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Background and objectives: Laryngoscopy and orotracheal intubation are invasive procedures that can generate tachycardia, arterial hypertension and arrhythmias. This study compares the effects of esmolol, magnesium sulfate and placebo on... more
Background and objectives: Laryngoscopy and orotracheal intubation are invasive procedures that can generate tachycardia, arterial hypertension and arrhythmias. This study compares the effects of esmolol, magnesium sulfate and placebo on this potential hemodynamic response. Method: A randomized clinical trial, double-blind, that evaluated patients between 18 and 65 years old, ASA I or II, requiring general anesthesia and orotracheal intubation to undergo elective surgery. The subjects were divided into three groups, the E group received 1.5 mg/kg of esmolol intravenous (IV), the M group 30 mg/kg of magnesium sulfate IV and the C receiving none of the adjuvants prior to anesthetic induction. Values of blood pressure and heart rate (HR) were recorded in five times (T) related to drug administration and intubation. Results: A total of 45 participants were studied. Group E was the only one that maintained stable HR in relation to baseline at all times. Group M had the highest mean systo...
Introduction: Intradialytic hypotension (IDH) is a major complication of hemodialysis, with a prevalence of about 25% during hemodialysis sessions, causing increased morbidity and mortality. Objective: To study the effects of sertraline... more
Introduction: Intradialytic hypotension (IDH) is a major complication of hemodialysis, with a prevalence of about 25% during hemodialysis sessions, causing increased morbidity and mortality. Objective: To study the effects of sertraline to prevent IDH in hemodialysis patients. Methods: This was a double-blind, crossover clinical trial comparing the use of sertraline versus placebo to reduce intradialytic hypotension. Results: Sixteen patients completed the two phases of the study during a 12-week period. The IDH prevalence was 32%. A comparison between intradialytic interventions, intradialytic symptoms, and IDH episodes revealed no statistical difference in the reduction of IDH episodes (p = 0.207) between the two intervention groups. However, the risk of IDH interventions was 60% higher in the placebo group compared to the sertraline group, and the risk of IDH symptoms was 40% higher in the placebo group compared to the sertraline group. Survival analysis using Kaplan-Meier estima...
Introduction: Pharmacological interactions are frequently observed in patients with chronic diseases, and their occurrence is proportional to the amount of medication used daily. Patients undergoing chemotherapy treatment commonly have... more
Introduction: Pharmacological interactions are frequently observed in patients with chronic diseases, and their occurrence is proportional to the amount of medication used daily. Patients undergoing chemotherapy treatment commonly have comorbidities, which favor a greater prevalence of polypharmacy, increasing the risk of drug interactions. Therefore, the aim of this study was to estimate the prevalence of drug interactions in patients undergoing intravenous chemotherapy treated at a hospital oncology service in southern Brazil. Methods: This was an observational study with a cross-sectional design that was carried out with the analysis of secondary data obtained through the review of medical records. The population assessed consisted of all cancer patients who received intravenous chemotherapy from October to December 2020. Results: Out of the 297 patients included in the study, 231 (77.8%) had at least 1 potential pharmacological interaction. In total, 1044 drug interactions were ...
Introduction: People living with the human immunodeficiency virus (HIV) are generally overweight or have an altered body composition as compared to healthy individuals, showing a change in nutritional profile over time. Objective: The aim... more
Introduction: People living with the human immunodeficiency virus (HIV) are generally overweight or have an altered body composition as compared to healthy individuals, showing a change in nutritional profile over time. Objective: The aim of the study was to characterize the nutritional status, estimate the prevalence of lipodystrophy, and examine the association between lipohypertrophy and lipid profile alterations, and other clinical data of HIV-infected individuals. Methods: This was a cross-sectional study on male and female subjects living with HIV, treated at a specialized outpatient clinic, aged 18 years old and over, whether using the antiretroviral therapy or not. Results: The sample consisted of 420 people with a mean age of 43.8 years (standard deviation 11.7). The length of time of the HIV infection averaged 74.6 months, and 91% of the respondents were on antiretroviral therapy. Lipodystrophy prevalence was 35.7%. Of these, 82 (54.7%) presented lipohypertrophy, 61 (40.7%...
Additional file 2. Checklist for measuring study quality (Downs & Black).
Purpose: This study evaluated the effects of 12 weeks of karate training on cardiometabolic parameters, oxidative stress, and inflammation in adolescents with overweight and obesity. Method: Seventy adolescents were randomized into 2... more
Purpose: This study evaluated the effects of 12 weeks of karate training on cardiometabolic parameters, oxidative stress, and inflammation in adolescents with overweight and obesity. Method: Seventy adolescents were randomized into 2 groups: control received nutritional and psychological interventions once a week for 12 weeks, and treatment received nutritional and psychological interventions once a week, plus 3 karate sessions per week, for 12 weeks. The main outcome measure was improvement in cardiometabolic parameters, oxidative stress, and inflammation. Results: After the intervention period, the treatment group showed a reduction in resting heart rate (77.86 [10.89]), high-density lipoprotein cholesterol (40.86 [8.31]), and triglycerides (75.18 [32.29]) and an increase in low-density lipoprotein cholesterol (95.64 [42.53]) in relation to pretraining. Regarding oxidative stress markers, there was a reduction in protein carbonylation (0.07 [0.06]) and nitric oxide (1.39 [1.11]) a...
Apesar de haver rigorosas determinacoes para avaliacao pre-anestesica do paciente cirurgico, cuidados no transoperatorio e no pos-operatorio, ainda se encontram relatos de complicacoes pos-operatorias. O presente estudo foi realizado a... more
Apesar de haver rigorosas determinacoes para avaliacao pre-anestesica do paciente cirurgico, cuidados no transoperatorio e no pos-operatorio, ainda se encontram relatos de complicacoes pos-operatorias. O presente estudo foi realizado a fim de identificar complicacoes pos-operatorias ocorridas na Sala de Recuperacao Pos-Anestesica (SRPA) em um Hospital Geral do Sul de Santa Catarina. Foram incluidos no estudo 350 pacientes que se submeteram a Anestesia Geral em cirurgias eletivas e de urgencia. Atraves de questionario aplicado na forma de entrevista, bem como pelas analises dos monitores cardiacos a beira leito dos pacientes, evidenciou-se 74,0% de complicacoes pos-operatorias. A complicacao mais comum encontrada foi dor no local cirurgico (56,9%), seguido de tontura (21,4%). A maioria dos pacientes apresentou apenas uma complicao (47,9%), sendo que apenas um paciente (0,4%) apresentou seis complicacoes. Houve tendencia de associacao entre o tipo de cirurgia e a ocorrencia complicaco...
RESUMO Introdução: O acesso à informação técnico-científica, principalmente por meio da Internet, aliado ao aumento do nível educacional das populações, tem feito surgir um paciente que busca informações sobre sua doença, sintomas,... more
RESUMO Introdução: O acesso à informação técnico-científica, principalmente por meio da Internet, aliado ao aumento do nível educacional das populações, tem feito surgir um paciente que busca informações sobre sua doença, sintomas, medicamentos e custos de ...
ABSTRACT Introduction Obesity, a multifactorial disease caused by the interaction between genetic characteristics, metabolism, lifestyle, and environmental factors, is a major global health problem and is currently defined as a pandemic... more
ABSTRACT Introduction Obesity, a multifactorial disease caused by the interaction between genetic characteristics, metabolism, lifestyle, and environmental factors, is a major global health problem and is currently defined as a pandemic phenomenon. This disease is determined by an interaction of several factors, but the imbalance between energy consumption and expenditure seems to be the crucial point. In some cases, there is no linearity between exposure to those factors that cause the onset of obesity. A striking example of the occurrence of obesity despite no obvious risk factors is that of obesity induced by viral infections. The most important of such viruses appears to be human adenovirus 36 (Adv36). Areas covered This review covers the relation between obesity and infection by Adv36 in humans. Also, discussed are the opportunities of prevention or treatment for the effects of Adv36 in human body. Expert opinion The role of Ad36 in the development of obesity has already been established. Future research should focus on the development of vaccines against this agent, drug discovery for infected individuals, and effective therapeutic uses of E4orf1 gene protein for diabetes and other diseases in clinical practice.
Objetivos: Avaliar o perfil dos pacientes submetidos ao cateterismo cardíaco e as complicações intra-hospitalares decorrentes da intervenção. Métodos: Coorte retrospectiva com análise transversal da linha de base realizada no período... more
Objetivos: Avaliar o perfil dos pacientes submetidos ao cateterismo cardíaco e as complicações intra-hospitalares decorrentes da intervenção. Métodos: Coorte retrospectiva com análise transversal da linha de base realizada no período entre 2007 e 2013, no setor de hemodinâmica de um hospital terciário da região sul do Brasil. O estudo incluiu pacientes submetidos ao cateterismo cardíaco diagnóstico ou terapêutico. Os dados foram extraídos de prontuários eletrônicos por meio de formulário padronizado e armazenados em base de dados para posterior análise. Resultados: Dos 994 pacientes avaliados, 584 (58,8%) eram do gênero masculino. A média de idade foi de 61,4 anos. Hipertensão arterial sistêmica foi o fator de risco mais prevalente, sendo seguida de dislipidemia e diabetes mellitus. Em relação à apresentação clínica, 550 (55,3%) pacientes tinham síndrome coronariana aguda, 402 (40,4%) angina estável e 42 (4,2%) eram assintomáticos. A cineangiocoronariografia foi normal em 152 (15,3%...
Objetivos: Analisar a sobrevida de pacientes submetidos à angioplastia com colocação de stent no Hospital Nossa Senhora da Conceição, em Tubarão, Santa Catarina. Métodos: Um estudo de coorte avaliou na linha de base o perfil... more
Objetivos: Analisar a sobrevida de pacientes submetidos à angioplastia com colocação de stent no Hospital Nossa Senhora da Conceição, em Tubarão, Santa Catarina. Métodos: Um estudo de coorte avaliou na linha de base o perfil sociodemográfico dos pacientes submetidos ao procedimento no período de janeiro a dezembro de 2009. Após pelo menos 16 meses, foram avaliadas sua evolução clínica e sobrevida. Resultados: Dos 84 pacientes estudados, 9,5% eram assintomáticos, 31% apresentavam angina estável, 21,4% angina instável, 32,2% tiveram infarto agudo do miocárdio tratado em menos de 24 horas de evolução e em 5,9% foi realizada intervenção após 24 horas do infarto. Quanto aos resultados da cineangiocoronariografia, 59,5% apresentavam obstrução uniarterial, 23,8% biarterial, 15,5% triarterial e 1,2% obstrução de todo o tronco coronário esquerdo. Com relação à sobrevida, 9,5% evoluíram a óbito, tendo como fatores predisponentes o padrão de obstrução coronariana (p<0,001). Pacientes assint...
Objective To describe fluid resuscitation practices in Brazilian intensive care units and to compare them with those of other countries participating in the Fluid-TRIPS. Methods This was a prospective, international, cross-sectional,... more
Objective To describe fluid resuscitation practices in Brazilian intensive care units and to compare them with those of other countries participating in the Fluid-TRIPS. Methods This was a prospective, international, cross-sectional, observational study in a convenience sample of intensive care units in 27 countries (including Brazil) using the Fluid-TRIPS database compiled in 2014. We described the patterns of fluid resuscitation use in Brazil compared with those in other countries and identified the factors associated with fluid choice. Results On the study day, 3,214 patients in Brazil and 3,493 patients in other countries were included, of whom 16.1% and 26.8% (p < 0.001) received fluids, respectively. The main indication for fluid resuscitation was impaired perfusion and/or low cardiac output (Brazil: 71.7% versus other countries: 56.4%, p < 0.001). In Brazil, the percentage of patients receiving crystalloid solutions was higher (97.7% versus 76.8%, p < 0.001), and 0.9% sodium chloride was the most commonly used crystalloid (62.5% versus 27.1%, p < 0.001). The multivariable analysis suggested that the albumin levels were associated with the use of both crystalloids and colloids, whereas the type of fluid prescriber was associated with crystalloid use only. Conclusion Our results suggest that crystalloids are more frequently used than colloids for fluid resuscitation in Brazil, and this discrepancy in frequencies is higher than that in other countries. Sodium chloride (0.9%) was the crystalloid most commonly prescribed. Serum albumin levels and the type of fluid prescriber were the factors associated with the choice of crystalloids or colloids for fluid resuscitation.
JUSTIFICATIVA E OBJETIVOS: Idosos sao mais suscetiveis a processos infecciosos, e a gripe causada por Influenza associa-se a graves complicacoes nesta faixa etaria. A vacinacao tem sido recomendada aos idosos, apesar de sua efetividade... more
JUSTIFICATIVA E OBJETIVOS: Idosos sao mais suscetiveis a processos infecciosos, e a gripe causada por Influenza associa-se a graves complicacoes nesta faixa etaria. A vacinacao tem sido recomendada aos idosos, apesar de sua efetividade ainda ser objeto de estudo.O objetivo desta pesquisa foi comparar a morbidade e mortalidade entre idosos vacinados e nao vacinados contra o virus da Influenza. METODO: Estudo observacional, tipo caso-controle, em que foram realizadas entrevistas com 133 idosos vacinados e 133 idosos nao vacinados, cadastrados previamente em banco de dados constituido por idosos residentes em Tubarao, SC, no ano de 2010. Alem de dados sociodemograficos, foram coletados dados sobre sintomas de vias respiratorias, procura por atendimento medico e internacoes no periodo em analise. O desfecho primario foi morte averiguada no momento da entrevista e os desfechos secundarios foram sintomas de acometimento das vias respiratorias, necessidade de atendimento medico e internaca...
We evaluated the safety, optimal dose, and preliminary effectiveness of a new-approach Africanized honeybee (Apis mellifera) Antivenom (AAV) in a phase I/II, multicenter, non-randomized, single-arm clinical trial involving 20 participants... more
We evaluated the safety, optimal dose, and preliminary effectiveness of a new-approach Africanized honeybee (Apis mellifera) Antivenom (AAV) in a phase I/II, multicenter, non-randomized, single-arm clinical trial involving 20 participants with multiple stings. Participants received 2 to 10 vials of AAV depending on the number of stings they suffered, or a predefined adjuvant, symptomatic, and complementary treatment. The primary safety endpoint was the occurrence of early adverse reactions within the first 24 h of treatment. Preliminary efficacy based on clinical evolution, including laboratory findings, was assessed at baseline and at various time points over the four following weeks. ELISA assays and mass spectrometry were used to estimate venom pharmacokinetics before, during, and after treatment. Twenty adult participants, i.e., 13 (65%) men and 7 (35%) women, with a median age of 44 years and a mean body surface area of 1.92 m2 (median = 1.93 m2) were recruited. The number of s...
Background Obesity is considered a top public health concern, and its prevalence is growing every day. Thus, interventions to address this problem should be encouraged and further studied. In this regard, the aim of this review was to... more
Background Obesity is considered a top public health concern, and its prevalence is growing every day. Thus, interventions to address this problem should be encouraged and further studied. In this regard, the aim of this review was to summarize the evidence of martial arts interventions to evaluate their effectiveness on the anthropometric and body composition parameters of overweight and obese subjects. Methods A systematic literature search was conducted on January 26, 2020 using the PubMed, Medline, Lilacs, Cochrane, and Scielo databases. Reference lists of eligible articles and relevant reviews have also been examined. All randomized clinical trials on martial arts that evaluated the anthropometric and body composition parameters of overweight and obese subjects were included, and a narrative synthesis of eligible studies was conducted in accordance with PRISMA guidelines. The Downs & Black checklist was used to assess the quality of the studies. This review was registered in th...
Resumo Apresenta-se o relato de experiência da integração entre serviços de saúde públicos e privados, gestores e universidade, para a vigilância e controle da epidemia de COVID-19 em Tubarão, SC, Brasil. A cidade, universitária, cenário... more
Resumo Apresenta-se o relato de experiência da integração entre serviços de saúde públicos e privados, gestores e universidade, para a vigilância e controle da epidemia de COVID-19 em Tubarão, SC, Brasil. A cidade, universitária, cenário de grande fluxo de pessoas de diferentes locais do país, foi um dos primeiros municípios do estado catarinense com transmissão comunitária do SARS-CoV-2. São detalhadas as medidas adotadas com a criação do Comitê de Monitoramento da COVID-19, do Centro de Operações de Emergências Municipais em Saúde, e do Plano de Contingência da Doença. Passados 100 dias de pandemia, foram 5.979 casos notificados e 431 (7,2%) confirmados, dos quais 5 (1,2%) foram a óbito. Decisões precoces – suspensão imediata das atividades de comércio e eventos com aglomeração – podem ter limitado a propagação do vírus. As parcerias estabelecidas trazem inovação e subsidiam a gestão pública nas tomadas de decisão pautadas em evidências científicas.
JUSTIFICATIVA E OBJETIVO: As dislipidemias sao uma das principais causas de morbidade e mortalidade por doencas car- diovasculares. O objetivo deste estudo foi avaliar o efeito hipo- lipemiante do extrato seco de Solanum melongena L.... more
JUSTIFICATIVA E OBJETIVO: As dislipidemias sao uma das principais causas de morbidade e mortalidade por doencas car- diovasculares. O objetivo deste estudo foi avaliar o efeito hipo- lipemiante do extrato seco de Solanum melongena L. (berinjela) versus placebo e sinvastatina, em pacientes com hipercolesterole- mia. METODOS: Foi realizado um ensaio clinico randomiza- do com 36 individuos adultos, hipercolesterolemicos, alocados em quatro grupos: Grupo 1, ao qual foi administrado placebo (n=10); Grupo 2, que recebeu extrato seco de berinjela (n=10; colesterol total=200 a 239mg/dL); Grupo 3 que tambem recebeu extrato seco de berinjela (n=9; colesterol total ?240mg/dL); e Grupo 4, que foi tratado com sinvastatina (n=7; colesterol total ?240mg/dL). Foram realizados exames laboratoriais na linha de base, apos 30, 60 e 90 dias de tratamento. RESULTADOS: Houve reducao significativa de colesterol total e LDL no Grupo 4 (p<0,001 e p=0,001, respectivamente). Os demais valores e grupos nao apresentaram diferenca no tratamento. CONCLU- SAO: O extrato seco de Solanum melongena L. nao apresentou diferenca estatisticamente significativa na reducao dos niveis do colesterol total, fracoes e triglicerideos quando comparado ao uso de sinvastatina ou placebo.(AU) BACKGROUND AND OBJETIVE: Dyslipidemia is the leading cause of morbidity and mortality from cardiovascular disease. The aim of this study was to evaluate the lipid-lowering effect of dry extracts of Solanum melongena L. (eggplant) versus placebo and simvastatin in patients with hypercholesterolemia. METHODS: A randomized clinical trial was performed on 36 adult subjects with hypercholesterolemia. They were divided into four groups: Group 1, which was treated with placebo (n=10); Group 2, that received dry extract of eggplant (n=10; total cholesterol=200 to 239mg/dL); Group 3, that also received dry extract of eggplant (n=9; total cholesterol ?240mg/dL) and Group 4, treated with simvastatin (n=7; total cholesterol ?240mg/dL). Laboratory tests were carried out at baseline and 30, 60 and 90 days after the start of treatment. RESULTS: There was a significant reduction in total cholesterol and LDL in Group 4 (p<0.001 and 0.001, respectively). There was no significant difference in cholesterol levels in the other groups because of treatment. CONCLUSION: The dry extract of Solanum melongena L. showed no statistically significant difference in reducing the levels of total cholesterol, fractions, and triglycerides, when compared with the use of simvastatin or placebo.(AU)
Population aging has evolved gradually. Polypharmacy to control disease associated with age-related physiological changes increases the risk of adverse drug reactions, including drug interactions among the elderly population. This study... more
Population aging has evolved gradually. Polypharmacy to control disease associated with age-related physiological changes increases the risk of adverse drug reactions, including drug interactions among the elderly population. This study was intended to assess the medications used by the elderly population, aiming at identifying the potentially inappropriate medications according to the Beers Criteria. We conducted a cross-sectional study on medical records to assess the use of medications by elderly patients admitted to the Hospital Nossa Senhora da Conceição in 2011. The variables included gender, age, reasons for admission, comorbidities, and medications used by the elderly patients. In total, we reviewed 440 medical records. Patients were predominantly male (51.6%). The total number of medications used was 5904, with an average of 13.4 per person. The three most commonly used drugs were dipyrone, omeprazole, and metoclopramide. The most frequently used drugs according to the Anatomical Therapeutic Chemical Classification (ATC) system were those of the alimentary tract and metabolism, nervous system, and cardiovascular system. Of the 255 types of drugs used, 42 (16.4%) were included in the Beers list, and the three most often used were metoclopramide, ketoprofen, and aspirin. The number of medications used per patient was substantial, and potentially inappropriate medications according to the Beers Criteria were significant as well.
A lipodistrofia associada ao HIV (LAHIV) acomete 40% a 50% dos pacientes infectados pelo vírus, mas sua prevalência no Brasil é desconhecida. O objetivo deste trabalho foi avaliar a prevalência de LAHIV entre adultos brasileiros... more
A lipodistrofia associada ao HIV (LAHIV) acomete 40% a 50% dos pacientes infectados pelo vírus, mas sua prevalência no Brasil é desconhecida. O objetivo deste trabalho foi avaliar a prevalência de LAHIV entre adultos brasileiros infectados, bem como sua relação com fatores de risco cardiovascular e síndrome metabólica (SM). Foram avaliados 180 pacientes maiores de 18 anos, infectados por HIV, atendidos no Ambulatório de Infectologia da Universidade Estadual de Londrina. Por meio de entrevista e revisão de prontuário, foram avaliados dados antropométricos, pressão arterial, antecedentes mórbidos pessoais e familiares, duração da infecção por HIV e da aids, drogas anti-retrovirais utilizadas, CD4+, carga viral, glicemia e perfil lipídico. A LAHIV foi definida como a presença de alterações corporais percebidas pelo próprio paciente e confirmadas ao exame clínico. A SM foi diagnosticada usando os critérios do Adult Treatment Panel III (NCEP-ATPIII), revistos e atualizados pela American ...
OBJETIVO: Identificar o padrão de utilização de medicamentos, nos últimos seis meses, em crianças entre zero e seis anos, em quatro creches de Tubarão, Santa Catarina, no ano de 2007. MÉTODOS: Estudo transversal realizado por meio de... more
OBJETIVO: Identificar o padrão de utilização de medicamentos, nos últimos seis meses, em crianças entre zero e seis anos, em quatro creches de Tubarão, Santa Catarina, no ano de 2007. MÉTODOS: Estudo transversal realizado por meio de questionário semi-estruturado, aplicado aos pais ou responsáveis pelas 413 crianças incluídas na pesquisa, após consentimento informado. Foram coletados dados sobre utilização de medicamentos e informações de saúde. A análise estatística foi feita com auxílio do programa Statistical Package for the Social Sciences 15.0. RESULTADOS: A média de idade das crianças foi 3,7±1,3 anos, sendo 195 (47%) meninas e 218 (53%) meninos. Dentre os adultos que responderam ao questionário, 75% eram mães e 43% tinham oito anos de estudo. Diante de situação de doença, 47% forneciam os medicamentos que tinham em casa. Das crianças pesquisadas, 82 (20%) apresentavam doença crônica e 75 (18%) portavam doença aguda no momento da pesquisa. Houve histórico de reações adversas a...
Safety, optimal minimum dose, and, preliminary effectiveness of a new generation Africanized honeybees (Apis mellifera) antivenom (AAV) were evaluated. A phase I/II, multicenter, non-randomized, single-arm clinical trial involving 20... more
Safety, optimal minimum dose, and, preliminary effectiveness of a new generation Africanized honeybees (Apis mellifera) antivenom (AAV) were evaluated. A phase I/II, multicenter, non-randomized, single-arm clinical trial involving 20 participants showing multiple stings were studied. Participants have received either 2 to 10 vials of AAV based on the stings number together with a predefined adjuvant, symptomatic, and complementary treatment schedule. The primary safety endpoint was the presence of early adverse reactions within the first 24 hours after treatment. Preliminary efficacy through clinical evolution, including laboratory tests, was assessed at baseline and over the following four weeks. ELISA assays and mass spectrometry estimated the venom pharmacokinetics before, during, and after treatment. Twenty adult participants, 13 (65%) males, and 7 (35%) females, with a median age of 44 years and a mean body surface of 1.92 m2 (median = 1.93 m2) were recruited. The median number...
At the end of 2019, a new disease with pandemic potential appeared in China. It was a novel coronavirus called coronavirus disease 2019 (COVID-19). Later, in the first quarter of 2020, the World Health Organization declared the outbreak... more
At the end of 2019, a new disease with pandemic potential appeared in China. It was a novel coronavirus called coronavirus disease 2019 (COVID-19). Later, in the first quarter of 2020, the World Health Organization declared the outbreak of this disease a pandemic. Elderly people, people with comorbidities, and health care professionals are more vulnerable to COVID-19. Obesity has been growing exponentially worldwide, affecting several age groups. It is a morbidity that is associated with genetic, epigenetic, environment factors and/or interaction between them. Obesity is associated with the development of several diseases including diabetes mellitus, mainly type 2. Diabetes affects a significant portion of the global population. Obesity and diabetes are among the main risk factors for the development of severe symptoms of COVID-19, and individuals with these conditions constitute a risk group. Based on a literature review on obesity in people with diabetes in the framework of the CO...
Introduction: the sexual risk behavior among adolescents may have consequences such as unwanted pregnancy and STDs, becoming a serious public health problem. Objective: to analyze sexual behavior and risk factors for unwanted pregnancy... more
Introduction: the sexual risk behavior among adolescents may have consequences such as unwanted pregnancy and STDs, becoming a serious public health problem. Objective: to analyze sexual behavior and risk factors for unwanted pregnancy and STDs among adolescents enrolled in secondary education in schools of the municipality of Tubarao, Santa Catarina. Methods: the sample consisted of adolescents enrolled in four schools chosen through raffl e. A self-administered questionnaire was used after consent. Chi-square test was used to analyze association between variables and Student’s t test for comparison of means. Results: Out of 379 respondents, 41.7% studied in private schools and 39.6% reported having had sexual intercourse. The mean age at fit sexual intercourse was 15±1.54 years, ranging between 9 and 19 years. Of those, only 55.3% reported consistent use of condoms, 46% used emergency contraception and 90.7% used contraceptive methods. There were four reports of past pregnancies, ...
Introducao: A obesidade e uma doenca cronica de origem multifatorial e associada a inumeras comorbidades, sendo um problema de saude publica. O tratamento convencional tem se mostrado ineficaz pois a maioria dos pacientes recupera o peso... more
Introducao: A obesidade e uma doenca cronica de origem multifatorial e associada a inumeras comorbidades, sendo um problema de saude publica. O tratamento convencional tem se mostrado ineficaz pois a maioria dos pacientes recupera o peso em pouco tempo. A cirurgia bariatrica tem se mostrado como uma alternativa eficaz para a perda de peso, controle de comorbidades e melhoria na qualidade de vida dos pacientes. Objetivo: Avaliar a condicao de saude e qualidade de vida no pos-operatorio tardio de pacientes submetidos a cirurgia bariatrica no ano de 2011. Materiais e metodos: Os pacientes foram entrevistados sobre os dados sociodemograficos, antropometricos, habitos de vida e comorbidades, e as mesmas informacoes pre-operatorias foram obtidas por revisao dos prontuarios. Foi aplicado questionarios Bariatric Analysis and Reporting Outcome System, e Whoqol Abreviado. Resultados: Foram entrevistados 59 pacientes, destes, 81,3% era mulheres, a maioria com idades entre 30 e 39 anos, e 78% e...
OBJETIVO: A sepse e uma sindrome altamente prevalente em unidades de terapia intensiva, associada a uma alta taxa de mortalidade com o diagnostico tardio. O objetivo desse estudo foi determinar a incidencia e perfil epidemiologico de... more
OBJETIVO: A sepse e uma sindrome altamente prevalente em unidades de terapia intensiva, associada a uma alta taxa de mortalidade com o diagnostico tardio. O objetivo desse estudo foi determinar a incidencia e perfil epidemiologico de sepse nosocomial, fatores de risco associados e a fonte da infeccao que possam auxiliar na criacao ou inclusao de medidas preveniveis. METODOS: Estudo observacional com delineamento de coorte historica. Foram revisadas as fichas de notificacao de infeccao disponiveis na Comissao de Controle de Infeccao Hospitalar, complementados com dados dos prontuarios eletronicos dos pacientes internados na unidade de terapia intensiva no ano de 2013. RESULTADOS: Houve 1.345 pacientes internados na UTI no ano de 2013 e 130 casos de sepse entre 96 pacientes, resultando numa taxa de incidencia de 9,7%. A maioria dos casos ocorreu entre homens (67,7%) e a media de idade foi de 62±16,4 anos. O tempo de permanencia hospitalar teve uma mediana de 36,5 dias. A fonte de infe...
JUSTIFICATIVA E OBJETIVOS: A sepse e uma importante causa de obitos em unidades de terapia intensiva (UTI). Pacientes que utilizam cateter venoso central apresentam risco elevado para desenvolver sepse, pois e porta de entrada para que... more
JUSTIFICATIVA E OBJETIVOS: A sepse e uma importante causa de obitos em unidades de terapia intensiva (UTI). Pacientes que utilizam cateter venoso central apresentam risco elevado para desenvolver sepse, pois e porta de entrada para que micro-organismos atinjam a circulacao sanguinea. O objetivo deste estudo foi estabelecer o perfil epidemiologico dos casos de sepse em pacientes adultos internados na UTI em um hospital escola no Sul do Brasil. METODO: Estudo epidemiologico com delineamento transversal. Foram revisados os prontuarios de pacientes notificados pela Comissao de Controle de Infeccao Hospitalar como sepse associada ao uso de cateter venoso central em UTI entre os anos de 2002 e 2009. Os dados coletados incluiram os perfis demograficos e clinicos dos casos de sepse. RESULTADOS: Dos 83 casos avaliados, 44 evoluiram para obito, sendo 63,9% homens. A media de idade foi de 48,6 ± 21,6 anos. O tempo medio de internacao foi de 19,8 dias, a comorbidade mais prevalente foi diabete ...
OBJECTIVE To identify risk factors associated with hepatitis C virus (HCV) seropositivity in human immunodeficiency virus (HIV)-infected patients. METHODS A paired case-control study adjusted by age and gender was conducted. It included... more
OBJECTIVE To identify risk factors associated with hepatitis C virus (HCV) seropositivity in human immunodeficiency virus (HIV)-infected patients. METHODS A paired case-control study adjusted by age and gender was conducted. It included adults coinfected with HIV and HCV (cases) and HIV mono-infected subjects (controls) using non-probability sampling. Data were collected through interviews and review of medical records. The chi-square test was used for comparing categorical variables and the Student's t-test or Wilcoxon (Mann-Whitney U) test for continuous variables. Confidence intervals (95%) were estimated along with crude and adjusted odds ratios using conditional logistic regression. RESULTS A total of 165 patients were surveyed, including 55 cases and 110 controls. The mean age was 43.6 ± 8.4 years, ranging from 19 to 64 years; 70.9% were male. Independent risk factors for HIV/HCV coinfection were education (up to eight years of schooling); age at first intercourse < 15 ...
Objetivo: Verificar a prevalencia de parasitosesintestinais nas criancas entre 0 e 6 anos matriculadasem creche filantropica em Tubarao (SC), no ano de 2007,avaliando possiveis fatores de risco e historia pregressade... more
Objetivo: Verificar a prevalencia de parasitosesintestinais nas criancas entre 0 e 6 anos matriculadasem creche filantropica em Tubarao (SC), no ano de 2007,avaliando possiveis fatores de risco e historia pregressade enteroparasitoses.Metodos: Estudo transversal realizado por meio dequestionario semi-estruturado aplicado aos pais ouresponsaveis das 75 criancas matriculadas na crecheem estudo, apos anuencia do termo de consentimento.Foram questionadas variaveis demograficas,socioeconomicas e fatores de risco para a infeccao porparasitas intestinais. Foi realizado examecoproparasitologico em todas as criancas, como empregodos metodos direto, Hoffman e Ritchie. O banco de dadose a analise estatistica foram feitos com auxilio doprograma SPSS versao 14.0.Resultados: Das 75 criancas estudadas, 57,3% eramdo genero masculino e a media de idade foi de 3,2±1,6anos. Os pais ou responsaveis apresentaram baixascondicoes socieconomicas, apesar de nao ter sidoencontrada associacao entre a escolari...
ABSTRACT Using psychiatric drugs to treat drug dependence and its comorbidities is very common. The objective of this study was to analyze the interactions between prescribed drugs for patients treated at a specialized mental health-care... more
ABSTRACT Using psychiatric drugs to treat drug dependence and its comorbidities is very common. The objective of this study was to analyze the interactions between prescribed drugs for patients treated at a specialized mental health-care center for persons who use drugs, located in the state of Santa Catarina, Brazil. A cross-sectional study was conducted on secondary data collected from 2010 to 2018. We reviewed the medical records of patients aged 18 years or older who took psychotropic drugs and had any type of substance dependence. The analysis of psychotropic drug interactions was conducted in three databases: Medscape, Drug Interactions Checker, and Micromedex. We included 1,022 of the 2,322 patients attending the care center during the study period. Psychotropic drug interactions were found in 779 (76.4%) study participants, and they presented 2,292 (100%) interactions, out of which 136 (6.0%) had minor clinical risk, 537 (23.4%) had moderate risk, and 1,619 (70.6%) had major risk for the patient, totaling 172 incompatible combinations between two psychotropic drugs. Of the total number of interactions, 128 were pharmacokinetic and 44 were pharmacodynamic. The high number of psychotropic drug interactions is a serious public health issue. Psychopharmacological treatment should be carefully addressed to be safe for the patient.

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