- Iraq-Thiqar
- 009647831066659
Bassam Abdulhussein Hasan Alsafee
University of Thi-Qar, Iraq, Chemistry, Faculty Member
- Lecturer in a college of Pharmacy MSc organic chemistryedit
Thymus vulgaris and Luarel (Laurus nobilis) leaves belong to Lamiaceae and Lauraceae family respectively. Both are popular plant in Iraq and main vegetable used in Iraqis food and cooking. Both leaves mentioned above possess... more
Thymus vulgaris and Luarel (Laurus nobilis) leaves belong to Lamiaceae and Lauraceae family respectively. Both are popular plant in Iraq and main vegetable used in Iraqis food and cooking. Both leaves mentioned above possess antibacterial, antiviral and antifungal functions and in commercial medicine as an essential component. Thymus vulgaris and Luarel (Laurus nobilis) leaves were extracted through cold method of extraction by acetone which called maceration. Then Phytochemical tests applied where showed present and absent some chemical compound as showed in table 1 and 2. In vitro antibacterial activity results were summarized in table 2, of Thymus vulgaris and Luarel leaves against some pathogenic bacterial strains Klebsiella, E. coli which separated from patients urine.
The present article reports the design of new fused, heterocyclic compounds by cyclocondensation. The structures formulae of designed compounds were identified by 1H-NMRe spectrum Ft-IR spectrum and C, H, N elemental analysis.... more
The present article reports the design of new fused, heterocyclic compounds by cyclocondensation. The structures formulae of designed compounds were identified by 1H-NMRe spectrum Ft-IR spectrum and C, H, N elemental analysis. Antibacterial activity of fused, heterocyclic studied against some pathogenic bacterial strains isolated from patients like E. coli, Klebsiellaae, Acinetobacter, Aeromonas, Staphylococcus and Streptococcus. Eventually, antibacterial of the fused heterocyclic compounds was exhibited significant growth inhibition against some pathogenic bacteria which considered an important source of new Antibacterial compounds. The results of such studies are discussed in this paper.
Sulfonamide group is a magic group introduced as the main core for different bioactivities in drug industry. Pharmacologically and according to its substitution, sulfonamide derivatives could be divided into antibacterial sulfonamides and... more
Sulfonamide group is a magic group introduced as the main core for different bioactivities in drug industry. Pharmacologically and according to its substitution, sulfonamide derivatives could be divided into antibacterial sulfonamides and non-anti-bacterial sulfonamides, the later includes a wide range of medical uses such as anti diabetic agents ,carbonic anhydrase inhibitors , antihypertensive, antiviral, anti-impotence agent , high-ceiling diuretics, antiepileptic's and anticancer agents. These different pharmacological properties were found through the serial derivitization of the basic chemical nucleus of sulfanilamide, which indicate that these group has the ability to interacts with different targets. The anticancer activity of sulfonamides derivatives were produced by different mechanism of actions such inhibition of carbonic anhydrase (CA) enzymes, arresting the cell cycle in the G1 phase, and microtubules disruption. In this review, we try to summarizes and classify the different mechanisms by which sulfonamides derivatives produce there antitumor activity with illustration of the most important derivatives in each mechanism.
Ginkgo biloba is a bioactive tree members of the family Ginkgoaceae. The absence of saponins, terpenoidss,co umarrins, proteinss,sterols, and anthraquinones was shown by phytoconstiunts screened from dried ginkgo bil oba leaves at the... more
Ginkgo biloba is a bioactive tree members of the family Ginkgoaceae. The absence of saponins, terpenoidss,co umarrins, proteinss,sterols, and anthraquinones was shown by phytoconstiunts screened from dried ginkgo bil oba leaves at the beginning of this research. Alkaloids, flavonoids, carbohydrates, tannins , glycosides and polyp henols are present. (flavanone glycoside) was subsequently extracted and isolated from dried ginkgo biloba leaf and distinguished by Ft-IR , Thin LC , melting point, lab testing spectra.
Grapefruit belongs to the Rutaceae family of bioactive citrus fruits. The absence of saponins, coumarins, terpenoids, sterols, proteins and ant hraquinones was shown by phytochemical screening of dried grapefruit peels at the beginning of... more
Grapefruit belongs to the Rutaceae family of bioactive citrus fruits. The absence of saponins, coumarins, terpenoids, sterols, proteins and ant hraquinones was shown by phytochemical screening of dried grapefruit peels at the beginning of this research. Alkaloids, flavonoids, sugars, tan nins , glycosides, and polyphenols are present. Naringenin (flavanone) and Naringin (glycoside flavanone) were subseq uently extracted and isolated from dried grapefruit (citrus fruit) peels. Spectra of FT_iR , thin layer chromotography TLC , point of melting and chemical examination testing its calculated. Over timee, certain pathogenic bacterial strains isolated from patients suc h as E.colii,Acinetobacter, Klebsiellla, Streptococcuus, Staphylococcus, Aeromonas have been studied against the antibacterial activity of Naringe nin and Naringenin. Naringenin (flavanone) subsequently demonstrated higher biological activity than the drugs Naringin and Cefuroxime.
Sulfonamides are one of the organosulphur compounds containing the-SO2NH2 and/or-SO2NH
Research Interests:
The present article reports the design of new fused, heterocyclic compounds by cyclocondensation. The structures formulae of designed compounds were identified by 1H-NMRe spectrum Ft-IR spectrum and C, H, N elemental analysis.... more
The present article reports the design of new fused, heterocyclic compounds by cyclocondensation. The structures formulae of designed compounds were identified by 1H-NMRe spectrum Ft-IR spectrum and C, H, N elemental analysis. Antibacterial activity of fused, heterocyclic studied against some pathogenic bacterial strains isolated from patients like E. coli, Klebsiellaae, Acinetobacter, Aeromonas, Staphylococcus and Streptococcus. Eventually, antibacterial of the fused heterocyclic compounds was exhibited significant growth inhibition against some pathogenic bacteria which considered an important source of new Antibacterial compounds. The results of such studies are discussed in this paper.
Research Interests:
The present article reports the design of new fused, heterocyclic compounds by cyclocondensation. The structures formulae of designed compounds were identified by 1H-NMRe spectrum Ft-IR spectrum and C, H, N elemental analysis.... more
The present article reports the design of new fused, heterocyclic compounds by cyclocondensation. The structures formulae of designed compounds were identified by 1H-NMRe spectrum Ft-IR spectrum and C, H, N elemental analysis. Antibacterial activity of fused, heterocyclic studied against some pathogenic bacterial strains isolated from patients like E. coli, Klebsiellaae, Acinetobacter, Aeromonas, Staphylococcus and Streptococcus. Eventually, antibacterial of the fused heterocyclic compounds was exhibited significant growth inhibition against some pathogenic bacteria which considered an important source of new Antibacterial compounds. The results of such studies are discussed in this paper.
Research Interests:
103 Synthesis , Identification and Antibactrial Activity of Some New Heterocyclic Compounds Contaning 1,3,4-Thiadiazole and 1,3,4-Oxadiazole Bearing Schiff Base Bassam Abdulhussein Hasan Alsafee1 , Maitham M. Abdulridha2, Ali Taher... more
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Synthesis , Identification and Antibactrial Activity of Some New Heterocyclic Compounds Contaning 1,3,4-Thiadiazole and 1,3,4-Oxadiazole Bearing Schiff Base
Bassam Abdulhussein Hasan Alsafee1 , Maitham M. Abdulridha2, Ali Taher Abbas3.
Thi-qar University ,College of Pharmacy 1,3, Technical institute of alshatra2, , Iraq 123
Author Email : Bassam_org@yahoo.com
Keywords:Antibacterial.Identification.Oxadiazole. Schiff bases. Syntheses .Thiadiazole
Abstract
1,3,4 -thiadiazole and 1,3,4 –Oxadiazole bearing Schiff bases derivatives were prepared in our study by reacting the 1,3,4 – thiadiazole part with 1,3,4-oxadiazole part in ethanol to produce 1,3,4-oxadiazole hydrazinyl-1,3,4-thiadiazole [C]. which were treated with aromatic aldehyde to produce of 1,3,4- thiadiazole hydrazinyl 1,3,4- oxadiazole bearing Schiff base D1 and D2 ,The structures of synthesized compound D1 and D2 have been identified on the principles of their mass, 1H-NMR,Ft-IR, Mass spectrum and C, H, N elemental analysis .The synthesized compounds C and D1 Which founded have a strong antimicrobial activity, were assessed to their antibacterial activity by inhibition the growth of 3 strains of Gram negative bacteria Pseudomonas auerogenosia , Escherichia coli and one strain which produce enzyme called extended spectrum Beta lactemse (ESBLs) and 2 strains of Gram positive bacteria such as Bacillus cereus and Staphylococcus aureus. Therefore the chemical compound [C] and [D1] it's an important source of new antimicrobial compounds to treat bacterial
Synthesis , Identification and Antibactrial Activity of Some New Heterocyclic Compounds Contaning 1,3,4-Thiadiazole and 1,3,4-Oxadiazole Bearing Schiff Base
Bassam Abdulhussein Hasan Alsafee1 , Maitham M. Abdulridha2, Ali Taher Abbas3.
Thi-qar University ,College of Pharmacy 1,3, Technical institute of alshatra2, , Iraq 123
Author Email : Bassam_org@yahoo.com
Keywords:Antibacterial.Identification.Oxadiazole. Schiff bases. Syntheses .Thiadiazole
Abstract
1,3,4 -thiadiazole and 1,3,4 –Oxadiazole bearing Schiff bases derivatives were prepared in our study by reacting the 1,3,4 – thiadiazole part with 1,3,4-oxadiazole part in ethanol to produce 1,3,4-oxadiazole hydrazinyl-1,3,4-thiadiazole [C]. which were treated with aromatic aldehyde to produce of 1,3,4- thiadiazole hydrazinyl 1,3,4- oxadiazole bearing Schiff base D1 and D2 ,The structures of synthesized compound D1 and D2 have been identified on the principles of their mass, 1H-NMR,Ft-IR, Mass spectrum and C, H, N elemental analysis .The synthesized compounds C and D1 Which founded have a strong antimicrobial activity, were assessed to their antibacterial activity by inhibition the growth of 3 strains of Gram negative bacteria Pseudomonas auerogenosia , Escherichia coli and one strain which produce enzyme called extended spectrum Beta lactemse (ESBLs) and 2 strains of Gram positive bacteria such as Bacillus cereus and Staphylococcus aureus. Therefore the chemical compound [C] and [D1] it's an important source of new antimicrobial compounds to treat bacterial
Research Interests:
1,3,4-oxadiazoles are important because of its versatile biological actions such as antimicrobial , antimalarial , anticonvulsant , hypoglycemic, also analgesic, anti-inflammatory, anticancer, anti-HIV agent .In the present study The... more
1,3,4-oxadiazoles are important because of its versatile biological actions such as antimicrobial , antimalarial
, anticonvulsant , hypoglycemic, also analgesic, anti-inflammatory, anticancer, anti-HIV agent
.In the present study The solid complexes of Fe(II), Cr(III), Co(II), Ni(II), and Cu(II)) with Synthesis of 4-[(5-
ethyl-1,3,4-oxadiazol-2-yl)sulfanyl]aniline have been synthesized and characterized by using the spectroscopic
IR,1HNMR, Mass as well as by elemental analyses C,H,N and Molar conductance they were
studied . It may be concluded that the ligands coordinate through Nitrogen and Sulfur as atoms shown
in Scheme (2). For all the complexes. The ligand acts as a didentate ligand coordinating through the
oxadiazole nitrogen and the Sulfur atom of 2-sulfanyl. This view is further supported by the appearance
of a band corresponding to the metal–nitrogen and the metal–Sulfur stretching vibration at 503–553
cm–1 and 474-484 cm–1 in the complexes. The physicochemical data suggest the octahedral geometry
for all complexes except for Ni and Ca complexes which where tetrahedral respectively.
, anticonvulsant , hypoglycemic, also analgesic, anti-inflammatory, anticancer, anti-HIV agent
.In the present study The solid complexes of Fe(II), Cr(III), Co(II), Ni(II), and Cu(II)) with Synthesis of 4-[(5-
ethyl-1,3,4-oxadiazol-2-yl)sulfanyl]aniline have been synthesized and characterized by using the spectroscopic
IR,1HNMR, Mass as well as by elemental analyses C,H,N and Molar conductance they were
studied . It may be concluded that the ligands coordinate through Nitrogen and Sulfur as atoms shown
in Scheme (2). For all the complexes. The ligand acts as a didentate ligand coordinating through the
oxadiazole nitrogen and the Sulfur atom of 2-sulfanyl. This view is further supported by the appearance
of a band corresponding to the metal–nitrogen and the metal–Sulfur stretching vibration at 503–553
cm–1 and 474-484 cm–1 in the complexes. The physicochemical data suggest the octahedral geometry
for all complexes except for Ni and Ca complexes which where tetrahedral respectively.
Oranges, fruits are bioactive citrus fruits belong to the Rutaceae, family. At the beginning of this study, Phytochemical screened of dried oranges peels showed the absence of coumarins, saponins, sterols, terpenoids, anthraqui-nones and... more
Oranges, fruits are bioactive citrus fruits belong to the Rutaceae, family. At the beginning of this study, Phytochemical screened of dried oranges peels showed the absence of coumarins, saponins, sterols, terpenoids, anthraqui-nones and protein. While the presence of flavonoids, alkaloids, carbohydrate, glycosides, tannins, polyphenol. Afterwards, Hesperetin (flavanone) and hes-peridins (flavanone glycoside) were extracted and isolated from dried oranges peels (citrus fruits) and characterized by FTIR spectra, TLC, melting point, Chemical test. In time antibacterial activity of Hesperetin and hesperi-dins studied against some pathogenic bacterial strains isolated from patients like Streptococcus, Acinetobacter, E.coli, Klebsiella, Staphylococcus, Aer-omonas. Eventually, Hesperetin (flavanone) showed a Higher biological activity significant than hesperidins and cefuroxime drugs.
Research Interests:
Black pepper (Piper nigrum) is belong to the Piperaceae family. Its a spices crop, which is used as to enhancing the digestion of food and an essential component in commercial medicine. The aim of this study to show the antibacterial... more
Black pepper (Piper nigrum) is belong to the Piperaceae family. Its a spices crop, which is used as to enhancing the digestion of food and an essential component in commercial medicine. The aim of this study to show the antibacterial activity of black pepper and the active compound of its (piperine alkaloid) and identify the structure by reagents, TLC technique and melting point. Antibacterial activity was checked) against. E.coli, Staphylococcus aureus, Pseudomonaas, Streptococcus, Aeromonnas, Klebsiellae, Acinetobacter, which were showed a good biological activity significant of piperine alkaloids compared to crude black pepper and synthetic drugs cefuroxime.
Research Interests:
Pegnum harmala is belong to Zygophyllaceaee family. It is a wild growing flowering plant which is possess antimicrobial functions and an essential component in commercial medicine, Traditionally revealed the smoke of its seeds is used as... more
Pegnum harmala is belong to Zygophyllaceaee family. It is a wild growing flowering plant which is possess antimicrobial functions and an essential component in commercial medicine, Traditionally revealed the smoke of its seeds is used as antiseptic. The aim of this study: harmala alkaloids (Harmaline, Harmalol, Harmol, Harmane, Harmine, tetra hydroharmine, acisine, acisinone) were isolated and chemically identified from Pegnum harmala seeds. Phytochemical screening of Pegnum harmala seeds showed the absence of flavonoids, Coumarin and resins and presence of alkaloids, saponins, tannins, glycosides, anthraquinons, terpenoids and steroids. In vitro antibacterial activity results were summarized in table 3 of Peganum harmala and its alkaloids against some pathogenic bacterial strains isolated from patients Streptococcus, Staphylococcus, Aeromonas, E.coli, klebsiella, Acinetobacter.
Research Interests:
Menthe and olive leaves is belong to Lamiaceae and Olea europaea family respectively. both a popular plant in Iraq and which. is possess antimicrobial, insecticidal properties and antifungal functions and an essential component in... more
Menthe and olive leaves is belong to Lamiaceae and Olea europaea family respectively. both a popular plant in Iraq and which. is possess antimicrobial, insecticidal properties and antifungal functions and an essential component in commercial..medicine, The aim. of this study: Menthe and olive leaves were extracted by acetone through cold method of extraction called maceration and screened Phytochemical to showed present and absent some chemical compound as showed in table no 1,2. In vitro antibacterial activity results were summarized in table No2.of Menthe and olive leaves against some pathogenic bacterial strains E.coli, klebsiella which separated from patients urine.
Research Interests:
1,3,4-Thiadiazole and 1,3,4-Oxadiazole five-member heterocyclic which has multi bioactivity like antibacterial, antidepressant, antidiabetic and antifungal activities. At the beginning of this study, 1,3,4-Thiadiazole containing 1,3,4-... more
1,3,4-Thiadiazole and 1,3,4-Oxadiazole five-member heterocyclic which has multi bioactivity like antibacterial,
antidepressant, antidiabetic and antifungal activities. At the beginning of this study, 1,3,4-Thiadiazole containing 1,3,4-
Oxadiazole derivatives bearing Schiff bases have been synthesized(TOSB). Afterwards, The chemical structures of a
synthesized compound identified on the principles of their 1H-NMR, Ft-IR, Mass spectrum and C, H, N elemental
analysis. In time antibacterial activity of 1,3,4-Thiadiazole containing 1,3,4-Oxadiazole Bearing Schiff Base (TOSB1) and
1,3,4-Thiadiazole Bearing Schiff Base (HTSB) studied against some pathogenic bacterial strains isolated from patients
like Streptococcus, Acinetobacter, E.coli, Klebsiella,Staphylococcus, Aeromonas. Eventually, In time antibacterial
activity of 1,3,4-Thiadiazole containing 1,3,4-Oxadiazole Bearing Schiff Base (TOSB) showed a Higher biological
activity significant than 1,3,4-Thiadiazole Bearing Schiff Base (HTSB). Therefore the chemical compound(TOSB) an
important source of new antimicrobial compounds to treat bacteria.
antidepressant, antidiabetic and antifungal activities. At the beginning of this study, 1,3,4-Thiadiazole containing 1,3,4-
Oxadiazole derivatives bearing Schiff bases have been synthesized(TOSB). Afterwards, The chemical structures of a
synthesized compound identified on the principles of their 1H-NMR, Ft-IR, Mass spectrum and C, H, N elemental
analysis. In time antibacterial activity of 1,3,4-Thiadiazole containing 1,3,4-Oxadiazole Bearing Schiff Base (TOSB1) and
1,3,4-Thiadiazole Bearing Schiff Base (HTSB) studied against some pathogenic bacterial strains isolated from patients
like Streptococcus, Acinetobacter, E.coli, Klebsiella,Staphylococcus, Aeromonas. Eventually, In time antibacterial
activity of 1,3,4-Thiadiazole containing 1,3,4-Oxadiazole Bearing Schiff Base (TOSB) showed a Higher biological
activity significant than 1,3,4-Thiadiazole Bearing Schiff Base (HTSB). Therefore the chemical compound(TOSB) an
important source of new antimicrobial compounds to treat bacteria.