Objectives The aim of this research was to study the intensity of cytokeratin 17 (CK17) in the pa... more Objectives The aim of this research was to study the intensity of cytokeratin 17 (CK17) in the parenchymal elements of rat’s submandibular salivary glands subjected to fractionated radiotherapy regimen that used for treatment of head and neck malignancy. Materials and Methods Twenty male albino rats were divided into two equal groups (normal and irradiated). The irradiated group received a radiation dose of 5 Grays daily for 5 days using therapeutic X-ray beam. Six months later, submandibular gland was dissected out and prepared for both histological and immunohistochemical studies. Results Submandibular gland of irradiated group showed two different types of histological alterations. The first alteration showed severe gland atrophy replaced by either fibrous or fatty tissues. In some sections, the gland exhibited proliferating activity in the form of profuse amounts of mitotic figures. Immunohistochemical examination of control glands displayed a mild cytoplasmic expression of CK17...
Background:Periodontal pathogens can induce
overproduction of free radicals and reactive
oxygen s... more Background:Periodontal pathogens can induce overproduction of free radicals and reactive oxygen species (ROS)that may increase periodontal tissue breakdown. Coenzyme Q10 (CoQ10) serves as potent endogenous antioxidant that act as a scavenger to ROS and may be suppress the periodontal inflammation. Aim:The present study was aimed to evaluate the clinical and immunologic effects of intrapocket application of CoQ10 as an adjunct to nonsurgical periodontal therapy. Materials and methods:Twenty eight mild to moderate chronic periodontitis patients with age ranged from 29 to 46 years. All individuals were carried out to scaling and root planning (SRP) and classified into group 1 (G1, treated by SRP only) and group 2 (G2, treated by COQ10 gel plus SRP). Clinical parameters; plaque index (PI), gingival index (GI), pocket depth (PD) and clinical attachment loss (CAL), in addition to gingival crevicularfluid (GCF) samples were obtained at baseline and 30days after treatment. Tumor necrosis factor- (TNF-) levels were evaluated by ELISA technique at both time intervals of periodontal therapy. Results: Clinical evaluation of both groups revealed a high significant improvement in all parameters at baseline and 30 days of treatment (P≤0.01). Whereas, more clinical improvement in G2 at 30 days compared to G1, but the difference was non-significant (P≥0.05). TNF- levels were significantly high reduced at 30 days versus to baseline in both groups (P≤0.01), in comparison between groups at 30 days TNF- levels reduced in G2 compared to G1, but there is no significant difference (P≥0.05). Conclusions:Topical application of CoQ10 as an adjunct to non-surgical periodontal therapy improve the clinical and immunologic findings, but it not considered a significantadjunct modality for periodontal therapy. Further studies needed to clarify clinical and immunological outcomes.
International Journal of Health Sciences & Research (www.ijhsr.org), 2017
Periodontitis is a chronic inflammatory disease that causes destruction of tooth-supporting tissu... more Periodontitis is a chronic inflammatory disease that causes destruction of tooth-supporting tissues. Interlukin-20 (IL-20) is a proinflammatory cytokine of the IL-10 family that is involved in some diseases; rheumatoid arthritis, psoriasis, and atherosclerosis. The purpose of this study was to evaluate the levels of IL-20 in gingival crevicular fluid (GCF) and serum of both chronic periodontitis patients and periodontal healthy subjects. Thirty systemically male subjects were categorized into group 1 (healthy) and group 2 (chronic periodontitis patients). The patients were clinically evaluated by; plaque index (PI), bleeding index (BI), probing pocket depth (PD) and clinical attachment loss (CAL). GCF and serum samples were obtained from all individuals to measure IL-20 levels by using of enzyme-linked immunosorbent assay (ELISA) technique. The levels of IL-20 in GCF were significantly higher in chronic periodontitis patients compared to healthy subjects (P ≤ 0.05). In addition, there was a positive correlation between GCF-IL-20 levels and PD (r = 0.800, P= 0.010). While, the serum levels of IL-20 in chronic periodontitis patients were not significant in comparison to healthy subjects (P ≥ 0.05). For Conclusion, significant increased levels of GCF-IL-20 in chronic periodontitis patients showed that IL-20 may have a role in pathogenesis of chronic periodontitis. Moreover, additional studies are required to clarify its role in periodontal diseases.
Objectives: The purpose of the present study was to determine the location and configuration of t... more Objectives: The purpose of the present study was to determine the location and configuration of the mandibular canal and related vital structures as a pre-implant assessment using Cone Beam Computed Tomography. Materials and Methods: 141CBCT scans were undertaken by Kodak 9500® Cone Beam 3D Systems and the scanning parameters were 90 kV, 10 mA, voxel size 0.2 mm and medium field of view. Results: The course of the mandibular canal reported (61.17%) catenary-like, (28.19%) progressive descent and (10.64%) had a straight pattern. The buccolingual dimension showed that the mandibular canal was located close to the lingual cortical plate (almost 2-3 mm) in the molar region and as it proceeds anteriorly it moves toward the buccal aspect of the mandible to emerge finally through the mental foramen. The vertical dimension showed that the canal was located almost 1 cm above the inferior border of the mandible and then ascended to reach the mental foramen, which is located 15.72mm (range 13.82-18.25 mm) above the inferior border of the mandible. Conclusions: Anatomic variations and lesions affecting the mandibular canal were common findings in the CBCT images of the mandible produced for dental implant planning. An awareness of these alterations is important for dentistry because some of them might require treatment, change oral surgery planning and difficult inferior alveolar nerve anesthetic block.
Background: Diabetes mellitus and smoking are considered as two major risk factors that influence... more Background: Diabetes mellitus and smoking are considered as two major risk factors that influence the severity and progression of periodontal disease. Severity and prevalence of periodontitis varies in different countries of the world and there are indications that may be extensive in developing more than high developed countries. Objective: The present study was designed to evaluate the periodontal conditions and severity of chronic periodontitis patients in relation to smoking and diabetes at Holy Mak-kah city. Materials and Methods: Two hundred and fifty-four patient adult male chronic periodon-titis patients were participated in this study, their age ranging from 24 to 60 years old with mean age of 37.50 ± 0.13 years. The patients were selected from enrolled individuals at screening unit in three dental centers at Makkah city. The selection of chronic periodon-titis patients were based on two major risk factors in presence or absence of smoking and diabetes mellitus and they categorized into the following four groups G1: Non diabetic nonsmokers, G2: Diabetic nonsmokers, G3: Non diabetic smokers, G4: Diabetic smokers. The periodontal status was evaluated by four clinical parameters: Plaque Index (PI), Bleeding Index (BI), Probing Pocket Depth (PD) and Clinical Attachment Loss (CAL). Results: The results were revealed the comparisons between the mean values of clinical parameters; PI was highly significant in G2 compared to G1 and G3. BI was significant in G2 versus to G1, and highly significant in G4 contrast to G1and G3. PD was significantly increased in G2 than G1, and highly significant in G4 related to G1, G2 and G3. CAL was significant in G4 compared to G3, highly significantly increased in G4 than G1 and G2, whereas, high significant in G4 contrast to G3. Severity forms of periodontitis in each group categorized into; mild, moderate and severe; G1 (60.72 %, 31.01%, 8.27 %), G2 (33.21%, 50.67 %, 16.12 %), G3 (37.02 %, 49.32 %, 13.66 %) and G4 (9.23 %, 50.42 %, 40.35 %). Severity of periodontitis in whole population; mild (35.04 %), moderate (45.36 %) and severe (19.60%). Conclusion: The clinical periodontal parameters represent poor periodontal conditions within the population, and presence of smoking and diabetes mellitus exaggerate the severity of periodontitis. Furthermore, widespread survey study is needed to clarify the percentage of prevalence, incidence and severity of periodontitis.
Background: Periodontal reconstructive therapy in furcation areas is highly interested in recent ... more Background: Periodontal reconstructive therapy in furcation areas is highly interested in recent years. There are several treatment modalities used alone and/or in combination to improved periodontal regeneration, including the bone substitutes as nanocrystalline hydroxyapatite (NcHA), guided tissue regeneration (GTR), root surface modifications, biological mediators and recently platelet rich fibrin (PRF).
Objectives The aim of this research was to study the intensity of cytokeratin 17 (CK17) in the pa... more Objectives The aim of this research was to study the intensity of cytokeratin 17 (CK17) in the parenchymal elements of rat’s submandibular salivary glands subjected to fractionated radiotherapy regimen that used for treatment of head and neck malignancy. Materials and Methods Twenty male albino rats were divided into two equal groups (normal and irradiated). The irradiated group received a radiation dose of 5 Grays daily for 5 days using therapeutic X-ray beam. Six months later, submandibular gland was dissected out and prepared for both histological and immunohistochemical studies. Results Submandibular gland of irradiated group showed two different types of histological alterations. The first alteration showed severe gland atrophy replaced by either fibrous or fatty tissues. In some sections, the gland exhibited proliferating activity in the form of profuse amounts of mitotic figures. Immunohistochemical examination of control glands displayed a mild cytoplasmic expression of CK17...
Background:Periodontal pathogens can induce
overproduction of free radicals and reactive
oxygen s... more Background:Periodontal pathogens can induce overproduction of free radicals and reactive oxygen species (ROS)that may increase periodontal tissue breakdown. Coenzyme Q10 (CoQ10) serves as potent endogenous antioxidant that act as a scavenger to ROS and may be suppress the periodontal inflammation. Aim:The present study was aimed to evaluate the clinical and immunologic effects of intrapocket application of CoQ10 as an adjunct to nonsurgical periodontal therapy. Materials and methods:Twenty eight mild to moderate chronic periodontitis patients with age ranged from 29 to 46 years. All individuals were carried out to scaling and root planning (SRP) and classified into group 1 (G1, treated by SRP only) and group 2 (G2, treated by COQ10 gel plus SRP). Clinical parameters; plaque index (PI), gingival index (GI), pocket depth (PD) and clinical attachment loss (CAL), in addition to gingival crevicularfluid (GCF) samples were obtained at baseline and 30days after treatment. Tumor necrosis factor- (TNF-) levels were evaluated by ELISA technique at both time intervals of periodontal therapy. Results: Clinical evaluation of both groups revealed a high significant improvement in all parameters at baseline and 30 days of treatment (P≤0.01). Whereas, more clinical improvement in G2 at 30 days compared to G1, but the difference was non-significant (P≥0.05). TNF- levels were significantly high reduced at 30 days versus to baseline in both groups (P≤0.01), in comparison between groups at 30 days TNF- levels reduced in G2 compared to G1, but there is no significant difference (P≥0.05). Conclusions:Topical application of CoQ10 as an adjunct to non-surgical periodontal therapy improve the clinical and immunologic findings, but it not considered a significantadjunct modality for periodontal therapy. Further studies needed to clarify clinical and immunological outcomes.
International Journal of Health Sciences & Research (www.ijhsr.org), 2017
Periodontitis is a chronic inflammatory disease that causes destruction of tooth-supporting tissu... more Periodontitis is a chronic inflammatory disease that causes destruction of tooth-supporting tissues. Interlukin-20 (IL-20) is a proinflammatory cytokine of the IL-10 family that is involved in some diseases; rheumatoid arthritis, psoriasis, and atherosclerosis. The purpose of this study was to evaluate the levels of IL-20 in gingival crevicular fluid (GCF) and serum of both chronic periodontitis patients and periodontal healthy subjects. Thirty systemically male subjects were categorized into group 1 (healthy) and group 2 (chronic periodontitis patients). The patients were clinically evaluated by; plaque index (PI), bleeding index (BI), probing pocket depth (PD) and clinical attachment loss (CAL). GCF and serum samples were obtained from all individuals to measure IL-20 levels by using of enzyme-linked immunosorbent assay (ELISA) technique. The levels of IL-20 in GCF were significantly higher in chronic periodontitis patients compared to healthy subjects (P ≤ 0.05). In addition, there was a positive correlation between GCF-IL-20 levels and PD (r = 0.800, P= 0.010). While, the serum levels of IL-20 in chronic periodontitis patients were not significant in comparison to healthy subjects (P ≥ 0.05). For Conclusion, significant increased levels of GCF-IL-20 in chronic periodontitis patients showed that IL-20 may have a role in pathogenesis of chronic periodontitis. Moreover, additional studies are required to clarify its role in periodontal diseases.
Objectives: The purpose of the present study was to determine the location and configuration of t... more Objectives: The purpose of the present study was to determine the location and configuration of the mandibular canal and related vital structures as a pre-implant assessment using Cone Beam Computed Tomography. Materials and Methods: 141CBCT scans were undertaken by Kodak 9500® Cone Beam 3D Systems and the scanning parameters were 90 kV, 10 mA, voxel size 0.2 mm and medium field of view. Results: The course of the mandibular canal reported (61.17%) catenary-like, (28.19%) progressive descent and (10.64%) had a straight pattern. The buccolingual dimension showed that the mandibular canal was located close to the lingual cortical plate (almost 2-3 mm) in the molar region and as it proceeds anteriorly it moves toward the buccal aspect of the mandible to emerge finally through the mental foramen. The vertical dimension showed that the canal was located almost 1 cm above the inferior border of the mandible and then ascended to reach the mental foramen, which is located 15.72mm (range 13.82-18.25 mm) above the inferior border of the mandible. Conclusions: Anatomic variations and lesions affecting the mandibular canal were common findings in the CBCT images of the mandible produced for dental implant planning. An awareness of these alterations is important for dentistry because some of them might require treatment, change oral surgery planning and difficult inferior alveolar nerve anesthetic block.
Background: Diabetes mellitus and smoking are considered as two major risk factors that influence... more Background: Diabetes mellitus and smoking are considered as two major risk factors that influence the severity and progression of periodontal disease. Severity and prevalence of periodontitis varies in different countries of the world and there are indications that may be extensive in developing more than high developed countries. Objective: The present study was designed to evaluate the periodontal conditions and severity of chronic periodontitis patients in relation to smoking and diabetes at Holy Mak-kah city. Materials and Methods: Two hundred and fifty-four patient adult male chronic periodon-titis patients were participated in this study, their age ranging from 24 to 60 years old with mean age of 37.50 ± 0.13 years. The patients were selected from enrolled individuals at screening unit in three dental centers at Makkah city. The selection of chronic periodon-titis patients were based on two major risk factors in presence or absence of smoking and diabetes mellitus and they categorized into the following four groups G1: Non diabetic nonsmokers, G2: Diabetic nonsmokers, G3: Non diabetic smokers, G4: Diabetic smokers. The periodontal status was evaluated by four clinical parameters: Plaque Index (PI), Bleeding Index (BI), Probing Pocket Depth (PD) and Clinical Attachment Loss (CAL). Results: The results were revealed the comparisons between the mean values of clinical parameters; PI was highly significant in G2 compared to G1 and G3. BI was significant in G2 versus to G1, and highly significant in G4 contrast to G1and G3. PD was significantly increased in G2 than G1, and highly significant in G4 related to G1, G2 and G3. CAL was significant in G4 compared to G3, highly significantly increased in G4 than G1 and G2, whereas, high significant in G4 contrast to G3. Severity forms of periodontitis in each group categorized into; mild, moderate and severe; G1 (60.72 %, 31.01%, 8.27 %), G2 (33.21%, 50.67 %, 16.12 %), G3 (37.02 %, 49.32 %, 13.66 %) and G4 (9.23 %, 50.42 %, 40.35 %). Severity of periodontitis in whole population; mild (35.04 %), moderate (45.36 %) and severe (19.60%). Conclusion: The clinical periodontal parameters represent poor periodontal conditions within the population, and presence of smoking and diabetes mellitus exaggerate the severity of periodontitis. Furthermore, widespread survey study is needed to clarify the percentage of prevalence, incidence and severity of periodontitis.
Background: Periodontal reconstructive therapy in furcation areas is highly interested in recent ... more Background: Periodontal reconstructive therapy in furcation areas is highly interested in recent years. There are several treatment modalities used alone and/or in combination to improved periodontal regeneration, including the bone substitutes as nanocrystalline hydroxyapatite (NcHA), guided tissue regeneration (GTR), root surface modifications, biological mediators and recently platelet rich fibrin (PRF).
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overproduction of free radicals and reactive
oxygen species (ROS)that may increase
periodontal tissue breakdown. Coenzyme Q10
(CoQ10) serves as potent endogenous antioxidant
that act as a scavenger to ROS and may be suppress
the periodontal inflammation.
Aim:The present study was aimed to evaluate the
clinical and immunologic effects of intrapocket
application of CoQ10 as an adjunct to nonsurgical
periodontal therapy.
Materials and methods:Twenty eight mild to
moderate chronic periodontitis patients with age
ranged from 29 to 46 years. All individuals were
carried out to scaling and root planning (SRP) and
classified into group 1 (G1, treated by SRP only)
and group 2 (G2, treated by COQ10 gel plus SRP).
Clinical parameters; plaque index (PI), gingival index (GI), pocket depth (PD) and clinical
attachment loss (CAL), in addition to gingival
crevicularfluid (GCF) samples were obtained at
baseline and 30days after treatment. Tumor
necrosis factor- (TNF-) levels were evaluated by
ELISA technique at both time intervals of
periodontal therapy.
Results: Clinical evaluation of both groups
revealed a high significant improvement in all
parameters at baseline and 30 days of treatment
(P≤0.01). Whereas, more clinical improvement in
G2 at 30 days compared to G1, but the difference
was non-significant (P≥0.05). TNF- levels were
significantly high reduced at 30 days versus to
baseline in both groups (P≤0.01), in comparison
between groups at 30 days TNF- levels reduced in
G2 compared to G1, but there is no significant
difference (P≥0.05). Conclusions:Topical application of CoQ10 as an adjunct to non-surgical periodontal therapy
improve the clinical and immunologic findings, but
it not considered a significantadjunct modality for
periodontal therapy. Further studies needed to
clarify clinical and immunological outcomes.
canal and related vital structures as a pre-implant assessment using Cone Beam Computed Tomography.
Materials and Methods: 141CBCT scans were undertaken by Kodak 9500® Cone Beam 3D Systems and the
scanning parameters were 90 kV, 10 mA, voxel size 0.2 mm and medium field of view.
Results: The course of the mandibular canal reported (61.17%) catenary-like, (28.19%) progressive descent and
(10.64%) had a straight pattern. The buccolingual dimension showed that the mandibular canal was located close
to the lingual cortical plate (almost 2-3 mm) in the molar region and as it proceeds anteriorly it moves toward
the buccal aspect of the mandible to emerge finally through the mental foramen. The vertical dimension showed
that the canal was located almost 1 cm above the inferior border of the mandible and then ascended to reach the
mental foramen, which is located 15.72mm (range 13.82-18.25 mm) above the inferior border of the mandible.
Conclusions: Anatomic variations and lesions affecting the mandibular canal were common findings in the
CBCT images of the mandible produced for dental implant planning. An awareness of these alterations is important
for dentistry because some of them might require treatment, change oral surgery planning and difficult
inferior alveolar nerve anesthetic block.
overproduction of free radicals and reactive
oxygen species (ROS)that may increase
periodontal tissue breakdown. Coenzyme Q10
(CoQ10) serves as potent endogenous antioxidant
that act as a scavenger to ROS and may be suppress
the periodontal inflammation.
Aim:The present study was aimed to evaluate the
clinical and immunologic effects of intrapocket
application of CoQ10 as an adjunct to nonsurgical
periodontal therapy.
Materials and methods:Twenty eight mild to
moderate chronic periodontitis patients with age
ranged from 29 to 46 years. All individuals were
carried out to scaling and root planning (SRP) and
classified into group 1 (G1, treated by SRP only)
and group 2 (G2, treated by COQ10 gel plus SRP).
Clinical parameters; plaque index (PI), gingival index (GI), pocket depth (PD) and clinical
attachment loss (CAL), in addition to gingival
crevicularfluid (GCF) samples were obtained at
baseline and 30days after treatment. Tumor
necrosis factor- (TNF-) levels were evaluated by
ELISA technique at both time intervals of
periodontal therapy.
Results: Clinical evaluation of both groups
revealed a high significant improvement in all
parameters at baseline and 30 days of treatment
(P≤0.01). Whereas, more clinical improvement in
G2 at 30 days compared to G1, but the difference
was non-significant (P≥0.05). TNF- levels were
significantly high reduced at 30 days versus to
baseline in both groups (P≤0.01), in comparison
between groups at 30 days TNF- levels reduced in
G2 compared to G1, but there is no significant
difference (P≥0.05). Conclusions:Topical application of CoQ10 as an adjunct to non-surgical periodontal therapy
improve the clinical and immunologic findings, but
it not considered a significantadjunct modality for
periodontal therapy. Further studies needed to
clarify clinical and immunological outcomes.
canal and related vital structures as a pre-implant assessment using Cone Beam Computed Tomography.
Materials and Methods: 141CBCT scans were undertaken by Kodak 9500® Cone Beam 3D Systems and the
scanning parameters were 90 kV, 10 mA, voxel size 0.2 mm and medium field of view.
Results: The course of the mandibular canal reported (61.17%) catenary-like, (28.19%) progressive descent and
(10.64%) had a straight pattern. The buccolingual dimension showed that the mandibular canal was located close
to the lingual cortical plate (almost 2-3 mm) in the molar region and as it proceeds anteriorly it moves toward
the buccal aspect of the mandible to emerge finally through the mental foramen. The vertical dimension showed
that the canal was located almost 1 cm above the inferior border of the mandible and then ascended to reach the
mental foramen, which is located 15.72mm (range 13.82-18.25 mm) above the inferior border of the mandible.
Conclusions: Anatomic variations and lesions affecting the mandibular canal were common findings in the
CBCT images of the mandible produced for dental implant planning. An awareness of these alterations is important
for dentistry because some of them might require treatment, change oral surgery planning and difficult
inferior alveolar nerve anesthetic block.