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2009, Indian Journal of Pharmaceutical Sciences
Journal of Young Pharmacists
Antiinflammatory activity of aqueous extract of barleria cristata leaves2009 •
Since ages Mallotus peltatus (Geist) Muell. Arg. var acuminatus (Euphorbiaceae) leaf and stem bark is used in folk medicine to cure intestinal ailments and skin infections. In several intestinal ailments, localized inflammation is of common occurrence and hence we have evaluated the antimicrobial as well as anti-inflammatory activity of M. peltatus leaf extract. The crude methanol extract of M. peltatus leaves was found to be active against Staphylococcus aureus , Staphylococcus saprophyticus , Streptococcus faecalis , Bacillus subtilis , Escherichia coli and Proteus mirabilis and the dermatophytic fungi Microsporum gypseum. The minimum inhibitory concentration (MIC) ranges from 128 to 2000 mg ml1 for bacteria and 128 mg ml1 for fungi, while the minimum bactericidal concentration (MBC) was 2/4-fold higher than MIC. The methanol/water fraction of the extract showed similar activity against Staphylococcus, Streptococcus , Bacillus and Proteus isolates. The anti-inflammatory activity of the extract against carrageenan (acute model) and dextran-induced (subacute model) rat paw oedema and cotton pellet-induced granuloma (chronic model) in rats were studied using indomethacin (10 mg kg1), a nonsteroid anti-inflammatory drug, as standard. The methanol extract at 200 and 400 mg kg1, and the n-butanol fractions A and B at 25 mg kg1, exhibited significant anti-inflammatory activity in Albino rats, compared with indomethacin. Phytochemical study revealed the presence of tannins, saponins, terpenoids, steroids and reducing sugars in the crude extract while the n-butanol fractions showed the presence of ursolic acid, b-sitosterol and some fatty acids as major compounds. Further study with fractions showed that the antibacterial and anti-inflammatory activity is due to either fraction A (ursolic acid) alone or the combination of fractions A and B (b-sitosterol and fatty acids) of the extract.
The present study was carried out to evaluate the anti-inflammatory and antipyretic properties of the aqueous leaf extract of H. rostellatus. Carrageenan-induced hind paw edema in rats, xylene-induced ear oedema in mice and cotton pellet-induced granuloma formation in rats were used to investigate anti-inflammatory activity, and brewer’s yeast-induced pyrexia in mice was used to determine antipyretic effect. Oral administration of the plant extract (50 and 100 mg/kg) exhibited a significant (p<0.05) inhibition of paw edema induced by carrageenan with a maximum inhibition of 62.68% recorded with the dose 100 mg/kg compared to the control. In the xylene-induced edema test, the extract at the same doses, also exhibited an anti-inflammatory activity. It was also demonstrate that H. rostellatus extract at similar doses reduced glaucomatous tissue formation in cotton pelletinduced granuloma test. These results indicate that the aqueous leaf extract of H. rostellatus possess anti-inflammatory and antipyretic properties
2010 •
Evidence-Based Complementary and Alternative Medicine
Inhibition of NO2, PGE2, TNF-𝜶, and iNOS EXpression by Shorea robusta L.: An Ethnomedicine Used for Anti-Inflammatory and Analgesic Activity2012 •
This paper is an attempt to evaluate the anti-inflammatory and analgesic activities and the possible mechanism of action of tender leaf extracts ofShorea robusta, traditionally used in ailments related to inflammation. The acetic-acid-induced writhing and tail flick tests were carried out for analgesic activity, while the anti-inflammatory activity was evaluated in carrageenan-and dextran- induced paw edema and cotton-pellet-induced granuloma model. The acetic-acid-induced vascular permeability, erythrocyte membrane stabilization, release of proinflammatory mediators (nitric oxide and prostaglandin E2), and cytokines (tumor necrosis factor-α, and interleukins-1β and -6) from lipopolysaccharide-stimulated human monocytic cell lines were assessed to understand the mechanism of action. The results revealed that both aqueous and methanol extract (400 mg/kg) caused significant reduction of writhing and tail flick, paw edema, granuloma tissue formation (P<0.01), vascular permeability, ...
2008 •
Summary The ethanol extract of Pongamia glabra Vent leaf gall (PG) was investigated for anti-inflammatory and analgesic activity at the doses (po) of 100, 200, and 400 mg/kg body weight. For evaluation of inflammation carrageenan-, histamine-and serotonininduced ...
Saudi Journal of Biological Sciences
Analgesic and anti-inflammatory studies of cyclopeptide alkaloid fraction of leaves of Ziziyphus nummularia2013 •
British Journal of Nutrition
α-Lipoic acid has anti-inflammatory and anti-oxidative properties: an experimental study in rats with carrageenan-induced acute and cotton pellet-induced chronic inflammations2011 •
Journal of Biologically Active Products from Nature
Evaluation of Anti-inflammatory Activity of Ficus benghalensis in Rats2012 •
Advances in pharmacological sciences
Analgesic and Anti-Inflammatory Activity of Pinus roxburghii Sarg2012 •
Anais da Academia Brasileira de Ciências
Anti-inflammatory effect of the ethanolic extract from Bowdichia virgilioides H.B.K stem bark2010 •
Environmental Toxicology and Pharmacology
Anti-inflammatory activity of four solvent fractions of ethanol extract of Mentha spicata L. investigated on acute and chronic inflammation induced rats2008 •
Medical Principles and Practice
Anti-Inflammatory and Antinociceptive Effects of Mitragyna speciosa Korth Methanolic Extract2009 •
Journal of Ethnopharmacology
Lysosomal membrane stabilization and anti-inflammatory activity of Clerodendrum phlomidis L.f., a traditional medicinal plant2011 •
Journal of Ethnopharmacology
Anti-inflammatory activity of Trichodesma indicum root extract in experimental animals2006 •
Journal of Ethnopharmacology
Anti-inflammatory activity of Dalbergia lanceolaria bark ethanol extract in mice and rats2007 •
International Journal of Pharmaceutics & Pharmacology
Evaluation of the Anti-inflammatory Activity and Ulcerogenic Risk of Sarenta, an Ivorian Herbal PreparationJournal of ethnopharmacology
Anti-inflammatory and analgesic properties of the leaf extracts and essential oil of< i> Lavandula angustifolia</i> Mill2003 •
Journal of Ethnopharmacology
Antiinflammatory effect of the aqueous extract from Rumex patientia L . roots1999 •
2009 •
Indian Journal of Pharmaceutical Sciences
In vitro and in vivo antiinflammatory activity of Clerodendrum paniculatum linn. leaves2013 •
Journal of Ethnopharmacology
Anti-inflammatory activity of Albizia lebbeck Benth., an ethnomedicinal plant, in acute and chronic animal models of inflammation2009 •
Basic & Clinical Pharmacology & Toxicology
Anti-Inflammatory and Analgesic Activities of the Aqueous Extract of Acacia karroo Stem Bark in Experimental Animals2008 •
Journal of Ethnopharmacology
Studies on the analgesic, anti-inflammatory and antipyretic effects of Parquetina nigrescens leaf extract2009 •
Revista Brasileira de Farmacognosia
Anti-inflammatory and analgesic activities of Hypericum brasiliense (Willd) standardized extract2008 •