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2018, Thorax
BackgroundA positional cloning study of bronchial hyper-responsiveness (BHR) at the 17p11 locus in the French Epidemiological study on the Genetics and Environment of Asthma (EGEA) families showed significant interaction between early-life environmental tobacco smoke (ETS) exposure and genetic variants located in DNAH9. This gene encodes the heavy chain subunit of axonemal dynein, which is involved with ATP in the motile cilia function.Our goal was to identify genetic variants at other genes interacting with ETS in BHR by investigating all genes belonging to the ‘ATP-binding’ and ‘ATPase activity’ pathways which include DNAH9, are targets of cigarette smoke and play a crucial role in the airway inflammation.MethodsFamily-based interaction tests between ETS-exposed and unexposed BHR siblings were conducted in 388 EGEA families. Twenty single-nucleotide polymorphisms (SNP) showing interaction signals (p≤5.10−3) were tested in the 253 Saguenay-Lac-Saint-Jean (SLSJ) families.ResultsOne ...
The European respiratory journal
Interaction between the DNAH9 gene and early smoke exposure in bronchial hyperresponsiveness2016 •
A previous genome-wide linkage scan of bronchial hyperresponsiveness (BHR) in the French Epidemiological study on the Genetics and Environment of Asthma (EGEA) families, performed in the presence of a gene×early-life environmental tobacco smoke (ETS) exposure interaction, showed the strongest interaction in the 17p11 region where linkage was detected only among unexposed siblings. Our goal was to conduct fine-scale mapping of 17p11 to identify single nucleotide polymorphisms (SNPs) interacting with ETS that influence BHR.Analyses were performed in 388 French EGEA asthmatic families, using a two-step strategy: 1) selection of SNPs displaying family-based association test (FBAT) association signals (p≤0.01) with BHR in unexposed siblings, and 2) a FBAT homogeneity test between exposed and unexposed siblings plus a robust log-linear interaction test.A single SNP reached the threshold (p≤3×10(-3)) for significant interaction with ETS using both interaction tests, after accounting for mu...
The European respiratory journal
Interaction between the <i>DNAH9</i> gene and early smoke exposure in bronchial hyperresponsiveness2016 •
Journal of Allergy and Clinical Immunology
Novel childhood asthma genes interact with in utero and early-life tobacco smoke exposure2013 •
2018 •
Asthma is a chronic inflammatory disease characterized by airway obstruction and hyper-responsiveness. It is a complex disorder influenced by genetic and environmental factors, which contribute to the clinical manifestations of asthma. Asthma may affect the lower respiratory tract, causing epithelial damage, mucus hyper-secretion, edema, bronchospasm, and airway remodeling. Genetic studies have uncovered single nucleotide polymorphisms (SNPs) associated with asthma. However, knowledge of the functional impact of these SNPs is lacking. Several genes associated with asthma have been well characterized on a functional level: ORMDL3, S1PR1, PHF11, F3, and ADAM33. Epigenetic modifications, which include DNA methylation, histone modification, and miRNA, affect transcriptional activity in multiple genetic pathways associated with the development of asthma. The aim of this paper is to describe the pathophysiology, etiology, genetics, and epigenetics of asthma and the factors contributing to...
2009 •
PLOS ONE
Adult onset asthma and interaction between genes and active tobacco smoking: The GABRIEL consortium2017 •
Pediatric Allergy and Immunology
Asthma severity, polymorphisms in 20p13 and their interaction with tobacco smoke exposure2013 •
2015 •
L'architettura delle città. the journal of the Scientific Society Ludovico Quaroni
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0506 715 53 10 Balıkesir Depo Isıtma Sistemleri
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Materials Circular Economy
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Openbaar Kunstbezit in Vlaanderen - brochure Arthur Merghelynck (1853-1908) Passies van een edelman
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Neuropharmacology
Auto-modulation of neuroactive steroids on GABAA receptors: A novel pharmacological effect2007 •
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Historical and Architectural Background of the Imperial palace and its surrounding building in Dire Dawa city
Historical and Architectural Background of the Imperial palace and its surrounding building in Dire Dawa city2024 •