)14-12/h1-9H; Kod: DZBUGLKDJFMEHC-UHFFFAOYAF
Svojstva
Molekulska formula	C13H9N
Molarna masa	179.22 g mol−1
Tačka topljenja	107 °C
Tačka ključanja	346 °C
pKa	5.60
	(šta je ovo?) (verifikuj) ; Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala
	Infobox references

Acridin, C₁₃H₉N, je organsko jedinjenje i azotno heterociklično jedinjenje.^[6]

Acridin je strukturno srodan sa antracenom. Kod njega je jedna od centralnih CH grupa antracena zamenjena azotom. Akridin je bezbojan čvrst materijal. On prvi put izolovan iz katrana. Acridin je sirovina u proizvodnji boja i niza lekova. Mnogi akridini, kao što je proflavin, isto tako imaju antiseptička svojstva. Akridin i srodni derivati se vezuju za DNK i RNK usled njihove sposobnosti da interkaliraju. Akridin-oranž (3,6-dimetilaminoakridin) je nukleinska kiselina koja je selektivna metahromatska boja sa primenom u određivanju ćelijskog ciklusa. Akridarsin je formalno izveden iz akridina zamenom atoma azota sa arsenikom, a akridofosfin zamenom sa fosforom.

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ Brown, H.C., et al., in Baude, E.A. and Nachod, F.C., Determination of Organic Structures by Physical Methods, Academic Press, New York, 1955.
↑ Clayden Jonathan, Nick Greeves, Stuart Warren, Peter Wothers (2001). Organic chemistry. Oxford, Oxfordshire: Oxford University Press. ISBN 0-19-850346-6.

Literatura

Synthesis of acridone in Organic Syntheses 19:6; Coll. Vol. 2:15 [1] from o-chlorobenzoic acid and aniline in a Goldberg reaction.
Synthesis of 9-aminoacridine in Organic Syntheses 22:5; Coll. Vol. 3:53. [2] from N-phenylanthranilic acid.

Spoljašnje veze

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[5] Brown, H.C., et al., in Baude, E.A. and Nachod, F.C., Determination of Organic Structures by Physical Methods, Academic Press, New York, 1955.

[6] Clayden Jonathan, Nick Greeves, Stuart Warren, Peter Wothers (2001). Organic chemistry. Oxford, Oxfordshire: Oxford University Press. ISBN 0-19-850346-6.

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