Tae-Ju Oh
University of Michigan, Periodontics and Oral Medicine, Faculty Member
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Consistency in clinical decision making may be necessary for reliable assessment of student performance and teaching effectiveness, yet little has been done to examine variation in periodontal diagnosis and treatment planning among dental... more
Consistency in clinical decision making may be necessary for reliable assessment of student performance and teaching effectiveness, yet little has been done to examine variation in periodontal diagnosis and treatment planning among dental school faculty. The purpose of this investigation was to examine variation among faculty in diagnosis and management of common periodontal diseases. Twenty‐seven clinical instructors (periodontists, general dentists, dental hygienists, and first‐ and second‐year periodontal graduate students) reviewed three web‐based cases and answered a brief questionnaire focusing on radiographic interpretation, periodontal diagnosis, and treatment planning. Response rates for the three cases ranged from 62 percent to 70 percent. Clinical instructors’ rating of percent bone loss in the majority of cases varied between three descriptive categories for the same tooth. Greater consistency in periodontal diagnosis was noted within the graduate student group as compar...
Research Interests: Health Sciences, Dentistry, Educational Technology, Educational Research, Faculty Development, and 15 moreMedicine, Dental Education, Clinical Decision Making, Humans, Case Study, Diagnosis, Graduate Student, Dental, Adult, Curriculum and Pedagogy, Bone Loss, Clinical Competence, Consensus Building, Gingivitis, and Dental Scaling
The current objective was to evaluate six groups of titanium membranes in a rat calvarial defect model, regarding the surface treatment with or without calcium-phosphate coating and surface topography with no, small, or large holes.... more
The current objective was to evaluate six groups of titanium membranes in a rat calvarial defect model, regarding the surface treatment with or without calcium-phosphate coating and surface topography with no, small, or large holes. Critical size defects (Ф = 8 mm, n = 42) were surgically created in rat calvaria, and then were treated by one of the six groups. Biopsies were obtained at 4 weeks (n = 5 per group) for micro-computed tomography and histomorphometric analyses. Fluorochrome bone markers were injected in two rats each group at 1 (Alizarin red), 3 (Calcein green) and 5 weeks (Oxytetracyclin yellow), followed by histological examination at 7 weeks to assess bone regeneration dynamic. At 4 weeks, the highest bone volume was observed in no-hole groups independent of surface treatment ( p < 0.05). Treated groups with no-hole and large-hole membranes showed increased bone mineral density than with respective non-treated groups ( p < 0.05). Histology exhibited an intimate b...
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Because osseointegration is now considered highly predictable, the current trend is to develop techniques that can provide function, esthetics, and comfort with a minimally invasive surgical approach. To achieve those goals, flapless... more
Because osseointegration is now considered highly predictable, the current trend is to develop techniques that can provide function, esthetics, and comfort with a minimally invasive surgical approach. To achieve those goals, flapless implant surgery using a tissue punch technique has been suggested. This paper presents two clinical cases of single-tooth implants placed in the esthetic region (anterior maxilla), which illustrate systematic approaches to flapless implant surgery for immediate and delayed loading protocol. For both cases, a tissue punch technique using a surgical guide fabricated with the aid of a radiographic stent was performed to provide access for implant site preparation and placement. The implants were loaded either immediately or 4 months after implant placement. With the planned flapless surgical technique, reduced operative time, accelerated postsurgical healing, and increased patient comfort and satisfaction were achieved. This paper also describes precaution...
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This study investigated the impact of implant support on the development of shear force and bending moment in mandibular free-end base removable partial dentures (RPDs). Three theoretical test models of unilateral mandibular free-end base... more
This study investigated the impact of implant support on the development of shear force and bending moment in mandibular free-end base removable partial dentures (RPDs). Three theoretical test models of unilateral mandibular free-end base RPDs were constructed to represent the base of tooth replacement, as follows: Model 1: first and second molars (M1 and M2); Model 2: second premolar (P2), M1, and M2; and Model 3: first premolar (P1), P2, M1, and M2. The implant support located either at M1 or M2 sites. The occlusal loading was concentrated at each replacement tooth to calculate the stress resultants developed in the RPD models using the free-body diagrams of shear force and bending moment. There was a trend of reduction in the peak shear force and bending moment when the base was supported by implant. However, the degree of reduction varied with the location of implant support. The moment reduced by 76% in Model 1, 58% in Model 2, and 42% in Model 3, when the implant location shifted from M1 to M2 sites. The shear forces and bending moments subjected to mandibular free-end base RPDs were found to decrease with the addition of implant support. However, the impact of implant support varied with the location of implant in this theoretical study.
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BackgroundThe aim was to evaluate the effects of recombinant human platelet‐derived growth factor‐BB (rhPDGF‐BB) and recombinant human fibroblast growth factor‐2 (rhFGF‐2) on treating periodontal intra‐bony defects, compared to the... more
BackgroundThe aim was to evaluate the effects of recombinant human platelet‐derived growth factor‐BB (rhPDGF‐BB) and recombinant human fibroblast growth factor‐2 (rhFGF‐2) on treating periodontal intra‐bony defects, compared to the control (carrier alone).MethodsElectronic and hand searches were performed to identify eligible studies. The weighed mean differences of linear defect fill (LDF), probing depth (PD) reduction, clinical attachment level (CAL) gain and gingival recession (GR) were calculated using random effect meta‐analysis.ResultsThe searches yielded 1018 articles, of which seven studies were included. Only one included study was considered at low risk of bias. The outcomes that reached statistical significance in comparison to carriers alone included: LDF (0.95 mm, 95% CI: 0.62–1.28 mm or 20.17%, 95% CI: 11.81–28.54%) and CAL gain (0.34 mm, 95% CI: 0.03–0.65 mm) for PDGF, and LDF (21.22%, 95% CI: 5.82–36.61%) for FGF‐2.ConclusionsWithin the limits of this review, rhPDGF‐...
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This study investigated the effects of anodization-cyclic precalcification-heat (APH) treatment on the bonding ability of Ca-P coating to the parent metal and osseointegration of Ti-6Al-7Nb implants. Eighteen Ti-6Al-7Nb discs, 9 untreated... more
This study investigated the effects of anodization-cyclic precalcification-heat (APH) treatment on the bonding ability of Ca-P coating to the parent metal and osseointegration of Ti-6Al-7Nb implants. Eighteen Ti-6Al-7Nb discs, 9 untreated and 9 APH-treated, were cultured with osteoblast cells in vitro, and the cellular differentiation ability was assayed at 1, 2, and 3 weeks. For in vivo testing, 28 Ti-6Al-7Nb implants (14 implants of each group) were inserted to rat tibias, and after each 4 and 6 weeks of implantation, bone bonding, and osseointegration were evaluated through removal torque and histological analysis. Osteoblast-culturing showed twice as much of the alkaline phosphatase activity on the treated surface at 3 weeks than on the untreated surface (p < 0.05). The treated implants exhibited higher removal torque values than the untreated ones (15.5 vs. 1.8 Ncm at 4 weeks and 19.7 vs. 2.6 Ncm at 6 weeks, p < 0.05). Moreover, the excellent bonding quality of coats was ...
Research Interests: Engineering, Materials Science, Health Sciences, Biomedical Engineering, Osseointegration, and 15 moreMaterials Science and Engineering, Dental Implants, Medicine, Animals, Male, Osteoblast, Delamination, Alkaline phosphatase, In Vivo, Implant, Oxides, Osteoblasts, Materials Testing, Dental Alloys, and Postoperative Period
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This article presents an innovative method for the fabrication of implant drill guides for partially edentulous patients. Using a light-polymerized composite material and drill blanks placed in the prosthodontically driven implant... more
This article presents an innovative method for the fabrication of implant drill guides for partially edentulous patients. Using a light-polymerized composite material and drill blanks placed in the prosthodontically driven implant position, surgical guides for each implant drill are constructed on the diagnostic cast. In addition to the size-customized implant surgical guides, a ridge crest preparation guide showing the proposed crown contour is used to adjust the tissue contour, if needed, during implant surgery.
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Background: Enamel matrix derivative (EMD) has been shown to promote periodontal wound healing and/or regeneration when applied to tooth root surfaces in soft tissue dehiscence models. In addition, guided tissue regeneration (GTR)‐based... more
Background: Enamel matrix derivative (EMD) has been shown to promote periodontal wound healing and/or regeneration when applied to tooth root surfaces in soft tissue dehiscence models. In addition, guided tissue regeneration (GTR)‐based root coverage using collagen membrane (GTRC) has shown promising results. However, limited information is available regarding how EMD may influence GTRC outcome.Methods: Twenty‐six patients with Miller's Class I or II gingival recession defects of 2.5 mm were recruited for the study. Subjects were randomly assigned to receive either EMD + collagen (EMDC; test group) or collagen membrane (GTRC; control group). Clinical parameters, including plaque index (PI), gingival index (GI), relative clinical attachment levels (RCAL) to the stent, recession depth (RD), recession width (RW), probing depth (PD), gingival tissue thickness (GTT), and width of keratinized gingiva (KG) were assessed at baseline, and 3 and 6 months after surgery. A repeated measure ...
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Background: Although several potential etiologic factors associated with retrograde peri‐implantitis (RPI) and potential treatment options have been discussed in the literature, the etiology has not been fully investigated and the... more
Background: Although several potential etiologic factors associated with retrograde peri‐implantitis (RPI) and potential treatment options have been discussed in the literature, the etiology has not been fully investigated and the definitive management methods remain undefined. We propose a decision‐making protocol for the treatment of RPI and provide new insight into the etiology of this process based on the findings from two clinical cases.Methods: The medical and dental histories of two patients who developed RPI were thoroughly reviewed. Both patients were treated according to the treatment guidelines proposed in this manuscript. Fluid from the lesions was collected to examine the presence of 11 bacterial species by molecular‐based microbial testing. Biopsies were also obtained for histopathologic examination.Results: Patient 1, previously diagnosed with human immunodeficiency virus infection, developed RPI 3 months after implant placement. Histopathologic examination revealed a...
Research Interests: Health Sciences, Dentistry, Macrophages, Dental Implants, Biopsy, and 15 moreDecision Trees, Humans, Female, Male, Bacteria, Connective tissue, Etiology, Immunocompromised host, Chlorhexidine, Eikenella corrodens, Bacterial infections, Lymphocytes, Clinical Protocols, Bone Transplantation, and HIV infections
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Background: Periodontal diseases are among the most frequent diseases affecting children and adolescents. These include gingivitis, localized or generalized aggressive periodontitis (a.k.a., early onset periodontitis which includes... more
Background: Periodontal diseases are among the most frequent diseases affecting children and adolescents. These include gingivitis, localized or generalized aggressive periodontitis (a.k.a., early onset periodontitis which includes generalized or localized prepubertal periodontitis and juvenile periodontitis) and periodontal diseases associated with systemic disorders. The best approach to managing periodontal diseases is prevention, followed by early detection and treatment.Methods: This paper reviews the current literature concerning the most common periodontal diseases affecting children: chronic gingivitis (or dental plaque‐induced gingival diseases) and early onset periodontitis (or aggressive periodontitis), including prepubertal and juvenile periodontitis. In addition, systemic diseases that affect the periodontium and oral lesions commonly found in young children are addressed. The prevalence, diagnostic characteristics, microbiology, host‐related factors, and therapeutic ma...
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Research Interests: Microbiology, Health Sciences, Dentistry, Biomedical Engineering, Biofilms, and 15 moreBiomarkers, Dental Implants, Medicine, Humans, Diabetes mellitus, Female, Male, Aged, Middle Aged, Longitudinal Studies, Biomarker, Implant, Dental Implant, Enzyme Linked Immunosorbent Assay, and Alveolar bone loss
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BackgroundThe crestal bone level and soft tissue dimension are essential for periodontal diagnosis and phenotype determination; yet, existing measurement methods have limitations. The aim of this clinical study was to evaluate the... more
BackgroundThe crestal bone level and soft tissue dimension are essential for periodontal diagnosis and phenotype determination; yet, existing measurement methods have limitations. The aim of this clinical study was to evaluate the correlation and accuracy of ultrasound in measuring periodontal dimensions, compared to direct clinical and cone‐beam computed tomography (CBCT) methods.MethodsA 24‐MHz ultrasound probe prototype, specifically designed for intraoral use, was employed. Periodontal soft tissue dimensions and crestal bone levels were measured at 40 teeth and 20 single missing tooth gaps from 20 patients scheduled to receive a dental implant surgery. The ultrasound images were interpreted by two calibrated examiners. Inter‐rater agreement was calculated by using inter‐rater correlation coefficient (ICC). Ultrasound readings were compared with direct clinical and CBCT readings by using ICC and Bland‐Altman analysis.ResultsThe following six parameters were measured: 1) interdent...
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ABSTRACT Background: Oral tissue engineered constructs have become an emerging treatment approach in periodontal regenerative medicine. The use of intra-oral soft tissue engineered products has demonstrated satisfactory results with less... more
ABSTRACT Background: Oral tissue engineered constructs have become an emerging treatment approach in periodontal regenerative medicine. The use of intra-oral soft tissue engineered products has demonstrated satisfactory results with less morbidity of surgical procedures. However, little is known about the mechanism of action during wound healing in cellularized tissue based approaches. Objective: The aim of this study was to investigate the role and significance of angiogenic biomarkers in wound healing of soft tissue regeneration procedures comparing living cellular construct (LCC) to autogenous free gingival grafts (FGG). Methods: Subjects with an insufficient zone of attached gingiva (≤ 1mm) were included in this study. Following informed consent, each subject was randomly assigned with either one test (LCC) or control (FGG) site. Wound fluid samples were collected at day 0 and weeks-1, -2, -3, and -4 postoperatively. The samples were analyzed using protein microarrays for the following angiogenic biomarkers: angiogenin (ANG), angiostatin (ANT), PDGF-BB, VEGF, FGF-2, IL-8, TIMP-1, TIMP-2, GM-CSF, and IP-10. Results: Forty-four subjects completed the study. Results demonstrated an increased expression of angiogenic biomarkers for the LCC group compared to the FGG group at all timepoints. A significant increase in expression of TIMP-2 and ANT was noticed for the LCC group over the FGG group at week 1 (p &lt; 0.05). In addition, levels of ANG, VEGF, IL-8, and TIMP-1 were highly expressed for the LCC group over the FGG group at 2 weeks (p &lt; 0.05). Conclusion: This human investigation provides early evidence of the angiogenic biomarker profile of LCC and FGG in soft tissue regeneration of oral mucosal defects. The results of this study demonstrate that LCC modulates the wound healing process by the stimulation of angiogenic-related biomarkers, which may have a positive impact on the regeneration of intra-oral soft tissues. Funded by NIH/NCRR UL1RR024986 and Organogenesis, Inc.
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Research Interests: Health Sciences, Dentistry, Prosthodontics, Rehabilitation, Cancer, and 15 moreRadiation Therapy, Dental Implants, Medicine, Humans, Head and Neck Cancer, Dentures, Mouth Diseases, Irradiation, Osteoradionecrosis, Radiation Injuries, Jaw Diseases, Risk Factors, Dental Implant, Oral Rehabilitation, and Head and neck neoplasms
Research Interests: Dentistry, Biomedical Engineering, Dental Implants, Medicine, Humans, and 15 moreProsthetic Dentistry, Mandible, Maxilla, Risk factors, Aged, Middle Aged, Gingiva, Adult, Implant, Dental Prosthesis Design, Retrospective Studies, Dental Plaque Index, Risk Factors, Alveolar bone loss, and Periodontal Pocket
Background: The purpose of this study is to assess the influence of the placement level of implants with a laser‐microtextured collar design on the outcomes of crestal bone and soft tissue levels. In addition, we assessed the vertical and... more
Background: The purpose of this study is to assess the influence of the placement level of implants with a laser‐microtextured collar design on the outcomes of crestal bone and soft tissue levels. In addition, we assessed the vertical and horizontal defect fill and identified factors that influenced clinical outcomes of immediate implant placement.Methods: Twenty‐four patients, each with a hopeless tooth (anterior or premolar region), were recruited to receive dental implants. Patients were randomly assigned to have the implant placed at the palatal crest or 1 mm subcrestally. Clinical parameters including the keratinized gingival (KG) width, KG thickness, horizontal defect depth (HDD), facial and interproximal marginal bone levels (MBLs), facial threads exposed, tissue–implant horizontal distance, gingival index (GI), and plaque index (PI) were assessed at baseline and 4 months after surgery. In addition, soft tissue profile measurements including the papilla index, papilla height ...
Research Interests: Health Sciences, Dentistry, Osseointegration, Treatment Outcome, Medicine, and 15 moreBone Regeneration, Periodontology, Humans, Female, Male, Middle Aged, Implant, Premolar, Analysis of Variance, Survival Rate, Dental Prosthesis Design, Tooth Extraction, Soft Tissue, Pilot Projects, and periodontium
Background: The need for keratinized mucosa (KM) or immobile keratinized mucosa (i.e., attached mucosa [AM]) for the maintenance of osseointegrated endosseous dental implants has been controversial. The purpose of this study was to... more
Background: The need for keratinized mucosa (KM) or immobile keratinized mucosa (i.e., attached mucosa [AM]) for the maintenance of osseointegrated endosseous dental implants has been controversial. The purpose of this study was to investigate the significance of KM in the maintenance of root‐form dental implants with different surfaces.Methods: A total of 339 endosseous dental implants in place for at least 3 years in 69 patients were evaluated. The width of KM and AM, modified plaque index (mPI), gingival index (GI), modified bleeding index (mBI), probing depth (PD), and average annual bone loss (ABL) were measured clinically and radiographically by a masked examiner. Based on the amounts of KM or AM, implants were categorized as follows: 1) KM <2 mm (KL); 2) KM ≥2 mm (KU); 3) AM <1 mm (AL); and 4) AM ≥1 mm (AU). Implants were further subdivided into the following four subgroups based on their surface configurations: 1) smooth surface implants (SI) with KM <2 mm (SKL); 2)...
Research Interests: Health Sciences, Dentistry, Dental Implants, Humans, Maintenance, and 15 moreFemale, Male, Aged, Adult, Implant, Analysis of Variance, Dental Plaque, Dental Plaque Index, Dental Implant, Cross Sectional Studies, Gingivitis, Keratins, Alveolar bone loss, Bleeding on probing, and Dental restoration failure
The success of dental implants is highly dependent on integration between the implant and intraoral hard/soft tissue. Initial breakdown of the implant‐tissue interface generally begins at the crestal region in successfully osseointegrated... more
The success of dental implants is highly dependent on integration between the implant and intraoral hard/soft tissue. Initial breakdown of the implant‐tissue interface generally begins at the crestal region in successfully osseointegrated endosteal implants, regardless of surgical approaches (submerged or nonsubmerged). Early crestal bone loss is often observed after the first year of function, followed by minimal bone loss (≤0.2 mm) annually thereafter. Six plausible etiologic factors are hypothesized, including surgical trauma, occlusal overload, peri‐implantitis, microgap, biologic width, and implant crest module. It is the purpose of this article to review and discuss each factor. Based upon currently available literature, the reformation of biologic width around dental implants, microgap if placed at or below the bone crest, occlusal overload, and implant crest module may be the most likely causes of early implant bone loss. Furthermore, it is important to note that other contr...
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Background: Recent investigations reported that osseointegration of titanium implants can be significantly reinforced with a nanostructure treated with anodic oxidation and heat treatment. This experimental study investigates the effect... more
Background: Recent investigations reported that osseointegration of titanium implants can be significantly reinforced with a nanostructure treated with anodic oxidation and heat treatment. This experimental study investigates the effect of bisphosphonates on the nanotubular implant surface in rats.Methods: Thirty‐six titanium implants were divided into three groups: 1) machine‐turned (MT), 2) anodized and heat‐treated (AH), and 3) anodized and heat‐ and bisphosphonate‐treated (AHB) groups. The 36 implants were randomly placed in both tibias of 18 male Wistar rats. After 2 and 4 weeks, the levels of osseointegration of the implants were evaluated by a removal torque test and microcomputerized tomography (μCT). Peri‐implant bone tissue on the extracted region was examined for the expression of type I collagen and osteocalcin.Results: The AHB group showed the highest removal torque at 2 and 4 weeks (13.92 ± 1.51 Ncm and 18.10 ± 2.15 Ncm, respectively) followed, in order, by the AH grou...
Research Interests: Chemistry, Health Sciences, Dentistry, Osseointegration, Dental Materials, and 15 moreDental Implants, Medicine, Periodontology, Animals, Male, Nanotubes, Osteocalcin, Implant, Dental Prosthesis Design, Osteogenesis, Bisphosphonates, Biocompatible Materials, Anodizing, Random Allocation, and Collagen type I
Background: The clinical outcomes of implants placed using the flapless approach have not yet been systematically investigated. Hence, the present systematic review and meta‐analysis aims to study the effect of the flapless technique on... more
Background: The clinical outcomes of implants placed using the flapless approach have not yet been systematically investigated. Hence, the present systematic review and meta‐analysis aims to study the effect of the flapless technique on implant survival rates (SRs) and marginal bone levels (MBLs) compared with the conventional flap approach.Methods: An electronic search of five databases (from 1990 to March 2013), including PubMed, Ovid (MEDLINE), EMBASE, Web of Science, and Cochrane Central, and a hand search of peer‐reviewed journals for relevant articles were performed. Human clinical trials with data on comparison of SR and changes in MBL between the flapless and conventional flap procedures, with at least five implants in each study group and a follow‐up period of at least 6 months, were included.Results: Twelve studies, including seven randomized controlled trials (RCTs), one cohort study, one pilot study, and three retrospective case‐controlled trials (CCTs), were included. T...
Research Interests: Health Sciences, Dentistry, Research Design, Survival Analysis, Treatment Outcome, and 14 moreDental Implants, Medicine, Periodontology, Review, Humans, Medline, Meta Analysis, Gingiva, Randomized Controlled Trial, Bias (Epidemiology), Gingival Recession, Confidence Interval, Alveolar bone loss, and Surgical Flaps
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Background: Factors influencing treatment outcomes in furcation defects remain to be studied. Therefore, the aim of the study was to evaluate the association between factors and clinical parameters that may influence treatment outcomes in... more
Background: Factors influencing treatment outcomes in furcation defects remain to be studied. Therefore, the aim of the study was to evaluate the association between factors and clinical parameters that may influence treatment outcomes in mandibular Class II furcation defects.Methods: Twenty‐seven systemically healthy subjects with a Class II buccal or lingual furcation defect in lower molars were treated. Clinical measurements (probing depth [PD], clinical attachment level [CAL], recession, mobility, plaque index [PI], and bleeding on probing [BOP]) and defect (vertical and horizontal defect depths) were obtained at initial and 6‐month reentry surgeries. Treatment modalities (e.g., nine each in the following three groups: open flap debridement [OFD] alone, bone graft [BG], and bone graft plus a bioabsorbable collagen membrane [BG + C]), anatomic factors (presence of cervical enamel projection, presence of cervical restorations/fixed prosthesis, and location of furcations [buccal or...
Research Interests: Health Sciences, Dentistry, Humans, Bone, Female, and 15 moreMale, Aged, Bone Marrow Transplantation, Adult, Analysis of Variance, Guided Tissue Regeneration, Debridement, Gingival Recession, Allograft, Logistic Models, Dental Scaling, Bone Transplantation, Alveolar bone loss, Bleeding on probing, and Furcation defects
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Background: Periodontitis is primarily a bacteria‐induced disease that can be modified by tooth‐related local factors. Cervical enamel projections (CEPs) are a common tooth anomaly that can act as contributing factors in the development... more
Background: Periodontitis is primarily a bacteria‐induced disease that can be modified by tooth‐related local factors. Cervical enamel projections (CEPs) are a common tooth anomaly that can act as contributing factors in the development of periodontitis. They are most commonly found at the buccal surfaces of mandibular molars.Methods: A 57‐year‐old female was referred to our clinic for treatment of chronic periodontitis. A clinical examination revealed moderate attachment loss that was localized to the palatal side of the maxillary second molars. The rest of the dentition was less affected, with a diagnosis of generalized slight chronic periodontitis. An initial non‐surgical periodontal treatment was provided followed by apically positioned flap surgery in the maxillary right and left posterior areas. At the time of surgery, CEPs were found where the periodontium was most affected.Results: Because surgical intervention exposed the CEPs, they were not removed. After the active therap...
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Research Interests: Health Sciences, Dentistry, Medicine, Bone Regeneration, Humans, and 15 moreCancellous bone, Female, Male, Mandible, Aged, Bone Marrow Transplantation, Adult, Analysis of Variance, Guided Tissue Regeneration, Debridement, Gingival Recession, Allograft, Dental Scaling, Bone Transplantation, and Furcation defects
Background: Guided tissue regeneration (GTR)‐based root coverage has been utilized to correct gingival recession defects with promising results. However, limited histologic information is available. Therefore, the aims of this study were... more
Background: Guided tissue regeneration (GTR)‐based root coverage has been utilized to correct gingival recession defects with promising results. However, limited histologic information is available. Therefore, the aims of this study were to clinically and histologically evaluate the efficacy of GTR‐based root coverage using collagen membrane (GTRC) and to compare the healing response to that of coronally advanced flaps (CAF).Methods: Standardized gingival recession defects were surgically created on the labial surfaces of the maxillary cuspids of 8 mongrel dogs. Plaque was allowed to accumulate for 8 weeks to develop a plaque‐infected recession defect. Full‐mouth scaling and root planing was then performed coincident with 4 weeks of oral hygiene. Defects were randomly assigned to receive either GTRC or CAF surgery. Four dogs each were sacrificed at 4 and 16 weeks post‐treatment. Clinical measurements included: percent root coverage, the amount of keratinized gingiva (KG), and probin...
Research Interests: Health Sciences, Dentistry, Regeneration, Membranes, Wound Healing, and 15 moreMedicine, Periodontology, Dogs, Collagen, Animals, Male, Connective tissue, Cementum, Guided Tissue Regeneration, Gingival Recession, Scaling and Root Planing, Comparison Studies, Random Allocation, periodontium, and Surgical Flaps
The use of intra-oral soft-tissue-engineered devices has demonstrated potential for oral mucosa regeneration. The aim of this study was to investigate the temporal expression of angiogenic biomarkers during wound healing of soft tissue... more
The use of intra-oral soft-tissue-engineered devices has demonstrated potential for oral mucosa regeneration. The aim of this study was to investigate the temporal expression of angiogenic biomarkers during wound healing of soft tissue reconstructive procedures comparing living cellular constructs (LCC) with autogenous free gingival grafts. Forty-four human participants bilaterally lacking sufficient zones of attached keratinized gingiva were randomly assigned to soft tissue surgery plus either LCC or autograft. Wound fluid samples were collected at baseline and weeks 1, 2, 3, and 4 post-operatively and analyzed for a panel of angiogenic biomarkers: angiogenin (ANG), angiostatin (ANT), PDGF-BB, VEGF, FGF-2, IL-8, TIMP-1, TIMP-2, GM-CSF, and IP-10. Results demonstrated a significant increase in expression of ANT, PDGF-BB, VEGF, FGF-2, and IL-8 for the LCC group over the autograft group at the early stages of wound repair. Although angiogenic biomarkers were modestly elevated for the ...