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This research reports on the robotic fabrication for the complex architectural geometries of three intersecting domes. The project explores systems for modules through a tessellated skin (a) of hexagonal tile modules that produce a macro... more
This research reports on the robotic fabrication for the complex architectural geometries of three intersecting domes. The project explores systems for modules through a tessellated skin (a) of hexagonal tile modules that produce a macro geometry for a doubly curved, non-developable surface; and the smooth micro geometry of an interpolating structural rib (b) that requires a customised manufacturing of modules and their integrated joints (c). It outlines the computational workflow between geometrical conditions, structural requirements, toolpath development, and fabrication process. The research concludes with a discussion of a new module and joint hybrid informed by stereotomic and timber joint techniques, which takes advantage of the six axis robotic fabrication for a standardized multiple face joint between modules of varying sizes that enables a form and force fitting connection.
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In the context of acoustic performance in architecture, this paper presents research into the computational design and robotic fabrication of surfaces with micro-geometries that can change the acoustic response of space. It explores the... more
In the context of acoustic performance in architecture, this paper presents research into the computational design and robotic fabrication of surfaces with micro-geometries that can change the acoustic response of space. It explores the design affordances for acoustically efficient patterns for sound scattering - between complex geometries, acoustical effects, and robotic fabrication. Spline curves pose a problem for the translation between geometry and material fabrication, specifically when a series of tests is required with a high degree of detail. Whereas 3D printed samples are impractically small, and CNC fabrication is limited by tool path axis, robotic fabrication enables precision for 1:10 scale model prototypes such as the quick sampling of sound discs that can be used to analyze acoustic scattering. Through a process of reverse engineering from parametric modeling to scale model production to physical simulation, the acoustic reflective properties of surface patterns are investigated for scattering coefficients, in order to derive statistical data on acoustic properties of these surfaces, and to deduce design rules.
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Complex curved surfaces posit challenges for manufacturing, but become more available through the range of toolpaths that come with 6-axis robotic fabrication. In this chapter, we present an in-progress report that explores the way in... more
Complex curved surfaces posit challenges for manufacturing, but become more available through the range of toolpaths that come with 6-axis robotic fabrication. In this chapter, we present an in-progress report that explores the way in which an industrial 6-axis robot can become an interdisciplinary research tool that produces space that is both immediate and responsive. We link a robotic code directly to acoustic equations, so that in a reverse engineering process, kuka|prc and robot reachability give boundary conditions for the consecutive design process. The chapter discusses a framework in which the robot is first used as subtractive manufacturing device for cutting an acoustically performative space, and indicates future research into the potential of a robotic assessment of complex geometries and the resulting acoustic performance. Through integration of acoustic behaviour and robotic fabrication parameters, the production of a space with three distinct ‘sound colorations’ becomes possible. Furthermore, future research is outlined whereby the robot acts as both hand and head: shaping an environment as both input and output device.
Research Interests: Robotics, Computer Architecture, High Performance Computing, Acoustics, Architecture, and 12 moreDigital Fabrication, Performativity, Soundscape Studies, Sound studies, Digital Architecture, Architectural Theory, Sound Design, Computational Design, ROBOT, Human Robot Interaction, Sound Studies, and Robotic Fabrication
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This essay discusses SmartStructuresLab2014, a postgraduate studio that approached the engineering of architecture in process. Relationships between form, force and structure are explored here as a dialogue between analogue design models,... more
This essay discusses SmartStructuresLab2014, a postgraduate studio that approached the engineering of architecture in process. Relationships between form, force and structure are explored here as a dialogue between analogue design models, computational design series, and engineered structural analysis and optimisations; through digital fabrication of 1:1 plywood prototypes, 1:20 skeleton structures and 3D printed form studies. SmartStructuresLab2014 reviewed engineering precedent of self-formation and rule-based designs, and extended these in a process of design iteration, structural behavior review and material affordances. This involved the full integration and seamless transition between 3D modelling (Rhino/McNeel Rhinoceros), parametric design (Grasshopper) and structural analysis (karamba) environments. Thus, a descriptive language of complex curved surfaces becomes available that combines parameterized geometry, finite element calculations and optimization algorithms in rule b...
This essay discusses SmartStructuresLab2014, a postgraduate studio that approached the engineering of architecture in process. Relationships between form, force and structure are explored here as a dialogue between analogue design models,... more
This essay discusses SmartStructuresLab2014, a postgraduate studio that approached the engineering of architecture in process. Relationships between form, force and structure are explored here as a dialogue between analogue design models, computational design series, and engineered structural analysis and optimisations; through digital fabrication of 1:1 plywood prototypes, 1:20 skeleton structures and 3D printed form studies. SmartStructuresLab2014 reviewed engineering precedent of self-formation and rule-based designs, and extended these in a process of design iteration, structural behavior review and material affordances. This involved the full integration and seamless transition between 3D modelling (Rhino/McNeel Rhinoceros), parametric design (Grasshopper) and structural analysis (karamba) environments. Thus, a descriptive language of complex curved surfaces becomes available that combines parameterized geometry, finite element calculations and optimization algorithms in rule b...
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The phase transition and nano-scale ordered structure of four types of blends prepared from four di-block copolymers, consisting of hydrophilic poly(ethylenoxide) and hydrophobic poly(methacrylate) derivative, PEOm-b-PMA(Az)n having... more
The phase transition and nano-scale ordered structure of four types of blends prepared from four di-block copolymers, consisting of hydrophilic poly(ethylenoxide) and hydrophobic poly(methacrylate) derivative, PEOm-b-PMA(Az)n having different PEO molecular length and same degree of polymerization of PMA(Az) were investigated. All blend systems formed hexagonal packed PEO cylinder structure, which was same with the nano-scale structure of these parent block copolymers. The SAXS and AFM observation suggested that the size of hexagonal structure of blend was larger than the average size of parent block copolymers. The melting enthalpy of PEO in blends was larger than the average value of parent block copolymers. DSC, SAXS and AFM observations indicated the miscible blend systems.
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ABSTRACT ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select... more
ABSTRACT ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
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High titer retroviral vector supernatant, produced in compliance with GMP, has always been a prerequisite for gene therapy purposes in clinical trials. But most vector production procedures have their limitations: the vector often leads... more
High titer retroviral vector supernatant, produced in compliance with GMP, has always been a prerequisite for gene therapy purposes in clinical trials. But most vector production procedures have their limitations: the vector often leads only to low titer supernatant, only a few harvest cycles can be done and harvest volumes are often small.In an effort to prepare for later phase
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We examined the relationship between denial/minimization and treatment perceptions using multiple measures of each construct in a sample of 185 adult male sex offenders. Denial/minimization was measured with the Comprehensive Inventory of... more
We examined the relationship between denial/minimization and treatment perceptions using multiple measures of each construct in a sample of 185 adult male sex offenders. Denial/minimization was measured with the Comprehensive Inventory of Denial—Sex Offender version (CID-SO), Sex Offender Acceptance of Responsibility Scales (SOARS), and an item from a risk assessment measure (Sexual Violence Risk-20; SVR-20). Treatment perceptions were measured with
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Enhanced proliferation of vascular smooth muscle cells (VSMCs) is one of the key features of the pathogenesis of atherosclerosis. The helix-loop-helix protein Inhibitor of DNA binding 3 (Id3) contributes to regulation of VSMC... more
Enhanced proliferation of vascular smooth muscle cells (VSMCs) is one of the key features of the pathogenesis of atherosclerosis. The helix-loop-helix protein Inhibitor of DNA binding 3 (Id3) contributes to regulation of VSMC proliferation in a redox-sensitive manner. We investigated the role of Id3 and its interaction with other redox-sensitive genes, the transcription factor Gut-enriched Krüppel-like factor (GKLF, KLF4) and the tumor suppressor gene p53 in the regulation of VSMC proliferation. Cultured rat aortic VSMCs were transfected with Id3 sense and antisense constructs. Overexpression of Id3 significantly enhanced VSMC proliferation. Id3 antisense transfection inhibited VSMC proliferation induced by the physiological stimuli insulin and platelet-derived growth factor (PDGF). Because p53 is essential for the regulation of proliferation processes, the effect of Id3 on p53 expression was investigated. Id3 overexpression led to decreased p53 protein expression. Co-transfection of p53 sense constructs inhibited the enhanced VSMC mitogenicity induced by Id3 sense transfection. GKLF overexpression, which causes growth arrest in VSMCs, reduced Id3 promoter activity and led to decreased Id3 expression. Id3-induced VSMC proliferation was abolished by GKLF sense co-transfection. Finally, strong Id3 expression was found in the neointima of human coronary artery atherosclerotic plaques but not in healthy coronary arteries. These findings reveal a relevant interaction of GKLF, Id3, and p53 for VSMC proliferation which might constitute a general mechanism of growth control in vascular cells.
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ABSTRACT In this work we demonstrate that the use of striated tapes from coated conductors (CCs) significantly reduces the dissipation of a cable made of tapes wound helically on a round core when it is exposed to AC magnetic field. The... more
ABSTRACT In this work we demonstrate that the use of striated tapes from coated conductors (CCs) significantly reduces the dissipation of a cable made of tapes wound helically on a round core when it is exposed to AC magnetic field. The coupling loss can vanish provided that the striations ensure electrical insulation between filaments and the cable length corresponds to an entire number of lay pitches. In our study we compare the magnetization loss in two cable models exposed to magnetic field perpendicular to their longitudinal axis. The overall geometry of the models was identical: each consisted of three tapes 4 mm wide that were placed with a pitch of 50 mm in a single layer on the 8 mm diameter round core. The cable length was designed to reach two complete tape pitches. In the first cable (the reference cable) tapes without striation were used; the second cable was prepared using similar tapes but striated to five filaments by laser processing. The AC loss was measured for cables without terminations as well as with low resistance terminations; this latter configuration simulates the conditions in a magnet winding. Our experiments have clearly shown the loss behavior expected in the regime of uncoupled filaments. In particular, at AC fields of 0.1 T amplitude the loss in the cable from striated tapes is five times lower than in the reference cable. Numerical models have explained the experimentally observed cable behavior in the whole range of AC fields.
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Enhanced proliferation of vascular smooth muscle cells (VSMCs) is one of the key features of the pathogenesis of atherosclerosis. The helix-loop-helix protein Inhibitor of DNA binding 3 (Id3) contributes to regulation of VSMC... more
Enhanced proliferation of vascular smooth muscle cells (VSMCs) is one of the key features of the pathogenesis of atherosclerosis. The helix-loop-helix protein Inhibitor of DNA binding 3 (Id3) contributes to regulation of VSMC proliferation in a redox-sensitive manner. We investigated the role of Id3 and its interaction with other redox-sensitive genes, the transcription factor Gut-enriched Krüppel-like factor (GKLF, KLF4) and the tumor suppressor gene p53 in the regulation of VSMC proliferation. Cultured rat aortic VSMCs were transfected with Id3 sense and antisense constructs. Overexpression of Id3 significantly enhanced VSMC proliferation. Id3 antisense transfection inhibited VSMC proliferation induced by the physiological stimuli insulin and platelet-derived growth factor (PDGF). Because p53 is essential for the regulation of proliferation processes, the effect of Id3 on p53 expression was investigated. Id3 overexpression led to decreased p53 protein expression. Co-transfection of p53 sense constructs inhibited the enhanced VSMC mitogenicity induced by Id3 sense transfection. GKLF overexpression, which causes growth arrest in VSMCs, reduced Id3 promoter activity and led to decreased Id3 expression. Id3-induced VSMC proliferation was abolished by GKLF sense co-transfection. Finally, strong Id3 expression was found in the neointima of human coronary artery atherosclerotic plaques but not in healthy coronary arteries. These findings reveal a relevant interaction of GKLF, Id3, and p53 for VSMC proliferation which might constitute a general mechanism of growth control in vascular cells.