bahlul awen
Universty Of Tripoli, Medicinal and Pharmaceutical, Faculty Member
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Research Interests: Mathematics, Chemistry, Analytical Chemistry, Chromatography, Dosage Form, and 15 moreAnalysis, Metformin, Methanol, High Performance Liquid Chromatography, Aprepitant, Carbamazepine, Food Sciences, Amlodipine, Linearity, Ammonium Acetate, Metformin Hydrochloride, Acetonitrile, Cefixime, capecitabine, and Elution
Objetivos: Elaborar y evaluar tiras subgingivales combinadas compuestas por Ofloxacino y metronidazol in vitro con alginato de calcio biodegradable. Metodos: las tiras se prepararon utilizando el metodo de evaporacion del disolvente. Se... more
Objetivos: Elaborar y evaluar tiras subgingivales combinadas compuestas por Ofloxacino y metronidazol in vitro con alginato de calcio biodegradable. Metodos: las tiras se prepararon utilizando el metodo de evaporacion del disolvente. Se uso una concentracion del 10% de CaCl2 para la gelificacion.de las tiras. Resultados: el grosor de las tiras se encuentra dentro de las recomendaciones (>320 μm). In vitro, la liberacion de la droga siguio una cinetica bifasica que fue suficiente para alcanzar la CMI e inhibir el crecimiento de microorganismos durante 5 dias. La “tasa de liberacion de la droga” es inversamente proporcional a la concentracion de polimero de la formulacion. La liberacion de la “droga” fue por difusion y en segunda fase por disolucion. Discusion: Las preparaciones OM1 y OM2 que contienen un 90 y un 75% de polimero respectivamente, podrian ser empleadas en liberacion controlada durante cinco dias en infecciones sublinguales. Siendo el alginato calcico biodegradable una buena eleccion como polimero retardante
Research Interests: Chemistry and Humanities
This article presents an identity based pharmacognostical study of the leaf and stem of Carduus benedictus (Compositae). Morphoanatomy of the leaf were studied using to aid pharmacognostical and taxonomical identification, using light and... more
This article presents an identity based pharmacognostical study of the leaf and stem of Carduus benedictus (Compositae). Morphoanatomy of the leaf were studied using to aid pharmacognostical and taxonomical identification, using light and confocal microscopy. The morphological, anatomical parameters and physic-chemical profile presented in this paper may be proposed as parameters to establish the authenticity of C. benedictus and can possibly help to differentiate the drug from its other related species.
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The present study aims at developing a simple, sensitive and specific liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the quantification of pantoprazole sodium (PS) in human plasma using pantoprazole D3 (PSD3) as... more
The present study aims at developing a simple, sensitive and specific liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the quantification of pantoprazole sodium (PS) in human plasma using pantoprazole D3 (PSD3) as internal standard (IS). Chromatographic separation was performed on Zorbax SB-C18, 4.6 mm x 75 mm, 3.5 microm, 80 A column with an isocratic mobile phase composed of 10 mM ammonium acetate (pH 7.10): acetonitrile (30:70, v/v), pumped at 0.6 mL/min. PS and PSD3 were detected with proton adducts at m/z 384.2-->200.1 and 387.1-->203.1 in multiple reaction monitoring (MRM) positive mode, respectively. Precipitation method was employed in the extraction of PS and PSD3 from the biological matrix. This method was validated over a linear concentration range of 10.00-3000.00 ng/mL with correlation coefficient (r) > or = 0.9997. Intra- and inter-day precision of PS were found to be within the range of 1.13-1.54 and 1.76-2.86, respectively. Both analytes were stable throughout freeze/thaw cycles, bench top and postoperative stability studies. This method was successfully utilized in the analysis of blood samples following oral administration of PS (40 mg) in healthy human volunteers.
Research Interests: Chemistry, Analytical Chemistry, Chromatography, Mass Spectrometry, Bioanalysis, and 15 moreMedicine, Linear models, Humans, Blood sampling, High Performance Liquid Chromatography, High Pressure Liquid Chromatography, Liquid Chromatography, Analysis of Variance, Correlation coefficient, Elsevier, Drug Stability, Area Under Curve, Pantoprazole, Biochemistry and cell biology, and Pharmacology and pharmaceutical sciences
In this study, the anti ulcerogenic effect of water extract obtained from the leaves of Pueraria Tuberosa[PT] was investigated using cold restraint stress(CRU), pyloric ligation(PL) & Ethanol induced (EtOH) induced gastric ulcer models in... more
In this study, the anti ulcerogenic effect of water extract obtained from the leaves of Pueraria Tuberosa[PT] was investigated using cold restraint stress(CRU), pyloric ligation(PL) & Ethanol induced (EtOH) induced gastric ulcer models in rats. The treatment with PT at higher dose significantly inhibited gastric lesions induced by CRU (76.6%), PL (80.1%) & EtOH (70.6%) respectively with equal potency of Omeperazole. In addition the effects of PT on HKATPase activity was determined. PT significantly inhibited HKATpase activity in EtOH induced ulcer model. PT accelerated the healing of EtOH induced ulcers by inhibiting HKATPase activity.
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Research Interests: Chemistry and Alkylation
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Abstract Aerial part of Salvia officinalis was collected from Al-Zawia,Libya and was subjected to hydro distillation in a Clevenger apparatus for 3 h. The yield of the pale yellow coloured oil was 0.4 % on fresh weight basis. Thirteen... more
Abstract Aerial part of Salvia officinalis was collected from Al-Zawia,Libya and was subjected to hydro distillation in a Clevenger apparatus for 3 h. The yield of the pale yellow coloured oil was 0.4 % on fresh weight basis. Thirteen components of the oil were identified by GC-MS which contained 90.3 % monoterpenoids and only (8.1 %) sesqui terpenoids. The essential oil and its fractions showed a significant antibacterial effect against E. faecalis and S. paratyphi.
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Simple aqueous titrimetric method is developed for the determination of metronidazole in tablets. The proposed method is based on the reduction of the nitro group to amino group of the molecule with zinc and 6M HCl. The reduced molecule... more
Simple aqueous titrimetric method is developed for the determination of metronidazole in tablets. The proposed method is based on the reduction of the nitro group to amino group of the molecule with zinc and 6M HCl. The reduced molecule was diazotised with sodium nitrite at 5-10 o C. The reactions were carried out in aqueous medium without the use of organic solvents. This method was validated by low values of statistical parameters viz, standard deviation, related standard deviation and standard error of mean. This method is novel, accurate and economic and eco-friendly. The proposed method is recommended for quality control, routine analysis and developed for academic purpose.
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... b, Mukkanti Khaggag, Chandrasekhar Kothapalli Bannothc, Kanchanamala Kanalaac, Rihana Parveen Shaikd, Ramalingam Peramane and Rajesh Goginenif. a Siddharth Institute of Pharmacy, Nalanda Educational Society, Kantepudi, Sattenapalli,... more
... b, Mukkanti Khaggag, Chandrasekhar Kothapalli Bannothc, Kanchanamala Kanalaac, Rihana Parveen Shaikd, Ramalingam Peramane and Rajesh Goginenif. a Siddharth Institute of Pharmacy, Nalanda Educational Society, Kantepudi, Sattenapalli, Guntur, India 522438. ...
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Research Interests: Analytical Chemistry, Chromatography, Kinetics, Mass Spectrometry, Oxidative Stress, and 15 moreMice, Animals, High Performance Liquid Chromatography, Buffers, Oxygen, Food Sciences, Correlation coefficient, Analytical Methods, Ofloxacin, Flow Rate, Hydrolysis, Drug Stability, Equipment Design, Ivermectin, and Levofloxacin
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Simple aqueous titrimetric method is developed for the determination of metronidazole in tablets. The proposed method is based on the reduct ion of the nitro group to amino group of the molecule with zinc and 6M HCl. The reduced molecule... more
Simple aqueous titrimetric method is developed for the determination of metronidazole in tablets. The proposed method is based on the reduct ion of the nitro group to amino group of the molecule with zinc and 6M HCl. The reduced molecule was diazotised with sodium nitrite at 5- 10 o C. The reactions were carried out in aqueous medium without the
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