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The objective of this experiment was to produce triphenylmethyl methyl ether (TPMME) via an S n 1 substitution reaction. The " reflux " method was applied to run the reaction. Methanol was mixed with triphenylmethyl chloride (TPMCl) and then added to a round-bottom flask to be heated and boiled for fifteen minutes. During the fifteen minutes of boiling, the vapors travelled through a simple distillation apparatus, leaving TPMME in the flask to be crystallized. The TPMME was recrystallized using vacuum filtration and tested for purity using a TLC test. The theoretical yield of the TPMME (2.000g) was used to calculate the % yield (50.45%) based on the mass of the recovered TPMME (1.009g). The results of the TLC tests between the product, starting material and a sample of the two combined, concluded that the TPMME was pure. This was determined because the R f value of the product (0.568) was very similar to the R f value of the pure TPMME (0.523) that was separated from the combined sample. Even though the % yield was on the lower side, the sample produced showed to be very pure.
Physical, Thermal and Spectroscopical Characterization of Biofield Treated Triphenylmethane: An Impact of Biofield Treatment
Physical, Thermal and Spectroscopical Characterization of Biofield Treated Triphenylmethane: An Impact of Biofield TreatmentTriphenylmethane is a synthetic dye used as antimicrobial agent and for the chemical visualization in thin layer chromatography of higher fatty acids, fatty alcohols, and aliphatic amines. The present study was an attempt to investigate the impact of biofield treatment on physical, thermal and spectroscopical charecteristics of triphenylmethane. The study was performed in two groups i.e., control and treatment. The treatment group subjected to Mr. Trivedi’s biofield treatment. The control and treated groups of triphenylmethane samples were characterized using X-ray diffraction (XRD), surface area analyzer, differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), Fourier transform infrared (FT-IR), ultraviolet-visible (UV-Vis) spectroscopy, and gas chromatography-mass spectrometry (GC-MS). XRD study revealed decreases in average crystallite size (14.22%) of treated triphenylmethane as compared to control sample. Surface area analysis showed a slight increase (0.42%) in surface area of treated sample with respect to control. DSC thermogram of treated triphenylmethane showed the slight increase in melting point and latent heat of fusion with respect to control. TGA analysis of control triphenylmethane showed weight loss by 45.99% and treated sample showed weight loss by 64.40%. The Tmax was also decreased by 7.17% in treated sample as compared to control. The FT-IR and UV spectroscopic result showed the similar pattern of spectra. The GC-MS analysis suggested a significant decrease in carbon isotopic abundance (expressed in δ13C, ‰) in treated sample (about 380 to 524‰) as compared to control. Based on these results, it is found that biofield treatment has the impact on physical, thermal and carbon isotopic abundance of treated triphenylmethane with respect to control.
Triphenylmethane is a synthetic dye used as antimicrobial agent and for the chemical visualization in thin layer chromatography of higher fatty acids, fatty alcohols, and aliphatic amines. The present study was an attempt to investigate the impact of biofield treatment on physical, thermal and spectroscopical charecteristics of triphenylmethane. The study was performed in two groups i.e., control and treatment. The treatment group subjected to Mr. Trivedi’s biofield treatment. The control and treated groups of triphenylmethane samples were characterized using X-ray diffraction (XRD), surface area analyzer, differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), Fourier transform infrared (FT-IR), ultraviolet-visible (UV-Vis) spectroscopy, and gas chromatographymass spectrometry (GC-MS). XRD study revealed decreases in average crystallite size (14.22%) of treated triphenylmethane as compared to control sample. Surface area analysis showed a slight increase (0.42%) in surface area of treated sample with respect to control. DSC thermogram of treated triphenylmethane showed the slight increase in melting point and latent heat of fusion with respect to control. TGA analysis of control triphenylmethane showed weight loss by 45.99% and treated sample showed weight loss by 64.40%. The Tmax was also decreased by 7.17% in treated sample as compared to control. The FT-IR and UV spectroscopic result showed the similar pattern of spectra. The GC-MS analysis suggested a significant decrease in carbon isotopic abundance (expressed in δ13C, ‰) in treated sample (about 380 to 524‰) as compared to control. Based on these results, it is found that biofield treatment has the impact on physical, thermal and carbon isotopic abundance of treated triphenylmethane with respect to control.
Catalysis Today
The 11C-radioisotopic study of methanol conversion on V-MCM-41: The influence of methyl iodide on the transformation2009 •
Journal of Chromatography A
Reversed-phase thin-layer and gas chromatographic retention behaviour of triphenylmethane derivatives1990 •
Jpc-journal of Planar Chromatography-modern Tlc
Quantitative structure-retention relationship and 3D molecular modeling studies of the unusual chromatographic behavior of triphenylmethane derivatives in RPTLC systems2009 •
Dual retention behavior is observed for triphenylmethane (TPM) derivatives in RPTLC on silica gel plates when the composition of acetone–water mobile phases is varied. The physicochemical and molecular properties of the TPM derivatives causing this unusual retention behavior have been investigated by traditional quantita¬tive structure–retention relationship (QSRR) modeling and by 3D molecular modeling. The QSRR studies were performed by using PLS regression analysis based upon use of selected sets of Dragon molecular descriptors and pharmacokinetically relevant VolSurf descriptors to identify the physicochemical properties that govern chromatographic behavior. Comparative molecular similarity indices analysis (CoMSIA) was used to create the 3D isoenergy con¬tours of favored and unfavored contributions of the molecular fields around the molecules in the RPTLC systems used. The dual reten¬tion behavior of the TPM derivatives can be attributed to the propensity of these molecules to become oriented with different parts of their surface toward the silica gel layer when mobile phases with high or low water content are used. This hypothesis was sup¬ported by the 3D modeling results, which revealed that the isoener-gy contours of the electrostatic, hydrophobic, and hydrogen bond acceptor fields of CoMSIA around the molecules were very different in systems with high or low water content. Furthermore, the VolSurf descriptors, which represent pharmacokinetic properties, correlat¬ed better with RM values measured using mobile phases with high water content than with those measured using mobile phases with low water content, and thus may be related to chromatographic behavior. Statistically significant PLS models with high predictive power (q2 > 0.8) have been developed for prediction of RM values for the four mobile phases used. Lipophilicity was found to be the most important molecular property governing the retention of TPM derivatives.
Canadian Journal of Chemistry
An efficient and selective method for the preparation of triphenylmethyl ethers of alcohols and nucleosides2010 •
A very simple and efficient method is described for the protection of alcohols and nucleosides with benzyl monomethoxytrityl and benzyl dimethoxytrityl ethers in the presence of diethylazodicarboxylate and a catalytic amount of ceric triflate. High selectivity was observed for the tritylation of 5′-OH function of nucleosides.
Journal of Analytical Sciences, Methods and Instrumentation
Triphenylmethanol and Tris(2-(hydroxymethyl)phenol) Derivatives: Synthesis and Application as Indicators for Acid-Base Volumetric TitrationBulletin of the Chemical Society of Ethiopia
<b>A solvent free and selective method for preparation of triphenylmethyl ethers of alcohols and nucleosides</b>2010 •
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