SB-258,585

SB-258,585
(IUPAC) ime
	4-Jodo-N-[4-metoksi-3-(4-metil-1-piperazinil)fenil]benzensulfonamid
Klinički podaci
Identifikatori
CAS broj	209480-63-7
ATC kod	nije dodeljen
PubChem	3248571
ChEMBL	CHEMBL60264
Hemijski podaci
Formula	C18H22IN3O3S
Mol. masa	487,354 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C18H22IN3O3S/c1-21-9-11-22(12-10-21)17-13-15(5-8-18(17)25-2)20-26(23,24)16-6-3-14(19)4-7-16/h3-8,13,20H,9-12H2,1-2H3 ; Key: BDHMSYNBSBZCAF-UHFFFAOYSA-N
Farmakoinformacioni podaci
Trudnoća	?
Pravni status

SB-258,585 je lek koji se koristi u naučnim istraživanjima. On deluje kao potentan, selektivan i oralno aktivan antagonist 5-HT₆ receptora, sa Ki od 8,9 nM.^[4] On se koristi u obliku ¹²⁵I radio obeleženoj formi za maporamke distribucije 5-HT₆ receptora u mozgu.^[5]^[6]

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ Hirst, WD; Minton, JA; Bromidge, SM; Moss, SF; Latter, AJ; Riley, G; Routledge, C; Middlemiss, DN i dr.. (2000). „Characterization of 125I-SB-258585 binding to human recombinant and native 5-HT6 receptors in rat, pig and human brain tissue”. British Journal of Pharmacology 130 (7): 1597–605. DOI:10.1038/sj.bjp.0703458. PMC 1572217. PMID 10928963.
↑ Roberts, JC; Reavill, C; East, SZ; Harrison, PJ; Patel, S; Routledge, C; Leslie, RA (2002). „The distribution of 5-HT(6) receptors in rat brain: an autoradiographic binding study using the radiolabelled 5-HT(6) receptor antagonist (125)ISB-258585”. Brain Research 934 (1): 49–57. DOI:10.1016/S0006-8993(02)02360-0. PMID 11937069.
↑ East, SZ; Burnet, PW; Leslie, RA; Roberts, JC; Harrison, PJ (2002). „5-HT6 receptor binding sites in schizophrenia and following antipsychotic drug administration: autoradiographic studies with 125ISB-258585”. Synapse 45 (3): 191–9. DOI:10.1002/syn.10097. PMID 12112397.

Spoljašnje veze

	Portal Medicina
	Portal Hemija

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[4] Hirst, WD; Minton, JA; Bromidge, SM; Moss, SF; Latter, AJ; Riley, G; Routledge, C; Middlemiss, DN i dr.. (2000). „Characterization of 125I-SB-258585 binding to human recombinant and native 5-HT6 receptors in rat, pig and human brain tissue”. British Journal of Pharmacology 130 (7): 1597–605. DOI:10.1038/sj.bjp.0703458. PMC 1572217. PMID 10928963.

[5] Roberts, JC; Reavill, C; East, SZ; Harrison, PJ; Patel, S; Routledge, C; Leslie, RA (2002). „The distribution of 5-HT(6) receptors in rat brain: an autoradiographic binding study using the radiolabelled 5-HT(6) receptor antagonist (125)ISB-258585”. Brain Research 934 (1): 49–57. DOI:10.1016/S0006-8993(02)02360-0. PMID 11937069.

[6] East, SZ; Burnet, PW; Leslie, RA; Roberts, JC; Harrison, PJ (2002). „5-HT6 receptor binding sites in schizophrenia and following antipsychotic drug administration: autoradiographic studies with 125ISB-258585”. Synapse 45 (3): 191–9. DOI:10.1002/syn.10097. PMID 12112397.

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